Low exertional inspiratory capacity is not related to dynamic inspiratory muscle weakness in heart failure.

Abstract:

:Reduction in inspiratory capacity (IC) during exercise has been reported in chronic heart failure (CHF). Since inspiratory muscle dysfunction may be present to a variable degree, the assumption that IC reduction during exercise represents an increase in end-expiratory lung volume must be made with caution. This interpretation is flawed if patients develop dynamic inspiratory muscle strength reduction, i.e., progressively lower esophageal (Pes) pressures as the IC maneuvers are repeated. Sixteen CHF patients and 9 age-matched controls performed an incremental exercise test with serial IC and respiratory pressure measurements. Regardless whether IC decreased or not with exercise (N = 4 and N = 12, respectively), Pes,IC remained stable. This was confirmed by similar Pes,sniff immediately upon exercise cessation (p > .05). No association was found between changes in IC and related Pes from rest to peak exercise. Owing to the lack of dynamic inspiratory muscle weakness, non-invasive indexes of lung mechanics can be reliably obtained from exercise IC in CHF.

authors

Plachi F,Balzan FM,Gass R,Dorneles RG,Zambiazi R,da Silva DP,Sanches PR,Clausell NO,Berton DC

doi

10.1016/j.resp.2018.04.005

subject

Has Abstract

pub_date

2018-08-01 00:00:00

pages

32-35

eissn

1569-9048

issn

1878-1519

pii

S1569-9048(18)30049-1

journal_volume

254

pub_type

杂志文章
  • Developmental trajectories, critical windows and phenotypic alteration during cardio-respiratory development.

    abstract::Embryo-environment interactions affecting cardio-respiratory development in vertebrates have been extensively studied, but an equally extensive conceptual framework for interpreting and interrelating these developmental events has lagged behind. In this review, we consider the conceptual constructs of "developmental p...

    journal_title:Respiratory physiology & neurobiology

    pub_type: 杂志文章,评审

    doi:10.1016/j.resp.2011.05.001

    authors: Burggren WW,Reyna KS

    更新日期:2011-08-31 00:00:00

  • The effect of diffusion in the respiratory tree on the alveolar amplitude response technique (AART).

    abstract::Theoretical data for the alveolar amplitude response technique (AART) (J. Appl. Physiol. 41 (1976) 419-424) for assessing lung function was simulated using a single path lung model. This model takes account of stratified inhomogeneities in gas concentrations within the respiratory tree. The data was inserted into prev...

    journal_title:Respiratory physiology & neurobiology

    pub_type: 杂志文章

    doi:10.1016/s1569-9048(03)00124-1

    authors: Whiteley JP,Gavaghan DJ,Hahn CE

    更新日期:2003-08-14 00:00:00

  • Integration of hindbrain and carotid body mechanisms that control the autonomic response to cardiorespiratory and glucoprivic insults.

    abstract::Autonomic reflex responses are critical in restoring changes to circulatory factors reduced beyond the domain of homeostasis. Intermittent hypoxia triggers repeated activation of chemoreflexes, resulting in baroreflex dysfunction and widespread changes in cellular and neuronal activity regulated by sensory/motor pathw...

    journal_title:Respiratory physiology & neurobiology

    pub_type: 杂志文章,评审

    doi:10.1016/j.resp.2018.08.008

    authors: Kakall ZM,Cohen EM,Farnham MMJ,Kim SJ,Nedoboy PE,Pilowsky PM

    更新日期:2019-07-01 00:00:00

  • The fall in exhaled nitric oxide with ventilation at low lung volumes in rabbits: an index of small airway injury.

    abstract::The mechanisms involved in the fall of exhaled nitric oxide (NOe) concentration occurring in normal, anesthetized open chest rabbits with prolonged mechanical ventilation (MV) at low lung volume have been investigated. NOe, pH of exhaled vapor condensate, serum prostaglandin E(2), and F(2alpha), tumor necrosis factor ...

    journal_title:Respiratory physiology & neurobiology

    pub_type: 杂志文章

    doi:10.1016/j.resp.2007.10.001

    authors: D'Angelo E,Koulouris NG,Della Valle P,Gentile G,Pecchiari M

    更新日期:2008-02-01 00:00:00

  • Hypoxic incubation creates differential morphological effects during specific developmental critical windows in the embryo of the chicken (Gallus gallus).

