SiO2-induced release of sVEGFRs from pulmonary macrophages.


BACKGROUND:The inhalation of silicon dioxide (SiO2) particles causes silicosis, a stubborn pulmonary disease that is characterized by alveolar inflammation during the early stage. Soluble cytokine receptors (SCRs) play important roles in regulating inflammation by either attenuating or promoting cytokine signaling. However, the role of SCRs in silicosis remains unknown. METHODS AND RESULTS:Luminex assays revealed increased soluble vascular endothelial growth factor receptor (sVEGFR) family levels in the plasma of silicosis patients. In an enzyme-linked immunosorbent assay (ELISA), cells from the differentiated human monocytic cell line U937 released sVEGFR family proteins after exposure to SiO2 (50μg/cm2). Further Western blot experiments revealed that VEGFR expression was also elevated in U937 cells. In contrast, levels of sVEGFR family members did not change in the supernatants of human umbilical vein endothelial cells (HUVECs) after exposure to SiO2 (50μg/cm2). Interestingly, VEGFR expression in HUVECs decreased after SiO2 treatment. In a scratch assay, HUVECs exhibited cell migration ability, indicating the acquisition of mesenchymal properties. CONCLUSION:Our findings highlight the important role of sVEGFRs in both inflammation and fibrosis induced by SiO2, suggesting a possible mechanism for the fibrogenic effects observed in pulmonary diseases associated with fibrosis.


Chao J,Lv Y,Chen J,Wang J,Yao H




Has Abstract


2018-01-01 00:00:00












  • Effect of oxygen in obstructive sleep apnea: role of loop gain.

    abstract::We compared the effect of oxygen on the apnea-hypopnea index (AHI) in six obstructive sleep apnea patients with a relatively high loop gain (LG) and six with a low LG. LG is a measure of ventilatory control stability. In the high LG group (unstable ventilatory control system), oxygen reduced the LG from 0.69+/-0.18 to...

    journal_title:Respiratory physiology & neurobiology

    pub_type: 杂志文章


    authors: Wellman A,Malhotra A,Jordan AS,Stevenson KE,Gautam S,White DP

    更新日期:2008-07-31 00:00:00

  • Validation of a quantitative method to measure neural respiratory drive in children during sleep.

    abstract:AIMS:Quantitatively measure and validate analysis of neural respiratory drive (NRD) using a commercial polysomnography system in children during sleep. METHOD:Surface electromyogram of the diaphragm (sEMGdi) recorded from primary snoring children were analysed. A subset was re-analysed to assess intra- and inter-inves...

    journal_title:Respiratory physiology & neurobiology

    pub_type: 杂志文章


    authors: Chuang SY,Teng A,Butler JE,Gandevia SC,Selvadurai H,Jaffe A

    更新日期:2017-05-01 00:00:00

  • Central histamine contributes to the inspiratory off-switch mechanism via H1 receptors in mice.

    abstract::Central histaminergic neurons are distributed in areas of the medulla and pons concerned with respiratory rhythm generation, but their effects on breathing pattern are unknown. We examined breathing pattern during hypercapnic responses in wild type (WT) and H1 receptor knockout (H1RKO) mice at 9-10 weeks of age before...

    journal_title:Respiratory physiology & neurobiology

    pub_type: 杂志文章


    authors: Miyamoto K,Iwase M,Kimura H,Homma I

    更新日期:2004-11-30 00:00:00

  • Low exertional inspiratory capacity is not related to dynamic inspiratory muscle weakness in heart failure.

    abstract::Reduction in inspiratory capacity (IC) during exercise has been reported in chronic heart failure (CHF). Since inspiratory muscle dysfunction may be present to a variable degree, the assumption that IC reduction during exercise represents an increase in end-expiratory lung volume must be made with caution. This interp...

    journal_title:Respiratory physiology & neurobiology

    pub_type: 杂志文章


    authors: Plachi F,Balzan FM,Gass R,Dorneles RG,Zambiazi R,da Silva DP,Sanches PR,Clausell NO,Berton DC

