Abstract：
:Hypoxia leads to pulmonary vasoconstriction in healthy men. However, the consequences on right ventricular function are not known. The effects of hypoxia on systolic pulmonary artery pressure (sPAP) and right ventricular function index (TEI) were assessed by Doppler echocardiography. Fourteen members of a Mount Everest expedition were monitored during acute hypoxic challenge at sea level, environmental hypoxia exposure at altitudes of 3440 m and 5245 m and 2 weeks after return to sea level. Subjects received either placebo or 50mg sildenafil in a double-blind randomised cross-over design. Under normoxia at baseline, mean sPAP was 17.1(S.E.M. 1.3) mm Hg, and TEI was 0.13(0.004). Both increased during acute hypoxia: sPAP 29.6(2.6) mm Hg, and TEI 0.35(0.06) (each p<0.01). At 5245 m sPAP was 29.1(1.7) and TEI was 0.43(0.05) in the placebo group, while in the sildenafil group, both sPAP and TEI were reduced to 22(1.5) mm Hg and 0.23(0.03) (each p<0.005), respectively. We conclude that in healthy individuals, exposure to acute hypoxia and sojourns at high altitude result in a small but significant increase in sPAP accompanied by an impairment of right ventricular function. Sildenafil significantly decreases sPAP and improves right ventricular function.
journal_name
Respir Physiol Neurobioljournal_title
Respiratory physiology & neurobiologyauthors
Reichenberger F,Kohstall MG,Seeger T,Olschewski H,Grimminger F,Seeger W,Ghofrani HAdoi
10.1016/j.resp.2007.07.005subject
Has Abstractpub_date
2007-11-15 00:00:00pages
196-201issue
2eissn
1569-9048issn
1878-1519pii
S1569-9048(07)00206-6journal_volume
159pub_type
临床试验,杂志文章,随机对照试验abstract：:Asthma is a chronic inflammatory disease, with an array of cells involved in the pathogenesis of the disease. The role of neutrophils in the development of bronchial asthma is found to be complex, as they may trigger activation of immunocompetent cells and are a potent source of free oxygen radicals and enzymes partic...
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journal_title：Respiratory physiology & neurobiology
pub_type： 杂志文章,评审
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journal_title：Respiratory physiology & neurobiology
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journal_title：Respiratory physiology & neurobiology
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pub_type： 杂志文章
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pub_type： 杂志文章
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更新日期：2011-07-31 00:00:00
