The cessation of breathing in the chicken embryo during cold-hypometabolism.

Abstract:

:The avian embryo toward end-incubation combines gas exchange through the chorioallantoic membrane (CAM) and pulmonary ventilation (V˙E). The main experiments examined breathing activity during cold-hypometabolism. Chicken embryos close to hatching were prepared for simultaneous measurements of oxygen consumption ( [Formula: see text] ) and carbon dioxide production ( [Formula: see text] ; open-flow methodology) and breathing frequency (f; barometric technique). As ambient (Ta) and egg temperature (Tegg) dropped, breathing eventually ceased at ∼18°C, when [Formula: see text] and [Formula: see text] were 22-28% of the normothermic values. With the eggshell experimentally covered to reduce CAM gas exchange breathing ceased at slightly lower [Formula: see text] and [Formula: see text] (17-18% of normothermia). Once breathing had stopped, egg exposure to hypoxia (10% or 5% O2) or hypercapnia (3% or 8% CO2) did not resume breathing, which recovered with re-warming. In normothermia, 10% O2 caused hypometabolism and tachypnea; differently, in 5% O2 [Formula: see text] dropped as much as with hypothermia and breathing stopped, to recover upon return in air. Correlation analysis among Ta, Tegg, [Formula: see text] , [Formula: see text] and f during cooling and re-warming indicated that f followed more closely the changes in [Formula: see text] and, especially, in [Formula: see text] than the changes in Ta or Tegg. Some considerations suggest that in this experimental model the cessation of breathing in hypothermia or severe hypoxia may be due to hypometabolism, while the lack of chemo-responses may have a different mechanistic basis.

authors

Ide R,Ide ST,Mortola JP

doi

10.1016/j.resp.2017.03.004

subject

Has Abstract

pub_date

2017-08-01 00:00:00

pages

19-29

eissn

1569-9048

issn

1878-1519

pii

S1569-9048(16)30178-1

journal_volume

242

pub_type

杂志文章
  • Orexinergic modulation of breathing across vigilance states.

    abstract::Basal respiration and respiratory reflex regulations are considerably different during the awake and sleep states. Tidal volume and respiratory frequency diminish during sleep, and hypoxic and hypercapnic ventilatory responses also decline during sleep. Reduced metabolic demand during sleep cannot completely explain t...

    journal_title:Respiratory physiology & neurobiology

    pub_type: 杂志文章,评审

    doi:10.1016/j.resp.2008.03.011

    authors: Kuwaki T

    更新日期:2008-12-10 00:00:00

  • CNS determinants of sleep-related worsening of airway functions: implications for nocturnal asthma.

    abstract::This review summarizes the recent neuroanatomical and physiological studies that form the neural basis for the state-dependent changes in airway resistance. Here, we review only the interactions between the brain regions generating quiet (non-rapid eye movement, NREM) and active (rapid eye movement, REM) sleep stages ...

    journal_title:Respiratory physiology & neurobiology

    pub_type: 杂志文章,评审

    doi:10.1016/j.resp.2005.07.009

    authors: Haxhiu MA,Rust CF,Brooks C,Kc P

    更新日期:2006-03-28 00:00:00

  • Autophagy inhibition protects from alveolar barrier dysfunction in LPS-induced ALI mice by targeting alveolar epithelial cells.

    abstract:OBJECTIVE:The aim of this study was to investigate whether autophagy is enhanced in alveolar epithelial cells as well as its role in alveolar barrier function of in lipopolysaccharide (LPS)-induced ALI mice. MATERIALS AND METHODS:Autophagy inhibitors, including 3-methyladenine (3-MA) and chloroquine (CLQ), and LPS wer...

    journal_title:Respiratory physiology & neurobiology

    pub_type: 杂志文章

    doi:10.1016/j.resp.2020.103532

    authors: Guo L,Wu X,Zhao S,Zhang X,Qian G,Li S

    更新日期:2021-01-01 00:00:00

  • Evolution of bubbles from gas micronuclei formed on the luminal aspect of ovine large blood vessels.

    abstract::It has been shown that tiny gas nanobubbles form spontaneously on a smooth hydrophobic surface submerged in water. These nanobubbles were shown to be the source of gas micronuclei from which bubbles evolved during decompression of silicon wafers. We suggest that the hydrophobic inner surface of blood vessels may be a ...

