Development of ventilatory chemoreflexes in Coturnix quail chicks.


:Compared to mammals, little is known about the development of the respiratory control system in birds. In the present study, ventilation and metabolism were measured in Coturnix quail chicks exposed to room air, hypoxia (11 % O2), and hypercapnia (4% CO2) at 0-1, 3-4, and 6-7 days posthatching (dph). Mass-specific ventilation and metabolic rate tended to increase between 0-1 and 3-4 dph and then decrease again between 3-4 and 6-7 dph. The magnitude of the hypoxic ventilatory response (HVR) increased with age. The HVR also exhibited a biphasic shape in younger quail: after the initial increase in ventilation, ventilation declined back to (0-1 dph), or toward (4 dph), baseline. Older chicks (6-7 dph) had a "sustained HVR" in which ventilation remained high throughout the hypoxic challenge. The biphasic HVR did not appear to be caused by a decline in metabolic rate; although hypoxic hypometabolism was observed in quail chicks in all three age groups, the metabolic response appeared to occur more slowly than the biphasic HVR. The biphasic ventilatory response was also specific to hypoxia since the hypercapnic ventilatory response (HCVR) was characterized by a sustained increase in ventilation in all three age groups. The magnitude of the HCVR decreased with age. These results point to several similarities in the development of ventilatory chemorflexes between Coturnix quail and newborn mammals, including age-dependent (1) increases in the HVR, (2) transitions from a biphasic to a sustained HVR, and (3) decreases in the HCVR. Whether homologous mechanisms underlie these developmental changes remains to be determined.


Song MJ,Pratt AE,Bavis RW




Has Abstract


2020-05-01 00:00:00












  • The cessation of breathing in the chicken embryo during cold-hypometabolism.

    abstract::The avian embryo toward end-incubation combines gas exchange through the chorioallantoic membrane (CAM) and pulmonary ventilation (V˙E). The main experiments examined breathing activity during cold-hypometabolism. Chicken embryos close to hatching were prepared for simultaneous measurements of oxygen consumption ( [Fo...

    journal_title:Respiratory physiology & neurobiology

    pub_type: 杂志文章


    authors: Ide R,Ide ST,Mortola JP

    更新日期:2017-08-01 00:00:00

  • Neuromolecular mechanisms mediating the effects of chronic intermittent hypoxia on adrenal medulla.

    abstract::Sleep disordered breathing (SDB) with recurrent apnea is a major health problem affecting several million adult men and women. Humans with SDB are prone to develop hypertension. Studies on rodents established that exposure to chronic intermittent hypoxia (CIH) alone is sufficient to induce hypertension similar to that...

    journal_title:Respiratory physiology & neurobiology

    pub_type: 杂志文章,评审


    authors: Kumar GK,Nanduri J,Peng YJ,Prabhakar NR

    更新日期:2015-04-01 00:00:00

  • Endogenous glutamatergic inputs to the Parabrachial Nucleus/Kölliker-Fuse Complex determine respiratory rate.

    abstract::The Kölliker-Fuse Nucleus (KF) has been widely investigated for its contribution to "inspiratory off-switch" while more recent studies showed that activation of the Parabrachial Nucleus (PBN) shortened expiratory duration. This study used an adult, in vivo, decerebrate rabbit model to delineate the contribution of eac...

    journal_title:Respiratory physiology & neurobiology

    pub_type: 杂志文章


    authors: Navarrete-Opazo AA,Cook-Snyder DR,Miller JR,Callison JJ,McCarthy N,Palkovic B,Stuth EAE,Zuperku EJ,Stucke AG

    更新日期:2020-06-01 00:00:00

  • Pulmonary blood flow generates cardiogenic oscillations.

    abstract::Cardiogenic oscillations are small waves produced by heartbeats, which are superimposed on the pressure and flow signals at the airway opening. The aim of this study was to investigate the role of the two main factors believed to generate these oscillations: (1) contact between heart and lungs and (2) pulmonary blood ...

    journal_title:Respiratory physiology & neurobiology

    pub_type: 杂志文章


    authors: Tusman G,Suarez-Sipmann F,Peces-Barba G,Climente C,Areta M,Arenas PG,Bohm SH

