Respiratory response to systemic inhibition of the Na+/H+ exchanger type 3 in intact rats.


:The Na+/H+ exchangers (NHEs) are a family of antiporters involved in the maintenance of neural steady-state intracellular pH. The NHE3 seems to be the predominant subtype in central chemosensitive cells. We aimed to analyze the effect of a selective NHE3 inhibition on the respiratory pattern in spontaneously breathing rats with intact vagi. Rats were intravenously infused for 10 min with the selective NHE3 inhibitor AVE1599 (Aventis Pharma Deustchland, 0.5 and 2 mg/kg) or with phosphate buffer. Whole-body plethysmography was used to monitor breathing pattern before, during, and up to 30 min after the drug infusion. Immunohistochemistry for the c-Fos protein was performed in the animal brains and c-Fos-positive cells were counted along the brainstem. Selective NHE3 inhibition induced a significant increase in the respiratory frequency and in the number of c-Fos immunopositive cells in the lateral parabrachial nucleus, the pre-Bötzinger complex and a rostral extension of the retrotrapezoid nucleus/parapyramidal region (p<0.05, ANOVA). We conclude that systemic administration of AVE1599 increases respiratory frequency and activates ponto-medullary areas implicated in the central control of breathing and chemoreception.


Ribas-Salgueiro JL,Matarredona ER,Sarmiento M,Ribas J,Pásaro R




Has Abstract


2009-02-28 00:00:00














  • Gz- and not Gi-proteins are coupled to pre-junctional μ-opioid receptors in bovine airways.

    abstract::We investigated the signal transmission pathway by which activation of μ-opioid receptors attenuates acetylcholine (ACh) release in bovine trachealis. Electrical stimulation (ES)-induced [(3)H]-ACh release was determined in bovine tracheal smooth muscle strips pre-incubated with either the Gi-protein inhibitor pertuss...

    journal_title:Respiratory physiology & neurobiology

    pub_type: 杂志文章


    authors: Baroffio M,Brichetto L,Franco L,Crimi E,Rehder K,Brusasco V

    更新日期:2013-10-01 00:00:00

  • Influence of chronic hyperoxia on the developmental time course of the hypoxic ventilatory response relative to other traits in rats.

    abstract::Newborn mammals exhibit a biphasic hypoxic ventilatory response (HVR) in which an initial increase in ventilation is followed by a decline back toward baseline levels. The magnitude of the secondary decline diminishes with postnatal age, but this transition occurs earlier in rat pups reared in moderate hyperoxia. This...

    journal_title:Respiratory physiology & neurobiology

    pub_type: 杂志文章


    authors: Pinette M,Bavis RW

    更新日期:2020-09-01 00:00:00

  • The influence of pulmonary receptors on respiratory drive in a rabbit model of pulmonary emphysema.

    abstract::We have observed that pulmonary rapidly adapting receptor activity is greater in emphysematous rats than in controls. Pulmonary receptor activity, if modified by lung disease, may produce an inappropriate drive to breathe which may be perceived as dyspnoea. To investigate the efferent (drive) component of this hypothe...

    journal_title:Respiratory physiology & neurobiology

    pub_type: 杂志文章


    authors: Dallak MA,Pirie LJ,Davies A

    更新日期:2007-04-16 00:00:00

  • Airflow pattern complexity during resting breathing in patients with COPD: effect of airway obstruction.

    abstract::We investigated the influence of airway obstruction in the complexity of the airflow pattern in COPD and its use as a marker of disease activity. The sample entropy (SampEnV') and the variability (SDV') of the airflow pattern were measured in a group of 88 subjects with various levels of airway obstruction. Airway obs...

    journal_title:Respiratory physiology & neurobiology

    pub_type: 杂志文章


    authors: Dames KK,Lopes AJ,de Melo PL

    更新日期:2014-02-01 00:00:00

  • Mechanics of respiratory muscles.

