Abstract：
:This paper presents a modelling framework in which the local stress environment of airway smooth muscle (ASM) cells may be predicted and cellular responses to local stress may be investigated. We consider an elastic axisymmetric model of a layer of connective tissue and circumferential ASM fibres embedded in parenchymal tissue and model the active contractile force generated by ASM via a stress acting along the fibres. A constitutive law is proposed that accounts for active and passive material properties as well as the proportion of muscle to connective tissue. The model predicts significantly different contractile responses depending on the proportion of muscle to connective tissue in the remodelled airway. We find that radial and hoop-stress distributions in remodelled muscle layers are highly heterogenous with distinct regions of compression and tension. Such patterns of stress are likely to have important implications, from a mechano-transduction perspective, on contractility, short-term cytoskeletal adaptation and long-term airway remodelling in asthma.
journal_name
Respir Physiol Neurobioljournal_title
Respiratory physiology & neurobiologyauthors
Brook BS,Peel SE,Hall IP,Politi AZ,Sneyd J,Bai Y,Sanderson MJ,Jensen OEdoi
10.1016/j.resp.2009.11.006subject
Has Abstractpub_date
2010-01-31 00:00:00pages
44-58issue
1eissn
1569-9048issn
1878-1519pii
S1569-9048(09)00368-1journal_volume
170pub_type
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pub_type： 杂志文章
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更新日期：2014-07-01 00:00:00
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journal_title：Respiratory physiology & neurobiology
pub_type： 临床试验,杂志文章
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更新日期：2004-06-25 00:00:00
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pub_type： 杂志文章,评审
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pub_type： 杂志文章
doi：10.1016/j.resp.2007.10.001
更新日期：2008-02-01 00:00:00
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pub_type： 杂志文章,评审
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更新日期：2011-08-15 00:00:00
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