    更新日期:2009-07-31 00:00:00

  • Effect of CPAP on sleep spindles in patients with OSA.

    abstract:OBJECTIVE:Consequences of OSAS include excessive daytime sleepiness, divided sleep architecture, impaired neurocognitive performance, and significant psychosocial disruption. In this study we aimed to evaluate sleep spindles changes before and after PAP treatment in patient with OSA. METHODS:Seventy-three consecutive ...

    journal_title:Respiratory physiology & neurobiology

    pub_type: 杂志文章


    authors: Yetkin O,Aydogan D

    更新日期:2018-01-01 00:00:00

  • Impact of sleep disordered breathing on carotid body size.

    abstract::We tested the hypotheses that: (1) carotid body size can be measured by computed tomographic angiography (CTA) with high inter-observer agreement, and (2) patients with sleep apnea exhibit larger carotid bodies than those without sleep apnea. A chart review was conducted from patients who underwent neck CTA and polyso...

    journal_title:Respiratory physiology & neurobiology

    pub_type: 杂志文章


    authors: Welch BT,Petersen-Jones HG,Eugene AR,Brinjikji W,Kallmes DF,Curry TB,Joyner MJ,Limberg JK

    更新日期:2017-02-01 00:00:00

  • The effect of moderate-intensity aerobic training on pulmonary function and estrogen receptor-alpha gene in postmenopausal women with vitamin D deficiency: A randomized control trial.

    abstract:BACKGROUND:The impact of aerobic training on pulmonary function by modulating gene expression of estrogen receptor-alpha (ERα), sex hormones and 25-hydroxy vitamin D (Vit D) in postmenopausal women (PMW) with Vit D deficiency is uncertain. OBJECTIVE:The purpose of this study was to examine the effect of 12 weeks of mo...

    journal_title:Respiratory physiology & neurobiology

    pub_type: 杂志文章


    authors: Malandish A,Tartibian B,Rahmati M,Afsargharehbagh R,Sheikhlou Z

    更新日期:2020-10-01 00:00:00

  • Respiratory modulation of lingual muscle activity across sleep-wake states in rats.

    abstract::In obstructive sleep apnea (OSA) patients, inspiratory activation (IA) of lingual muscles protects the upper airway from collapse. We aimed to determine when rats' lingual muscles exhibit IA. In 5 Sprague-Dawley and 3 Wistar rats, we monitored cortical EEG and lingual, diaphragmatic and nuchal electromyograms (EMGs), ...

    journal_title:Respiratory physiology & neurobiology

    pub_type: 杂志文章


    authors: Stettner GM,Rukhadze I,Mann GL,Lei Y,Kubin L

    更新日期:2013-09-15 00:00:00

  • MicroRNA-328 is involved in wound repair process in human bronchial epithelial cells.

    abstract::Our aim was to investigate the role of microRNA on epithelial wound repair by global microRNA silencing. We have also analysed the influence of five miRNAs (miR-328, miR-342, miR-411, miR-609, miR-888, previously identified) on wound repair in 16HBE14o-bronchial epithelial cell line. Cells were transfected with siRNAs...

    journal_title:Respiratory physiology & neurobiology

    pub_type: 杂志文章


    authors: Narożna B,Langwinski W,Jackson C,Lackie P,Holloway JW,Szczepankiewicz A

    更新日期:2017-08-01 00:00:00

  • Respiratory control during air-breathing exercise in humans following an 8 h exposure to hypoxia.

    abstract::Hypoxic exposure lasting a few hours results in an elevation of ventilation and a lowering of end-tidal P(CO2) (P(ET(CO2))) that persists on return to breathing air. We sought to determine whether this increment in ventilation is fixed (hypothesis 1), or whether it increases in proportion to the rise in metabolic rate...

    journal_title:Respiratory physiology & neurobiology

    pub_type: 临床试验,杂志文章


    authors: Herigstad M,Fatemian M,Robbins PA

    更新日期:2008-08-31 00:00:00

  • Respiratory responses to intermittent hypoxia in unsedated piglets: relation to substance P binding in brainstem.