    更新日期:2018-08-01 00:00:00

  • Relaxin-3 receptor (RXFP3) activation in the nucleus of the solitary tract modulates respiratory rate and the arterial chemoreceptor reflex in rat.

    abstract::The neuropeptide relaxin-3 is expressed by the pontine nucleus incertus. Relaxin-3 and synthetic agonist peptides modulate arousal and cognitive processes via activation of the relaxin-family peptide 3 receptor (RXFP3). Despite the presence of RXFP3 in the nucleus of the solitary tract (NTS), the ability of RXFP3 to m...

    journal_title:Respiratory physiology & neurobiology

    pub_type: 杂志文章


    authors: Furuya WI,Dhingra RR,Gundlach AL,Hossain MA,Dutschmann M

    更新日期:2020-01-01 00:00:00

  • Influence of dietary nitrate supplementation on physiological and cognitive responses to incremental cycle exercise.

    abstract::Dietary inorganic nitrate supplementation causes physiological effects which may enhance exercise tolerance. However it is not known whether nitrate might alter cognitive function during exercise. In a double-blind, cross-over study, sixteen subjects ingested either nitrate-rich beetroot juice or a placebo and complet...

    journal_title:Respiratory physiology & neurobiology

    pub_type: 杂志文章


    authors: Thompson KG,Turner L,Prichard J,Dodd F,Kennedy DO,Haskell C,Blackwell JR,Jones AM

    更新日期:2014-03-01 00:00:00

  • The blood transfer conductance for nitric oxide: Infinite vs. finite θNO.

    abstract::Whether the specific blood transfer conductance for nitric oxide (NO) with hemoglobin (θNO) is finite or infinite is controversial but important in the calculation of alveolar capillary membrane conductance (DmCO) and pulmonary capillary blood volume (VC) from values of lung diffusing capacity for carbon monoxide (DLC...

    journal_title:Respiratory physiology & neurobiology

    pub_type: 杂志文章,评审


    authors: Coffman KE,Chase SC,Taylor BJ,Johnson BD

    更新日期:2017-07-01 00:00:00

  • Impact of short term forced oral breathing induced by nasal occlusion on respiratory function in mice.

    abstract::Inconsistent findings regarding the experimental nasal obstruction on respiratory functions in small animals have been reported. The purpose of this study was to investigate the impact of short term forced oral breathing on respiratory functions as well as the therapeutic implication of esophageal intubation in BALB/c...

    journal_title:Respiratory physiology & neurobiology

    pub_type: 杂志文章


    authors: Xie J,Xi Y,Zhang Q,Lai K,Zhong N

    更新日期:2015-01-01 00:00:00

  • Adenosine A2A receptors interact with GABAergic pathways to modulate respiration in neonatal piglets.

    abstract::GABA and adenosine contribute to respiratory inhibition in early postnatal life. In this study the adenosine A2A receptor agonist CGS21680 was used to evaluate adenosine receptor specificity and the interrelation of adenosine and GABA in the inhibition of inspiratory drive. In neonatal piglets (n = 10), CGS21680 was i...

    journal_title:Respiratory physiology & neurobiology

    pub_type: 杂志文章


    authors: Wilson CG,Martin RJ,Jaber M,Abu-Shaweesh J,Jafri A,Haxhiu MA,Zaidi S

    更新日期:2004-07-20 00:00:00

  • How does lobeline injected intravenously produce a cough?

    abstract::In order to examine, whether the lobeline-induced cough is a true reflex or a voluntary effort to get rid of its irritating sensations in the upper respiratory tract, we systematically studied the cough response to lobeline, of subjects who were unable to make conscious discriminations i.e. were either comatose (n=4) ...

    journal_title:Respiratory physiology & neurobiology

    pub_type: 临床试验,杂志文章


    authors: Raj H,Bakshi GS,Tiwari RR,Anand A,Paintal AS

    更新日期:2005-01-15 00:00:00

  • Regulation of alveolar fluid clearance and ENaC expression in lung by exogenous angiotensin II.

    abstract::Angiotensin II (Ang II) has been demonstrated as a pro-inflammatory effect in acute lung injury, but studies of the effect of Ang II on the formation of pulmonary edema and alveolar filling remains unclear. Therefore, in this study the regulation of alveolar fluid clearance (AFC) and the expression of epithelial sodiu...

