DLNO/DLCO ratio evolution under targeted therapy in patients with pulmonary hypertension.


:The ratio of the diffusing capacity of the lung for carbon monoxide (DLCO) and for nitric oxide (DLNO) measured simultaneously is modified in patients with precapillary pulmonary hypertension (PH). The potential impact of targeted therapy on the DLCO/DLNO ratio is unknown. Simultaneous measurements of DLNO and DLCO were performed at baseline, 3-4 month follow-up (first evaluation) and 12-month follow-up (second evaluation) after initiation of targeted PH therapies in incident cases of precapillary PH. The main outcome was the change in DLNO/DLCO ratio under treatment between baseline and the first evaluation. Twenty-nine patients were included (mean age: 66.8 years, 62.1% female). No significant change in the DLNO/DLCO ratio was found between baseline and the first evaluation. Similarly, no significant differences were noted with regard to changes in Dm or Vc, the DLNO/DLCO ratio in different patient subgroups, or in the 20 patients evaluated at the second follow-up. Within the limitations of this study, the DLNO/DLCO ratio is not useful in monitoring the response to treatment in PH.


Catella J,Costes F,Gaultier JB,Court Fortune I,Tulane C,De Magalhaes E,Accassat S,Chomette-Ballereau S,Chapelle C,Bertoletti L




Has Abstract


2020-08-01 00:00:00












  • Effect of medroxyprogesterone on inspiratory flow shapes during sleep in postmenopausal women.

    abstract::We previously showed that medroxyprogesterone acetate (MPA) effectively decreases the arterial CO(2) levels in postmenopausal women with partial upper airway obstruction. The aim of the present study was to analyze the effects of MPA on the inspiratory flow shapes during sleep. Eight postmenopausal women with hypoxemi...

    journal_title:Respiratory physiology & neurobiology

    pub_type: 临床试验,杂志文章


    authors: Saaresranta T,Aittokallio T,Polo-Kantola P,Helenius H,Polo O

    更新日期:2003-03-03 00:00:00

  • Asthmatic cough and airway oxidative stress.

    abstract::The mechanisms of cough in asthma are unclear. Asthma is associated with an oxidative stress. Many reactive oxygen species sensitize or activate sensory C-fibers which are capable to induce cough. It was hypothesized that oxidative stress in the airways might contribute to the cough severity in asthma. Exhaled breath ...

    journal_title:Respiratory physiology & neurobiology

    pub_type: 杂志文章


    authors: Koskela HO,Purokivi MK,Nieminen RM,Moilanen E

    更新日期:2012-05-31 00:00:00

  • Cough reflex sensitivity does not correlate with the esophageal sensitivity to acid in patients with gastroesophageal reflux disease.

    abstract::The sensitization of cough reflex observed in patients with gastroesophageal reflux disease (GERD) is attributed to activation of vagal C-fibers innervating the esophagus by acid, while the heartburn in GERD is mediated by esophageal acid sensitive C-fibers derived from (dorsal root ganglia) DRG. Here we explored the ...

    journal_title:Respiratory physiology & neurobiology

    pub_type: 杂志文章


    authors: Duricek M,Nosakova L,Zatko T,Pecova R,Hyrdel R,Banovcin P Jr

    更新日期:2018-11-01 00:00:00

  • Inflammatory related changes in lung tissue mechanics after bleomycin-induced lung injury.

    abstract::The impact of lung remodelling in respiratory mechanics has been widely studied in bleomycin-induced lung injury. However, little is known regarding the relationship between the amount of lung inflammation and pulmonary tissue mechanics. For this purpose, rats were intratracheally instilled with bleomycin (n=29) or sa...

    journal_title:Respiratory physiology & neurobiology

    pub_type: 杂志文章


    authors: Pinart M,Serrano-Mollar A,Negri EM,Cabrera R,Rocco PR,Romero PV

    更新日期:2008-02-01 00:00:00

  • Ovarian steroids act as respiratory stimulant and antioxidant against the causes and consequences of sleep-apnea in women.

