Cough reflex sensitivity does not correlate with the esophageal sensitivity to acid in patients with gastroesophageal reflux disease.

Abstract:

:The sensitization of cough reflex observed in patients with gastroesophageal reflux disease (GERD) is attributed to activation of vagal C-fibers innervating the esophagus by acid, while the heartburn in GERD is mediated by esophageal acid sensitive C-fibers derived from (dorsal root ganglia) DRG. Here we explored the relationship between cough reflex sensitivity (CRS) and esophageal sensitivity to acid. We evaluated CRS to capsaicin inhalation and esophageal sensitivity to acid (intensity of heartburn evoked by esophageal infusions of acid pH = 3, 2 and 1) in patients with GERD and chronic heartburn before and 3 months after proton pump inhibitor (PPI) treatment. There was no correlation between CRS and esophageal sensitivity to acid at any pH tested. PPI treatment substantially reduced esophageal sensitivity to acid but did not affect CRS. We conclude that a simple direct relationship between CRS and esophageal sensitivity to acid is unlikely. The results indicate that spinal and vagal afferent pathways from the esophagus are probably influenced separately in subjects with GERD.

authors

Duricek M,Nosakova L,Zatko T,Pecova R,Hyrdel R,Banovcin P Jr

doi

10.1016/j.resp.2018.03.011

subject

Has Abstract

pub_date

2018-11-01 00:00:00

pages

25-29

eissn

1569-9048

issn

1878-1519

pii

S1569-9048(17)30392-0

journal_volume

257

pub_type

杂志文章
  • Mechanical factors in the development of the vascular bed.

    abstract::During embryonic development, blood flow is needed not only to nourish the developing embryo but is also important for shaping the vascular network such that it becomes hemodynamically efficient. The first blood vessels form a network called the capillary plexus. After the onset of blood flow, the capillary plexus rem...

    journal_title:Respiratory physiology & neurobiology

    pub_type: 杂志文章,评审

    doi:10.1016/j.resp.2011.03.026

    authors: Jones EA

    更新日期:2011-08-31 00:00:00

  • Inflammatory and immunomodulatory mechanisms in the carotid body.

    abstract::Evidence is available about the role of inflammatory/immunological factors in the physiology and plasticity of the carotid body, with potential clinical implications in obstructive sleep apnea syndrome and sudden infant death syndrome. In humans, lymphomonocytic aggregations (chronic carotid glomitis) have been report...

    journal_title:Respiratory physiology & neurobiology

    pub_type: 杂志文章,评审

    doi:10.1016/j.resp.2013.02.017

    authors: Porzionato A,Macchi V,De Caro R,Di Giulio C

    更新日期:2013-06-01 00:00:00

  • An astrocyte toxin influences the pattern of breathing and the ventilatory response to hypercapnia in neonatal rats.

    abstract::Recent in vitro data suggest that astrocytes may modulate respiration. To examine this question in vivo, we treated 5-day-old rat pups with methionine sulfoximine (MS), a compound that alters carbohydrate and glutamate metabolism in astrocytes, but not neurons. MS-treated pups displayed a reduced breathing frequency (...

    journal_title:Respiratory physiology & neurobiology

    pub_type: 杂志文章

    doi:10.1016/j.resp.2005.01.009

    authors: Young JK,Dreshaj IA,Wilson CG,Martin RJ,Zaidi SI,Haxhiu MA

    更新日期:2005-05-12 00:00:00

  • Prenatal development of the pulmonary surfactant system and the influence of hypoxia.

    abstract::Pulmonary surfactant fulfils diverse functions at the lung air-liquid interface of all air-breathing vertebrates. Neurohormonal regulation of surfactant synthesis and secretion is highly conserved among non-mammalian amniotes. Although the pattern of surfactant lipid maturation is similar among species, the onset and ...

    journal_title:Respiratory physiology & neurobiology

    pub_type: 杂志文章,评审

    doi:10.1016/j.resp.2011.05.015

    authors: Orgeig S,Morrison JL,Daniels CB

    更新日期:2011-08-31 00:00:00

  • Side-stream tobacco smoke-induced airway hyperresponsiveness in early postnatal period is involved nerve growth factor.

