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Lubricating effect of sialomucin and hyaluronan on pleural mesothelium.

Abstract：

:Coefficient of kinetic friction (μ) between rabbit visceral and parietal pleura, sliding in vitro at physiological velocities and load, increases markedly after blotting mesothelial surface with filter paper; this increase is only partially reduced by wetting blotted mesothelium with Ringer solution. Given that mesothelial surface is covered by a thick coat with sialomucin and hyaluronan, we tested whether addition of sialomucin or hyaluronan solution after blotting lowers μ more than Ringer alone. Actually, these macromolecules lowered μ more than Ringer, so that μ was no longer significantly higher than its preblotting value. Moreover, Ringer addition, after washout of macromolecule solution, increased μ, in line with their dilution. These findings indicate that mesothelial blotting removes part of these molecules from the coat covering mesothelial surface, and their relevance for pleural lubrication. Transmission electron micrographs of pleural specimens after mesothelial blotting showed that microvilli were partially or largely removed from mesothelium, consistent with a substantial loss of macromolecules normally entrapped among them.

journal_name

Respir Physiol Neurobiol

journal_title

Respiratory physiology & neurobiology

authors

Bodega F,Pecchiari M,Sironi C,Porta C,Arnaboldi F,Barajon I,Agostoni E

doi

10.1016/j.resp.2011.10.006

subject

Has Abstract

pub_date

2012-01-15 00:00:00

pages

34-9

issue

1

eissn

1569-9048

issn

1878-1519

pii

S1569-9048(11)00356-9

journal_volume

180

pub_type

杂志文章

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