    abstract::Hypoxia inhibits vertebrate development, but the magnitude and timing of organ-specific effects are poorly understood. Chick embryos were exposed continuously to hypoxia (15% O2) throughout Days 1-6, 6-12, 12-18 or Days 1-18 of development, followed by morphometric measurements of major organ systems. Early hypoxic ex...

    journal_title:Respiratory physiology & neurobiology

    pub_type: 杂志文章

    doi:10.1016/j.resp.2004.09.005

    authors: Chan T,Burggren W

    更新日期:2005-02-15 00:00:00

  • Obesity: challenges to ventilatory control during exercise--a brief review.

    abstract::Obesity is a national health issue in the US. Among the many physiological changes induced by obesity, it also presents a unique challenge to ventilatory control during exercise due to increased metabolic demand of moving larger limbs, increased work of breathing due to extra weight on the chest wall, and changes in b...

    journal_title:Respiratory physiology & neurobiology

    pub_type: 杂志文章,评审

    doi:10.1016/j.resp.2013.05.019

    authors: Babb TG

    更新日期:2013-11-01 00:00:00

  • Pre-junctional muscarinic autoreceptors in bovine airways.

    abstract:UNLABELLED:We searched for pre-junctional inhibitory muscarinic receptors in isolated bovine trachealis strips and bronchial rings. Electric stimulation (ES)-induced tritiated acetylcholine ([(3)H]-ACh)-release and isometric contractions were determined in muscles incubated with the non-selective muscarinic agonist pil...

    journal_title:Respiratory physiology & neurobiology

    pub_type: 杂志文章

    doi:10.1016/j.resp.2011.10.007

    authors: Baroffio M,Crimi E,Brichetto L,Zappi L,Rehder K,Brusasco V

    更新日期:2012-01-15 00:00:00

  • Exhaled nasal nitric oxide output is reduced in humans at night during the sleep period.

    abstract::The physiologic function of nasal nitric oxide (NO) release is unknown. In prior experiments, topical NG-nitro-L-arginine methyl ester (L-NAME) on nasal mucosa reduced exhaled nasal NO output and caused daytime sleepiness. We hypothesized that nasal NO output is reduced at night during the sleep period. We measured ex...

    journal_title:Respiratory physiology & neurobiology

    pub_type: 杂志文章

    doi:10.1016/j.resp.2006.08.002

    authors: O'Hearn DJ,Giraud GD,Sippel JM,Edwards C,Chan B,Holden WE

    更新日期:2007-04-16 00:00:00

  • Glucocorticoids inhibits the repair of airway epithelial cells via the activation of wnt pathway.

    abstract:BACKGROUND:The purpose of this study was to explore the effect of Wnt pathway on the inhibition of airway epithelial cells repair by glucocorticoid. MATERIALS AND METHODS:The expression of E-cadherin in asthma mice model was detected by immunocytochemistry. XAV939 was used to treat 16HBE, and the expressions of relate...

    journal_title:Respiratory physiology & neurobiology

    pub_type: 杂志文章

    doi:10.1016/j.resp.2019.103283

    authors: Yu Z,Jiang Y,Sun C

    更新日期:2020-01-01 00:00:00

  • Side-stream tobacco smoke-induced airway hyperresponsiveness in early postnatal period is involved nerve growth factor.

    abstract::Epidemiological studies have shown that children are more susceptible to adverse respiratory effects of passive smoking than adults. The goal of this study is to elucidate the possible neural mechanism induced by exposure to passive smoking during early life. Postnatal day (PD) 2 and PD 21 mice were exposed to side-st...

    journal_title:Respiratory physiology & neurobiology

    pub_type: 杂志文章

    doi:10.1016/j.resp.2015.11.009

    authors: Wu ZX,Hunter DD,Batchelor TP,Dey RD

    更新日期:2016-03-01 00:00:00

  • Neuromuscular adaptations to respiratory muscle inactivity.

    abstract::Cervical spinal cord injury results in significant functional impairment. It is important to understand the neuroplasticity in response to inactivity of respiratory muscles in order to prevent any associated effects that limit functional recovery. Recent studies have examined the mechanisms involved in inactivity-indu...