    abstract::Evidence supports the importance of ovarian hormones as potential tools against sleep apneas in women. On one hand, progesterone is largely acknowledged as being a respiratory stimulant that reduces the frequency of apneas, but the underlying mechanisms remain poorly understood. Recent studies in mice showed that the ...

    journal_title:Respiratory physiology & neurobiology

    pub_type: 杂志文章,评审


    authors: Boukari R,Laouafa S,Ribon-Demars A,Bairam A,Joseph V

    更新日期:2017-05-01 00:00:00

  • Effects on breathing of agonists to μ-opioid or GABAA receptors dialyzed into the ventral respiratory column of awake and sleeping goats.

    abstract::Pulmonary ventilation (V̇I) in awake and sleeping goats does not change when antagonists to several excitatory G protein-coupled receptors are dialyzed unilaterally into the ventral respiratory column (VRC). Concomitant changes in excitatory neuromodulators in the effluent mock cerebral spinal fluid (mCSF) suggest neu...

    journal_title:Respiratory physiology & neurobiology

    pub_type: 杂志文章


    authors: Langer TM 3rd,Neumueller SE,Crumley E,Burgraff NJ,Talwar S,Hodges MR,Pan L,Forster HV

    更新日期:2017-05-01 00:00:00

  • Mice-to-men comparison of inhaled drug-aerosol deposition and clearance.

    abstract::Part of the effective prediction of the pharmacokinetics of drugs (or toxic particles) requires extrapolation of experimental data sets from animal studies to humans. As the respiratory tracts of rodents and humans are anatomically very different, there is a need to study airflow and drug-aerosol deposition patterns i...

    journal_title:Respiratory physiology & neurobiology

    pub_type: 杂志文章


    authors: Kolanjiyil AV,Kleinstreuer C,Kleinstreuer NC,Pham W,Sadikot RT

    更新日期:2019-02-01 00:00:00

  • Airflow pattern complexity during resting breathing in patients with COPD: effect of airway obstruction.

    abstract::We investigated the influence of airway obstruction in the complexity of the airflow pattern in COPD and its use as a marker of disease activity. The sample entropy (SampEnV') and the variability (SDV') of the airflow pattern were measured in a group of 88 subjects with various levels of airway obstruction. Airway obs...

    journal_title:Respiratory physiology & neurobiology

    pub_type: 杂志文章


    authors: Dames KK,Lopes AJ,de Melo PL

    更新日期:2014-02-01 00:00:00

  • Mechanics of respiratory muscles.

    abstract::Lung ventilation is a mechanical process in which the respiratory muscles are acting in concert to remove air in and out of the lungs. Any alteration in the performance of the respiratory muscle may reduce the effectiveness of ventilation. Thus, early diagnosis of their weakness is vital for treatment and rehabilitati...

    journal_title:Respiratory physiology & neurobiology

    pub_type: 杂志文章,评审


    authors: Ratnovsky A,Elad D,Halpern P

    更新日期:2008-11-30 00:00:00

  • Vascular KATP channels mitigate severe muscle O2 delivery-utilization mismatch during contractions in chronic heart failure rats.

    abstract::The vascular ATP-sensitive K+ (KATP) channel is a mediator of skeletal muscle microvascular oxygenation (PO2mv) during contractions in health. We tested the hypothesis that KATP channel function is preserved in chronic heart failure (CHF) and therefore its inhibition would reduce PO2mv and exacerbate the time taken to...

    journal_title:Respiratory physiology & neurobiology

    pub_type: 杂志文章


    authors: Holdsworth CT,Ferguson SK,Colburn TD,Fees AJ,Craig JC,Hirai DM,Poole DC,Musch TI

    更新日期:2017-04-01 00:00:00

  • Validation of a quantitative method to measure neural respiratory drive in children during sleep.

    abstract:AIMS:Quantitatively measure and validate analysis of neural respiratory drive (NRD) using a commercial polysomnography system in children during sleep. METHOD:Surface electromyogram of the diaphragm (sEMGdi) recorded from primary snoring children were analysed. A subset was re-analysed to assess intra- and inter-inves...

