Systemic inflammation impairs respiratory chemoreflexes and plasticity.

Abstract:

:Many lung and central nervous system disorders require robust and appropriate physiological responses to assure adequate breathing. Factors undermining the efficacy of ventilatory control will diminish the ability to compensate for pathology, threatening life itself. Although most of these same disorders are associated with systemic and/or neuroinflammation, and inflammation affects neural function, we are only beginning to understand interactions between inflammation and any aspect of ventilatory control (e.g. sensory receptors, rhythm generation, chemoreflexes, plasticity). Here we review available evidence, and present limited new data suggesting that systemic (or neural) inflammation impairs two key elements of ventilatory control: chemoreflexes and respiratory motor (versus sensory) plasticity. Achieving an understanding of mechanisms whereby inflammation undermines ventilatory control is fundamental since inflammation may diminish the capacity for natural, compensatory responses during pathological states, and the ability to harness respiratory plasticity as a therapeutic strategy in the treatment of devastating breathing disorders, such as during cervical spinal injury or motor neuron disease.

authors

Huxtable AG,Vinit S,Windelborn JA,Crader SM,Guenther CH,Watters JJ,Mitchell GS

doi

10.1016/j.resp.2011.06.017

subject

Has Abstract

pub_date

2011-09-30 00:00:00

pages

482-9

issue

3

eissn

1569-9048

issn

1878-1519

pii

S1569-9048(11)00230-8

journal_volume

178

pub_type

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