    journal_title:Respiratory physiology & neurobiology

    pub_type: 杂志文章

    doi:10.1016/j.resp.2013.04.013

    authors: Arieli R,Marmur A

    更新日期:2013-08-01 00:00:00

  • Development of ventilatory chemoreflexes in Coturnix quail chicks.

    abstract::Compared to mammals, little is known about the development of the respiratory control system in birds. In the present study, ventilation and metabolism were measured in Coturnix quail chicks exposed to room air, hypoxia (11 % O2), and hypercapnia (4% CO2) at 0-1, 3-4, and 6-7 days posthatching (dph). Mass-specific ven...

    journal_title:Respiratory physiology & neurobiology

    pub_type: 杂志文章

    doi:10.1016/j.resp.2020.103411

    authors: Song MJ,Pratt AE,Bavis RW

    更新日期:2020-05-01 00:00:00

  • The effect of diffusion in the respiratory tree on the alveolar amplitude response technique (AART).

    abstract::Theoretical data for the alveolar amplitude response technique (AART) (J. Appl. Physiol. 41 (1976) 419-424) for assessing lung function was simulated using a single path lung model. This model takes account of stratified inhomogeneities in gas concentrations within the respiratory tree. The data was inserted into prev...

    journal_title:Respiratory physiology & neurobiology

    pub_type: 杂志文章

    doi:10.1016/s1569-9048(03)00124-1

    authors: Whiteley JP,Gavaghan DJ,Hahn CE

    更新日期:2003-08-14 00:00:00

  • Effects of dietary inorganic nitrate on static and dynamic breath-holding in humans.

    abstract::Inorganic nitrate has been shown to reduce oxygen cost during exercise. Since the nitrate-nitrite-NO pathway is facilitated during hypoxia, we investigated the effects of dietary nitrate on oxygen consumption and cardiovascular responses during apnea. These variables were measured in two randomized, double-blind, plac...

    journal_title:Respiratory physiology & neurobiology

    pub_type: 杂志文章,随机对照试验

    doi:10.1016/j.resp.2012.09.008

    authors: Schiffer TA,Larsen FJ,Lundberg JO,Weitzberg E,Lindholm P

    更新日期:2013-01-15 00:00:00

  • Cardiorespiratory responses and reduced apneic time to cold-water face immersion after high intensity exercise.

    abstract::Apnea after exercise may evoke a neurally mediated conflict that may affect apneic time and create a cardiovascular strain. The physiological responses, induced by apnea with face immersion in cold water (10 °C), after a 3-min exercise bout, at 85% of VO2max,were examined in 10 swimmers. A pre-selected 40-s apnea, com...

    journal_title:Respiratory physiology & neurobiology

    pub_type: 杂志文章

    doi:10.1016/j.resp.2015.07.014

    authors: Konstantinidou S,Soultanakis H

    更新日期:2016-01-01 00:00:00

  • Lung function and respiratory muscle strength and their relationship with weightlifting strength and body composition in non-athletic males.

    abstract::The aim of this study was to examine whether lung function and respiratory muscle strength are associated with weightlifting strength and body composition in non-athletic males. A total 51 males with resistance training experience participated. One-repetition maximum tests were performed for the bench press, squat and...

    journal_title:Respiratory physiology & neurobiology

    pub_type: 杂志文章

    doi:10.1016/j.resp.2021.103616

    authors: Hackett DA,Sabag A

    更新日期:2021-01-14 00:00:00

  • Regulation of alveolar fluid clearance and ENaC expression in lung by exogenous angiotensin II.

    abstract::Angiotensin II (Ang II) has been demonstrated as a pro-inflammatory effect in acute lung injury, but studies of the effect of Ang II on the formation of pulmonary edema and alveolar filling remains unclear. Therefore, in this study the regulation of alveolar fluid clearance (AFC) and the expression of epithelial sodiu...

    journal_title:Respiratory physiology & neurobiology

    pub_type: 杂志文章

    doi:10.1016/j.resp.2011.11.009

    authors: Deng J,Wang DX,Deng W,Li CY,Tong J,Ma H

    更新日期:2012-04-15 00:00:00

  • Haematological acclimation and re-acclimation to hypoxia in the mouse.

    abstract::Haematological responses throughout 4 w of initial acclimation (IA) and three paradigms of re-acclimation (RA) to hypoxia (FI(O₂)) were examined in female mice. We hypothesised that (i) haematological responses would be increased during re-exposure, resulting in greater O₂-carrying capacity in RA compared to IA; and (...

