Abstract：
:We previously found that maternal cigarette smoke (CS) exposure resulted in impairment of central chemoreception and oxidative stress and mitochondrial dysfunction of parafacial respiratory group (pFRG, a critical site for mammalian central chemoreception) in neonatal rats. The present work was carried out to identify if maternal CS exposure could disturb the glutamate (GLU)-ergic and γ-aminobutyric acid (GABA)-ergic balance in pFRG of neonatal rats. We found that maternal CS exposure induced a decrease in GLU content and consequently in GLU/GABA ratio in pFRG of neonatal rats. Maternal CS exposure also decreased glutamine content and glutaminase and glutamine synthetase activity in offspring pFRG. In addition, expression of vesicular glutamate transporter 2 was depressed, and those of glutamate transporter 1 and GABA transporter 3 were elevated by maternal CS exposure. These results indicate that maternal CS exposure leads to a disturbance of GLU/GABA balance in pFRG of the neonatal rats, which might contribute to the suppression of central chemoreception in maternal CS-exposed offspring.
journal_name
Respir Physiol Neurobioljournal_title
Respiratory physiology & neurobiologyauthors
Fu Y,Lei F,Wang J,Wang W,Zheng Ydoi
10.1016/j.resp.2020.103383subject
Has Abstractpub_date
2020-03-01 00:00:00pages
103383eissn
1569-9048issn
1878-1519pii
S1569-9048(19)30416-1journal_volume
274pub_type
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pub_type： 杂志文章
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journal_title：Respiratory physiology & neurobiology
pub_type： 杂志文章,评审
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pub_type： 杂志文章,评审
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journal_title：Respiratory physiology & neurobiology
pub_type： 杂志文章
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