    abstract::Epidemiological studies have shown that children are more susceptible to adverse respiratory effects of passive smoking than adults. The goal of this study is to elucidate the possible neural mechanism induced by exposure to passive smoking during early life. Postnatal day (PD) 2 and PD 21 mice were exposed to side-st...

    journal_title:Respiratory physiology & neurobiology

    pub_type: 杂志文章

    doi:10.1016/j.resp.2015.11.009

    authors: Wu ZX,Hunter DD,Batchelor TP,Dey RD

    更新日期:2016-03-01 00:00:00

  • Neuromodulation of hypoglossal motoneurons during sleep.

    abstract::Hypoglossal motoneurons are influenced by a variety of neuromodulators, some of which change dynamically across sleep-wake states to alter motoneuron excitability and responses to pharmacological manipulations. Determining the mechanisms underlying the modulation of hypoglossal motoneurons during sleep is relevant to ...

    journal_title:Respiratory physiology & neurobiology

    pub_type: 杂志文章,评审

    doi:10.1016/j.resp.2008.06.012

    authors: Horner RL

    更新日期:2008-12-10 00:00:00

  • Maximal O(2) consumption: Effects of gravity withdrawal and resumption.

    abstract::Maximal O(2) consumption (V(O)(2) max) is an index of integrated cardiopulmonary function. After having defined it, discussed its limitation, and described its measurement, we present data during and after space flight and simulation. During gravity withdrawal, V(O)(2) max stays unchanged. It suddenly drops when the s...

    journal_title:Respiratory physiology & neurobiology

    pub_type: 杂志文章

    doi:10.1016/j.resp.2009.03.012

    authors: Ferretti G,Capelli C

    更新日期:2009-10-01 00:00:00

  • Analysis of heart rate and oxygen uptake kinetics studied by two different pseudo-random binary sequence work rate amplitudes.

    abstract:PURPOSE:The aim of the study was to compare the kinetics responses of heart rate (HR), pulmonary (V˙O2pulm) and predicted muscular (V˙O2musc) oxygen uptake between two different pseudo-random binary sequence (PRBS) work rate (WR) amplitudes both below anaerobic threshold. METHODS:Eight healthy individuals performed tw...

    journal_title:Respiratory physiology & neurobiology

    pub_type: 杂志文章

    doi:10.1016/j.resp.2017.03.001

    authors: Drescher U,Koschate J,Schiffer T,Schneider S,Hoffmann U

    更新日期:2017-06-01 00:00:00

  • Validation of a two-compartment model of ventilation/perfusion distribution.

    abstract::Ventilation (V (A)) to perfusion (Q ) heterogeneity (V (A)/Q ) analyses by a two-compartment lung model (2C), utilizing routine gas exchange measurements and a computer solution to account for O(2) and CO(2) measurements, were compared with multiple inert gas elimination technique (MIGET) analyses and a multi-compartm...

    journal_title:Respiratory physiology & neurobiology

    pub_type: 杂志文章

    doi:10.1016/j.resp.2005.06.002

    authors: Loeppky JA,Caprihan A,Altobelli SA,Icenogle MV,Scotto P,Vidal Melo MF

    更新日期:2006-03-28 00:00:00

  • Gain modulation of respiratory neurons.

    abstract::A possible mechanism underlying adaptive control of the respiratory system is gain modulation of the discharge frequency (F(n)) patterns of medullary respiratory neurons mediated by GABA(A) receptors. Antagonism of GABA(A) receptors with bicuculline results in an F(n) pattern that is an amplified replica of the underl...

    journal_title:Respiratory physiology & neurobiology

    pub_type: 杂志文章,评审

    doi:10.1016/s1569-9048(02)00042-3

    authors: Zuperku EJ,McCrimmon DR

    更新日期:2002-07-01 00:00:00

  • Vagotomy reverses established allergen-induced airway hyperreactivity to methacholine in the mouse.

    abstract::We evaluated the role of vagal reflexes in a mouse model of allergen-induced airway hyperreactivity. Mice were actively sensitized to ovalbumin then exposed to the allergen via inhalation. Prior to ovalbumin inhalation, mice also received intratracheally-instilled particulate matter in order to boost the allergic resp...

