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Posture primarily affects lung tissue distribution with minor effect on blood flow and ventilation.

Abstract：

:We used quantitative single photon emission computed tomography to estimate the proportion of the observed redistribution of blood flow and ventilation that is due to lung tissue shift with a change in posture. Seven healthy volunteers were studied awake, breathing spontaneously. Regional blood flow and ventilation were marked using radiotracers that remain fixed in the lung after administration. The radiotracers were administered in prone or supine at separate occasions, at both occasions followed by imaging in both postures. Images showed greater blood flow and ventilation to regions dependent at the time of imaging, regardless of posture at radiotracer administration. The results suggest that a shift in lung parenchyma has a major influence on the imaged distributions. We conclude that a change from the supine to the prone posture primarily causes a change in the vertical distribution of lung tissue. The effect on the vertical distribution of blood flow and ventilation within the lung parenchyma is much less.

journal_name

Respir Physiol Neurobiol

journal_title

Respiratory physiology & neurobiology

authors

Petersson J,Rohdin M,Sánchez-Crespo A,Nyrén S,Jacobsson H,Larsson SA,Lindahl SG,Linnarsson D,Neradilek B,Polissar NL,Glenny RW,Mure M

doi

10.1016/j.resp.2006.11.001

subject

Has Abstract

pub_date

2007-06-15 00:00:00

pages

293-303

issue

3

eissn

1569-9048

issn

1878-1519

pii

S1569-9048(06)00295-3

journal_volume

156

pub_type

杂志文章

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