    journal_title:Respiratory physiology & neurobiology

    pub_type: 杂志文章,评审

    doi:10.1016/j.resp.2009.09.002

    authors: Mantilla CB,Sieck GC

    更新日期:2009-11-30 00:00:00

  • Acute Influenza A infection induces bronchial hyper-responsiveness in mice.

    abstract::This study aimed to determine whether the route of administration of methacholine (MCh) influenced the pattern of airway hyper-responsiveness (AHR) in mice. BALB/c mice were inoculated with a 50-microL volume containing 10(4.5)-pfu Influenza virus A/Mem/1/71(H3N1) or media. MCh responsiveness in vivo [inhaled (0.01-30...

    journal_title:Respiratory physiology & neurobiology

    pub_type: 杂志文章

    doi:10.1016/j.resp.2008.06.011

    authors: Bozanich EM,Gualano RC,Zosky GR,Larcombe AN,Turner DJ,Hantos Z,Sly PD

    更新日期:2008-08-31 00:00:00

  • Panic disorder and control of breathing.

    abstract::Anxiety disorders, particularly panic disorder (PD), are associated with respiratory abnormalities. PD consists of unexpected panic attacks (PA) with anxiety, fear and many autonomic and respiratory symptoms. There is a substantial body of literature demonstrating that stimulation of respiration is a common event in p...

    journal_title:Respiratory physiology & neurobiology

    pub_type: 社论,评审

    doi:10.1016/j.resp.2008.07.011

    authors: Nardi AE,Freire RC,Zin WA

    更新日期:2009-05-30 00:00:00

  • Electric synapses in the carotid body-nerve complex.

    abstract::Slices of rat carotid bodies, or cultured glomus cells, were used to study intercellular coupling. This phenomenon occurs because gap junctions allow passage of currents and dyes from one cell to another. There is a two-way resistive coupling between glomus cells (GC/GC coupling), which is accompanied by activity of i...

    journal_title:Respiratory physiology & neurobiology

    pub_type: 杂志文章,评审

    doi:10.1016/j.resp.2007.01.013

    authors: Eyzaguirre C

    更新日期:2007-07-01 00:00:00

  • Genetic CLC-1 chloride channel deficiency modifies diaphragm muscle isometric contractile properties.

    abstract::Genetic deficiency of the muscle chloride channel CLC-1 leads to myotonia congenita in humans as well as myotonia in mice and goats. The hallmark of myotonia is delayed muscle relaxation due to persistent electrical discharges in the muscle. The present study tested the hypothesis that performance of CLC-1 deficient d...

    journal_title:Respiratory physiology & neurobiology

    pub_type: 杂志文章

    doi:10.1016/j.resp.2006.07.003

    authors: van Lunteren E,Moyer M,Pollarine J

    更新日期:2007-03-15 00:00:00

  • Mice-to-men comparison of inhaled drug-aerosol deposition and clearance.

    abstract::Part of the effective prediction of the pharmacokinetics of drugs (or toxic particles) requires extrapolation of experimental data sets from animal studies to humans. As the respiratory tracts of rodents and humans are anatomically very different, there is a need to study airflow and drug-aerosol deposition patterns i...

    journal_title:Respiratory physiology & neurobiology

    pub_type: 杂志文章

    doi:10.1016/j.resp.2018.11.003

    authors: Kolanjiyil AV,Kleinstreuer C,Kleinstreuer NC,Pham W,Sadikot RT

    更新日期:2019-02-01 00:00:00

  • Effects of diaphragm activation on airway pressure generation during lower thoracic spinal cord stimulation.

    abstract::Lower thoracic spinal cord stimulation (SCS) results in the generation of large positive airway pressures. The potential effects of diaphragm co-activation during SCS were investigated in 10 anesthetized dogs. Diaphragm compound action potentials (CMAPs) were present during SCS at the T10 and T12 levels. In group 1, a...

    journal_title:Respiratory physiology & neurobiology

    pub_type: 杂志文章

    doi:10.1016/j.resp.2007.06.007

    authors: DiMarco AF,Kowalski KE,Romaniuk JR

    更新日期:2007-10-15 00:00:00

  • Maximal inspiratory mouth pressure in Japanese elite male athletes.