    journal_title:Respiratory physiology & neurobiology

    pub_type: 杂志文章


    authors: Deng J,Wang DX,Deng W,Li CY,Tong J,Ma H

    更新日期:2012-04-15 00:00:00

  • Ventilatory pattern and chemosensitivity in M1 and M3 muscarinic receptor knockout mice.

    abstract::Acetylcholine (ACh) acting through muscarinic receptors is thought to be involved in the control of breathing, notably in central and peripheral chemosensory afferents and in regulations related to sleep-wake states. By using whole-body plethysmography, we compared baseline breathing at rest and ventilatory responses ...

    journal_title:Respiratory physiology & neurobiology

    pub_type: 杂志文章


    authors: Boudinot E,Yamada M,Wess J,Champagnat J,Foutz AS

    更新日期:2004-02-25 00:00:00

  • Effects of cigarette smoke and chronic hypoxia on airways remodeling and resistance. Clinical significance.

    abstract::Previously we have reported that association of cigarette smoke (CS) and chronic hypoxia (CH) interact positively to physiopathologically remodel pulmonary circulation. In present study we have exposed guinea pigs to CS smoke (four cigarettes/day; 3 months; CS) and to chronic hypoxia (12% O(2), 15 days; CH) alone or i...

    journal_title:Respiratory physiology & neurobiology

    pub_type: 杂志文章


    authors: Olea E,Ferrer E,Prieto-Lloret J,Gonzalez-Martin C,Vega-Agapito V,Gonzalez-Obeso E,Agapito T,Peinado V,Obeso A,Barbera JA,Gonzalez C

    更新日期:2011-12-15 00:00:00

  • The crossed phrenic phenomenon and recovery of function following spinal cord injury.

    abstract::This review will focus on neural plasticity and recovery of respiratory function after spinal cord injury and feature the "crossed phrenic phenomenon" (CPP) as a model for demonstrating such plasticity and recovery. A very brief summary of the earlier literature on the CPP will be followed by a more detailed review of...

    journal_title:Respiratory physiology & neurobiology

    pub_type: 杂志文章,评审


    authors: Goshgarian HG

    更新日期:2009-11-30 00:00:00

  • Effect of hypoxia on expiratory muscle activity in fetal sheep.

    abstract::The fetal respiratory response to acute hypoxia is characterized by depression, often to apnea. This study examined the effect of hypoxia on the electromyogram (EMG) of the thyroarytenoid (TA) muscle. Under anesthesia catheters were placed in the fetal sheep carotid artery, fourth cerebral ventricle, trachea and amnio...

    journal_title:Respiratory physiology & neurobiology

    pub_type: 杂志文章


    authors: Bissonnette JM,Hohimer AR,Knopp SJ

    更新日期:2010-04-30 00:00:00

  • Dynamic pulmonary hyperinflation occurs without expiratory flow limitation in chronic heart failure during exercise.

    abstract::To assess the occurrence of tidal expiratory flow limitation (EFL) and/or dynamic pulmonary hyperinflation (DH) in chronic heart failure (CHF) during exercise 15 patients with stable systolic CHF, aged 69 ± 6yr, underwent pulmonary function testing and incremental cardio-pulmonary exercise testing. They subsequently p...

    journal_title:Respiratory physiology & neurobiology

    pub_type: 杂志文章


    authors: Chiari S,Torregiani C,Boni E,Bassini S,Vizzardi E,Tantucci C

    更新日期:2013-10-01 00:00:00

  • Absence of mutations in HCRT, HCRTR1 and HCRTR2 in patients with ROHHAD.

    abstract:BACKGROUND AND OBJECTIVES:Rapid-onset obesity with hypothalamic dysfunction, hypoventilation, and autonomic dysregulation (ROHHAD) is a rare pediatric disease of unknown cause. Here, in response to a recent case report describing a ROHHAD patient who suffered from secondary narcolepsy confirmed by an absence of hypocre...