    abstract::Respiratory responses to single intermittent hypoxia (5 min 21% O(2), 5 min 8% O(2) X6) in 5-6, 10-11, 21-22 and 26-27 day-old piglets, and to recurrent six daily intermittent hypoxia in 10-11 and 26-27 day-old piglets were assessed. Substance P binding in the piglets' brainstem immediately after the last hypoxic epis...

    journal_title:Respiratory physiology & neurobiology

    pub_type: 杂志文章


    authors: Laferrière A,Moss IR

    更新日期:2004-10-12 00:00:00

  • Short-term expiratory muscle strength training attenuates sleep apnea and improves sleep quality in patients with obstructive sleep apnea.

    abstract::This study investigated the effects of 5 weeks of expiratory muscle strength training (EMST) on sleep apnea, sleep quality, and respiratory muscle strength in patients with different levels of obstructive sleep apnea (OSA). Twenty-five outpatients who received a diagnosis of OSA participated in the study and were assi...

    journal_title:Respiratory physiology & neurobiology

    pub_type: 杂志文章,随机对照试验


    authors: Kuo YC,Song TT,Bernard JR,Liao YH

    更新日期:2017-09-01 00:00:00

  • Dyspnoea in children. Does development alter the perception of breathlessness?

    abstract::Dyspnoea, the perception of an unpleasant and/or uncomfortable sensation of breathlessness, offers several physiological, anatomical and teleological analogies with pain. Pain perception has been shown to exist in the newborn, suggesting that dyspnoea may also occur from birth onwards. The perception of breathlessness...

    journal_title:Respiratory physiology & neurobiology

    pub_type: 社论,评审


    authors: Schweitzer C,Marchal F

    更新日期:2009-05-30 00:00:00

  • Vagotomy reverses established allergen-induced airway hyperreactivity to methacholine in the mouse.

    abstract::We evaluated the role of vagal reflexes in a mouse model of allergen-induced airway hyperreactivity. Mice were actively sensitized to ovalbumin then exposed to the allergen via inhalation. Prior to ovalbumin inhalation, mice also received intratracheally-instilled particulate matter in order to boost the allergic resp...

    journal_title:Respiratory physiology & neurobiology

    pub_type: 杂志文章


    authors: McAlexander MA,Gavett SH,Kollarik M,Undem BJ

    更新日期:2015-07-01 00:00:00

  • Effects of dietary inorganic nitrate on static and dynamic breath-holding in humans.

    abstract::Inorganic nitrate has been shown to reduce oxygen cost during exercise. Since the nitrate-nitrite-NO pathway is facilitated during hypoxia, we investigated the effects of dietary nitrate on oxygen consumption and cardiovascular responses during apnea. These variables were measured in two randomized, double-blind, plac...

    journal_title:Respiratory physiology & neurobiology

    pub_type: 杂志文章,随机对照试验


    authors: Schiffer TA,Larsen FJ,Lundberg JO,Weitzberg E,Lindholm P

    更新日期:2013-01-15 00:00:00

  • Flow limitation and dysanapsis in children and adolescents with exertional dyspnea.

    abstract::The consequence of dysanapsis, quantitated by dysanapsis ratio (DR), on expiratory flow limitation (EFL) during exercise in pediatric subjects was examined. EFL occurred in 80 (56%) subjects from an enriched sample of children and adolescents tested during investigation of exertional dyspnea. DR was lower in subjects ...

    journal_title:Respiratory physiology & neurobiology

    pub_type: 杂志文章


    authors: Pianosi PT

    更新日期:2018-06-01 00:00:00

  • Interaction of tobacco smoke exposure and ovalbumin-sensitization promotes goblet cell and submucosal gland metaplasia in guinea pigs.

    abstract::Exposure to irritants such as tobacco smoke (TS) causes acute airway inflammation. Chronic exposure may cause airway remodeling contributing to enhanced airway resistance. We hypothesize that combining airway sensitization and inhalation of irritants enhances the number of mucous producing cells beyond either agent al...

    journal_title:Respiratory physiology & neurobiology

    pub_type: 杂志文章


    authors: Pavuluri S,Hanus V,Bergren DR

    更新日期:2013-12-01 00:00:00

  • The impact of micro-embolism size on haemodynamic changes in the pulmonary micro-circulation.

