Plasticity of peripheral mechanisms of cough.

Abstract:

:The cough reflex pathway is characterized by a remarkable plasticity often resulting in a persistent and uncontrollable urge to cough during airway inflammation. In many instances cough becomes up regulated to the extent that ceases to fulfill its defensive role in protecting the airways. The exact mechanisms underlying this plasticity are unknown and likely involves a variety of factors influencing the function of the peripheral and central nervous system. This review outlines the evidence of increased cough sensitivity during airway disease. This is followed by a discussion of the peripheral mechanisms involved including the potential role of inflammatory mediators, neutrophins and changes in the airway mucosal structure. A greater understanding of the mechanisms leading to enhanced cough should lead to the development of more effective therapeutic strategies.

authors

Carr MJ,Lee LY

doi

10.1016/j.resp.2005.11.003

keywords:

subject

Has Abstract

pub_date

2006-07-28 00:00:00

pages

298-311

issue

3

eissn

1569-9048

issn

1878-1519

pii

S1569-9048(05)00274-0

journal_volume

152

pub_type

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