    journal_title:Respiratory physiology & neurobiology

    pub_type: 杂志文章

    doi:10.1016/j.resp.2013.07.018

    authors: MacNutt MJ,Rupert JL,Sheel AW

    更新日期:2013-10-01 00:00:00

  • Vertebrate brains at the pilot light.

    abstract::While the brains of most vertebrates are unable to tolerate more than a few minutes of anoxia, some freshwater turtles (Trachemys and Chrysemys), crucian carp (Carassius carassius) and frogs (Rana pipens and Rana temporaria) can survive anoxia for hours to months. Obviously, anoxia tolerance has evolved separately sev...

    journal_title:Respiratory physiology & neurobiology

    pub_type: 杂志文章,评审

    doi:10.1016/j.resp.2004.03.013

    authors: Lutz PL,Nilsson GE

    更新日期:2004-08-12 00:00:00

  • Respiratory response to systemic inhibition of the Na+/H+ exchanger type 3 in intact rats.

    abstract::The Na+/H+ exchangers (NHEs) are a family of antiporters involved in the maintenance of neural steady-state intracellular pH. The NHE3 seems to be the predominant subtype in central chemosensitive cells. We aimed to analyze the effect of a selective NHE3 inhibition on the respiratory pattern in spontaneously breathing...

    journal_title:Respiratory physiology & neurobiology

    pub_type: 杂志文章

    doi:10.1016/j.resp.2008.12.011

    authors: Ribas-Salgueiro JL,Matarredona ER,Sarmiento M,Ribas J,Pásaro R

    更新日期:2009-02-28 00:00:00

  • Impact of short term forced oral breathing induced by nasal occlusion on respiratory function in mice.

    abstract::Inconsistent findings regarding the experimental nasal obstruction on respiratory functions in small animals have been reported. The purpose of this study was to investigate the impact of short term forced oral breathing on respiratory functions as well as the therapeutic implication of esophageal intubation in BALB/c...

    journal_title:Respiratory physiology & neurobiology

    pub_type: 杂志文章

    doi:10.1016/j.resp.2014.09.024

    authors: Xie J,Xi Y,Zhang Q,Lai K,Zhong N

    更新日期:2015-01-01 00:00:00

  • Electrophysiological alterations in diaphragm muscle caused by abdominal ischemia-reperfusion.

    abstract::Ischemia-reperfusion injury is the major complication of abdominal aortic surgery, and it mainly affects the lower extremities and remote organs. In the present study, the electrophysiological alterations in diaphragm that underlie the post-operative respiratory dysfunction were investigated. Wistar Albino rats were r...

    journal_title:Respiratory physiology & neurobiology

    pub_type: 杂志文章

    doi:10.1016/j.resp.2016.12.015

    authors: Tuncer S,Dalkilic N,Burat I

    更新日期:2017-04-01 00:00:00

  • Neuromodulation of hypoglossal motoneurons during sleep.

    abstract::Hypoglossal motoneurons are influenced by a variety of neuromodulators, some of which change dynamically across sleep-wake states to alter motoneuron excitability and responses to pharmacological manipulations. Determining the mechanisms underlying the modulation of hypoglossal motoneurons during sleep is relevant to ...

    journal_title:Respiratory physiology & neurobiology

    pub_type: 杂志文章,评审

    doi:10.1016/j.resp.2008.06.012

    authors: Horner RL

    更新日期:2008-12-10 00:00:00

  • Activation of opioid μ-receptors, but not δ- or κ-receptors, switches pulmonary C-fiber-mediated rapid shallow breathing into an apnea in anesthetized rats.

    abstract::Rapid shallow breathing (RSB) is mainly mediated by bronchopulmonary C-fibers (PCFs). We asked whether this RSB could be modulated by opioids. In anesthetized rats right atrial bolus injection of phenylbiguanide (PBG) to evoke RSB was repeated after: (1) intravenously giving fentanyl (μ-receptor agonist), DPDPE (δ-rec...

    journal_title:Respiratory physiology & neurobiology

    pub_type: 杂志文章

    doi:10.1016/j.resp.2012.06.032

    authors: Zhang Z,Zhang C,Zhou M,Xu F

    更新日期:2012-09-30 00:00:00

  • Upright posture increases oxyhemoglobin saturation in Peruvian highlanders.