    journal_title:Respiratory physiology & neurobiology

    pub_type: 杂志文章

    doi:10.1016/j.resp.2015.03.007

    authors: McAlexander MA,Gavett SH,Kollarik M,Undem BJ

    更新日期:2015-07-01 00:00:00

  • Maximal inspiratory mouth pressure in Japanese elite male athletes.

    abstract::Maximal inspiratory mouth pressure (MIP) is a common measurement of inspiratory muscle strength, which is often used in a variety of exercises to evaluate the effects of inspiratory muscle training. An understanding of elite athletes' MIP characteristics is needed to guide sport-specific inspiratory muscle training pr...

    journal_title:Respiratory physiology & neurobiology

    pub_type: 杂志文章

    doi:10.1016/j.resp.2016.05.004

    authors: Ohya T,Hagiwara M,Chino K,Suzuki Y

    更新日期:2016-08-01 00:00:00

  • Does menstrual cycle phase affect lung diffusion capacity during exercise?

    abstract::Resting lung diffusing capacity (DLCO) decreases during the early and late-follicular phases of the menstrual cycle presumably due to capillary blood volume (VC) changes; however, it is not known if these differences exist during exercise. We hypothesized that DLCO would increase during the mid-luteal phase of the men...

    journal_title:Respiratory physiology & neurobiology

    pub_type: 杂志文章

    doi:10.1016/j.resp.2014.10.014

    authors: Smith JR,Brown KR,Murphy JD,Harms CA

    更新日期:2015-01-01 00:00:00

  • The blood transfer conductance for nitric oxide: Infinite vs. finite θNO.

    abstract::Whether the specific blood transfer conductance for nitric oxide (NO) with hemoglobin (θNO) is finite or infinite is controversial but important in the calculation of alveolar capillary membrane conductance (DmCO) and pulmonary capillary blood volume (VC) from values of lung diffusing capacity for carbon monoxide (DLC...

    journal_title:Respiratory physiology & neurobiology

    pub_type: 杂志文章,评审

    doi:10.1016/j.resp.2016.12.007

    authors: Coffman KE,Chase SC,Taylor BJ,Johnson BD

    更新日期:2017-07-01 00:00:00

  • Effect of acetazolamide on respiratory muscle fatigue in humans.

    abstract::Previous studies have demonstrated that carbonic anhydrase inhibition with acetazolamide reduces exercise capacity. The mechanism responsible for this early fatigue is unclear, but may be partly mediated by impaired respiratory muscle function. Inspiratory muscle strength and endurance were assessed in seven healthy m...

    journal_title:Respiratory physiology & neurobiology

    pub_type: 杂志文章

    doi:10.1016/j.resp.2012.08.023

    authors: Gonzales JU,Scheuermann BW

    更新日期:2013-01-15 00:00:00

  • Alterations in oropharyngeal sensory evoked potentials (PSEP) with Parkinson's disease.

    abstract::Movement of a food bolus from the oral cavity into the oropharynx activates pharyngeal sensory mechanoreceptors. Using electroencephalography, somatosensory cortical-evoked potentials resulting from oropharyngeal mechanical stimulation (PSEP) have been studied in young healthy individuals. However, limited information...

    journal_title:Respiratory physiology & neurobiology

    pub_type: 杂志文章

    doi:10.1016/j.resp.2016.04.004

    authors: Pitts T,Hegland KW,Sapienza CM,Bolser DC,Davenport PW

    更新日期:2016-07-15 00:00:00

  • The effect of cannabinoids on dinitrofluorobenzene-induced experimental asthma in mice.

    abstract::Cannabinoids have anti-inflammatory effects and can produce bronchodilation in the airways. We have investigated the effects of cannabinoids on tracheal hyperreactivity and airway inflammation in dinitrofluorobenzene (DNFB)-induced experimental non-atopic asthma in mice. 5-hydroxytryptamine (5-HT)-induced contraction ...

    journal_title:Respiratory physiology & neurobiology

    pub_type: 杂志文章

    doi:10.1016/j.resp.2016.05.012

    authors: Bozkurt TE,Kaya Y,Durlu-Kandilci NT,Onder S,Sahin-Erdemli I

    更新日期:2016-09-01 00:00:00

  • Sleep structure and periodic breathing in Tibetans and Han at simulated altitude of 5000 m.