    abstract::Lung ventilation is a mechanical process in which the respiratory muscles are acting in concert to remove air in and out of the lungs. Any alteration in the performance of the respiratory muscle may reduce the effectiveness of ventilation. Thus, early diagnosis of their weakness is vital for treatment and rehabilitati...

    journal_title:Respiratory physiology & neurobiology

    pub_type: 杂志文章,评审


    authors: Ratnovsky A,Elad D,Halpern P

    更新日期:2008-11-30 00:00:00

  • SiO2-induced release of sVEGFRs from pulmonary macrophages.

    abstract:BACKGROUND:The inhalation of silicon dioxide (SiO2) particles causes silicosis, a stubborn pulmonary disease that is characterized by alveolar inflammation during the early stage. Soluble cytokine receptors (SCRs) play important roles in regulating inflammation by either attenuating or promoting cytokine signaling. How...

    journal_title:Respiratory physiology & neurobiology

    pub_type: 杂志文章


    authors: Chao J,Lv Y,Chen J,Wang J,Yao H

    更新日期:2018-01-01 00:00:00

  • Ventilation-perfusion relationships in pulmonary arterial hypertension: effect of intravenous and inhaled prostacyclin treatment.

    abstract:UNLABELLED:In seven patients with idiopathic or secondary pulmonary arterial hypertension (PAH), ventilation-perfusion (V (A)/Q ) relationships were measured during a right heart catheterization using the multiple inert-gas elimination technique before and during intravenous infusion with epoprostenol (EPO), and follow...

    journal_title:Respiratory physiology & neurobiology

    pub_type: 杂志文章


    authors: Bratel T,Lagerstrand L,Brodin LA,Nowak J,Randmaa I

    更新日期:2007-08-15 00:00:00

  • Regulation of adenosine 5'-triphosphate (ATP)-gated P2X(4) receptors on tracheal smooth muscle cells.

    abstract::We examined the effects of extracellular adenosine 5'-triphosphate (ATP) on single airway smooth muscle (ASM) cells from porcine trachea using a patch-clamp technique. ATP induced a sustained inward current. Phospholipase C inhibitor U-73122 failed to inhibit the current, suggesting the involvement of P2X receptor. A ...

    journal_title:Respiratory physiology & neurobiology

    pub_type: 杂志文章


    authors: Nagaoka M,Nara M,Tamada T,Kume H,Oguma T,Kikuchi T,Zaini J,Moriya T,Ichinose M,Tamura G,Hattori T

    更新日期:2009-03-31 00:00:00

  • Does menstrual cycle phase affect lung diffusion capacity during exercise?

    abstract::Resting lung diffusing capacity (DLCO) decreases during the early and late-follicular phases of the menstrual cycle presumably due to capillary blood volume (VC) changes; however, it is not known if these differences exist during exercise. We hypothesized that DLCO would increase during the mid-luteal phase of the men...

    journal_title:Respiratory physiology & neurobiology

    pub_type: 杂志文章


    authors: Smith JR,Brown KR,Murphy JD,Harms CA

    更新日期:2015-01-01 00:00:00

  • Plasticity of respiratory structures--adaptive remodeling of fish gills induced by ambient oxygen and temperature.

    abstract::While a large surface area combined with short diffusion distances make fish gills well suited for gas exchange, these properties leads to costly water and ion fluxes and exposure to toxic substances and pathogens. Thus, gill morphology is likely to be a compromise between opposing demands. It has become clear that so...

    journal_title:Respiratory physiology & neurobiology

    pub_type: 杂志文章,评审


    authors: Sollid J,Nilsson GE

    更新日期:2006-11-01 00:00:00

  • A theoretical analysis of the carotid body chemoreceptor response to O2 and CO2 pressure changes.

    abstract::A simple mathematical model of the carotid body chemoreceptor response is presented. The model assumes that the static chemoreceptor characteristic depends on oxygen saturation in the arterial blood and on CO2 arterial concentration. The values of O2 saturation and of CO2 concentration are computed, from pressure, usi...

