Abstract：
:The mass spectrometer (MS) traditionally has been the instrument of choice for measuring cardiac output (Q (T)) non-invasively using the foreign gas uptake method. However, the size and cost of the MS has hampered widespread adoption of this technique outside of the laboratory. Here, we present results, from six normal human subjects at rest and during exercise, of simultaneous Q (T) measurements by an MS and a new, portable infrared (IR) device developed in our laboratories. These measurements are made using on the open-circuit acetylene uptake method. The IR device measures inspired and end-tidal concentrations of acetylene, sulfur hexafluoride, and carbon dioxide by IR absorption spectroscopy with a 10-90% response time of 43 ms; accurate measurements were made down to sample flow rates of 50 mL min(-1). Excellent correlation [Q (T)(IR)=0.98 Q (T)(MS), R(2)=0.94] was observed between instruments across the range from rest to heavy exercise. These results suggest that the IR device, which is small, light-weight, and rugged may enable the foreign gas uptake method to be used in clinical, field, and point-of-care settings for Q (T) measurement.
journal_name
Respir Physiol Neurobioljournal_title
Respiratory physiology & neurobiologyauthors
Baum MM,Moss JA,Kumar S,Wagner PDdoi
10.1016/j.resp.2005.09.010keywords:
subject
Has Abstractpub_date
2006-09-28 00:00:00pages
191-201issue
2eissn
1569-9048issn
1878-1519pii
S1569-9048(05)00258-2journal_volume
153pub_type
临床试验,杂志文章abstract：:Carotid body (CB) chemoreceptors are the main sensors detecting systemic hypoxia. Studies in animals revealed that dopamine and histamine may serve as transmitters between the chemoreceptor cells and the afferent nerve. To gain insight whether histamine and dopamine could play a role in the human CB and thus be import...
journal_title：Respiratory physiology & neurobiology
pub_type： 杂志文章
doi：10.1016/j.resp.2008.10.016
更新日期：2009-02-28 00:00:00
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journal_title：Respiratory physiology & neurobiology
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更新日期：2016-09-01 00:00:00
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journal_title：Respiratory physiology & neurobiology
pub_type： 杂志文章
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journal_title：Respiratory physiology & neurobiology
pub_type： 杂志文章,评审
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更新日期：2016-04-01 00:00:00
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journal_title：Respiratory physiology & neurobiology
pub_type： 临床试验,杂志文章
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更新日期：2006-02-28 00:00:00
abstract：:The consequence of dysanapsis, quantitated by dysanapsis ratio (DR), on expiratory flow limitation (EFL) during exercise in pediatric subjects was examined. EFL occurred in 80 (56%) subjects from an enriched sample of children and adolescents tested during investigation of exertional dyspnea. DR was lower in subjects ...
journal_title：Respiratory physiology & neurobiology
pub_type： 杂志文章
doi：10.1016/j.resp.2018.03.013
更新日期：2018-06-01 00:00:00
abstract：:The mechanisms involved in the fall of exhaled nitric oxide (NOe) concentration occurring in normal, anesthetized open chest rabbits with prolonged mechanical ventilation (MV) at low lung volume have been investigated. NOe, pH of exhaled vapor condensate, serum prostaglandin E(2), and F(2alpha), tumor necrosis factor ...
journal_title：Respiratory physiology & neurobiology
pub_type： 杂志文章
doi：10.1016/j.resp.2007.10.001
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journal_title：Respiratory physiology & neurobiology
pub_type： 杂志文章
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更新日期：2017-04-01 00:00:00
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journal_title：Respiratory physiology & neurobiology
pub_type： 杂志文章,评审
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journal_title：Respiratory physiology & neurobiology
pub_type： 社论,评审
doi：10.1016/j.resp.2008.09.012
更新日期：2009-05-30 00:00:00
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journal_title：Respiratory physiology & neurobiology
pub_type： 杂志文章,评审
doi：10.1016/j.resp.2009.06.005
更新日期：2009-11-30 00:00:00
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journal_title：Respiratory physiology & neurobiology
pub_type： 杂志文章
doi：10.1016/j.resp.2020.103572
更新日期：2020-11-05 00:00:00
abstract：:Expression of the transcription factor FOXP2 is linked to brain circuits that control motor function and speech. Investigation of FOXP2 protein expression in respiratory areas of the ponto-medullary brainstem of adult rat revealed distinct rostro-caudal expression gradients. A high density of FOXP2 immunoreactive nucl...