    journal_title:Respiratory physiology & neurobiology

    pub_type: 杂志文章


    authors: Barclay SF,Rand CM,Gray PA,Gibson WT,Wilson RJ,Berry-Kravis EM,Ize-Ludlow D,Bech-Hansen NT,Weese-Mayer DE

    更新日期:2016-01-15 00:00:00

  • Effect of lung volume reduction surgery for emphysema on diaphragm function.

    abstract::Preoperative prediction of a successful outcome following lung volume reduction surgery (LVRS) for emphysema is imperfect. One mechanism could be improvement in respiratory muscle function yet controversy exists regarding the magnitude and mechanism of such an improvement. Therefore, we measured diaphragm strength in ...

    journal_title:Respiratory physiology & neurobiology

    pub_type: 临床试验,杂志文章


    authors: Hamnegård CH,Polkey MI,Thylen A,Nilsson F,Schersten H,Bake B

    更新日期:2006-02-28 00:00:00

  • Lubricating effect of sialomucin and hyaluronan on pleural mesothelium.

    abstract::Coefficient of kinetic friction (μ) between rabbit visceral and parietal pleura, sliding in vitro at physiological velocities and load, increases markedly after blotting mesothelial surface with filter paper; this increase is only partially reduced by wetting blotted mesothelium with Ringer solution. Given that mesoth...

    journal_title:Respiratory physiology & neurobiology

    pub_type: 杂志文章


    authors: Bodega F,Pecchiari M,Sironi C,Porta C,Arnaboldi F,Barajon I,Agostoni E

    更新日期:2012-01-15 00:00:00

  • Interaction between defects in ventilatory and thermoregulatory control in mice lacking 5-HT neurons.

    abstract::We have previously shown that mice with near-complete absence of 5-HT neurons (Lmx1bf/f/p) display a blunted hypercapnic ventilatory response (HCVR) and impaired cold-induced thermogenesis, but have normal baseline ventilation (), core body temperature (TCore) and hypoxic ventilatory responses (HVR) at warm ambient te...

    journal_title:Respiratory physiology & neurobiology

    pub_type: 杂志文章


    authors: Hodges MR,Richerson GB

    更新日期:2008-12-31 00:00:00

  • Non-nutritive swallowing and respiration coordination in full-term newborn lambs.

    abstract::Swallowing is a powerful inhibitor of respiratory rhythm in infants. The present study was aimed at investigating the influence of states of alertness on non-nutritive swallowing (NNS) frequency, on NNS and respiration coordination, and on bursts of NNS frequency in newborn lambs. Six full term newborn lambs were inst...

    journal_title:Respiratory physiology & neurobiology

    pub_type: 杂志文章


    authors: Reix P,Fortier PH,Niyonsenga T,Arsenault J,Létourneau P,Praud JP

    更新日期:2003-03-28 00:00:00

  • Respiration-related control of abdominal motoneurons.

    abstract::The abdominal muscles form part of the expiratory pump in cooperation with the other expiratory muscles, primarily the internal intercostal and triangularis sterni muscles. The discharge of abdominal muscles is divided into four main patterns: augmenting, plateau, spindle and decrementing. The patterns tend to be spec...

    journal_title:Respiratory physiology & neurobiology

    pub_type: 杂志文章,评审


    authors: Iizuka M

    更新日期:2011-10-15 00:00:00

  • Acute Influenza A infection induces bronchial hyper-responsiveness in mice.

    abstract::This study aimed to determine whether the route of administration of methacholine (MCh) influenced the pattern of airway hyper-responsiveness (AHR) in mice. BALB/c mice were inoculated with a 50-microL volume containing 10(4.5)-pfu Influenza virus A/Mem/1/71(H3N1) or media. MCh responsiveness in vivo [inhaled (0.01-30...

    journal_title:Respiratory physiology & neurobiology

    pub_type: 杂志文章


    authors: Bozanich EM,Gualano RC,Zosky GR,Larcombe AN,Turner DJ,Hantos Z,Sly PD

    更新日期:2008-08-31 00:00:00

  • Hypoxia-induced ventilatory responses in conscious mice: gender differences in ventilatory roll-off and facilitation.