    journal_title:Respiratory physiology & neurobiology

    pub_type: 杂志文章


    authors: Ursino M,Magosso E

    更新日期:2002-03-01 00:00:00

  • Right and left vagus nerves regulate breathing by multiplicative interaction.

    abstract::Although it has been recognized for more than a century, we still do not know how the two vagus nerves interact to produce Hering-Breuer reflex. In the current study, we tested the hypothesis that the vagus nerves interact via a multiplicative effect. We examined the Hering-Breuer reflex before and after unilateral (f...

    journal_title:Respiratory physiology & neurobiology

    pub_type: 杂志文章


    authors: Song N,Liu J,Proctor M,Yu J

    更新日期:2015-12-01 00:00:00

  • Effects on breathing of agonists to μ-opioid or GABAA receptors dialyzed into the ventral respiratory column of awake and sleeping goats.

    abstract::Pulmonary ventilation (V̇I) in awake and sleeping goats does not change when antagonists to several excitatory G protein-coupled receptors are dialyzed unilaterally into the ventral respiratory column (VRC). Concomitant changes in excitatory neuromodulators in the effluent mock cerebral spinal fluid (mCSF) suggest neu...

    journal_title:Respiratory physiology & neurobiology

    pub_type: 杂志文章


    authors: Langer TM 3rd,Neumueller SE,Crumley E,Burgraff NJ,Talwar S,Hodges MR,Pan L,Forster HV

    更新日期:2017-05-01 00:00:00

  • Cardiovascular responses to dry apnoeas at exercise in air and in pure oxygen.

    abstract::If, as postulated, the end of the steady state phase (φ2) of cardiovascular responses to apnoea corresponds to the physiological breaking point, then we may hypothesize that φ2 should become visible if exercise apnoeas are performed in pure oxygen. We tested this hypothesis on 9 professional divers by means of continu...

    journal_title:Respiratory physiology & neurobiology

    pub_type: 杂志文章


    authors: Taboni A,Vinetti G,Bruseghini P,Camelio S,D'Elia M,Moia C,Ferretti G,Fagoni N

    更新日期:2018-09-01 00:00:00

  • A breath-holding challenge in panic disorder patients, their healthy first-degree relatives, and normal controls.

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    journal_title:Respiratory physiology & neurobiology

    pub_type: 杂志文章


    authors: Nardi AE,Nascimento I,Valença AM,Lopes FL,Zin WA,Mezzasalma MA,Versiani M

    更新日期:2002-10-23 00:00:00

  • Responses induced by acetylcholine and ATP in the rabbit petrosal ganglion.

    abstract::Acetylcholine and ATP appear to mediate excitatory transmission between receptor (glomus) cells and the petrosal ganglion (PG) neuron terminals in the carotid body. In most species these putative transmitters are excitatory, while inhibitory effects had been reported in the rabbit. We studied the effects of the applic...

    journal_title:Respiratory physiology & neurobiology

    pub_type: 杂志文章


    authors: Soto CR,Ortiz FC,Vargas RV,Arroyo J,Alcayaga J

    更新日期:2010-07-31 00:00:00

  • Neural drive to respiratory muscles in the spontaneously breathing rat pup.

    abstract::The neonatal rodent serves as useful and appropriate model within which to study respiratory system development. Despite an extensive literature that documents respiratory control in vitro, in vivo studies have relied upon whole body plethysmography to determine measures of respiratory frequency and tidal volume. Howe...

    journal_title:Respiratory physiology & neurobiology

    pub_type: 杂志文章


    authors: Kidder IJ,Mudery JA,Bailey EF

    更新日期:2014-10-01 00:00:00

  • Effects of dietary inorganic nitrate on static and dynamic breath-holding in humans.

