Non-invasive measurement of cardiac output: evaluation of new infrared absorption spectrometer.


:The mass spectrometer (MS) traditionally has been the instrument of choice for measuring cardiac output (Q (T)) non-invasively using the foreign gas uptake method. However, the size and cost of the MS has hampered widespread adoption of this technique outside of the laboratory. Here, we present results, from six normal human subjects at rest and during exercise, of simultaneous Q (T) measurements by an MS and a new, portable infrared (IR) device developed in our laboratories. These measurements are made using on the open-circuit acetylene uptake method. The IR device measures inspired and end-tidal concentrations of acetylene, sulfur hexafluoride, and carbon dioxide by IR absorption spectroscopy with a 10-90% response time of 43 ms; accurate measurements were made down to sample flow rates of 50 mL min(-1). Excellent correlation [Q (T)(IR)=0.98 Q (T)(MS), R(2)=0.94] was observed between instruments across the range from rest to heavy exercise. These results suggest that the IR device, which is small, light-weight, and rugged may enable the foreign gas uptake method to be used in clinical, field, and point-of-care settings for Q (T) measurement.


Baum MM,Moss JA,Kumar S,Wagner PD





Has Abstract


2006-09-28 00:00:00














  • Regulation of alveolar fluid clearance and ENaC expression in lung by exogenous angiotensin II.

    abstract::Angiotensin II (Ang II) has been demonstrated as a pro-inflammatory effect in acute lung injury, but studies of the effect of Ang II on the formation of pulmonary edema and alveolar filling remains unclear. Therefore, in this study the regulation of alveolar fluid clearance (AFC) and the expression of epithelial sodiu...

    journal_title:Respiratory physiology & neurobiology

    pub_type: 杂志文章


    authors: Deng J,Wang DX,Deng W,Li CY,Tong J,Ma H

    更新日期:2012-04-15 00:00:00

  • Glucocorticoids inhibits the repair of airway epithelial cells via the activation of wnt pathway.

    abstract:BACKGROUND:The purpose of this study was to explore the effect of Wnt pathway on the inhibition of airway epithelial cells repair by glucocorticoid. MATERIALS AND METHODS:The expression of E-cadherin in asthma mice model was detected by immunocytochemistry. XAV939 was used to treat 16HBE, and the expressions of relate...

    journal_title:Respiratory physiology & neurobiology

    pub_type: 杂志文章


    authors: Yu Z,Jiang Y,Sun C

    更新日期:2020-01-01 00:00:00

  • Site of inflammation influences site of hyperresponsiveness in experimental asthma.

    abstract:BACKGROUND:Our recently developed murine asthma model is capable of inducing airway-specific chronic inflammatory changes and remodeling, features of human asthma commonly missing in conventional animal models. OBJECTIVES:To validate this model by site-specific physiological evaluation of hyperresponsiveness. METHODS...

    journal_title:Respiratory physiology & neurobiology

    pub_type: 杂志文章


    authors: Collins RA,Sly PD,Turner DJ,Herbert C,Kumar RK

    更新日期:2003-12-16 00:00:00

  • Alveolar barrier function assessed by hydrophobic and hydrophilic fluorescent solutes in rabbit lung.

    abstract::Loss of alveolar barrier function is important in the development of pulmonary edema, but quantitation of its integrity has been difficult in the intact lung. We report a new non-radioactive method to assess paracellular and transcellular permeability of alveolar barrier in buffer-perfused rabbit lungs. Changes in alv...

    journal_title:Respiratory physiology & neurobiology

    pub_type: 杂志文章


    authors: Huang YC,Piantadosi CA

    更新日期:2002-10-23 00:00:00

  • Recent findings in cardiovascular physiology with space travel.

    abstract::The cardiovascular system undergoes major changes in stress with space flight primarily related to the elimination of the head-to-foot gravitational force. A major observation has been that the central venous pressure is not elevated early in space flight yet stroke volume is increased at least early in flight. Recent...

    journal_title:Respiratory physiology & neurobiology

    pub_type: 杂志文章


    authors: Hughson RL

    更新日期:2009-10-01 00:00:00

  • Effects of bi-level positive airway pressure on ventilatory and perceptual responses to exercise in comorbid heart failure-COPD.

