Abstract：
:Our aim was to determine whether maternal cigarette smoking affects arousal and ventilatory responses to hypoxia in infants. Infants born to non-smoking (NS, n = 15) and smoking mothers (SM, n= 9) were studied at 2-5 weeks, 2-3 and 5-6 months. Ventilatory responses to 15% O(2) were determined preceding arousal. At each age and in both groups, infants aroused more frequently and earlier to hypoxia in active sleep (AS) than quiet sleep (QS). Arousal latency was longer in SM infants (in QS) at 5-6 months (P < 0.05). Baseline respiratory parameters were not different between groups, except that, at 2-3 months, SM infants had higher SP(O2) during AS than NS infants. Maternal smoking did not affect ventilatory responses preceding hypoxia-induced arousal in either sleep-state at any age. We conclude that mild hypoxia stimulates ventilation and arousal in infants up to 6 months and that arousability is depressed in SM infants at 5-6 months; however, ventilatory responses preceding arousal are not adversely affected by smoking.
journal_name
Respir Physiol Neurobioljournal_title
Respiratory physiology & neurobiologyauthors
Parslow PM,Cranage SM,Adamson TM,Harding R,Horne RSdoi
10.1016/j.resp.2004.01.004keywords:
subject
Has Abstractpub_date
2004-04-20 00:00:00pages
77-87issue
1eissn
1569-9048issn
1878-1519pii
S1569904804000096journal_volume
140pub_type
临床试验,杂志文章abstract：:The fetal respiratory response to acute hypoxia is characterized by depression, often to apnea. This study examined the effect of hypoxia on the electromyogram (EMG) of the thyroarytenoid (TA) muscle. Under anesthesia catheters were placed in the fetal sheep carotid artery, fourth cerebral ventricle, trachea and amnio...
journal_title：Respiratory physiology & neurobiology
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更新日期：2010-04-30 00:00:00
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更新日期：2016-07-15 00:00:00
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journal_title：Respiratory physiology & neurobiology
pub_type： 杂志文章,评审
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更新日期：2012-11-15 00:00:00
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journal_title：Respiratory physiology & neurobiology
pub_type： 杂志文章
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journal_title：Respiratory physiology & neurobiology
pub_type： 杂志文章
doi：10.1016/j.resp.2004.07.013
更新日期：2004-10-12 00:00:00
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journal_title：Respiratory physiology & neurobiology
pub_type： 临床试验,杂志文章
doi：10.1016/j.resp.2004.09.001
更新日期：2005-01-15 00:00:00
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pub_type： 杂志文章
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journal_title：Respiratory physiology & neurobiology
pub_type： 杂志文章
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更新日期：2016-10-01 00:00:00
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journal_title：Respiratory physiology & neurobiology
pub_type： 杂志文章,评审
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更新日期：2011-08-31 00:00:00
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journal_title：Respiratory physiology & neurobiology
pub_type： 杂志文章
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更新日期：2016-09-01 00:00:00
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journal_title：Respiratory physiology & neurobiology
pub_type： 杂志文章,评审
doi：10.1016/j.resp.2011.01.003
更新日期：2011-10-15 00:00:00
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journal_title：Respiratory physiology & neurobiology
pub_type： 杂志文章
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更新日期：2020-01-01 00:00:00
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journal_title：Respiratory physiology & neurobiology
pub_type： 杂志文章
doi：10.1016/j.resp.2007.08.009
更新日期：2008-01-01 00:00:00
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pub_type： 杂志文章
doi：10.1016/j.resp.2014.07.018
更新日期：2014-10-01 00:00:00
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journal_title：Respiratory physiology & neurobiology
pub_type： 杂志文章
doi：10.1016/j.resp.2019.04.007
更新日期：2019-08-01 00:00:00
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pub_type： 杂志文章
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更新日期：2020-05-01 00:00:00
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journal_title：Respiratory physiology & neurobiology
pub_type： 杂志文章
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pub_type： 杂志文章,多中心研究,随机对照试验
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更新日期：2018-08-01 00:00:00
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journal_title：Respiratory physiology & neurobiology
pub_type： 杂志文章
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更新日期：2003-08-14 00:00:00
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更新日期：2013-02-01 00:00:00
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更新日期：2020-03-01 00:00:00
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pub_type： 杂志文章,评审
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更新日期：2004-12-15 00:00:00
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pub_type： 杂志文章,评审
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更新日期：2003-09-16 00:00:00
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journal_title：Respiratory physiology & neurobiology
pub_type： 杂志文章
doi：10.1016/j.resp.2012.11.010
更新日期：2013-02-01 00:00:00
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journal_title：Respiratory physiology & neurobiology
pub_type： 杂志文章
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更新日期：2019-02-01 00:00:00
abstract：:Infants who are born premature can have persistent apnea beyond term gestation, reemergence of apnea associated with inflammation during infancy, increased risk of sudden unexplained death, and sleep disorder breathing during infancy and childhood. The autonomic nervous system, particularly the central neural networks...
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更新日期：2020-03-01 00:00:00