    abstract::Inorganic nitrate has been shown to reduce oxygen cost during exercise. Since the nitrate-nitrite-NO pathway is facilitated during hypoxia, we investigated the effects of dietary nitrate on oxygen consumption and cardiovascular responses during apnea. These variables were measured in two randomized, double-blind, plac...

    journal_title:Respiratory physiology & neurobiology

    pub_type: 杂志文章,随机对照试验


    authors: Schiffer TA,Larsen FJ,Lundberg JO,Weitzberg E,Lindholm P

    更新日期:2013-01-15 00:00:00

  • Nasal highflow eliminates CO2 from lower airways.

    abstract:INTRODUCTION:Nasal highflow (NHF) has a growing evidence in treatment of hypoxemic respiratory failure. There are preliminary data available about use in acute and chronic type-II-respiratory failure. Unfortunately underlying mechanisms of NHF are not well understood. Increase in airway pressure seems too small to expl...

    journal_title:Respiratory physiology & neurobiology

    pub_type: 杂志文章


    authors: Bräunlich J,Goldner F,Wirtz H

    更新日期:2017-08-01 00:00:00

  • Mechanical factors in the development of the vascular bed.

    abstract::During embryonic development, blood flow is needed not only to nourish the developing embryo but is also important for shaping the vascular network such that it becomes hemodynamically efficient. The first blood vessels form a network called the capillary plexus. After the onset of blood flow, the capillary plexus rem...

    journal_title:Respiratory physiology & neurobiology

    pub_type: 杂志文章,评审


    authors: Jones EA

    更新日期:2011-08-31 00:00:00

  • Biphasic airway-lung response to anaphylactic shock in Brown Norway rats.

    abstract::Bronchospasm may be part of the response to systemic anaphylaxis in humans. The anaphylactic shock has been characterized in allergic rats, but little data are available on the concurrent changes in airway-lung mechanics. The aim was to describe the respiratory resistance (Rrs) and reactance (Xrs) response to ovalbumi...

    journal_title:Respiratory physiology & neurobiology

    pub_type: 杂志文章


    authors: Barthel G,Zheng F,Demoulin B,Davidson J,Montémont C,Gaburro J,Mertes PM,Marchal F

    更新日期:2013-10-01 00:00:00

  • Intermittent hypoxia-induced cardiorespiratory long-term facilitation: A new role for microglia.

    abstract::Intermittent hypoxia induces plasticity in neural networks controlling breathing and cardiovascular function. Studies demonstrate that mechanisms causing cardiorespiratory plasticity rely on intracellular signalling pathways that are activated by specific neurotransmitters. Peptides such as serotonin, PACAP and orexin...

    journal_title:Respiratory physiology & neurobiology

    pub_type: 杂志文章,评审


    authors: Kim SJ,Kim YJ,Kakall Z,Farnham MM,Pilowsky PM

    更新日期:2016-06-01 00:00:00

  • Reappraisal of DLCO adjustment to interpret the adaptive response of the air-blood barrier to hypoxia.

    abstract::DLCO measured in hypoxia must be corrected due to the higher affinity (increase in coefficient θ) of CO with Hb. We propose an adjustment accounting for individual changes in the equation relating DLCO to subcomponents Dm (membrane diffusive capacity) and Vc (lung capillary volume): 1/DLCO=1/Dm+1/θVc. We adjusted the ...

    journal_title:Respiratory physiology & neurobiology

    pub_type: 杂志文章


    authors: Beretta E,Lanfranconi F,Grasso GS,Bartesaghi M,Alemayehu HK,Miserocchi G

    更新日期:2017-04-01 00:00:00

  • Protective role of peroxisome proliferator-activated receptor β/δ in acute lung injury induced by prolonged hyperbaric hyperoxia in rats.

    abstract::Peroxisome proliferator-activated receptor (PPAR)-β/δ is a transcription factor that belongs to the PPAR family, but the role of PPAR-β/δ in acute lung injury (ALI) induced by hyperbaric oxygen is unknown. In this study we investigated if PPAR-β/δ activation protects from hyperoxia-induced ALI in a rat model. ALI was ...