    abstract::Tibetans are the oldest population living permanently at high altitude. They possess several adaptations to low oxygen pressure that improve oxygen transport. We hypothesised that native Tibetans have mechanisms allowing them to maintain a better sleep structure and oxygenation during sleep at high altitude than newco...

    journal_title:Respiratory physiology & neurobiology

    pub_type: 杂志文章

    doi:10.1016/s1569-9048(03)00081-8

    authors: Pływaczewski R,Wu TY,Wang XQ,Cheng HW,Sliwiński PS,Zieliński J

    更新日期:2003-07-16 00:00:00

  • Dietary nitrate supplementation opposes the elevated diaphragm blood flow in chronic heart failure during submaximal exercise.

    abstract::Chronic heart failure (CHF) results in a greater cost of breathing and necessitates an elevated diaphragm blood flow (BF). Dietary nitrate (NO3‾) supplementation lowers the cost of exercise. We hypothesized that dietary NO3‾ supplementation would attenuate the CHF-induced greater cost of breathing and thus the heighte...

    journal_title:Respiratory physiology & neurobiology

    pub_type: 杂志文章

    doi:10.1016/j.resp.2017.09.017

    authors: Smith JR,Ferguson SK,Hageman KS,Harms CA,Poole DC,Musch TI

    更新日期:2018-01-01 00:00:00

  • Validity of the allometric cascade model at submaximal and maximal metabolic rates in exercising men.

    abstract::The dependence of metabolic rate (MR) on body mass (M) is described by the general allometric equation MR=aM(b), where, a is a proportionality coefficient and b is the mass exponent. Darveau et al. [Nature 417 (2002), 166] proposed a novel 'multiple-causes' allometric cascade model as a unifying principle of the scali...

    journal_title:Respiratory physiology & neurobiology

    pub_type: 杂志文章

    doi:10.1016/s1569-9048(03)00027-2

    authors: Batterham AM,Jackson AS

    更新日期:2003-04-15 00:00:00

  • Central histamine contributes to the inspiratory off-switch mechanism via H1 receptors in mice.

    abstract::Central histaminergic neurons are distributed in areas of the medulla and pons concerned with respiratory rhythm generation, but their effects on breathing pattern are unknown. We examined breathing pattern during hypercapnic responses in wild type (WT) and H1 receptor knockout (H1RKO) mice at 9-10 weeks of age before...

    journal_title:Respiratory physiology & neurobiology

    pub_type: 杂志文章

    doi:10.1016/j.resp.2004.07.016

    authors: Miyamoto K,Iwase M,Kimura H,Homma I

    更新日期:2004-11-30 00:00:00

  • Respiration-related control of abdominal motoneurons.

    abstract::The abdominal muscles form part of the expiratory pump in cooperation with the other expiratory muscles, primarily the internal intercostal and triangularis sterni muscles. The discharge of abdominal muscles is divided into four main patterns: augmenting, plateau, spindle and decrementing. The patterns tend to be spec...

    journal_title:Respiratory physiology & neurobiology

    pub_type: 杂志文章,评审

    doi:10.1016/j.resp.2011.01.003

    authors: Iizuka M

    更新日期:2011-10-15 00:00:00

  • Lung function and respiratory muscle strength and their relationship with weightlifting strength and body composition in non-athletic males.

    abstract::The aim of this study was to examine whether lung function and respiratory muscle strength are associated with weightlifting strength and body composition in non-athletic males. A total 51 males with resistance training experience participated. One-repetition maximum tests were performed for the bench press, squat and...

    journal_title:Respiratory physiology & neurobiology

    pub_type: 杂志文章

    doi:10.1016/j.resp.2021.103616

    authors: Hackett DA,Sabag A

    更新日期:2021-01-14 00:00:00

  • Secretion movement during manual lung inflation and mechanical ventilation.

    abstract::This project aimed to investigate the direction of artificial sputum movement during mechanical ventilation (MV) and bagging (MH) using a tube model. Three solutions of artificial sputum (ultrasonic gel, viscosity 100, 200 and 300 poise (P)) were prepared. About 1 ml of gel was placed in a glass tube connected to a te...