journal_title：Respiratory physiology & neurobiology
pub_type： 杂志文章
doi：10.1016/j.resp.2018.01.014
更新日期：2018-04-01 00:00:00
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journal_title：Respiratory physiology & neurobiology
pub_type： 杂志文章,评审
doi：10.1016/j.resp.2008.07.018
更新日期：2008-12-10 00:00:00
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journal_title：Respiratory physiology & neurobiology
pub_type： 临床试验,杂志文章
doi：10.1016/j.resp.2004.09.001
更新日期：2005-01-15 00:00:00
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journal_title：Respiratory physiology & neurobiology
pub_type： 杂志文章
doi：10.1016/j.resp.2017.09.005
更新日期：2018-01-01 00:00:00
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journal_title：Respiratory physiology & neurobiology
pub_type： 历史文章,杂志文章,评审
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更新日期：2015-10-01 00:00:00
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journal_title：Respiratory physiology & neurobiology
pub_type： 杂志文章,评审
doi：10.1016/j.resp.2017.09.003
更新日期：2018-10-01 00:00:00
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journal_title：Respiratory physiology & neurobiology
pub_type： 杂志文章
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更新日期：2020-03-01 00:00:00
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journal_title：Respiratory physiology & neurobiology
pub_type： 杂志文章
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更新日期：2009-07-31 00:00:00
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journal_title：Respiratory physiology & neurobiology
pub_type： 杂志文章,评审
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更新日期：2018-01-01 00:00:00
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journal_title：Respiratory physiology & neurobiology
pub_type： 杂志文章,评审
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更新日期：2020-12-14 00:00:00
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journal_title：Respiratory physiology & neurobiology
pub_type： 杂志文章
doi：10.1016/j.resp.2007.09.012
更新日期：2008-02-01 00:00:00
abstract：:Changes in pulmonary hemodynamics modify the mechanical properties of the lungs. The effects of alterations in pulmonary capillary pressure (Pc) were investigated on the airway and lung tissue mechanics during positive-pressure ventilation and following lung recruitment maneuvers. Isolated, mechanically normoventilate...
journal_title：Respiratory physiology & neurobiology
pub_type： 杂志文章
doi：10.1016/j.resp.2006.12.004
更新日期：2007-08-01 00:00:00
abstract：:The South American lungfish (Lepidosiren paradoxa) has an arterial P(O(2)) (Pa(O(2))) as high as 70-100 mmHg, corresponding to Hb-O(2) saturations from 90% to 95%, which indicates a moderate cardiovascular right to left (R-L) shunt. In hyperoxia (50% O(2)), we studied animals in: (1) aerated water combined with aerial...
journal_title：Respiratory physiology & neurobiology
pub_type： 杂志文章
doi：10.1016/j.resp.2010.06.004
更新日期：2010-08-31 00:00:00
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journal_title：Respiratory physiology & neurobiology
pub_type： 杂志文章
doi：10.1016/j.resp.2015.05.009
更新日期：2015-08-15 00:00:00
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journal_title：Respiratory physiology & neurobiology
pub_type： 杂志文章
doi：10.1016/j.resp.2017.09.008
更新日期：2018-01-01 00:00:00
abstract：:Submaximal exercise diaphragm blood flow (BF) is elevated in young chronic heart failure (CHF) rats, while it is unknown if this occurs in older animals. Respiratory and hindlimb muscle BFs (radiolabeled microspheres) were measured at rest and during submaximal exercise (20m/min, 5% grade) in older healthy (n=7) and C...
journal_title：Respiratory physiology & neurobiology
pub_type： 杂志文章
doi：10.1016/j.resp.2017.05.002
更新日期：2017-09-01 00:00:00
abstract：:The acid-base balance of arterial blood is important for the clinical management of seriously ill patients, especially patients with acute lung injury or acute respiratory distress syndrome. We developed a novel fluorosensor for continuous blood pH monitoring and evaluated its performance both in vitro and in vivo in ...
journal_title：Respiratory physiology & neurobiology
pub_type： 杂志文章
doi：10.1016/j.resp.2011.03.009
更新日期：2011-07-31 00:00:00