    journal_title:Respiratory physiology & neurobiology

    pub_type: 杂志文章


    authors: Chuang SY,Teng A,Butler JE,Gandevia SC,Selvadurai H,Jaffe A

    更新日期:2017-05-01 00:00:00

  • Effects of dietary inorganic nitrate on static and dynamic breath-holding in humans.

    abstract::Inorganic nitrate has been shown to reduce oxygen cost during exercise. Since the nitrate-nitrite-NO pathway is facilitated during hypoxia, we investigated the effects of dietary nitrate on oxygen consumption and cardiovascular responses during apnea. These variables were measured in two randomized, double-blind, plac...

    journal_title:Respiratory physiology & neurobiology

    pub_type: 杂志文章,随机对照试验


    authors: Schiffer TA,Larsen FJ,Lundberg JO,Weitzberg E,Lindholm P

    更新日期:2013-01-15 00:00:00

  • Amelioration of allergic asthma by Ziziphora clinopodioides via upregulation of aquaporins and downregulation of IL4 and IL5.

    abstract::Ziziphora clinopodioides has been frequently used as an anti asthmatic plant in traditional medication. Recent work explores the anti-asthmatic activity of Z. clinopodioides in allergen-induced asthmatic mice. Intraperitoneal sensitization followed by intranasal challenge were given with ovalbumin (allergen) to develo...

    journal_title:Respiratory physiology & neurobiology

    pub_type: 杂志文章


    authors: Ahsan F,Shabbir A,Shahzad M,Mobashar A,Sharif M,Basheer MI,Tareen RB,Syed NI

    更新日期:2019-08-01 00:00:00

  • Chronic mountain sickness score was related with health status score but not with hemoglobin levels at high altitudes.

    abstract::Chronic mountain sickness (CMS) or lack of adaptation to live in high altitudes is related to environmental hypoxia and excessive erythrocytosis (EE) (hemoglobin >21 and >19 g/dL for men and women, respectively). Diagnosis of CMS ("Qinghai CMS Score") is based on seven signs/symptoms (breathlessness and/or palpitation...

    journal_title:Respiratory physiology & neurobiology

    pub_type: 杂志文章


    authors: Gonzales GF,Rubio J,Gasco M

    更新日期:2013-08-15 00:00:00

  • Vagotomy reverses established allergen-induced airway hyperreactivity to methacholine in the mouse.

    abstract::We evaluated the role of vagal reflexes in a mouse model of allergen-induced airway hyperreactivity. Mice were actively sensitized to ovalbumin then exposed to the allergen via inhalation. Prior to ovalbumin inhalation, mice also received intratracheally-instilled particulate matter in order to boost the allergic resp...

    journal_title:Respiratory physiology & neurobiology

    pub_type: 杂志文章


    authors: McAlexander MA,Gavett SH,Kollarik M,Undem BJ

    更新日期:2015-07-01 00:00:00

  • Morphological analysis of the trachea and pattern of breathing in βENaC-Tg mice.

    abstract::Cystic fibrosis (CF) is caused by mutations in the CFTR (cystic fibrosis transmembrane conductance regulator) gene which is a Cl- channel and a regulator of the epithelial Na+ channel (ENaC). We have recently shown that newborn CFTR-deficient mice exhibit abnormalities of the tracheal cartilage leading to altered vent...

    journal_title:Respiratory physiology & neurobiology

    pub_type: 杂志文章


    authors: Bonora M,Riffault L,Marie S,Mall M,Clement A,Tabary O

    更新日期:2011-09-15 00:00:00

  • Vertebrate brains at the pilot light.

    abstract::While the brains of most vertebrates are unable to tolerate more than a few minutes of anoxia, some freshwater turtles (Trachemys and Chrysemys), crucian carp (Carassius carassius) and frogs (Rana pipens and Rana temporaria) can survive anoxia for hours to months. Obviously, anoxia tolerance has evolved separately sev...

    journal_title:Respiratory physiology & neurobiology

    pub_type: 杂志文章,评审


    authors: Lutz PL,Nilsson GE

    更新日期:2004-08-12 00:00:00

  • Chest wall kinematics during voluntary cough in neuromuscular patients.