    journal_title:Respiratory physiology & neurobiology

    pub_type: 杂志文章

    doi:10.1016/s1569-9048(02)00071-x

    authors: Jones AY

    更新日期:2002-09-04 00:00:00

  • Right and left vagus nerves regulate breathing by multiplicative interaction.

    abstract::Although it has been recognized for more than a century, we still do not know how the two vagus nerves interact to produce Hering-Breuer reflex. In the current study, we tested the hypothesis that the vagus nerves interact via a multiplicative effect. We examined the Hering-Breuer reflex before and after unilateral (f...

    journal_title:Respiratory physiology & neurobiology

    pub_type: 杂志文章

    doi:10.1016/j.resp.2015.07.015

    authors: Song N,Liu J,Proctor M,Yu J

    更新日期:2015-12-01 00:00:00

  • Effect of hypoxia on expiratory muscle activity in fetal sheep.

    abstract::The fetal respiratory response to acute hypoxia is characterized by depression, often to apnea. This study examined the effect of hypoxia on the electromyogram (EMG) of the thyroarytenoid (TA) muscle. Under anesthesia catheters were placed in the fetal sheep carotid artery, fourth cerebral ventricle, trachea and amnio...

    journal_title:Respiratory physiology & neurobiology

    pub_type: 杂志文章

    doi:10.1016/j.resp.2010.03.003

    authors: Bissonnette JM,Hohimer AR,Knopp SJ

    更新日期:2010-04-30 00:00:00

  • CO2 relaxation of the rat lung parenchymal strip.

    abstract::Evidence from liquid-filled rat lungs supported the presence of CO2-dependent, active relaxation of parenchyma under normoxia by unknown mechanisms (Emery et al., 2007). This response may improve matching of alveolar ventilation (V˙A) to perfusion (Q˙) by increasing compliance and V˙A in overperfused (high CO2) region...

    journal_title:Respiratory physiology & neurobiology

    pub_type: 杂志文章

    doi:10.1016/j.resp.2012.12.014

    authors: Emery MJ,Eveland RL,Min JH,Hildebrandt J,Swenson ER

    更新日期:2013-03-01 00:00:00

  • Hypoxic incubation creates differential morphological effects during specific developmental critical windows in the embryo of the chicken (Gallus gallus).

    abstract::Hypoxia inhibits vertebrate development, but the magnitude and timing of organ-specific effects are poorly understood. Chick embryos were exposed continuously to hypoxia (15% O2) throughout Days 1-6, 6-12, 12-18 or Days 1-18 of development, followed by morphometric measurements of major organ systems. Early hypoxic ex...

    journal_title:Respiratory physiology & neurobiology

    pub_type: 杂志文章

    doi:10.1016/j.resp.2004.09.005

    authors: Chan T,Burggren W

    更新日期:2005-02-15 00:00:00

  • The fall in exhaled nitric oxide with ventilation at low lung volumes in rabbits: an index of small airway injury.

    abstract::The mechanisms involved in the fall of exhaled nitric oxide (NOe) concentration occurring in normal, anesthetized open chest rabbits with prolonged mechanical ventilation (MV) at low lung volume have been investigated. NOe, pH of exhaled vapor condensate, serum prostaglandin E(2), and F(2alpha), tumor necrosis factor ...

    journal_title:Respiratory physiology & neurobiology

    pub_type: 杂志文章

    doi:10.1016/j.resp.2007.10.001

    authors: D'Angelo E,Koulouris NG,Della Valle P,Gentile G,Pecchiari M

    更新日期:2008-02-01 00:00:00

  • The sensing of respiratory gases in fish: Mechanisms and signalling pathways.

    abstract::Chemoreception in fish is critical for sensing changes in the chemical composition of the external and internal environments and is often the first step in a cascade of events leading to cardiorespiratory and metabolic adjustments. Of paramount importance is the ability to sense changes in the levels of the three resp...

    journal_title:Respiratory physiology & neurobiology

    pub_type: 杂志文章,评审

    doi:10.1016/j.resp.2015.06.007

    authors: Perry SF,Tzaneva V

    更新日期:2016-04-01 00:00:00