Abstract:
:Classical understanding of airway lumen narrowing in asthma has held that the isometric force generated by airway smooth muscle (ASM) must be at every instant in a static mechanical equilibrium with the external load against which the muscle has shortened. It has been established recently, however, that this balance of static forces does not apply in the setting of tidal loading as occurs during breathing and must give way to the broader concepts of (1). the perturbed contractile state that exists far from static equilibrium conditions and (2). mechanical plasticity of the ASM cell. Here we describe the hypothesis that the well-established static contractile state, the newly-elaborated perturbed contractile state, as well as the remarkable mechanical plasticity of the ASM cell, are all subsumed under a rubric that is at once surprising, unifying and mechanistic. The specific hypothesis suggested is that the ASM cell behaves as a glassy material [Phys. Rev. Lett. 87 (2001) 148102]. A glass is a material that has the disordered molecular state of a liquid and, at the same time, the rigidity of a solid. If the hypothesis is true, then the ability of the ASM cytoskeleton (CSK) to deform, to flow and to remodel would be determined by an effective temperature-called the noise temperature-representing the level of jostling (i.e. molecular noise or agitation) present in the intracellular microenvironment. The abilities of the CSK to deform, to flow and to reorganize represent basic biological processes that underlie a variety of higher cell functions. If supported by the data, therefore, this integrative hypothesis might have implications in medicine and biology that go beyond the immediate issues of smooth muscle shortening and its role in asthma.
journal_name
Respir Physiol Neurobioljournal_title
Respiratory physiology & neurobiologyauthors
Fabry B,Fredberg JJdoi
10.1016/s1569-9048(03)00141-1keywords:
subject
Has Abstractpub_date
2003-09-16 00:00:00pages
109-24issue
2-3eissn
1569-9048issn
1878-1519pii
S1569904803001411journal_volume
137pub_type
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journal_title:Respiratory physiology & neurobiology
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journal_title:Respiratory physiology & neurobiology
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journal_title:Respiratory physiology & neurobiology
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journal_title:Respiratory physiology & neurobiology
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journal_title:Respiratory physiology & neurobiology
pub_type: 社论,评审
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journal_title:Respiratory physiology & neurobiology
pub_type: 杂志文章
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journal_title:Respiratory physiology & neurobiology
pub_type: 杂志文章
doi:10.1016/s1569-9048(02)00204-5
更新日期:2003-02-19 00:00:00
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journal_title:Respiratory physiology & neurobiology
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更新日期:2009-10-01 00:00:00
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journal_title:Respiratory physiology & neurobiology
pub_type: 杂志文章
doi:10.1016/j.resp.2017.11.004
更新日期:2018-01-01 00:00:00
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journal_title:Respiratory physiology & neurobiology
pub_type: 杂志文章,评审
doi:10.1016/j.resp.2010.01.004
更新日期:2010-04-15 00:00:00
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journal_title:Respiratory physiology & neurobiology
pub_type: 杂志文章
doi:10.1016/j.resp.2014.07.018
更新日期:2014-10-01 00:00:00
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pub_type: 杂志文章
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更新日期:2020-03-01 00:00:00
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journal_title:Respiratory physiology & neurobiology
pub_type: 杂志文章
doi:10.1016/j.resp.2020.103572
更新日期:2020-11-05 00:00:00
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journal_title:Respiratory physiology & neurobiology
pub_type: 杂志文章
doi:10.1016/j.resp.2013.07.021
更新日期:2013-10-01 00:00:00
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journal_title:Respiratory physiology & neurobiology
pub_type: 杂志文章
doi:10.1016/j.resp.2010.03.005
更新日期:2010-04-30 00:00:00
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journal_title:Respiratory physiology & neurobiology
pub_type: 杂志文章
doi:10.1016/j.resp.2017.08.015
更新日期:2018-01-01 00:00:00
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journal_title:Respiratory physiology & neurobiology
pub_type: 杂志文章
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更新日期:2020-08-01 00:00:00
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journal_title:Respiratory physiology & neurobiology
pub_type: 杂志文章
doi:10.1016/j.resp.2017.03.010
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journal_title:Respiratory physiology & neurobiology
pub_type: 杂志文章
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更新日期:2020-10-01 00:00:00
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journal_title:Respiratory physiology & neurobiology
pub_type: 杂志文章
doi:10.1016/j.resp.2006.07.003
更新日期:2007-03-15 00:00:00
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journal_title:Respiratory physiology & neurobiology
pub_type: 杂志文章
doi:10.1016/j.resp.2015.11.009
更新日期:2016-03-01 00:00:00
abstract::Hypoxia leads to pulmonary vasoconstriction in healthy men. However, the consequences on right ventricular function are not known. The effects of hypoxia on systolic pulmonary artery pressure (sPAP) and right ventricular function index (TEI) were assessed by Doppler echocardiography. Fourteen members of a Mount Everes...
journal_title:Respiratory physiology & neurobiology
pub_type: 临床试验,杂志文章,随机对照试验
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更新日期:2007-11-15 00:00:00
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journal_title:Respiratory physiology & neurobiology
pub_type: 杂志文章
doi:10.1016/j.resp.2015.11.002
更新日期:2016-01-15 00:00:00
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journal_title:Respiratory physiology & neurobiology
pub_type: 杂志文章
doi:10.1016/j.resp.2009.06.001
更新日期:2009-07-31 00:00:00
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journal_title:Respiratory physiology & neurobiology
pub_type: 杂志文章
doi:10.1016/j.resp.2004.12.002
更新日期:2005-04-15 00:00:00
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journal_title:Respiratory physiology & neurobiology
pub_type: 杂志文章
doi:10.1016/j.resp.2014.05.010
更新日期:2014-08-15 00:00:00
abstract::Sleep-disordered breathing is accompanied by neural injury that affects a wide range of physiological systems which include processes for sensing chemoreception and airflow, driving respiratory musculature, timing circuitry for coordination of breathing patterning, and integration of blood pressure mechanisms with res...
journal_title:Respiratory physiology & neurobiology
pub_type: 杂志文章,评审
doi:10.1016/j.resp.2013.04.021
更新日期:2013-09-15 00:00:00
abstract::Quality of life and prognosis of patients with myotonic dystrophy type 1 (MD1) often depend on the degree of lung function impairment. This study was designed to assess the respective prevalence of ventilatory restriction, hypoxaemia and hypercapnia in MD1 patients and to determine whether postural changes in lung fun...
journal_title:Respiratory physiology & neurobiology
pub_type: 杂志文章
doi:10.1016/j.resp.2014.01.006
更新日期:2014-03-01 00:00:00