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Short intermittent hypoxic exposures augment ventilation but do not alter regional cerebral and muscle oxygenation during hypoxic exercise.

Abstract：

:This study investigated the effects of four exposures to normobaric hypoxia (SIH group; FIO₂ = 0.120, N=10) or placebo-control normoxia (Control group; FIO₂ = 0.209, N=9) on cardio-respiratory responses to hypoxic exercise. Before and after the exposures all subjects performed a constant power test (CP) to exhaustion in hypoxia FIO₂ = 0.120 at a work load corresponding to 75% of previously determined normoxic VO₂ peak. Arterial oxygen saturation (SPO₂) and minute ventilation (V(E)) were measured continuously. NIRS was used to monitor regional changes in oxygenated, de-oxygenated and total hemoglobin concentrations of the frontal cortex, vastus lateralis and serratus anterior. Although neither group improved CP time, the SIH group exhibited increases in both V(E) (+15%; P<0.05) and SPO₂ (+4%; P<0.05) after intermittent hypoxia. No physiologically significant differences were observed during exercise in vastus lateralis, serratus anterior and cerebral oxygenation between groups and testing periods. These data suggest that normobaric SIH enhances hypoxic exercise V(E) and SPO₂ without affecting regional oxygenation or time to exhaustion.

journal_name

Respir Physiol Neurobiol

journal_title

Respiratory physiology & neurobiology

authors

Debevec T,Mekjavic IB

doi

10.1016/j.resp.2012.02.008

subject

Has Abstract

pub_date

2012-04-30 00:00:00

pages

132-42

issue

2

eissn

1569-9048

issn

1878-1519

pii

S1569-9048(12)00048-1

journal_volume

181

pub_type

杂志文章,评审

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