Abstract：
:The consequence of dysanapsis, quantitated by dysanapsis ratio (DR), on expiratory flow limitation (EFL) during exercise in pediatric subjects was examined. EFL occurred in 80 (56%) subjects from an enriched sample of children and adolescents tested during investigation of exertional dyspnea. DR was lower in subjects with vs without EFL during exercise: (0.055 ± 0.015 vs 0.067 ± 0.017, p < 0.001), and lower ratio correlated with greater extent of EFL (r = -0.64, p < 0.001). EFL was seen more often in boys: 67% vs 46% (p = 0.01), as girls had higher DR (0.063 ± 0.016 vs 0.056 ± 0.018, p = 0.007). Lower FEV1 (95 ± 17 vs 102 ± 15%predicted, p < 0.005) and FEF50 (3.47 ± 1.28 vs 4.08 ± 1.20 L s-1, p = 0.002) distinguished those with vs without EFL. Inspiratory capacity rose (IC) steadily, as work increased among those with EFL, whereas it fell to back resting levels after an initial rise in subjects without EFL. Low DR predicts EFL in pediatric subjects. Adjusting operating lung volume during exercise can mitigate EFL but this strategy may contribute to exertional dyspnea.
journal_name
Respir Physiol Neurobioljournal_title
Respiratory physiology & neurobiologyauthors
Pianosi PTdoi
10.1016/j.resp.2018.03.013subject
Has Abstractpub_date
2018-06-01 00:00:00pages
58-63eissn
1569-9048issn
1878-1519pii
S1569-9048(17)30449-4journal_volume
252-253pub_type
杂志文章abstract：:We tested the hypotheses that: (1) carotid body size can be measured by computed tomographic angiography (CTA) with high inter-observer agreement, and (2) patients with sleep apnea exhibit larger carotid bodies than those without sleep apnea. A chart review was conducted from patients who underwent neck CTA and polyso...
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