Abstract：
:The function of a motor neuron and the muscle fibers it innervates (i.e., a motor unit) determines neuromotor output. Unlike other skeletal muscles, respiratory muscles (e.g., the diaphragm, DIAm) must function from birth onwards in sustaining ventilation. DIAm motor units are capable of both ventilatory and non-ventilatory behaviors, including expulsive behaviors important for airway clearance. There is significant diversity in motor unit properties across different types of motor units in the DIAm. The mechanisms underlying the development and maintenance of motor unit diversity in respiratory muscles (including the DIAm) are not well understood. Recent studies suggest that trophic factor influences contribute to this diversity. Remarkably little is known about the expression of trophic factors and their receptors in phrenic motor neurons. This review will focus on the contribution of trophic factors to the establishment and maintenance of motor unit diversity in the DIAm, during development and in response to injury or disease.
journal_name
Respir Physiol Neurobioljournal_title
Respiratory physiology & neurobiologyauthors
Mantilla CB,Sieck GCdoi
10.1016/j.resp.2008.07.018subject
Has Abstractpub_date
2008-12-10 00:00:00pages
252-62issue
1-2eissn
1569-9048issn
1878-1519pii
S1569-9048(08)00208-5journal_volume
164pub_type
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更新日期：2013-01-15 00:00:00
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更新日期：2014-01-01 00:00:00
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更新日期：2017-01-01 00:00:00
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