Abstract：
:Evidence from liquid-filled rat lungs supported the presence of CO2-dependent, active relaxation of parenchyma under normoxia by unknown mechanisms (Emery et al., 2007). This response may improve matching of alveolar ventilation (V˙A) to perfusion (Q˙) by increasing compliance and V˙A in overperfused (high CO2) regions, and decrease V˙A in underperfused regions. Here, we have more directly studied CO2-dependent parenchymal relaxation and tested a hypothesized role for actin-myosin interaction in this effect. Lung parenchymal strips (∼1.5mm×1.5mm×15mm) from 16 rats were alternately exposed to normoxic hypocapnia ( [Formula: see text] ) or hypercapnia ( [Formula: see text] ). Seven specimens were used to construct length-tension curves, and nine were tested with and without the myosin blocker 2,3-butanedione monoxime (BDM). The results demonstrate substantial, reversible CO2-dependent changes in parenchyma strip recoil (up to 23%) and BDM eliminates this effect, supporting a potentially important role for parenchymal myosin in V˙A/Q˙ matching.
journal_name
Respir Physiol Neurobioljournal_title
Respiratory physiology & neurobiologyauthors
Emery MJ,Eveland RL,Min JH,Hildebrandt J,Swenson ERdoi
10.1016/j.resp.2012.12.014subject
Has Abstractpub_date
2013-03-01 00:00:00pages
33-9issue
1eissn
1569-9048issn
1878-1519pii
S1569-9048(12)00391-6journal_volume
186pub_type
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pub_type： 临床试验,杂志文章
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pub_type： 杂志文章,评审
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更新日期：2018-06-01 00:00:00
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pub_type： 杂志文章
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更新日期：2013-11-01 00:00:00
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pub_type： 杂志文章,评审
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更新日期：2008-12-10 00:00:00
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doi：10.1016/j.resp.2020.103444
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更新日期：2008-12-10 00:00:00
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pub_type： 临床试验,杂志文章
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更新日期：2020-03-01 00:00:00
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