A biomechanical model of agonist-initiated contraction in the asthmatic airway.

Abstract:

:This paper presents a modelling framework in which the local stress environment of airway smooth muscle (ASM) cells may be predicted and cellular responses to local stress may be investigated. We consider an elastic axisymmetric model of a layer of connective tissue and circumferential ASM fibres embedded in parenchymal tissue and model the active contractile force generated by ASM via a stress acting along the fibres. A constitutive law is proposed that accounts for active and passive material properties as well as the proportion of muscle to connective tissue. The model predicts significantly different contractile responses depending on the proportion of muscle to connective tissue in the remodelled airway. We find that radial and hoop-stress distributions in remodelled muscle layers are highly heterogenous with distinct regions of compression and tension. Such patterns of stress are likely to have important implications, from a mechano-transduction perspective, on contractility, short-term cytoskeletal adaptation and long-term airway remodelling in asthma.

authors

Brook BS,Peel SE,Hall IP,Politi AZ,Sneyd J,Bai Y,Sanderson MJ,Jensen OE

doi

10.1016/j.resp.2009.11.006

subject

Has Abstract

pub_date

2010-01-31 00:00:00

pages

44-58

issue

1

eissn

1569-9048

issn

1878-1519

pii

S1569-9048(09)00368-1

journal_volume

170

pub_type

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