    abstract::Muscular diseases are characterized by progressive loss of muscle strength, resulting in cough ineffectiveness with its deleterious effects on the respiratory system. Assessment of cough effectiveness is therefore a prominent component of the clinical evaluation and respiratory care in these patients. Owing to uneven ...

    journal_title:Respiratory physiology & neurobiology

    pub_type: 杂志文章


    authors: Lanini B,Masolini M,Bianchi R,Binazzi B,Romagnoli I,Gigliotti F,Scano G

    更新日期:2008-03-20 00:00:00

  • AMP-activated protein kinase and chemotransduction in the carotid body.

    abstract::AMP-activated protein kinase (AMPK) is a key component of a kinase cascade that regulates energy balance at the cellular level. Our recent research has raised the possibility that AMPK may also function to couple hypoxic inhibition of mitochondrial oxidative phosphorylation to O(2)-sensitive K(+) channel inhibition an...

    journal_title:Respiratory physiology & neurobiology

    pub_type: 杂志文章,评审


    authors: Wyatt CN,Evans AM

    更新日期:2007-07-01 00:00:00

  • Expression of the transcription factor FOXP2 in brainstem respiratory circuits of adult rat is restricted to upper-airway pre-motor areas.

    abstract::Expression of the transcription factor FOXP2 is linked to brain circuits that control motor function and speech. Investigation of FOXP2 protein expression in respiratory areas of the ponto-medullary brainstem of adult rat revealed distinct rostro-caudal expression gradients. A high density of FOXP2 immunoreactive nucl...

    journal_title:Respiratory physiology & neurobiology

    pub_type: 杂志文章


    authors: Stanić D,Dhingra RR,Dutschmann M

    更新日期:2018-04-01 00:00:00

  • Cardiorespiratory responses and reduced apneic time to cold-water face immersion after high intensity exercise.

    abstract::Apnea after exercise may evoke a neurally mediated conflict that may affect apneic time and create a cardiovascular strain. The physiological responses, induced by apnea with face immersion in cold water (10 °C), after a 3-min exercise bout, at 85% of VO2max,were examined in 10 swimmers. A pre-selected 40-s apnea, com...

    journal_title:Respiratory physiology & neurobiology

    pub_type: 杂志文章


    authors: Konstantinidou S,Soultanakis H

    更新日期:2016-01-01 00:00:00

  • Breathing challenges in Rett syndrome: lessons learned from humans and animal models.

    abstract::Breathing disturbances are a major challenge in Rett Syndrome (RTT). These disturbances are more pronounced during wakefulness; but irregular breathing occurs also during sleep. During the day patients can exhibit alternating bouts of hypoventilation and irregular hyperventilation. But there is significant individual ...

    journal_title:Respiratory physiology & neurobiology

    pub_type: 杂志文章,评审


    authors: Ramirez JM,Ward CS,Neul JL

    更新日期:2013-11-01 00:00:00

  • Pulmonary mechanics and lung histology in acute lung injury induced by Bothrops jararaca venom.

    abstract::Pulmonary mechanics [static (Est) and dynamic (Edyn) elastances, resistive (DeltaP1) and viscoelastic pressures (DeltaP2)], histology, and bronchoalveolar lavage fluid (BALF) from BALB/c mice were analysed 1, 24, 48 and 72 h after intravenous injection of saline or Bothrops jararaca crude venom [0.3 (V0.3) or 1 (V1) m...

    journal_title:Respiratory physiology & neurobiology

    pub_type: 杂志文章


    authors: Silveira KS,Boechem NT,do Nascimento SM,Murakami YL,Barboza AP,Melo PA,Castro P,de Moraes VL,Rocco PR,Zin WA

    更新日期:2004-01-15 00:00:00

  • M(1)/M(3) and M(2)/M(4) muscarinic receptor double-knockout mice present distinct respiratory phenotypes.

    abstract::We investigated the role of muscarinic acetylcholine receptors in the control of breathing. Baseline breathing at rest and ventilatory responses to brief exposures to hypoxia (10% O(2)) and hypercapnia (3% and 5% CO(2)), measured by whole-body plethysmography in partially restrained animals, were compared in mice lack...

