Abstract:
:Cervical spinal cord injury results in significant functional impairment. It is important to understand the neuroplasticity in response to inactivity of respiratory muscles in order to prevent any associated effects that limit functional recovery. Recent studies have examined the mechanisms involved in inactivity-induced neuroplasticity of diaphragm motor units. Both spinal hemisection at C2 (C2HS) and tetrodotoxin (TTX)-induced phrenic nerve blockade result in diaphragm paralysis and inactivity of axon terminals. However, phrenic motoneurons are inactive with C2HS but remain active after TTX. Diaphragm muscle fibers ipsilateral to C2HS display minimal changes post-injury. Neuromuscular transmission is enhanced following C2HS but impaired following TTX. Synaptic vesicle pool size at diaphragm neuromuscular junctions increases after C2HS, but decreases after TTX. Thus, inactivity-induced neuromuscular plasticity reflects specific adaptations that depend on inactivity at the motoneuron rather than at axon terminals or muscle fibers. These results indicate that neuromuscular transmission and functional properties of diaphragm fibers can be maintained after spinal cord injury, providing a substrate for functional recovery and/or specific therapeutic approaches such as phrenic pacing.
journal_name
Respir Physiol Neurobioljournal_title
Respiratory physiology & neurobiologyauthors
Mantilla CB,Sieck GCdoi
10.1016/j.resp.2009.09.002subject
Has Abstractpub_date
2009-11-30 00:00:00pages
133-40issue
2eissn
1569-9048issn
1878-1519pii
S1569-9048(09)00262-6journal_volume
169pub_type
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journal_title:Respiratory physiology & neurobiology
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journal_title:Respiratory physiology & neurobiology
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journal_title:Respiratory physiology & neurobiology
pub_type: 杂志文章,评审
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journal_title:Respiratory physiology & neurobiology
pub_type: 杂志文章
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pub_type: 杂志文章
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journal_title:Respiratory physiology & neurobiology
pub_type: 杂志文章
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更新日期:2020-10-01 00:00:00
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journal_title:Respiratory physiology & neurobiology
pub_type: 杂志文章
doi:10.1016/j.resp.2007.06.002
更新日期:2007-10-15 00:00:00
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journal_title:Respiratory physiology & neurobiology
pub_type: 杂志文章
doi:10.1016/j.resp.2019.03.002
更新日期:2019-05-01 00:00:00
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journal_title:Respiratory physiology & neurobiology
pub_type: 杂志文章
doi:10.1016/j.resp.2018.03.011
更新日期:2018-11-01 00:00:00
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journal_title:Respiratory physiology & neurobiology
pub_type: 杂志文章
doi:10.1016/j.resp.2014.09.022
更新日期:2015-04-01 00:00:00
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journal_title:Respiratory physiology & neurobiology
pub_type: 杂志文章
doi:10.1016/j.resp.2019.04.015
更新日期:2019-08-01 00:00:00
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journal_title:Respiratory physiology & neurobiology
pub_type: 杂志文章
doi:10.1016/j.resp.2017.11.011
更新日期:2018-01-01 00:00:00
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journal_title:Respiratory physiology & neurobiology
pub_type: 杂志文章,评审
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journal_title:Respiratory physiology & neurobiology
pub_type: 杂志文章
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journal_title:Respiratory physiology & neurobiology
pub_type: 杂志文章
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更新日期:2007-05-14 00:00:00
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journal_title:Respiratory physiology & neurobiology
pub_type: 杂志文章,评审
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journal_title:Respiratory physiology & neurobiology
pub_type: 杂志文章
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更新日期:2014-03-01 00:00:00
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journal_title:Respiratory physiology & neurobiology
pub_type: 杂志文章
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更新日期:2012-05-31 00:00:00
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journal_title:Respiratory physiology & neurobiology
pub_type: 杂志文章
doi:10.1016/j.resp.2014.01.006
更新日期:2014-03-01 00:00:00
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更新日期:2016-09-01 00:00:00
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journal_title:Respiratory physiology & neurobiology
pub_type: 杂志文章,评审
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更新日期:2013-11-01 00:00:00
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journal_title:Respiratory physiology & neurobiology
pub_type: 杂志文章,评审
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更新日期:2004-11-15 00:00:00
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journal_title:Respiratory physiology & neurobiology
pub_type: 杂志文章,评审
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