    abstract::Embolus occlusion of pulmonary arteries can result in elevated pulmonary blood pressures, often resulting in pulmonary hypertension (PH). Experimental observations have shown that small emboli (diameter <170 μm) can have a disproportionate effect on pulmonary vascular resistance (PVR) compared with larger emboli for t...

    journal_title:Respiratory physiology & neurobiology

    pub_type: 杂志文章


    authors: Clark AR,Burrowes KS,Tawhai MH

    更新日期:2011-03-15 00:00:00

  • Arterial blood gas analysis utility in predicting lung injury in blunt chest trauma.

    abstract:BACKGROUND:thoracic trauma is one of the leading causes of death in all age groups and accounts for 25-50 % of all traumatic injuries. With the term lung injury in blunt chest trauma, we identified a spectrum of conditions: lung contusion, pneumothorax and haemothorax. The aim of this study was to evaluate the utility ...

    journal_title:Respiratory physiology & neurobiology

    pub_type: 杂志文章


    authors: Carlino MV,Guarino M,Izzo A,Carbone D,Arnone MI,Mancusi C,Sforza A

    更新日期:2020-03-01 00:00:00

  • Degeneracy as a substrate for respiratory regulation.

    abstract::Recent studies in vivo and in vitro suggest that both respiratory rhythmogenesis and its central chemosensory modulation arise from multiple, mechanistically and/or anatomically distinct networks whose outputs are similar. These observations are consistent with degeneracy, defined as the ability of structurally distin...

    journal_title:Respiratory physiology & neurobiology

    pub_type: 杂志文章,评审


    authors: Mellen NM

    更新日期:2010-06-30 00:00:00

  • Neural drive to respiratory muscles in the spontaneously breathing rat pup.

    abstract::The neonatal rodent serves as useful and appropriate model within which to study respiratory system development. Despite an extensive literature that documents respiratory control in vitro, in vivo studies have relied upon whole body plethysmography to determine measures of respiratory frequency and tidal volume. Howe...

    journal_title:Respiratory physiology & neurobiology

    pub_type: 杂志文章


    authors: Kidder IJ,Mudery JA,Bailey EF

    更新日期:2014-10-01 00:00:00

  • Postnatal development of eupneic ventilation and metabolism in rats chronically exposed to moderate hyperoxia.

    abstract::Newborn rats chronically exposed to moderate hyperoxia (60% O2) exhibit abnormal respiratory control, including decreased eupneic ventilation. To further characterize this plasticity and explore its proximate mechanisms, rats were exposed to either 21% O2 (Control) or 60% O2 (Hyperoxia) from birth until studied at 3-1...

    journal_title:Respiratory physiology & neurobiology

    pub_type: 杂志文章


    authors: Bavis RW,van Heerden ES,Brackett DG,Harmeling LH,Johnson SM,Blegen HJ,Logan S,Nguyen GN,Fallon SC

    更新日期:2014-07-01 00:00:00

  • Dynamics of metabolic compensation and hematological changes in chicken (Gallus gallus) embryos exposed to hypercapnia with varying oxygen.

    abstract::In day 15 chicken embryos, we determined the time course responses of acid-base balance and hematological respiratory variables during 24h exposure to 15, 20, 40 or 90% O(2), in the presence of 5% CO(2). Hypercapnic respiratory acidosis was initially (2h) only slightly (∼20%) compensated by metabolic alkalosis in norm...

    journal_title:Respiratory physiology & neurobiology

    pub_type: 杂志文章


    authors: Mueller CA,Tazawa H,Burggren WW

    更新日期:2013-01-15 00:00:00

  • Arousal and ventilatory responses to hypoxia in sleeping infants: effects of maternal smoking.

    abstract::Our aim was to determine whether maternal cigarette smoking affects arousal and ventilatory responses to hypoxia in infants. Infants born to non-smoking (NS, n = 15) and smoking mothers (SM, n= 9) were studied at 2-5 weeks, 2-3 and 5-6 months. Ventilatory responses to 15% O(2) were determined preceding arousal. At eac...

