Abstract：
:Our aim was to determine whether maternal cigarette smoking affects arousal and ventilatory responses to hypoxia in infants. Infants born to non-smoking (NS, n = 15) and smoking mothers (SM, n= 9) were studied at 2-5 weeks, 2-3 and 5-6 months. Ventilatory responses to 15% O(2) were determined preceding arousal. At each age and in both groups, infants aroused more frequently and earlier to hypoxia in active sleep (AS) than quiet sleep (QS). Arousal latency was longer in SM infants (in QS) at 5-6 months (P < 0.05). Baseline respiratory parameters were not different between groups, except that, at 2-3 months, SM infants had higher SP(O2) during AS than NS infants. Maternal smoking did not affect ventilatory responses preceding hypoxia-induced arousal in either sleep-state at any age. We conclude that mild hypoxia stimulates ventilation and arousal in infants up to 6 months and that arousability is depressed in SM infants at 5-6 months; however, ventilatory responses preceding arousal are not adversely affected by smoking.
journal_name
Respir Physiol Neurobioljournal_title
Respiratory physiology & neurobiologyauthors
Parslow PM,Cranage SM,Adamson TM,Harding R,Horne RSdoi
10.1016/j.resp.2004.01.004keywords:
subject
Has Abstractpub_date
2004-04-20 00:00:00pages
77-87issue
1eissn
1569-9048issn
1878-1519pii
S1569904804000096journal_volume
140pub_type
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pub_type： 杂志文章
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pub_type： 杂志文章
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pub_type： 杂志文章,评审
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journal_title：Respiratory physiology & neurobiology
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