Influence of dietary nitrate supplementation on physiological and cognitive responses to incremental cycle exercise.

Abstract:

:Dietary inorganic nitrate supplementation causes physiological effects which may enhance exercise tolerance. However it is not known whether nitrate might alter cognitive function during exercise. In a double-blind, cross-over study, sixteen subjects ingested either nitrate-rich beetroot juice or a placebo and completed a continuous cycle exercise test involving 20min stages at 50% and 70% V˙O2peak and a final stage at 90% V˙O2peak until volitional exhaustion. Cognitive tasks were completed before, during and after exercise. In the dietary nitrate condition: plasma [nitrite] increased (p<0.01), systolic blood pressure decreased (p<0.05) and there was a trend for a reduced oxygen uptake at 50% V˙O2peak. Tissue oxygenation improved across exercise intensities and exercise tolerance was greater at 90% V˙O2peak (p<0.05). Rating of perceived exertion, energy levels and cognitive performance were similar between conditions with mental fatigue being evident from 70% V˙O2peak onwards (p<0.05). Dietary nitrate supplementation enhanced short-term endurance exercise performance with concomitant mental fatigue but did not improve cognitive performance post-fatigue.

authors

Thompson KG,Turner L,Prichard J,Dodd F,Kennedy DO,Haskell C,Blackwell JR,Jones AM

doi

10.1016/j.resp.2013.12.015

subject

Has Abstract

pub_date

2014-03-01 00:00:00

pages

11-20

eissn

1569-9048

issn

1878-1519

pii

S1569-9048(13)00412-6

journal_volume

193

pub_type

杂志文章
  • Integration of hindbrain and carotid body mechanisms that control the autonomic response to cardiorespiratory and glucoprivic insults.

    abstract::Autonomic reflex responses are critical in restoring changes to circulatory factors reduced beyond the domain of homeostasis. Intermittent hypoxia triggers repeated activation of chemoreflexes, resulting in baroreflex dysfunction and widespread changes in cellular and neuronal activity regulated by sensory/motor pathw...

    journal_title:Respiratory physiology & neurobiology

    pub_type: 杂志文章,评审

    doi:10.1016/j.resp.2018.08.008

    authors: Kakall ZM,Cohen EM,Farnham MMJ,Kim SJ,Nedoboy PE,Pilowsky PM

    更新日期:2019-07-01 00:00:00

  • Long-term exposure to cigarette smoke impairs lung function and increases HMGB-1 expression in mice.

    abstract::Cigarette smoke (CS)-induced emphysema is caused by a continuous inflammatory response in the lower respiratory tract. The development of the condition is believed to be mediated by oxidant-antioxidant imbalance. This paper describes the effects of long-term CS exposure on alveolar cell recruitment, antioxidant defens...

    journal_title:Respiratory physiology & neurobiology

    pub_type: 杂志文章

    doi:10.1016/j.resp.2011.03.023

    authors: Bezerra FS,Valença SS,Pires KM,Lanzetti M,Pimenta WA,Schmidt AC,Porto LC,Zin WA

    更新日期:2011-07-31 00:00:00

  • Glucocorticoids inhibits the repair of airway epithelial cells via the activation of wnt pathway.

    abstract:BACKGROUND:The purpose of this study was to explore the effect of Wnt pathway on the inhibition of airway epithelial cells repair by glucocorticoid. MATERIALS AND METHODS:The expression of E-cadherin in asthma mice model was detected by immunocytochemistry. XAV939 was used to treat 16HBE, and the expressions of relate...

    journal_title:Respiratory physiology & neurobiology

    pub_type: 杂志文章

    doi:10.1016/j.resp.2019.103283

    authors: Yu Z,Jiang Y,Sun C

    更新日期:2020-01-01 00:00:00

  • Modelling pulmonary blood flow.

    abstract::Computational model analysis has been used widely to understand and interpret complexity of interactions in the pulmonary system. Pulmonary blood transport is a multi-scale phenomenon that involves scale-dependent structure and function, therefore requiring different model assumptions for the microcirculation and the ...

    journal_title:Respiratory physiology & neurobiology

    pub_type: 杂志文章,评审

    doi:10.1016/j.resp.2008.02.016

    authors: Tawhai MH,Burrowes KS

    更新日期:2008-11-30 00:00:00

  • Blood gases and cardiovascular shunt in the South American lungfish (Lepidosiren paradoxa) during normoxia and hyperoxia.