    journal_title:Respiratory physiology & neurobiology

    pub_type: 临床试验,杂志文章


    authors: Parslow PM,Cranage SM,Adamson TM,Harding R,Horne RS

    更新日期:2004-04-20 00:00:00

  • Whole blood hypoxia-related gene expression reveals novel pathways to obstructive sleep apnea in humans.

    abstract::In this study, our goal was to identify the key genes that are associated with obstructive sleep apnea (OSA). Thirty-five volunteers underwent full in-lab polysomnography and, according to the sleep apnea hypopnea index (AHI), were classified into control, mild-to-moderate OSA and severe OSA groups. Severe OSA patient...

    journal_title:Respiratory physiology & neurobiology

    pub_type: 杂志文章


    authors: Perry JC,Guindalini C,Bittencourt L,Garbuio S,Mazzotti DR,Tufik S

    更新日期:2013-12-01 00:00:00

  • Effects of bi-level positive airway pressure on ventilatory and perceptual responses to exercise in comorbid heart failure-COPD.

    abstract::This study tested the hypothesis that, by increasing the volume available for tidal expansion (inspiratory capacity, IC), bi-level positive airway pressure (BiPAP™) would lead to greater beneficial effects on dyspnea and exercise intolerance in comorbid heart failure (HF)-chronic obstructive pulmonary disease (COPD) t...

    journal_title:Respiratory physiology & neurobiology

    pub_type: 杂志文章


    authors: Souza A,Sperandio PA,Mazzuco A,Alencar MCN,Arbex FF,Oliveira M,Medeiros W,Rocha A,Nery LE,O Donnell DE,Neder JA

    更新日期:2019-08-01 00:00:00

  • Expression of the transcription factor FOXP2 in brainstem respiratory circuits of adult rat is restricted to upper-airway pre-motor areas.

    abstract::Expression of the transcription factor FOXP2 is linked to brain circuits that control motor function and speech. Investigation of FOXP2 protein expression in respiratory areas of the ponto-medullary brainstem of adult rat revealed distinct rostro-caudal expression gradients. A high density of FOXP2 immunoreactive nucl...

    journal_title:Respiratory physiology & neurobiology

    pub_type: 杂志文章


    authors: Stanić D,Dhingra RR,Dutschmann M

    更新日期:2018-04-01 00:00:00

  • Intermittent hypoxia-induced cardiorespiratory long-term facilitation: A new role for microglia.

    abstract::Intermittent hypoxia induces plasticity in neural networks controlling breathing and cardiovascular function. Studies demonstrate that mechanisms causing cardiorespiratory plasticity rely on intracellular signalling pathways that are activated by specific neurotransmitters. Peptides such as serotonin, PACAP and orexin...

    journal_title:Respiratory physiology & neurobiology

    pub_type: 杂志文章,评审


    authors: Kim SJ,Kim YJ,Kakall Z,Farnham MM,Pilowsky PM

    更新日期:2016-06-01 00:00:00

  • M(1)/M(3) and M(2)/M(4) muscarinic receptor double-knockout mice present distinct respiratory phenotypes.

    abstract::We investigated the role of muscarinic acetylcholine receptors in the control of breathing. Baseline breathing at rest and ventilatory responses to brief exposures to hypoxia (10% O(2)) and hypercapnia (3% and 5% CO(2)), measured by whole-body plethysmography in partially restrained animals, were compared in mice lack...

    journal_title:Respiratory physiology & neurobiology

    pub_type: 杂志文章


    authors: Boudinot E,Champagnat J,Foutz AS

    更新日期:2008-03-20 00:00:00

  • Airway smooth muscle growth from the perspective of animal models.

    abstract::Airway smooth muscle maintains airway tone and may assist in adjusting ventilation distribution within the normal lung. Alterations in the properties or the quantity of ASM are likely responsible for some instances of airways hyperresponsiveness to bronchoconstrictive stimuli that is a characteristic of diseases such ...

    journal_title:Respiratory physiology & neurobiology

    pub_type: 杂志文章,评审


    authors: Martin JG,Ramos-Barbón D

    更新日期:2003-09-16 00:00:00