Lubricating effect of sialomucin and hyaluronan on pleural mesothelium.


:Coefficient of kinetic friction (μ) between rabbit visceral and parietal pleura, sliding in vitro at physiological velocities and load, increases markedly after blotting mesothelial surface with filter paper; this increase is only partially reduced by wetting blotted mesothelium with Ringer solution. Given that mesothelial surface is covered by a thick coat with sialomucin and hyaluronan, we tested whether addition of sialomucin or hyaluronan solution after blotting lowers μ more than Ringer alone. Actually, these macromolecules lowered μ more than Ringer, so that μ was no longer significantly higher than its preblotting value. Moreover, Ringer addition, after washout of macromolecule solution, increased μ, in line with their dilution. These findings indicate that mesothelial blotting removes part of these molecules from the coat covering mesothelial surface, and their relevance for pleural lubrication. Transmission electron micrographs of pleural specimens after mesothelial blotting showed that microvilli were partially or largely removed from mesothelium, consistent with a substantial loss of macromolecules normally entrapped among them.


Bodega F,Pecchiari M,Sironi C,Porta C,Arnaboldi F,Barajon I,Agostoni E




Has Abstract


2012-01-15 00:00:00














  • Influence of hypercapnic acidosis and hypoxia on abdominal expiratory nerve activity in the rat.

    abstract::We studied the influence of hypercapnic acidosis and hypoxia on the neural drive to abdominal muscles in anesthetized and decerebrate rats; this information is unavailable despite widespread use of the rat as an experimental model in respiratory physiology and neurobiology. To minimize confounding influences from rece...

    journal_title:Respiratory physiology & neurobiology

    pub_type: 杂志文章


    authors: Iizuka M,Fregosi RF

    更新日期:2007-08-01 00:00:00

  • Medullary serotonin neurons and central CO2 chemoreception.

    abstract::Serotonergic (5-HT) neurons are putative central respiratory chemoreceptors, aiding in the brain's ability to detect arterial changes in PCO2 and implement appropriate ventilatory responses to maintain blood homeostasis. These neurons are in close proximity to large medullary arteries and are intrinsically chemosensit...

    journal_title:Respiratory physiology & neurobiology

    pub_type: 杂志文章,评审


    authors: Corcoran AE,Hodges MR,Wu Y,Wang W,Wylie CJ,Deneris ES,Richerson GB

    更新日期:2009-08-31 00:00:00

  • Examining work-to-rest ratios to optimize upper body sprint interval training.

    abstract::The objective was to compare the metabolic influence of varying work-to-rest ratios during upper body sprint interval training (SIT). Forty-two recreationally-trained men were randomized into a training group [10 s work - 2 min of rest (10:2) or 4 min of rest (10:4), or 30 s work - 4 min of rest (30:4)] or a control g...

    journal_title:Respiratory physiology & neurobiology

    pub_type: 杂志文章,随机对照试验


    authors: La Monica MB,Fukuda DH,Starling-Smith TM,Clark NW,Morales J,Hoffman JR,Stout JR

    更新日期:2019-04-01 00:00:00

  • The fall in exhaled nitric oxide with ventilation at low lung volumes in rabbits: an index of small airway injury.

    abstract::The mechanisms involved in the fall of exhaled nitric oxide (NOe) concentration occurring in normal, anesthetized open chest rabbits with prolonged mechanical ventilation (MV) at low lung volume have been investigated. NOe, pH of exhaled vapor condensate, serum prostaglandin E(2), and F(2alpha), tumor necrosis factor ...

    journal_title:Respiratory physiology & neurobiology

    pub_type: 杂志文章


    authors: D'Angelo E,Koulouris NG,Della Valle P,Gentile G,Pecchiari M

    更新日期:2008-02-01 00:00:00

  • Correlations between the circadian patterns of body temperature, metabolism and breathing in rats.