    abstract::Maximal inspiratory mouth pressure (MIP) is a common measurement of inspiratory muscle strength, which is often used in a variety of exercises to evaluate the effects of inspiratory muscle training. An understanding of elite athletes' MIP characteristics is needed to guide sport-specific inspiratory muscle training pr...

    journal_title:Respiratory physiology & neurobiology

    pub_type: 杂志文章

    doi:10.1016/j.resp.2016.05.004

    authors: Ohya T,Hagiwara M,Chino K,Suzuki Y

    更新日期:2016-08-01 00:00:00

  • TRPM8 channel is involved in the ventilatory response to CO2 mediating hypercapnic Ca2+ responses.

    abstract::The role of TRP channels in the ventilatory response to CO2 was investigated in vivo. To this end, the respiration of unrestrained adult TRPM8-, TRPV1- and TRPV4-channel knockout mice was measured using whole-body plethysmography. Under control conditions and hyperoxic hypercapnia, no difference in respiratory paramet...

    journal_title:Respiratory physiology & neurobiology

    pub_type: 杂志文章

    doi:10.1016/j.resp.2019.03.002

    authors: Hirata Y,Suzuki Y,Tominaga M,Oku Y

    更新日期:2019-05-01 00:00:00

  • New insights into the mechanisms controlling urea excretion in fish gills.

    abstract::Not long ago, urea was believed to freely diffuse across plasma membranes. The discovery of specialized proteins to facilitate the movement of urea across the fish gill, similar to those found in mammalian kidney, was exciting, and at the same time, perplexing; especially considering the fact that, aside from elasmobr...

    journal_title:Respiratory physiology & neurobiology

    pub_type: 杂志文章,评审

    doi:10.1016/j.resp.2012.06.002

    authors: McDonald MD,Gilmour KM,Walsh PJ

    更新日期:2012-12-01 00:00:00

  • CNS determinants of sleep-related worsening of airway functions: implications for nocturnal asthma.

    abstract::This review summarizes the recent neuroanatomical and physiological studies that form the neural basis for the state-dependent changes in airway resistance. Here, we review only the interactions between the brain regions generating quiet (non-rapid eye movement, NREM) and active (rapid eye movement, REM) sleep stages ...

    journal_title:Respiratory physiology & neurobiology

    pub_type: 杂志文章,评审

    doi:10.1016/j.resp.2005.07.009

    authors: Haxhiu MA,Rust CF,Brooks C,Kc P

    更新日期:2006-03-28 00:00:00

  • Postnatal development of eupneic ventilation and metabolism in rats chronically exposed to moderate hyperoxia.

    abstract::Newborn rats chronically exposed to moderate hyperoxia (60% O2) exhibit abnormal respiratory control, including decreased eupneic ventilation. To further characterize this plasticity and explore its proximate mechanisms, rats were exposed to either 21% O2 (Control) or 60% O2 (Hyperoxia) from birth until studied at 3-1...

    journal_title:Respiratory physiology & neurobiology

    pub_type: 杂志文章

    doi:10.1016/j.resp.2014.03.010

    authors: Bavis RW,van Heerden ES,Brackett DG,Harmeling LH,Johnson SM,Blegen HJ,Logan S,Nguyen GN,Fallon SC

    更新日期:2014-07-01 00:00:00

  • Respiratory responses to olfactory stimuli in Parkinson's disease.

    abstract::There are many reports of olfactory impairment in patients with Parkinson's disease (PD) and the impairment can be observed before the appearance of typical PD symptom. Accordingly, olfactory screening tests may predict disease onset and indicates a need for early treatment before classic signs of the disease. Olfacti...

    journal_title:Respiratory physiology & neurobiology

    pub_type: 杂志文章

    doi:10.1016/j.resp.2008.01.003

    authors: Masaoka Y,Satoh H,Kawamura M,Homma I

    更新日期:2008-04-30 00:00:00

  • Sleep disordered breathing following spinal cord injury.

    abstract::Individuals with spinal cord injury (SCI) commonly complain about difficulty in sleeping. Although various sleep disordered breathing definitions and indices are used that make comparisons between studies difficult, it seems evident that the frequency of sleep disorders is higher in individuals with SCI, especially wi...