    abstract::The South American lungfish (Lepidosiren paradoxa) has an arterial P(O(2)) (Pa(O(2))) as high as 70-100 mmHg, corresponding to Hb-O(2) saturations from 90% to 95%, which indicates a moderate cardiovascular right to left (R-L) shunt. In hyperoxia (50% O(2)), we studied animals in: (1) aerated water combined with aerial...

    journal_title:Respiratory physiology & neurobiology

    pub_type: 杂志文章

    doi:10.1016/j.resp.2010.06.004

    authors: Bassi M,Giusti H,da Silva GS,Amin-Naves J,Glass ML

    更新日期:2010-08-31 00:00:00

  • Ventilation-perfusion relationships in pulmonary arterial hypertension: effect of intravenous and inhaled prostacyclin treatment.

    abstract:UNLABELLED:In seven patients with idiopathic or secondary pulmonary arterial hypertension (PAH), ventilation-perfusion (V (A)/Q ) relationships were measured during a right heart catheterization using the multiple inert-gas elimination technique before and during intravenous infusion with epoprostenol (EPO), and follow...

    journal_title:Respiratory physiology & neurobiology

    pub_type: 杂志文章

    doi:10.1016/j.resp.2007.03.003

    authors: Bratel T,Lagerstrand L,Brodin LA,Nowak J,Randmaa I

    更新日期:2007-08-15 00:00:00

  • The sensing of respiratory gases in fish: Mechanisms and signalling pathways.

    abstract::Chemoreception in fish is critical for sensing changes in the chemical composition of the external and internal environments and is often the first step in a cascade of events leading to cardiorespiratory and metabolic adjustments. Of paramount importance is the ability to sense changes in the levels of the three resp...

    journal_title:Respiratory physiology & neurobiology

    pub_type: 杂志文章,评审

    doi:10.1016/j.resp.2015.06.007

    authors: Perry SF,Tzaneva V

    更新日期:2016-04-01 00:00:00

  • Laryngeal narrowing during nasal ventilation does not originate from bronchopulmonary C-fibers.

    abstract::We previously showed that nasal pressure support ventilation (nPSV) can lead to active inspiratory laryngeal narrowing, which originates from the stimulation of bronchopulmonary receptors. Among the three major types of bronchopulmonary receptors, which are variably stimulated by lung distension, C-fiber endings are r...

    journal_title:Respiratory physiology & neurobiology

    pub_type: 杂志文章

    doi:10.1016/j.resp.2014.07.014

    authors: Samson N,Niane L,Nault S,Nadeau C,Praud JP

    更新日期:2014-10-01 00:00:00

  • Effect of increased diaphragm activation on diaphragm power spectrum center frequency.

    abstract::Increased transdiaphragmatic pressure, reduced muscle blood flow, and increased duty cycle have all been associated with a reduction in the center frequency (CFdi) of the diaphragm's electrical activity (EAdi). However, the specific influence of diaphragm activation on CFdi is unknown. We evaluated whether increased d...

    journal_title:Respiratory physiology & neurobiology

    pub_type: 杂志文章

    doi:10.1016/j.resp.2004.11.006

    authors: Spahija J,Beck J,Lindström L,Bégin P,de Marchie M,Sinderby C

    更新日期:2005-03-01 00:00:00

  • Vascular KATP channels mitigate severe muscle O2 delivery-utilization mismatch during contractions in chronic heart failure rats.

    abstract::The vascular ATP-sensitive K+ (KATP) channel is a mediator of skeletal muscle microvascular oxygenation (PO2mv) during contractions in health. We tested the hypothesis that KATP channel function is preserved in chronic heart failure (CHF) and therefore its inhibition would reduce PO2mv and exacerbate the time taken to...

    journal_title:Respiratory physiology & neurobiology

    pub_type: 杂志文章

    doi:10.1016/j.resp.2017.01.009

    authors: Holdsworth CT,Ferguson SK,Colburn TD,Fees AJ,Craig JC,Hirai DM,Poole DC,Musch TI

    更新日期:2017-04-01 00:00:00

  • Acute and chronic responses of the upper airway to inspiratory loading in healthy awake humans: an MRI study.

    abstract::We assessed upper airway responses to acute and chronic inspiratory loading. In Experiment I, 11 healthy subjects underwent T(2)-weighted magnetic resonance imaging (MRI) of upper airway dilator muscles (genioglossus and geniohyoid) before and up to 10 min after a single bout of pressure threshold inspiratory muscle t...