    abstract::It had been demonstrated previously that the circadian patterns of activity and state of arousal are not essential for the manifestation of the daily patterns of pulmonary ventilation (V(E)), tidal volume (V(T)) and breathing frequency (f). In this study we investigated the extent of the linkage between the circadian ...

    journal_title:Respiratory physiology & neurobiology

    pub_type: 杂志文章


    authors: Mortola JP

    更新日期:2007-02-15 00:00:00

  • Does menstrual cycle phase affect lung diffusion capacity during exercise?

    abstract::Resting lung diffusing capacity (DLCO) decreases during the early and late-follicular phases of the menstrual cycle presumably due to capillary blood volume (VC) changes; however, it is not known if these differences exist during exercise. We hypothesized that DLCO would increase during the mid-luteal phase of the men...

    journal_title:Respiratory physiology & neurobiology

    pub_type: 杂志文章


    authors: Smith JR,Brown KR,Murphy JD,Harms CA

    更新日期:2015-01-01 00:00:00

  • Ventilatory pattern and chemosensitivity in M1 and M3 muscarinic receptor knockout mice.

    abstract::Acetylcholine (ACh) acting through muscarinic receptors is thought to be involved in the control of breathing, notably in central and peripheral chemosensory afferents and in regulations related to sleep-wake states. By using whole-body plethysmography, we compared baseline breathing at rest and ventilatory responses ...

    journal_title:Respiratory physiology & neurobiology

    pub_type: 杂志文章


    authors: Boudinot E,Yamada M,Wess J,Champagnat J,Foutz AS

    更新日期:2004-02-25 00:00:00

  • Numerical simulation of respiratory flow patterns within human lung.

    abstract::A computational fluid dynamics (CFD) modelling approach is used to study the unsteady respiratory airflow dynamics within a human lung. The three-dimensional asymmetric bifurcation model of the central airway based on the morphological data given by Horsfield et al. (J. Appl. Physiol. 67 (1971) 207) was used in the pr...

    journal_title:Respiratory physiology & neurobiology

    pub_type: 杂志文章


    authors: Calay RK,Kurujareon J,Holdø AE

    更新日期:2002-04-01 00:00:00

  • Inflammatory related changes in lung tissue mechanics after bleomycin-induced lung injury.

    abstract::The impact of lung remodelling in respiratory mechanics has been widely studied in bleomycin-induced lung injury. However, little is known regarding the relationship between the amount of lung inflammation and pulmonary tissue mechanics. For this purpose, rats were intratracheally instilled with bleomycin (n=29) or sa...

    journal_title:Respiratory physiology & neurobiology

    pub_type: 杂志文章


    authors: Pinart M,Serrano-Mollar A,Negri EM,Cabrera R,Rocco PR,Romero PV

    更新日期:2008-02-01 00:00:00

  • Salbutamol improves markers of epithelial function in mice with chronic allergic pulmonary inflammation.

    abstract::We investigated the effects of salbutamol on the markers of epithelial function in a murine model of chronic allergic pulmonary inflammation by recording the ciliary beat frequency (CBF) and the transepithelial potential difference (PD) in vivo. Mice were sensitized and received four challenges of ovalbumin (OVA group...

    journal_title:Respiratory physiology & neurobiology

    pub_type: 杂志文章


    authors: Toledo AC,Arantes-Costa FM,Macchione M,Saldiva PH,Negri EM,Lorenzi-Filho G,Martins MA

    更新日期:2011-07-31 00:00:00

  • Neural drive to respiratory muscles in the spontaneously breathing rat pup.

    abstract::The neonatal rodent serves as useful and appropriate model within which to study respiratory system development. Despite an extensive literature that documents respiratory control in vitro, in vivo studies have relied upon whole body plethysmography to determine measures of respiratory frequency and tidal volume. Howe...

    journal_title:Respiratory physiology & neurobiology

    pub_type: 杂志文章


    authors: Kidder IJ,Mudery JA,Bailey EF

    更新日期:2014-10-01 00:00:00

  • Effect of supine posture on airway blood flow and pulmonary function in stable heart failure.

