Abstract：
:Recently, we have shown that the expired CO2 gas volume versus tidal volume (VCO2-VT) curve is a useful tool for assessing unevenness of ventilation because it allows the separation of tidal volume into three functional compartments: (a) the CO2-free expired air (V0), (b) the transitional volume (Vtr), (c) the alveolar volume (VA) and the measurement of alveolar FCO2 during resting breathing in normal subjects and patients with COPD. In this paper, we have investigated whether changes pertaining to unevenness of ventilation taking place immediately after the administration of methacholine can be assessed using the VCO2-VT curve in asthmatic patients. The VCO2-VT curve was obtained during tidal breathing from 16 stable asthmatic patients who underwent a methacholine challenge test. It has been found that the Vtr, and hence Bohr's dead space (VD,Bohr = V0 + Vtr), over tidal volume ratios were significantly increased immediately after the methacholine administration, whilst the V0 over tidal volume ratio was not affected. The change of the above ratios was not related to the percentage decrease of FEV1.0 following methacholine administration.
journal_name
Respir Physiol Neurobioljournal_title
Respiratory physiology & neurobiologyauthors
Koulouris NG,Latsi P,Stavrou E,Chroneou A,Gaga M,Jordanoglou Jdoi
10.1016/j.resp.2004.01.005keywords:
subject
Has Abstractpub_date
2004-06-25 00:00:00pages
293-300issue
3eissn
1569-9048issn
1878-1519pii
S1569904804000114journal_volume
140pub_type
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journal_title：Respiratory physiology & neurobiology
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journal_title：Respiratory physiology & neurobiology
pub_type： 杂志文章
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journal_title：Respiratory physiology & neurobiology
pub_type： 杂志文章
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journal_title：Respiratory physiology & neurobiology
pub_type： 杂志文章
doi：10.1016/j.resp.2017.03.003
更新日期：2017-08-01 00:00:00
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journal_title：Respiratory physiology & neurobiology
pub_type： 杂志文章
doi：10.1016/j.resp.2007.10.010
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journal_title：Respiratory physiology & neurobiology
pub_type： 杂志文章,评审
doi：10.1016/j.resp.2008.03.011
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pub_type： 杂志文章
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pub_type： 杂志文章
doi：10.1016/j.resp.2016.08.009
更新日期：2017-04-01 00:00:00
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pub_type： 杂志文章
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journal_title：Respiratory physiology & neurobiology
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journal_title：Respiratory physiology & neurobiology
pub_type： 杂志文章
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pub_type： 杂志文章,评审
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pub_type： 杂志文章
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journal_title：Respiratory physiology & neurobiology
pub_type： 临床试验,杂志文章
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journal_title：Respiratory physiology & neurobiology
pub_type： 杂志文章
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更新日期：2013-01-15 00:00:00
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