    journal_title:Respiratory physiology & neurobiology

    pub_type: 临床试验,杂志文章

    doi:10.1016/j.resp.2007.01.008

    authors: How SC,McConnell AK,Taylor BJ,Romer LM

    更新日期:2007-08-01 00:00:00

  • The evolutionary origin of the mammalian diaphragm.

    abstract::The comparatively low compliance of the mammalian lung results in an evolutionary dilemma: the origin and evolution of this bronchoalveolar lung into a high-performance gas-exchange organ results in a high work of breathing that cannot be achieved without the coupled evolution of a muscular diaphragm. However, despite...

    journal_title:Respiratory physiology & neurobiology

    pub_type: 杂志文章,评审

    doi:10.1016/j.resp.2010.01.004

    authors: Perry SF,Similowski T,Klein W,Codd JR

    更新日期:2010-04-15 00:00:00

  • Reappraisal of DLCO adjustment to interpret the adaptive response of the air-blood barrier to hypoxia.

    abstract::DLCO measured in hypoxia must be corrected due to the higher affinity (increase in coefficient θ) of CO with Hb. We propose an adjustment accounting for individual changes in the equation relating DLCO to subcomponents Dm (membrane diffusive capacity) and Vc (lung capillary volume): 1/DLCO=1/Dm+1/θVc. We adjusted the ...

    journal_title:Respiratory physiology & neurobiology

    pub_type: 杂志文章

    doi:10.1016/j.resp.2016.08.009

    authors: Beretta E,Lanfranconi F,Grasso GS,Bartesaghi M,Alemayehu HK,Miserocchi G

    更新日期:2017-04-01 00:00:00

  • Sensitivity of bronchopulmonary receptors to cold and heat mediated by transient receptor potential cation channel subtypes in an ex vivo rat lung preparation.

    abstract::Changes in airway temperature can result in respiratory responses such as cough, bronchoconstriction and mucosal secretion after cold exposure and hyperventilation after heat exposure. In the present investigation, we examined the activity of bronchopulmonary receptors in response to activators of thermo-sensitive tra...

    journal_title:Respiratory physiology & neurobiology

    pub_type: 杂志文章

    doi:10.1016/j.resp.2011.05.011

    authors: Zhou Y,Sun B,Li Q,Luo P,Dong L,Rong W

    更新日期:2011-08-15 00:00:00

  • 24-h blood pressure in Space: The dark side of being an astronaut.

    abstract::Inflight 24-h profiles of blood pressure (BP) and heart rate (HR) were recorded in 2 ESA-astronauts by automatic upper arm cuff measurements. In one astronaut this was combined with Portapres continuous finger blood pressure recordings. It was the intention to contrast the latter to 24-h recordings in an earlier Head-...

    journal_title:Respiratory physiology & neurobiology

    pub_type: 杂志文章

    doi:10.1016/j.resp.2009.05.006

    authors: Karemaker JM,Berecki-Gisolf J

    更新日期:2009-10-01 00:00:00

  • The effect of cannabinoids on dinitrofluorobenzene-induced experimental asthma in mice.

    abstract::Cannabinoids have anti-inflammatory effects and can produce bronchodilation in the airways. We have investigated the effects of cannabinoids on tracheal hyperreactivity and airway inflammation in dinitrofluorobenzene (DNFB)-induced experimental non-atopic asthma in mice. 5-hydroxytryptamine (5-HT)-induced contraction ...

    journal_title:Respiratory physiology & neurobiology

    pub_type: 杂志文章

    doi:10.1016/j.resp.2016.05.012

    authors: Bozkurt TE,Kaya Y,Durlu-Kandilci NT,Onder S,Sahin-Erdemli I

    更新日期:2016-09-01 00:00:00

  • Volume feedback during cough in anesthetized cats, effects of occlusions and modulation summary.

    abstract::The study investigates the effects of 6 occlusion conditions on the mechanically induced cough reflex in 15 anesthetized (pentobarbital) spontaneously breathing cats (14♂, 1♀). Esophageal pressure and integrated EMG activities of inspiratory (I) diaphragm and expiratory (E) abdominal muscles were recorded and analyzed...

    journal_title:Respiratory physiology & neurobiology

    pub_type: 杂志文章

    doi:10.1016/j.resp.2020.103547

    authors: Poliacek I,Veternik M,Martvon L,Simera M,Pitts T,Kotmanova Z,Babalova L,Kralikova O,Cibulkova L,Jakus J,Plevkova J

