Abstract:
:We used quantitative single photon emission computed tomography to estimate the proportion of the observed redistribution of blood flow and ventilation that is due to lung tissue shift with a change in posture. Seven healthy volunteers were studied awake, breathing spontaneously. Regional blood flow and ventilation were marked using radiotracers that remain fixed in the lung after administration. The radiotracers were administered in prone or supine at separate occasions, at both occasions followed by imaging in both postures. Images showed greater blood flow and ventilation to regions dependent at the time of imaging, regardless of posture at radiotracer administration. The results suggest that a shift in lung parenchyma has a major influence on the imaged distributions. We conclude that a change from the supine to the prone posture primarily causes a change in the vertical distribution of lung tissue. The effect on the vertical distribution of blood flow and ventilation within the lung parenchyma is much less.
journal_name
Respir Physiol Neurobioljournal_title
Respiratory physiology & neurobiologyauthors
Petersson J,Rohdin M,Sánchez-Crespo A,Nyrén S,Jacobsson H,Larsson SA,Lindahl SG,Linnarsson D,Neradilek B,Polissar NL,Glenny RW,Mure Mdoi
10.1016/j.resp.2006.11.001subject
Has Abstractpub_date
2007-06-15 00:00:00pages
293-303issue
3eissn
1569-9048issn
1878-1519pii
S1569-9048(06)00295-3journal_volume
156pub_type
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