    abstract::This study tested the hypothesis that, by increasing the volume available for tidal expansion (inspiratory capacity, IC), bi-level positive airway pressure (BiPAP™) would lead to greater beneficial effects on dyspnea and exercise intolerance in comorbid heart failure (HF)-chronic obstructive pulmonary disease (COPD) t...

    journal_title:Respiratory physiology & neurobiology

    pub_type: 杂志文章


    authors: Souza A,Sperandio PA,Mazzuco A,Alencar MCN,Arbex FF,Oliveira M,Medeiros W,Rocha A,Nery LE,O Donnell DE,Neder JA

    更新日期:2019-08-01 00:00:00

  • ATP-sensitive K+ channel inhibition in rats decreases kidney and skeletal muscle blood flow without increasing sympathetic nerve discharge.

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    journal_title:Respiratory physiology & neurobiology

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    authors: Colburn TD,Holdsworth CT,Craig JC,Hirai DM,Montgomery S,Poole DC,Musch TI,Kenney MJ

    更新日期:2020-07-01 00:00:00

  • Chronic intermittent hyperoxia alters the development of the hypoxic ventilatory response in neonatal rats.

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    journal_title:Respiratory physiology & neurobiology

    pub_type: 杂志文章


    authors: Logan S,Tobin KE,Fallon SC,Deng KS,McDonough AB,Bavis RW

    更新日期:2016-01-01 00:00:00

  • Right and left vagus nerves regulate breathing by multiplicative interaction.

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    journal_title:Respiratory physiology & neurobiology

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    authors: Song N,Liu J,Proctor M,Yu J

    更新日期:2015-12-01 00:00:00

  • Low exertional inspiratory capacity is not related to dynamic inspiratory muscle weakness in heart failure.

    abstract::Reduction in inspiratory capacity (IC) during exercise has been reported in chronic heart failure (CHF). Since inspiratory muscle dysfunction may be present to a variable degree, the assumption that IC reduction during exercise represents an increase in end-expiratory lung volume must be made with caution. This interp...

    journal_title:Respiratory physiology & neurobiology

    pub_type: 杂志文章


    authors: Plachi F,Balzan FM,Gass R,Dorneles RG,Zambiazi R,da Silva DP,Sanches PR,Clausell NO,Berton DC

    更新日期:2018-08-01 00:00:00

  • Impact of sleep disordered breathing on carotid body size.

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    journal_title:Respiratory physiology & neurobiology

    pub_type: 杂志文章


    authors: Welch BT,Petersen-Jones HG,Eugene AR,Brinjikji W,Kallmes DF,Curry TB,Joyner MJ,Limberg JK

    更新日期:2017-02-01 00:00:00

  • Haematological acclimation and re-acclimation to hypoxia in the mouse.

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    journal_title:Respiratory physiology & neurobiology

    pub_type: 杂志文章


    authors: MacNutt MJ,Rupert JL,Sheel AW

    更新日期:2013-10-01 00:00:00

  • Recruitment maneuver: RAMP versus CPAP pressure profile in a model of acute lung injury.

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    authors: Riva DR,Contador RS,Baez-Garcia CS,Xisto DG,Cagido VR,Martini SV,Morales MM,Rocco PR,Faffe DS,Zin WA

    更新日期:2009-10-31 00:00:00

  • Effects of mitochondrial poisons on glutathione redox potential and carotid body chemoreceptor activity.

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    journal_title:Respiratory physiology & neurobiology

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    authors: Gomez-Niño A,Agapito MT,Obeso A,Gonzalez C

    更新日期:2009-01-01 00:00:00

  • Regulation of adenosine 5'-triphosphate (ATP)-gated P2X(4) receptors on tracheal smooth muscle cells.

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    authors: Nagaoka M,Nara M,Tamada T,Kume H,Oguma T,Kikuchi T,Zaini J,Moriya T,Ichinose M,Tamura G,Hattori T

    更新日期:2009-03-31 00:00:00

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    更新日期:2006-03-28 00:00:00

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    authors: Khelifa MB,Salem HB,Sfaxi R,Chatti S,Rouatbi S,Saad HB

    更新日期:2018-01-01 00:00:00

  • Effects of Eucalyptol in respiratory system mechanics on acute lung injury after exposure to short-term cigarette smoke.

    abstract::Eucalyptol is a compound that has demonstrated antioxidant, anti-inflammatory and bronchodilator effects, but there are no investigations about the effects of this constituent on the respiratory system mechanics in relation to acute lung injury caused by short-term cigarette smoke (CS) exposure. In view of the above, ...