    更新日期:2021-01-01 00:00:00

  • Is the probable spillage of the lung surfactant dipalmitoylphosphatidylcholine the ultimate source of diabetes type 1?

    abstract::The lung surfactant dipalmitoylphosphatidylcholine (DPPC) most probably leaks into the blood, settling on the luminal aspect of blood vessels to create active hydrophobic spots (AHS). Nanobubbles are formed at these spots from dissolved gas. We hypothesized that when a large molecule in the blood comes into contact wi...

    journal_title:Respiratory physiology & neurobiology

    pub_type: 杂志文章

    doi:10.1016/j.resp.2020.103615

    authors: Arieli R,Khatib S,Khattib A,Bukovetzky E,Gottfried OD

    更新日期:2021-01-06 00:00:00

  • Overview: the neurochemistry of respiratory control.

    abstract::This special issue of Respiratory Physiology and Neurobiology surveys a broad range of topics focused on the neurochemical control of breathing. A variety of approaches have integrated the neurochemistry of breathing with the physiology of individual neurons, with the neuroanatomy of brainstem and forebrain respirator...

    journal_title:Respiratory physiology & neurobiology

    pub_type: 社论

    doi:10.1016/j.resp.2008.07.021

    authors: McCrimmon DR,Mitchell GS,Alheid GF

    更新日期:2008-12-10 00:00:00

  • The cessation of breathing in the chicken embryo during cold-hypometabolism.

    abstract::The avian embryo toward end-incubation combines gas exchange through the chorioallantoic membrane (CAM) and pulmonary ventilation (V˙E). The main experiments examined breathing activity during cold-hypometabolism. Chicken embryos close to hatching were prepared for simultaneous measurements of oxygen consumption ( [Fo...

    journal_title:Respiratory physiology & neurobiology

    pub_type: 杂志文章

    doi:10.1016/j.resp.2017.03.004

    authors: Ide R,Ide ST,Mortola JP

    更新日期:2017-08-01 00:00:00

  • Absence of mutations in HCRT, HCRTR1 and HCRTR2 in patients with ROHHAD.

    abstract:BACKGROUND AND OBJECTIVES:Rapid-onset obesity with hypothalamic dysfunction, hypoventilation, and autonomic dysregulation (ROHHAD) is a rare pediatric disease of unknown cause. Here, in response to a recent case report describing a ROHHAD patient who suffered from secondary narcolepsy confirmed by an absence of hypocre...

    journal_title:Respiratory physiology & neurobiology

    pub_type: 杂志文章

    doi:10.1016/j.resp.2015.11.002

    authors: Barclay SF,Rand CM,Gray PA,Gibson WT,Wilson RJ,Berry-Kravis EM,Ize-Ludlow D,Bech-Hansen NT,Weese-Mayer DE

    更新日期:2016-01-15 00:00:00

  • Abraham Guz memorial: Still unresolved hypotheses: Lung reflexes and perceptions of breathing.

    abstract::This article constitutes a review of the studies performed by the group of the late A. Guz and other authors on the subjects of lung reflexes and perceptions of respiration. The experimental data suggest that the lung inflation and deflation reflexes are present in man, mediated by large myelinated afferent nerve fibr...

    journal_title:Respiratory physiology & neurobiology

    pub_type: 历史文章,杂志文章,评审

    doi:10.1016/j.resp.2015.06.005

    authors: Noble MI

    更新日期:2015-10-01 00:00:00

  • The effect of moderate-intensity aerobic training on pulmonary function and estrogen receptor-alpha gene in postmenopausal women with vitamin D deficiency: A randomized control trial.

    abstract:BACKGROUND:The impact of aerobic training on pulmonary function by modulating gene expression of estrogen receptor-alpha (ERα), sex hormones and 25-hydroxy vitamin D (Vit D) in postmenopausal women (PMW) with Vit D deficiency is uncertain. OBJECTIVE:The purpose of this study was to examine the effect of 12 weeks of mo...

    journal_title:Respiratory physiology & neurobiology

    pub_type: 杂志文章

    doi:10.1016/j.resp.2020.103510

    authors: Malandish A,Tartibian B,Rahmati M,Afsargharehbagh R,Sheikhlou Z

    更新日期:2020-10-01 00:00:00

  • Perinatal development of respiratory motoneurons.

    abstract::Breathing movements require the coordinated recruitment of cranial and spinal motoneurons innervating muscles of the upper airway and ribcage. A significant part of respiratory motoneuron development and maturation occurs prenatally to support the generation of fetal breathing movements in utero and sustained breathin...