    abstract:BACKGROUND:The aim of this study was to determine the relationship between body position, pulmonary function (PF) and bronchial blood flow (Q(aw)) in a group of heart failure (HF) and control subjects. METHODS:Thirty-six subjects were studied: 24 stable, ambulatory HF patients (HF: LVEF=27±6%, age=65±9 yr) and 12 age-...

    journal_title:Respiratory physiology & neurobiology

    pub_type: 杂志文章


    authors: Ceridon ML,Morris NR,Olson TP,Lalande S,Johnson BD

    更新日期:2011-09-15 00:00:00

  • Embryonic development of endothermy.

    abstract::During embryonic development of homeothermic animals like birds and mammals transition from ectothermy to endothermy occurs especially in precocial species of both taxa. Based on some evolutionary aspects of the development of endothermy the review focuses on the prenatal development of endothermy and of the thermoreg...

    journal_title:Respiratory physiology & neurobiology

    pub_type: 杂志文章,评审


    authors: Tzschentke B,Rumpf M

    更新日期:2011-08-31 00:00:00

  • Allometric scaling of maximal metabolic rate in mammals: muscle aerobic capacity as determinant factor.

    abstract::Maximal metabolic rate (MMR) of mammals scales differently from basal metabolic rate (BMR). This is first shown by scrutinizing data reported on exercise-induced Vo2 max in 34 eutherian mammalian species covering a body mass range of 7 g-500 kg. Vo2 max was found to scale with the 0.872 (+/-0.029, 95% confidence limit...

    journal_title:Respiratory physiology & neurobiology

    pub_type: 杂志文章,评审


    authors: Weibel ER,Bacigalupe LD,Schmitt B,Hoppeler H

    更新日期:2004-05-20 00:00:00

  • Impact of sleep disordered breathing on carotid body size.

    abstract::We tested the hypotheses that: (1) carotid body size can be measured by computed tomographic angiography (CTA) with high inter-observer agreement, and (2) patients with sleep apnea exhibit larger carotid bodies than those without sleep apnea. A chart review was conducted from patients who underwent neck CTA and polyso...

    journal_title:Respiratory physiology & neurobiology

    pub_type: 杂志文章


    authors: Welch BT,Petersen-Jones HG,Eugene AR,Brinjikji W,Kallmes DF,Curry TB,Joyner MJ,Limberg JK

    更新日期:2017-02-01 00:00:00

  • Hypoxic incubation creates differential morphological effects during specific developmental critical windows in the embryo of the chicken (Gallus gallus).

    abstract::Hypoxia inhibits vertebrate development, but the magnitude and timing of organ-specific effects are poorly understood. Chick embryos were exposed continuously to hypoxia (15% O2) throughout Days 1-6, 6-12, 12-18 or Days 1-18 of development, followed by morphometric measurements of major organ systems. Early hypoxic ex...

    journal_title:Respiratory physiology & neurobiology

    pub_type: 杂志文章


    authors: Chan T,Burggren W

    更新日期:2005-02-15 00:00:00

  • The evolutionary origin of the mammalian diaphragm.

    abstract::The comparatively low compliance of the mammalian lung results in an evolutionary dilemma: the origin and evolution of this bronchoalveolar lung into a high-performance gas-exchange organ results in a high work of breathing that cannot be achieved without the coupled evolution of a muscular diaphragm. However, despite...

    journal_title:Respiratory physiology & neurobiology

    pub_type: 杂志文章,评审


    authors: Perry SF,Similowski T,Klein W,Codd JR

    更新日期:2010-04-15 00:00:00

  • Effects of Eucalyptol in respiratory system mechanics on acute lung injury after exposure to short-term cigarette smoke.

