Abstract:
:In response to the increase in oxygen tension at birth, the resistance pulmonary arteries dilate, while the ductus arteriosus constricts. Although modulated by the endothelium, these opposite responses are intrinsic to the vascular smooth muscle. While still controversial, it seems likely that during normoxia the production of reactive oxygen species (ROS) increases and the smooth muscle cell cytoplasm is more oxidized in both pulmonary arteries and ductus, compared to hypoxia. However, the effect of changes in the endogenous redox status or the addition of a redox agent, oxidizing or reducing, is exactly opposite in the two vessels. A reducing agent, dithiothreitol, like hypoxia, in the pulmonary artery will inhibit potassium current, cause depolarization, increase cytosolic calcium and lead to contraction. Responses to dithiothreitol in the ductus are opposite and removal of endogenous H(2)O(2) by intracellular catalase in the ductus increases potassium current. Oxygen sensing in both vessels is probably mediated by redox effects on both calcium influx and calcium release from the sarcoplasmic reticulum (SR).
journal_name
Respir Physiol Neurobioljournal_title
Respiratory physiology & neurobiologyauthors
Weir EK,Hong Z,Porter VA,Reeve HLdoi
10.1016/s1569-9048(02)00054-xkeywords:
subject
Has Abstractpub_date
2002-08-22 00:00:00pages
121-30issue
1eissn
1569-9048issn
1878-1519pii
S156990480200054Xjournal_volume
132pub_type
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