    abstract::At high altitude, hypoxia amplifies oxyhemoglobin saturation (SPO2) swings with changes in respiratory mechanics. Our objective was to examine the effects of posture on SPO2 and determine predictors of postural SPO2 changes in highlanders. 50 native highlanders from Puno, Peru (3825 m) assumed supine and upright-seate...

    journal_title:Respiratory physiology & neurobiology

    pub_type: 杂志文章

    doi:10.1016/j.resp.2019.04.015

    authors: Arias RS,Etienne B,Polotsky VY,Checkley W,Schwartz AR,Pham LV

    更新日期:2019-08-01 00:00:00

  • Different respiratory behaviors disclosed by induced bronchoconstriction in mild asthma patients.

    abstract::Respiratory responses to bronchoconstriction in asthma have been partially assessed and their significance is unclear. In 44 mild asthma patients we investigated respiratory responses during increasing levels of methacholine-induced bronchoconstriction. Inspiratory muscle activity, tidal volume, inspiratory and expira...

    journal_title:Respiratory physiology & neurobiology

    pub_type: 杂志文章

    doi:10.1016/j.resp.2013.08.013

    authors: Lavorini F,Magni C,Chellini E,Camiciottoli G,Pistolesi M,Fontana GA

    更新日期:2013-12-01 00:00:00

  • Effects on breathing of agonists to μ-opioid or GABAA receptors dialyzed into the ventral respiratory column of awake and sleeping goats.

    abstract::Pulmonary ventilation (V̇I) in awake and sleeping goats does not change when antagonists to several excitatory G protein-coupled receptors are dialyzed unilaterally into the ventral respiratory column (VRC). Concomitant changes in excitatory neuromodulators in the effluent mock cerebral spinal fluid (mCSF) suggest neu...

    journal_title:Respiratory physiology & neurobiology

    pub_type: 杂志文章

    doi:10.1016/j.resp.2017.01.007

    authors: Langer TM 3rd,Neumueller SE,Crumley E,Burgraff NJ,Talwar S,Hodges MR,Pan L,Forster HV

    更新日期:2017-05-01 00:00:00

  • Differential responses of autonomic function in sea level residents, acclimatized lowlanders at >3500 m and Himalayan high altitude natives at >3500 m: A cross-sectional study.

    abstract::We studied the differential responses of autonomic function in sea level residents (SLR), acclimatized lowlanders (ALH) in high altitude (HA) and HA natives (HAN) at >3500 m. Out of 771 male volunteers included in this cross-sectional study, SLR, ALH and HAN groups were comprised of 351, 307 and 113 volunteers, respec...

    journal_title:Respiratory physiology & neurobiology

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1016/j.resp.2018.04.002

    authors: Dhar P,Sharma VK,Das SK,Barhwal K,Hota SK,Singh SB

    更新日期:2018-08-01 00:00:00

  • Supine changes in lung function correlate with chronic respiratory failure in myotonic dystrophy patients.

    abstract::Quality of life and prognosis of patients with myotonic dystrophy type 1 (MD1) often depend on the degree of lung function impairment. This study was designed to assess the respective prevalence of ventilatory restriction, hypoxaemia and hypercapnia in MD1 patients and to determine whether postural changes in lung fun...

    journal_title:Respiratory physiology & neurobiology

    pub_type: 杂志文章

    doi:10.1016/j.resp.2014.01.006

    authors: Poussel M,Kaminsky P,Renaud P,Laroppe J,Pruna L,Chenuel B

    更新日期:2014-03-01 00:00:00

  • A tidal ventilation model for oxygenation in respiratory failure.

    abstract::We develop tidal-ventilation pulmonary gas-exchange equations that allow pulmonary shunt to have different values during expiration and inspiration, in accordance with lung collapse and recruitment during lung dysfunction (Am. J. Respir. Crit. Care Med. 158 (1998) 1636). Their solutions are tested against published an...

    journal_title:Respiratory physiology & neurobiology

    pub_type: 杂志文章

    doi:10.1016/s1569-9048(03)00066-1

    authors: Whiteley JP,Farmery AD,Gavaghan DJ,Hahn CE

    更新日期:2003-06-12 00:00:00

  • The crossed phrenic phenomenon and recovery of function following spinal cord injury.

    abstract::This review will focus on neural plasticity and recovery of respiratory function after spinal cord injury and feature the "crossed phrenic phenomenon" (CPP) as a model for demonstrating such plasticity and recovery. A very brief summary of the earlier literature on the CPP will be followed by a more detailed review of...

