Abstract:
:The impact of lung remodelling in respiratory mechanics has been widely studied in bleomycin-induced lung injury. However, little is known regarding the relationship between the amount of lung inflammation and pulmonary tissue mechanics. For this purpose, rats were intratracheally instilled with bleomycin (n=29) or saline (n=8) and sacrificed at 3, 7, or 15 days. Forced oscillatory mechanics as well as indices of remodelling (elastic fibre content and hydroxyproline) and inflammation (myeloperoxidase content, total cell count, alveolar wall thickness, and lung water content) were studied in lung tissue strips. Tissue resistance increased significantly at day 15, while hysteresivity was significantly higher in bleomycin group compared to control at all time points. Elastic fibres, hydroxyproline and myeloperoxidase contents augmented after bleomycin at days 7 and 15. Tissue resistance and hysteresivity were significantly correlated with myeloperoxidase, elastic fibre and lung water content. In conclusion, inflammatory structural changes and elastogenesis are the main determinants for hysteretic changes in this 2-week bleomycin-induced lung injury model.
journal_name
Respir Physiol Neurobioljournal_title
Respiratory physiology & neurobiologyauthors
Pinart M,Serrano-Mollar A,Negri EM,Cabrera R,Rocco PR,Romero PVdoi
10.1016/j.resp.2007.09.012subject
Has Abstractpub_date
2008-02-01 00:00:00pages
196-203issue
2eissn
1569-9048issn
1878-1519pii
S1569-9048(07)00264-9journal_volume
160pub_type
杂志文章abstract::Cigarette smoke (CS)-induced emphysema is caused by a continuous inflammatory response in the lower respiratory tract. The development of the condition is believed to be mediated by oxidant-antioxidant imbalance. This paper describes the effects of long-term CS exposure on alveolar cell recruitment, antioxidant defens...
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journal_title:Respiratory physiology & neurobiology
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journal_title:Respiratory physiology & neurobiology
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journal_title:Respiratory physiology & neurobiology
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更新日期:2009-10-31 00:00:00
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journal_title:Respiratory physiology & neurobiology
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journal_title:Respiratory physiology & neurobiology
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journal_title:Respiratory physiology & neurobiology
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journal_title:Respiratory physiology & neurobiology
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