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    authors: Gondim FL,Serra DS,Cavalcante FSÁ

    更新日期:2019-08-01 00:00:00

  • Influence of chronic hyperoxia on the developmental time course of the hypoxic ventilatory response relative to other traits in rats.

    abstract::Newborn mammals exhibit a biphasic hypoxic ventilatory response (HVR) in which an initial increase in ventilation is followed by a decline back toward baseline levels. The magnitude of the secondary decline diminishes with postnatal age, but this transition occurs earlier in rat pups reared in moderate hyperoxia. This...

    journal_title:Respiratory physiology & neurobiology

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    更新日期:2020-09-01 00:00:00

  • Relaxin-3 receptor (RXFP3) activation in the nucleus of the solitary tract modulates respiratory rate and the arterial chemoreceptor reflex in rat.

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    journal_title:Respiratory physiology & neurobiology

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    authors: Furuya WI,Dhingra RR,Gundlach AL,Hossain MA,Dutschmann M

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  • Aerobic exercise training without weight loss reduces dyspnea on exertion in obese women.

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    authors: Bernhardt V,Stickford JL,Bhammar DM,Babb TG

    更新日期:2016-01-15 00:00:00

  • 24-h blood pressure in Space: The dark side of being an astronaut.

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    authors: Karemaker JM,Berecki-Gisolf J

    更新日期:2009-10-01 00:00:00

  • Role of aquaporins in lung liquid physiology.

    abstract::Aquaporins (AQPs) are small, integral membrane proteins that facilitate water transport across cell membranes in response to osmotic gradients. Water transport across epithelia and endothelia in the peripheral lung and airways occurs during airway hydration, alveolar fluid transport and submucosal gland secretion. Sev...

    journal_title:Respiratory physiology & neurobiology

    pub_type: 杂志文章,评审


    authors: Verkman AS

    更新日期:2007-12-15 00:00:00

  • Maternal cigarette smoke exposure disturbs glutamate/GABA balance in pFRG of neonatal rats.

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    pub_type: 杂志文章


    authors: Fu Y,Lei F,Wang J,Wang W,Zheng Y

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    journal_title:Respiratory physiology & neurobiology

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    authors: Catella J,Costes F,Gaultier JB,Court Fortune I,Tulane C,De Magalhaes E,Accassat S,Chomette-Ballereau S,Chapelle C,Bertoletti L

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  • Gz- and not Gi-proteins are coupled to pre-junctional μ-opioid receptors in bovine airways.

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    journal_title:Respiratory physiology & neurobiology

    pub_type: 杂志文章


    authors: Baroffio M,Brichetto L,Franco L,Crimi E,Rehder K,Brusasco V

    更新日期:2013-10-01 00:00:00

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    journal_title:Respiratory physiology & neurobiology

    pub_type: 杂志文章


    authors: Pitts T,Hegland KW,Sapienza CM,Bolser DC,Davenport PW

    更新日期:2016-07-15 00:00:00

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    journal_title:Respiratory physiology & neurobiology

    pub_type: 杂志文章


    authors: Petersson J,Rohdin M,Sánchez-Crespo A,Nyrén S,Jacobsson H,Larsson SA,Lindahl SG,Linnarsson D,Neradilek B,Polissar NL,Glenny RW,Mure M

    更新日期:2007-06-15 00:00:00

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    journal_title:Respiratory physiology & neurobiology

    pub_type: 社论


    authors: McCrimmon DR,Mitchell GS,Alheid GF

    更新日期:2008-12-10 00:00:00

  • Breath-holding test in evaluation of peripheral chemoreflex sensitivity in healthy subjects.

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    journal_title:Respiratory physiology & neurobiology

    pub_type: 杂志文章


    authors: Trembach N,Zabolotskikh I

    更新日期:2017-01-01 00:00:00