    journal_title:Respiratory physiology & neurobiology

    pub_type: 杂志文章,评审

    doi:10.1016/j.resp.2009.06.005

    authors: Goshgarian HG

    更新日期:2009-11-30 00:00:00

  • Impact of sleep disordered breathing on carotid body size.

    abstract::We tested the hypotheses that: (1) carotid body size can be measured by computed tomographic angiography (CTA) with high inter-observer agreement, and (2) patients with sleep apnea exhibit larger carotid bodies than those without sleep apnea. A chart review was conducted from patients who underwent neck CTA and polyso...

    journal_title:Respiratory physiology & neurobiology

    pub_type: 杂志文章

    doi:10.1016/j.resp.2016.10.013

    authors: Welch BT,Petersen-Jones HG,Eugene AR,Brinjikji W,Kallmes DF,Curry TB,Joyner MJ,Limberg JK

    更新日期:2017-02-01 00:00:00

  • Serotonin transporter null male mouse pups have lower ventilation in air and 5% CO2 at postnatal ages P15 and P25.

    abstract::In Wild Type (WT) and serotonin transporter (5HTT) null mice, we studied oxygen consumption, ventilation and heart rate in air and 5% CO(2) at postnatal (P) days P5, P15, and P25 using either a head-out (younger mice) or whole body plethysmograph (older mice). Body weight and temperature did not differ between the gro...

    journal_title:Respiratory physiology & neurobiology

    pub_type: 杂志文章

    doi:10.1016/j.resp.2011.02.006

    authors: Penatti E,Barina A,Schram K,Li A,Nattie E

    更新日期:2011-06-30 00:00:00

  • Neutrophils in asthma--a review.

    abstract::Asthma is a chronic inflammatory disease, with an array of cells involved in the pathogenesis of the disease. The role of neutrophils in the development of bronchial asthma is found to be complex, as they may trigger activation of immunocompetent cells and are a potent source of free oxygen radicals and enzymes partic...

    journal_title:Respiratory physiology & neurobiology

    pub_type: 杂志文章,评审

    doi:10.1016/j.resp.2014.12.004

    authors: Ciepiela O,Ostafin M,Demkow U

    更新日期:2015-04-01 00:00:00

  • The role of aquaporin-1 (AQP1) expression in a murine model of lipopolysaccharide-induced acute lung injury.

    abstract::A murine model of lipopolysaccharide (LPS)-induced acute lung injury (ALI) was used to evaluate whether aquaporin-1 (AQP1) is involved in lung inflammation and lung edema formation. Swiss strain mice (n = 122) had LPS (5 mg/kg) instilled intratracheally (IT), and were then treated with either 0.9 % saline or dexametha...

    journal_title:Respiratory physiology & neurobiology

    pub_type: 杂志文章

    doi:10.1016/j.resp.2004.05.001

    authors: Su X,Song Y,Jiang J,Bai C

    更新日期:2004-08-20 00:00:00

  • Long-term exposure to cigarette smoke impairs lung function and increases HMGB-1 expression in mice.

    abstract::Cigarette smoke (CS)-induced emphysema is caused by a continuous inflammatory response in the lower respiratory tract. The development of the condition is believed to be mediated by oxidant-antioxidant imbalance. This paper describes the effects of long-term CS exposure on alveolar cell recruitment, antioxidant defens...

    journal_title:Respiratory physiology & neurobiology

    pub_type: 杂志文章

    doi:10.1016/j.resp.2011.03.023

    authors: Bezerra FS,Valença SS,Pires KM,Lanzetti M,Pimenta WA,Schmidt AC,Porto LC,Zin WA

    更新日期:2011-07-31 00:00:00

  • Hypocapnia is associated with increased upper airway expiratory resistance during sleep.

    abstract::We hypothesized that hypocapnia is responsible for increased expiratory resistance during NREM sleep. Hypocapnia was induced by hypoxic hyperventilation in 21 subjects (aged 29.4 ± 7.8 yrs, 10 women, BMI 24.4 ± 4.3 kg/m(2)). Isocapnic hypoxia was induced in 12 subjects of whom, 6 underwent hypocapnic hypoxia in the sa...

    journal_title:Respiratory physiology & neurobiology

    pub_type: 杂志文章

    doi:10.1016/j.resp.2011.04.004

    authors: Sankri-Tarbichi AG,Richardson NN,Chowdhuri S,Rowley JA,Safwan Badr M

    更新日期:2011-07-31 00:00:00