SiO2-induced release of sVEGFRs from pulmonary macrophages.

Abstract:

BACKGROUND:The inhalation of silicon dioxide (SiO2) particles causes silicosis, a stubborn pulmonary disease that is characterized by alveolar inflammation during the early stage. Soluble cytokine receptors (SCRs) play important roles in regulating inflammation by either attenuating or promoting cytokine signaling. However, the role of SCRs in silicosis remains unknown. METHODS AND RESULTS:Luminex assays revealed increased soluble vascular endothelial growth factor receptor (sVEGFR) family levels in the plasma of silicosis patients. In an enzyme-linked immunosorbent assay (ELISA), cells from the differentiated human monocytic cell line U937 released sVEGFR family proteins after exposure to SiO2 (50μg/cm2). Further Western blot experiments revealed that VEGFR expression was also elevated in U937 cells. In contrast, levels of sVEGFR family members did not change in the supernatants of human umbilical vein endothelial cells (HUVECs) after exposure to SiO2 (50μg/cm2). Interestingly, VEGFR expression in HUVECs decreased after SiO2 treatment. In a scratch assay, HUVECs exhibited cell migration ability, indicating the acquisition of mesenchymal properties. CONCLUSION:Our findings highlight the important role of sVEGFRs in both inflammation and fibrosis induced by SiO2, suggesting a possible mechanism for the fibrogenic effects observed in pulmonary diseases associated with fibrosis.

authors

Chao J,Lv Y,Chen J,Wang J,Yao H

doi

10.1016/j.resp.2017.08.015

subject

Has Abstract

pub_date

2018-01-01 00:00:00

pages

1-8

eissn

1569-9048

issn

1878-1519

pii

S1569-9048(17)30169-6

journal_volume

247

pub_type

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