    journal_title:Respiratory physiology & neurobiology

    pub_type: 杂志文章,评审

    doi:10.1016/j.resp.2005.03.017

    authors: Greer JJ,Funk GD

    更新日期:2005-11-15 00:00:00

  • Exercise intensity and middle cerebral artery dynamics in humans.

    abstract::Despite its necessity for understanding healthy brain aging, the influence of exercise intensity on cerebrovascular kinetics is currently unknown. We, therefore characterized middle cerebral artery blood flow velocity (MCAv) kinetics associated with two exercise intensities: low and moderate. We hypothesized that incr...

    journal_title:Respiratory physiology & neurobiology

    pub_type: 杂志文章

    doi:10.1016/j.resp.2019.01.013

    authors: Witte E,Liu Y,Ward JL,Kempf KS,Whitaker A,Vidoni ED,Craig JC,Poole DC,Billinger SA

    更新日期:2019-04-01 00:00:00

  • Effect of accessory ostia on maxillary sinus ventilation: a computational fluid dynamics (CFD) study.

    abstract::We evaluated, by CFD simulation, effects of accessory ostium (AO) on maxillary sinus ventilation. A three-dimensional nasal model was constructed from an adult CT scan with two left maxillary AOs (sinus I) and one right AO (sinus II), then compared to an identical control model with all AOs sealed (sinuses III and IV)...

    journal_title:Respiratory physiology & neurobiology

    pub_type: 杂志文章

    doi:10.1016/j.resp.2012.06.026

    authors: Zhu JH,Lee HP,Lim KM,Gordon BR,Wang de Y

    更新日期:2012-08-15 00:00:00

  • Alterations in oropharyngeal sensory evoked potentials (PSEP) with Parkinson's disease.

    abstract::Movement of a food bolus from the oral cavity into the oropharynx activates pharyngeal sensory mechanoreceptors. Using electroencephalography, somatosensory cortical-evoked potentials resulting from oropharyngeal mechanical stimulation (PSEP) have been studied in young healthy individuals. However, limited information...

    journal_title:Respiratory physiology & neurobiology

    pub_type: 杂志文章

    doi:10.1016/j.resp.2016.04.004

    authors: Pitts T,Hegland KW,Sapienza CM,Bolser DC,Davenport PW

    更新日期:2016-07-15 00:00:00

  • Developmental trajectories, critical windows and phenotypic alteration during cardio-respiratory development.

    abstract::Embryo-environment interactions affecting cardio-respiratory development in vertebrates have been extensively studied, but an equally extensive conceptual framework for interpreting and interrelating these developmental events has lagged behind. In this review, we consider the conceptual constructs of "developmental p...

    journal_title:Respiratory physiology & neurobiology

    pub_type: 杂志文章,评审

    doi:10.1016/j.resp.2011.05.001

    authors: Burggren WW,Reyna KS

    更新日期:2011-08-31 00:00:00

  • The ventilatory response to carbon dioxide and sustained hypoxia is enhanced after episodic hypoxia in OSA patients.

    abstract::Our primary hypothesis was that the acute ventilatory response to carbon dioxide in the presence of sustained hypoxia {VRCO2 (hypoxia)} or hyperoxia {VRCO2 (hyperoxia)} would increase in subjects with obstructive sleep apnea (OSA) after exposure to episodic hypoxia. Secondarily, we hypothesized that chronic (i.e. year...

    journal_title:Respiratory physiology & neurobiology

    pub_type: 临床试验,杂志文章

    doi:10.1016/j.resp.2005.04.019

    authors: Khodadadeh B,Badr MS,Mateika JH

    更新日期:2006-02-28 00:00:00

  • Role of central hydrogen sulfide on ventilatory and cardiovascular responses to hypoxia in spontaneous hypertensive rats.

    abstract::Central hydrogen sulfide (H2S) has been reported to act as a gaseous neuromodulator involved in the ventilatory and cardiovascular control of normotensive rats, whereas no information is available in spontaneously hypertensive rats (SHR). We recorded minute ventilation (VE), mean arterial pressure (MAP) and heart rate...

    journal_title:Respiratory physiology & neurobiology

    pub_type: 杂志文章

    doi:10.1016/j.resp.2016.05.016

    authors: Sabino JP,Traslaviña GA,Branco LG

    更新日期:2016-09-01 00:00:00