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Ventilation-perfusion relationships in pulmonary arterial hypertension: effect of intravenous and inhaled prostacyclin treatment.

Abstract：

UNLABELLED:In seven patients with idiopathic or secondary pulmonary arterial hypertension (PAH), ventilation-perfusion (V (A)/Q ) relationships were measured during a right heart catheterization using the multiple inert-gas elimination technique before and during intravenous infusion with epoprostenol (EPO), and following 5 months of 20 microg inhaled iloprost taken three times daily (ILO). Pre-treatment pulmonary vascular resistance (PVR) was 9.3+/-5.0 mmHg/l/min and the dispersion of perfusion and ventilation for V (A)/Q -ratios was increased. EPO reduced PVR by 20%, and increased cardiac output, shunt, and mixed venous oxygenation (SV(O2)). The arterial oxygen tension (Pa(O2)) remained unchanged. Basal central haemodynamics did not change after 5 months of ILO. Fifteen minutes after ILO, PVR decreased by 20%, and the shunt, SV(O2), and Pa(O2) remained unaltered. CONCLUSIONS:In secondary PAH with normal lung volumes, significant V (A)/Q mismatching occurred. The PVR was reduced to a similar degree during EPO and after ILO, but only EPO increased the shunt and SV(O2). EPO and ILO did not significantly affect the Pa(O2).

journal_name

Respir Physiol Neurobiol

journal_title

Respiratory physiology & neurobiology

authors

Bratel T,Lagerstrand L,Brodin LA,Nowak J,Randmaa I

doi

10.1016/j.resp.2007.03.003

subject

Has Abstract

pub_date

2007-08-15 00:00:00

pages

59-69

issue

1

eissn

1569-9048

issn

1878-1519

pii

S1569-9048(07)00086-9

journal_volume

158

pub_type

杂志文章

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