Abstract：
:In Wild Type (WT) and serotonin transporter (5HTT) null mice, we studied oxygen consumption, ventilation and heart rate in air and 5% CO(2) at postnatal (P) days P5, P15, and P25 using either a head-out (younger mice) or whole body plethysmograph (older mice). Body weight and temperature did not differ between the groups. Oxygen consumption differed significantly only in females at P15 when it was reduced in 5HTT nulls (P<0.01). Heart rate similarly differed only in female 5HTT nulls at P15 being decreased in both air and CO(2) (P<0.01). Ventilation in air and 5% CO(2) was significant reduced via an effect on tidal volume at P15 (P<0.02) and P25 (P<0.05) but only in males. Ventilation in air and 5% CO(2) was greater in 5HTT null females at P25. We conclude that the gender specific effect (male predominant) on the CO(2) response reported in 5HTT null adult mice (Li and Nattie, 2008, J. Physiol. 586.9, 2321-2329, 2008) appears to have origins in early postnatal life (P15) when ventilation in both air and 5% CO(2) is reduced.
journal_name
Respir Physiol Neurobioljournal_title
Respiratory physiology & neurobiologyauthors
Penatti E,Barina A,Schram K,Li A,Nattie Edoi
10.1016/j.resp.2011.02.006subject
Has Abstractpub_date
2011-06-30 00:00:00pages
61-5issue
1eissn
1569-9048issn
1878-1519pii
S1569-9048(11)00056-5journal_volume
177pub_type
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