Abstract:
:Haematological responses throughout 4 w of initial acclimation (IA) and three paradigms of re-acclimation (RA) to hypoxia (FI(O₂)) were examined in female mice. We hypothesised that (i) haematological responses would be increased during re-exposure, resulting in greater O₂-carrying capacity in RA compared to IA; and (ii) further improvements would occur when abbreviating the de-acclimation period to 1 w (RA↓DA) or extending the IA period to 8 w (RA↑IA). The serum [EPO] response was blunted in all RA groups compared to IA but the resulting reticulocyte response was similar in all experimental groups. The [Hb] response was the same in RA and RA↓DA as in IA but was blunted in RA↑IA due to a reduction in mean corpuscular Hb. The sensitivity of EPO-producing cells appears blunted but the sensitivity of erythroid precursors to EPO is enhanced by recent hypoxic exposure. Erythropoietic regulation is altered during RA in a manner that is dependent on the paradigm of initial exposure.
journal_name
Respir Physiol Neurobioljournal_title
Respiratory physiology & neurobiologyauthors
MacNutt MJ,Rupert JL,Sheel AWdoi
10.1016/j.resp.2013.07.018subject
Has Abstractpub_date
2013-10-01 00:00:00pages
153-61issue
1eissn
1569-9048issn
1878-1519pii
S1569-9048(13)00262-0journal_volume
189pub_type
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