    abstract::The aim of this study was to compare the ventilatory responses of C57BL6 female and male mice during a 15 min exposure to a hypoxic-hypercapnic (H-H) or a hypoxic (10% O(2), 90% N(2)) challenge and subsequent return to room air. The ventilatory responses to H-H were similar in males and females whereas there were pron...

    journal_title:Respiratory physiology & neurobiology

    pub_type: 杂志文章


    authors: Palmer LA,May WJ,deRonde K,Brown-Steinke K,Gaston B,Lewis SJ

    更新日期:2013-02-01 00:00:00

  • Trophic factor expression in phrenic motor neurons.

    abstract::The function of a motor neuron and the muscle fibers it innervates (i.e., a motor unit) determines neuromotor output. Unlike other skeletal muscles, respiratory muscles (e.g., the diaphragm, DIAm) must function from birth onwards in sustaining ventilation. DIAm motor units are capable of both ventilatory and non-venti...

    journal_title:Respiratory physiology & neurobiology

    pub_type: 杂志文章,评审


    authors: Mantilla CB,Sieck GC

    更新日期:2008-12-10 00:00:00

  • ATP in central respiratory control: a three-part signaling system.

    abstract::The landmark demonstrations in 2005 that ATP released centrally during hypoxia and hypercapnia contributes to the respective ventilatory responses validated a decade-old hypothesis and ignited interest in the potential significance of P2 receptor signaling in central respiratory control. Our objective in this review i...

    journal_title:Respiratory physiology & neurobiology

    pub_type: 杂志文章,评审


    authors: Funk GD,Huxtable AG,Lorier AR

    更新日期:2008-12-10 00:00:00

  • Respiratory factors do not limit maximal symptom-limited exercise in patients with mild cystic fibrosis lung disease.

    abstract::To evaluate whether respiratory factors limit exercise capacity in patients with mild cystic fibrosis (CF) lung disease (mean FEV(1) = 76 +/- 7.7% predicted) we stressed the respiratory system of seven patients using added dead space (V(D)). Primary outcomes were exercise duration (Ex(dur)) and maximal oxygen uptake (...

    journal_title:Respiratory physiology & neurobiology

    pub_type: 杂志文章


    authors: Dodd JD,Barry SC,Gallagher CG

    更新日期:2006-06-01 00:00:00

  • Comparisons of effects of intravenous and inhaled methacholine on airway physiology in a murine asthma model.

    abstract::Airway responses to intravenous (i.v.) and inhaled (i.h.) delivery of methacholine (MCh) in BALB/c and C57BL/6 mouse strains have been compared with and without ovalbumin (OVA)-induced airway inflammation. Bronchial reactivity to MCh was assessed in anaesthetised and tracheostomised animals by using an animal ventilat...

    journal_title:Respiratory physiology & neurobiology

    pub_type: 杂志文章


    authors: Jonasson S,Hedenstierna G,Hedenström H,Hjoberg J

    更新日期:2009-02-28 00:00:00

  • Sensitivity of bronchopulmonary receptors to cold and heat mediated by transient receptor potential cation channel subtypes in an ex vivo rat lung preparation.

    abstract::Changes in airway temperature can result in respiratory responses such as cough, bronchoconstriction and mucosal secretion after cold exposure and hyperventilation after heat exposure. In the present investigation, we examined the activity of bronchopulmonary receptors in response to activators of thermo-sensitive tra...

    journal_title:Respiratory physiology & neurobiology

    pub_type: 杂志文章


    authors: Zhou Y,Sun B,Li Q,Luo P,Dong L,Rong W

    更新日期:2011-08-15 00:00:00

  • Efficient mucociliary transport relies on efficient regulation of ciliary beating.

    abstract::The respiratory mucociliary epithelium is a synchronized and highly effective waste-disposal system. It uses mucus as a vehicle, driven by beating cilia, to transport unwanted particles, trapped in the mucus, away from the respiratory system. The ciliary machinery can function in at least two different modes: a low ra...

    journal_title:Respiratory physiology & neurobiology

    pub_type: 杂志文章,评审


    authors: Braiman A,Priel Z

    更新日期:2008-11-30 00:00:00