Abstract：
:In previous calculations of how the O2 transport system limits .VO2(max), it was reasonably assumed that mitochondrial P(O2) (Pm(O2)) could be neglected (set to zero). However, in reality, Pm(O2) must exceed zero and the red cell to mitochondrion diffusion gradient may therefore be reduced, impairing diffusive transport of O2 and .VO2(max). Accordingly, we investigated the influence of Pm(O2) on these calculations by coupling previously used equations for O2 transport to one for mitochondrial respiration relating mitochondrial .VO2 to P(O2). This hyperbolic function, characterized by its P50 and V˙MAX, allowed Pm(O2) to become a model output (rather than set to zero as previously). Simulations using data from exercising normal subjects showed that at .VO2(max), Pm(O2) was usually <1mmHg, and that the effects on .VO2(max) were minimal. However, when O2 transport capacity exceeded mitochondrial V˙MAX, or if P50 were elevated,Pm(O2) often reached double digit values, thereby reducing the diffusion gradient and significantly decreasing .VO2(max).
journal_name
Respir Physiol Neurobioljournal_title
Respiratory physiology & neurobiologyauthors
Cano I,Mickael M,Gomez-Cabrero D,Tegnér J,Roca J,Wagner PDdoi
10.1016/j.resp.2013.08.020subject
Has Abstractpub_date
2013-12-01 00:00:00pages
477-83issue
3eissn
1569-9048issn
1878-1519pii
S1569-9048(13)00302-9journal_volume
189pub_type
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