Abstract：
:A deficiency of surfactant proteins A and D has been proposed as a mechanism in airway remodeling, which is one characteristic of chronic obstructive pulmonary disease (COPD). We recently showed that in vitro nicotine exposure induces Wnt3a/β-catenin activation, which is a pathway that has also been implicated in altering levels of SP-A and SP-D. Nicotine induced activation of protein kinase C(PKC), and the involvement of PKC in mediating Wnt signaling has been demonstrated previously. The main aim of this study was to investigate whether human bronchial epithelial cells reduce levels of SP-A and SP-D in vitro following nicotine stimulation via the Wnt3a/β-catenin and PKC signaling pathway. We showed that nicotine activated the Wnt3a/β-catenin and PKC signaling pathway, and this activation was accompanied by a decrease in SP-A and SP-D expression. Knockdown of Wnt3a with small interfering RNA (siRNA) prevented translocation of β-catenin into the nucleus and reduction levels of SP-A and SP-D. Furthermore, a PKC inhibitor partially prevented these effects,which suggests in HBECs, Wnt3a/β-catenin and PKC pathways interact during nicotine-reduced levels of SP-A and SP-D. These results suggest that HBECs reduce the levels of surfactant proteins A and D in vitro via the Wnt3a/β-catenin and PKC signaling pathway upon nicotine stimulation.
journal_name
Respir Physiol Neurobioljournal_title
Respiratory physiology & neurobiologyauthors
Zou W,Liu S,Hu J,Sheng Q,He F,Li B,Ran Pdoi
10.1016/j.resp.2015.10.004subject
Has Abstractpub_date
2016-01-15 00:00:00pages
1-10eissn
1569-9048issn
1878-1519pii
S1569-9048(15)30058-6journal_volume
221pub_type
杂志文章abstract：:We compared by non-invasive technique the adaptive response of alveolar capillary network to edemagenic conditions (exercise and high altitude [HA, PIO2 107mmHg] in subjects with different resting sea level (SL) capillary blood volume (normalized to alveolar volume, Vc/Va): Group 1 (N=10, Vc/Va=16.1±6.8ml/L- mean±SD) ...
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pub_type： 杂志文章,多中心研究,随机对照试验
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更新日期：2016-09-01 00:00:00
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更新日期：2012-04-15 00:00:00
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journal_title：Respiratory physiology & neurobiology
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更新日期：2008-11-30 00:00:00
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journal_title：Respiratory physiology & neurobiology
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更新日期：2003-12-16 00:00:00
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journal_title：Respiratory physiology & neurobiology
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更新日期：2015-12-01 00:00:00