    journal_title:Respiratory physiology & neurobiology

    pub_type: 杂志文章,评审

    doi:10.1016/j.resp.2009.08.014

    authors: Biering-Sørensen F,Jennum P,Laub M

    更新日期:2009-11-30 00:00:00

  • Airway nociceptors activated by pro-inflammatory cytokines.

    abstract::The present studies evaluate whether the vagus nerves link the lungs' immune and neural systems by transmitting information through pulmonary nociceptors. Single unit activities from pulmonary nociceptors [C fiber receptors (CFRs) and high threshold Adelta fiber receptors (HTARs)] were recorded from the cervical vagus...

    journal_title:Respiratory physiology & neurobiology

    pub_type: 杂志文章

    doi:10.1016/j.resp.2006.11.005

    authors: Yu J,Lin S,Zhang J,Otmishi P,Guardiola JJ

    更新日期:2007-05-14 00:00:00

  • Spinal pathways mediating phrenic activation during high frequency spinal cord stimulation.

    abstract::High frequency spinal cord stimulation (HF-SCS) is a method of inspiratory muscle activation resulting in phrenic motoneuron activation via stimulation of spinal cord pathways. The specific pathways mediating this response, however, are unknown. The aim of this study was to assess the potential role of upper cervical ...

    journal_title:Respiratory physiology & neurobiology

    pub_type: 杂志文章

    doi:10.1016/j.resp.2012.12.003

    authors: Dimarco AF,Kowalski KE

    更新日期:2013-03-01 00:00:00

  • Aerobic exercise training without weight loss reduces dyspnea on exertion in obese women.

    abstract::Dyspnea on exertion (DOE) is a common symptom in obesity. We investigated whether aerobic exercise training without weight loss could reduce DOE. Twenty-two otherwise healthy obese women participated in a 12-week supervised aerobic exercise training program, exercising 30 min/day at 70-80% heart rate reserve, 4 days/w...

    journal_title:Respiratory physiology & neurobiology

    pub_type: 杂志文章

    doi:10.1016/j.resp.2015.11.004

    authors: Bernhardt V,Stickford JL,Bhammar DM,Babb TG

    更新日期:2016-01-15 00:00:00

  • Pulmonary rehabilitation and BDNF levels in patients with chronic obstructive pulmonary disease: A pilot study.

    abstract:BACKGROUND:COPD physiopathology involves multiple pathways and evidence indicates that brain-derived neurotrophic factor (BDNF) is an important biomarker associated with parameters of COPD severity. This study aimed to analyze the time course of the effects of a pulmonary rehabilitation program (PRP) on BDNF levels and...

    journal_title:Respiratory physiology & neurobiology

    pub_type: 杂志文章

    doi:10.1016/j.resp.2018.07.011

    authors: de Araujo CLP,da Silva IRV,Reinaldo GP,Peccin PK,Pochmann D,Teixeira PJZ,Elsner VR,Dal Lago P

    更新日期:2019-01-01 00:00:00

  • An astrocyte toxin influences the pattern of breathing and the ventilatory response to hypercapnia in neonatal rats.

    abstract::Recent in vitro data suggest that astrocytes may modulate respiration. To examine this question in vivo, we treated 5-day-old rat pups with methionine sulfoximine (MS), a compound that alters carbohydrate and glutamate metabolism in astrocytes, but not neurons. MS-treated pups displayed a reduced breathing frequency (...

    journal_title:Respiratory physiology & neurobiology

    pub_type: 杂志文章

    doi:10.1016/j.resp.2005.01.009

    authors: Young JK,Dreshaj IA,Wilson CG,Martin RJ,Zaidi SI,Haxhiu MA

    更新日期:2005-05-12 00:00:00

  • Pulmonary blood flow generates cardiogenic oscillations.

    abstract::Cardiogenic oscillations are small waves produced by heartbeats, which are superimposed on the pressure and flow signals at the airway opening. The aim of this study was to investigate the role of the two main factors believed to generate these oscillations: (1) contact between heart and lungs and (2) pulmonary blood ...

    journal_title:Respiratory physiology & neurobiology

    pub_type: 杂志文章

    doi:10.1016/j.resp.2009.04.026

    authors: Tusman G,Suarez-Sipmann F,Peces-Barba G,Climente C,Areta M,Arenas PG,Bohm SH

    更新日期:2009-07-31 00:00:00