Abstract：
:The South American lungfish (Lepidosiren paradoxa) has an arterial P(O(2)) (Pa(O(2))) as high as 70-100 mmHg, corresponding to Hb-O(2) saturations from 90% to 95%, which indicates a moderate cardiovascular right to left (R-L) shunt. In hyperoxia (50% O(2)), we studied animals in: (1) aerated water combined with aerial hyperoxia, which increased Pa(O(2)) from 78+/-2 to 114+/-3 mmHg and (2) and aquatic hyperoxia (50% O(2)) combined room air, which gradually increased Pa(O(2)) from 75+/-4 mmHg to as much as 146+/-10 mmHg. Further, the hyperoxia (50%) depressed pulmonary ventilation from 58+/-13 to 5.5+/-3.0 mLBTPSkgh(-1), and Pa(CO(2)) increased from 20+/-2 to 31+/-4 mmHg, while pHa became reduced from 7.56+/-0.03 to 7.31+/-0.09. At the same time, venous P(O(2)) (Pv(O(2))) rose from 40.0+/-2.3 to 46.4+/-1.2 mmHg and, concomitantly, Pv(CO(2)) increased from 23.2+/-1.1 to 32.2+/-0.5 mmHg. R-L shunts were estimated to about 19%, which is moderate when compared to most amphibians.
journal_name
Respir Physiol Neurobioljournal_title
Respiratory physiology & neurobiologyauthors
Bassi M,Giusti H,da Silva GS,Amin-Naves J,Glass MLdoi
10.1016/j.resp.2010.06.004subject
Has Abstractpub_date
2010-08-31 00:00:00pages
47-50issue
1eissn
1569-9048issn
1878-1519pii
S1569-9048(10)00222-3journal_volume
173pub_type
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pub_type： 杂志文章
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更新日期：2006-06-01 00:00:00
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更新日期：2019-08-01 00:00:00
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pub_type： 临床试验,杂志文章
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更新日期：2004-04-20 00:00:00
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更新日期：2012-03-15 00:00:00
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