    journal_title:Respiratory physiology & neurobiology

    pub_type: 杂志文章


    authors: Boudinot E,Champagnat J,Foutz AS

    更新日期:2008-03-20 00:00:00

  • Nasal highflow eliminates CO2 from lower airways.

    abstract:INTRODUCTION:Nasal highflow (NHF) has a growing evidence in treatment of hypoxemic respiratory failure. There are preliminary data available about use in acute and chronic type-II-respiratory failure. Unfortunately underlying mechanisms of NHF are not well understood. Increase in airway pressure seems too small to expl...

    journal_title:Respiratory physiology & neurobiology

    pub_type: 杂志文章


    authors: Bräunlich J,Goldner F,Wirtz H

    更新日期:2017-08-01 00:00:00

  • Analysis of heart rate and oxygen uptake kinetics studied by two different pseudo-random binary sequence work rate amplitudes.

    abstract:PURPOSE:The aim of the study was to compare the kinetics responses of heart rate (HR), pulmonary (V˙O2pulm) and predicted muscular (V˙O2musc) oxygen uptake between two different pseudo-random binary sequence (PRBS) work rate (WR) amplitudes both below anaerobic threshold. METHODS:Eight healthy individuals performed tw...

    journal_title:Respiratory physiology & neurobiology

    pub_type: 杂志文章


    authors: Drescher U,Koschate J,Schiffer T,Schneider S,Hoffmann U

    更新日期:2017-06-01 00:00:00

  • ATP-sensitive K+ channel inhibition in rats decreases kidney and skeletal muscle blood flow without increasing sympathetic nerve discharge.

    abstract::ATP-sensitive K+ (KATP) channels contribute to exercise-induced hyperemia in skeletal muscle either locally by vascular hyperpolarization or by sympathoinhibition and decreased sympathetic vasoconstriction. However, mean arterial pressure (MAP) regulation via baroreceptors and subsequent efferent activity may confound...

    journal_title:Respiratory physiology & neurobiology

    pub_type: 杂志文章


    authors: Colburn TD,Holdsworth CT,Craig JC,Hirai DM,Montgomery S,Poole DC,Musch TI,Kenney MJ

    更新日期:2020-07-01 00:00:00

  • Validation of a two-compartment model of ventilation/perfusion distribution.

    abstract::Ventilation (V (A)) to perfusion (Q ) heterogeneity (V (A)/Q ) analyses by a two-compartment lung model (2C), utilizing routine gas exchange measurements and a computer solution to account for O(2) and CO(2) measurements, were compared with multiple inert gas elimination technique (MIGET) analyses and a multi-compartm...

    journal_title:Respiratory physiology & neurobiology

    pub_type: 杂志文章


    authors: Loeppky JA,Caprihan A,Altobelli SA,Icenogle MV,Scotto P,Vidal Melo MF

    更新日期:2006-03-28 00:00:00

  • Postnatal development of eupneic ventilation and metabolism in rats chronically exposed to moderate hyperoxia.

    abstract::Newborn rats chronically exposed to moderate hyperoxia (60% O2) exhibit abnormal respiratory control, including decreased eupneic ventilation. To further characterize this plasticity and explore its proximate mechanisms, rats were exposed to either 21% O2 (Control) or 60% O2 (Hyperoxia) from birth until studied at 3-1...

    journal_title:Respiratory physiology & neurobiology

    pub_type: 杂志文章


    authors: Bavis RW,van Heerden ES,Brackett DG,Harmeling LH,Johnson SM,Blegen HJ,Logan S,Nguyen GN,Fallon SC

    更新日期:2014-07-01 00:00:00

  • Maximal inspiratory mouth pressure in Japanese elite male athletes.

    abstract::Maximal inspiratory mouth pressure (MIP) is a common measurement of inspiratory muscle strength, which is often used in a variety of exercises to evaluate the effects of inspiratory muscle training. An understanding of elite athletes' MIP characteristics is needed to guide sport-specific inspiratory muscle training pr...

    journal_title:Respiratory physiology & neurobiology

    pub_type: 杂志文章


    authors: Ohya T,Hagiwara M,Chino K,Suzuki Y

    更新日期:2016-08-01 00:00:00