    abstract::Eucalyptol is a compound that has demonstrated antioxidant, anti-inflammatory and bronchodilator effects, but there are no investigations about the effects of this constituent on the respiratory system mechanics in relation to acute lung injury caused by short-term cigarette smoke (CS) exposure. In view of the above, ...

    journal_title:Respiratory physiology & neurobiology

    pub_type: 杂志文章


    authors: Gondim FL,Serra DS,Cavalcante FSÁ

    更新日期:2019-08-01 00:00:00

  • Nitric oxide inhibitor altitude-dependently elevates pulmonary arterial pressure in high-altitude adapted yaks.

    abstract::We studied the effect of N(w)-nitro-L-arginine (NLA) on yak pulmonary vascular tone in a climatic (hypobaric/hyperbaric adjusted) chamber. Five young male yaks that had been born and reared at an altitude greater than 3800 m a.s.l. were used. After measuring control values, 20 mg/kg of NLA was administered via the jug...

    journal_title:Respiratory physiology & neurobiology

    pub_type: 杂志文章


    authors: Ishizaki T,Koizumi T,Ruan Z,Wang Z,Chen Q,Sakai A

    更新日期:2005-04-15 00:00:00

  • MicroRNA-328 is involved in wound repair process in human bronchial epithelial cells.

    abstract::Our aim was to investigate the role of microRNA on epithelial wound repair by global microRNA silencing. We have also analysed the influence of five miRNAs (miR-328, miR-342, miR-411, miR-609, miR-888, previously identified) on wound repair in 16HBE14o-bronchial epithelial cell line. Cells were transfected with siRNAs...

    journal_title:Respiratory physiology & neurobiology

    pub_type: 杂志文章


    authors: Narożna B,Langwinski W,Jackson C,Lackie P,Holloway JW,Szczepankiewicz A

    更新日期:2017-08-01 00:00:00

  • Brainstem-mediated sniffing and respiratory modulation during odor stimulation.

    abstract::The trigeminal and olfactory systems interact during sensory processing of odor. Here, we investigate odor-evoked modulations of brainstem respiratory networks in a decerebrated perfused brainstem preparation of rat with intact olfactory bulbs. Intranasal application of non-trigeminal odors (rose) did not evoke respir...

    journal_title:Respiratory physiology & neurobiology

    pub_type: 杂志文章


    authors: Pérez de Los Cobos Pallares F,Bautista TG,Stanić D,Egger V,Dutschmann M

    更新日期:2016-11-01 00:00:00

  • Obesity: challenges to ventilatory control during exercise--a brief review.

    abstract::Obesity is a national health issue in the US. Among the many physiological changes induced by obesity, it also presents a unique challenge to ventilatory control during exercise due to increased metabolic demand of moving larger limbs, increased work of breathing due to extra weight on the chest wall, and changes in b...

    journal_title:Respiratory physiology & neurobiology

    pub_type: 杂志文章,评审


    authors: Babb TG

    更新日期:2013-11-01 00:00:00

  • Dyspnoea in children. Does development alter the perception of breathlessness?

    abstract::Dyspnoea, the perception of an unpleasant and/or uncomfortable sensation of breathlessness, offers several physiological, anatomical and teleological analogies with pain. Pain perception has been shown to exist in the newborn, suggesting that dyspnoea may also occur from birth onwards. The perception of breathlessness...

    journal_title:Respiratory physiology & neurobiology

    pub_type: 社论,评审


    authors: Schweitzer C,Marchal F

    更新日期:2009-05-30 00:00:00

  • Histaminergic and dopaminergic traits in the human carotid body.

    abstract::Carotid body (CB) chemoreceptors are the main sensors detecting systemic hypoxia. Studies in animals revealed that dopamine and histamine may serve as transmitters between the chemoreceptor cells and the afferent nerve. To gain insight whether histamine and dopamine could play a role in the human CB and thus be import...