    journal_title:Respiratory physiology & neurobiology

    pub_type: 杂志文章


    authors: Bao XC,Fang YQ,You P,Zhang S,Ma J

    更新日期:2014-08-01 00:00:00

  • Early postnatal exposure to allergen and ozone leads to hyperinnervation of the pulmonary epithelium.

    abstract::Airway injury in infant monkeys exposed to ozone and/or house dust mite allergen (HDMA) is associated with a loss of epithelial innervation. In this study, we evaluated for persistence/recovery of the altered epithelial innervation. Thirty-day-old rhesus monkeys were exposed to repeated episodes of HDMA and/or ozone f...

    journal_title:Respiratory physiology & neurobiology

    pub_type: 杂志文章


    authors: Kajekar R,Pieczarka EM,Smiley-Jewell SM,Schelegle ES,Fanucchi MV,Plopper CG

    更新日期:2007-01-15 00:00:00

  • Premature birth, homeostatic plasticity and respiratory consequences of inflammation.

    abstract::Infants who are born premature can have persistent apnea beyond term gestation, reemergence of apnea associated with inflammation during infancy, increased risk of sudden unexplained death, and sleep disorder breathing during infancy and childhood. The autonomic nervous system, particularly the central neural networks...

    journal_title:Respiratory physiology & neurobiology

    pub_type: 杂志文章,评审


    authors: Gauda EB,McLemore GL

    更新日期:2020-03-01 00:00:00

  • Recent findings in cardiovascular physiology with space travel.

    abstract::The cardiovascular system undergoes major changes in stress with space flight primarily related to the elimination of the head-to-foot gravitational force. A major observation has been that the central venous pressure is not elevated early in space flight yet stroke volume is increased at least early in flight. Recent...

    journal_title:Respiratory physiology & neurobiology

    pub_type: 杂志文章


    authors: Hughson RL

    更新日期:2009-10-01 00:00:00

  • Vascular KATP channels mitigate severe muscle O2 delivery-utilization mismatch during contractions in chronic heart failure rats.

    abstract::The vascular ATP-sensitive K+ (KATP) channel is a mediator of skeletal muscle microvascular oxygenation (PO2mv) during contractions in health. We tested the hypothesis that KATP channel function is preserved in chronic heart failure (CHF) and therefore its inhibition would reduce PO2mv and exacerbate the time taken to...

    journal_title:Respiratory physiology & neurobiology

    pub_type: 杂志文章


    authors: Holdsworth CT,Ferguson SK,Colburn TD,Fees AJ,Craig JC,Hirai DM,Poole DC,Musch TI

    更新日期:2017-04-01 00:00:00

  • Studying respiratory rhythm generation in a developing bird: Hatching a new experimental model using the classic in vitro brainstem-spinal cord preparation.

    abstract::It has been more than thirty years since the in vitro brainstem-spinal cord preparation was first presented as a method to study automatic breathing behaviors in the neonatal rat. This straightforward preparation has led to an incredible burst of information about the location and coordination of several spontaneously...

    journal_title:Respiratory physiology & neurobiology

    pub_type: 杂志文章


    authors: Vincen-Brown MA,Whitesitt KC,Quick FG,Pilarski JQ

    更新日期:2016-04-01 00:00:00

  • The locus coeruleus and central chemosensitivity.

    abstract::The locus coeruleus (LC) lies in the dorsal pons and supplies noradrenergic (NA) input to many regions of the brain, including respiratory control areas. The LC may provide tonic input for basal respiratory drive and is involved in central chemosensitivity since focal acidosis of the region stimulates ventilation and ...

    journal_title:Respiratory physiology & neurobiology

    pub_type: 杂志文章,评审


    authors: Gargaglioni LH,Hartzler LK,Putnam RW

    更新日期:2010-10-31 00:00:00