    journal_title:Respiratory physiology & neurobiology

    pub_type: 杂志文章


    authors: Lazarov NE,Reindl S,Fischer F,Gratzl M

    更新日期:2009-02-28 00:00:00

  • Inter-individual differences in control of alveolar capillary blood volume in exercise and hypoxia.

    abstract::We compared by non-invasive technique the adaptive response of alveolar capillary network to edemagenic conditions (exercise and high altitude [HA, PIO2 107mmHg] in subjects with different resting sea level (SL) capillary blood volume (normalized to alveolar volume, Vc/Va): Group 1 (N=10, Vc/Va=16.1±6.8ml/L- mean±SD) ...

    journal_title:Respiratory physiology & neurobiology

    pub_type: 杂志文章


    authors: Bartesaghi M,Beretta E,Pollastri L,Scotti V,Mandolesi G,Lanfranconi F,Miserocchi G

    更新日期:2014-01-01 00:00:00

  • Breathing disturbances in a model of Rett syndrome: A potential involvement of the glycine receptor α3 subunit?

    abstract::The glycine receptor α3 subunit is known to be a target for cAMP/PKA-mediated phosphorylation and regulation. Mice that lack this subunit are apparently normal but the 5-HT1A-receptor mediated modulation of respiratory network activity is disturbed. Since the intracellular cAMP-concentration is reduced in mice that la...

    journal_title:Respiratory physiology & neurobiology

    pub_type: 杂志文章


    authors: Mesuret G,Dannenberg J,Arnoldt M,Grützner AA,Niebert M,Hülsmann S

    更新日期:2018-01-01 00:00:00

  • Low exertional inspiratory capacity is not related to dynamic inspiratory muscle weakness in heart failure.

    abstract::Reduction in inspiratory capacity (IC) during exercise has been reported in chronic heart failure (CHF). Since inspiratory muscle dysfunction may be present to a variable degree, the assumption that IC reduction during exercise represents an increase in end-expiratory lung volume must be made with caution. This interp...

    journal_title:Respiratory physiology & neurobiology

    pub_type: 杂志文章


    authors: Plachi F,Balzan FM,Gass R,Dorneles RG,Zambiazi R,da Silva DP,Sanches PR,Clausell NO,Berton DC

    更新日期:2018-08-01 00:00:00

  • TRPM8 channel is involved in the ventilatory response to CO2 mediating hypercapnic Ca2+ responses.

    abstract::The role of TRP channels in the ventilatory response to CO2 was investigated in vivo. To this end, the respiration of unrestrained adult TRPM8-, TRPV1- and TRPV4-channel knockout mice was measured using whole-body plethysmography. Under control conditions and hyperoxic hypercapnia, no difference in respiratory paramet...

    journal_title:Respiratory physiology & neurobiology

    pub_type: 杂志文章


    authors: Hirata Y,Suzuki Y,Tominaga M,Oku Y

    更新日期:2019-05-01 00:00:00

  • Effect of CPAP on sleep spindles in patients with OSA.

    abstract:OBJECTIVE:Consequences of OSAS include excessive daytime sleepiness, divided sleep architecture, impaired neurocognitive performance, and significant psychosocial disruption. In this study we aimed to evaluate sleep spindles changes before and after PAP treatment in patient with OSA. METHODS:Seventy-three consecutive ...

    journal_title:Respiratory physiology & neurobiology

    pub_type: 杂志文章


    authors: Yetkin O,Aydogan D

    更新日期:2018-01-01 00:00:00

  • Lung function and respiratory muscle strength and their relationship with weightlifting strength and body composition in non-athletic males.

    abstract::The aim of this study was to examine whether lung function and respiratory muscle strength are associated with weightlifting strength and body composition in non-athletic males. A total 51 males with resistance training experience participated. One-repetition maximum tests were performed for the bench press, squat and...

    journal_title:Respiratory physiology & neurobiology

    pub_type: 杂志文章


    authors: Hackett DA,Sabag A

    更新日期:2021-01-14 00:00:00