当前位置： SCI文献检索 > RESPIRATORY PHYSIOLOGY & NEUROBIOLOGY期刊下所有文献 > Validation of a two-compartment model of ventilation/perfusion distribution.

Validation of a two-compartment model of ventilation/perfusion distribution.

Abstract：

:Ventilation (V (A)) to perfusion (Q ) heterogeneity (V (A)/Q ) analyses by a two-compartment lung model (2C), utilizing routine gas exchange measurements and a computer solution to account for O(2) and CO(2) measurements, were compared with multiple inert gas elimination technique (MIGET) analyses and a multi-compartment (MC) model. The 2C and MC estimates of V (A)/Q mismatch were obtained in 10 healthy subjects, 43 patients having chronic obstructive pulmonary disease (COPD) and in 14 dog experiments where hemodynamics and acid-base status were manipulated with gas mixtures, fluid loading and tilt-table stressors. MIGET comparisons with 2C were made on 6 patients and 32 measurements in healthy subjects before and after exercise at normoxia and altitude hypoxia. Statistically significant correlations for logarithmic standard deviations of V (A)/Q distributions (SD(V (A)/Q )) were obtained for all 2C comparisons, with similar values between 2C and both other methods in the 1.1-1.5 range, compatible with mild to moderate COPD. 2C tended to overestimate MC and MIGET values at low and underestimate them at high SD(V (A)/Q ) values. SD(V (A)/Q ) weighted by Q agreed better with MC and MIGET estimates in the normal range, whereas SD(V (A)/Q ) weighted by V (A) was closer to MC at higher values because the V (A)-weighted SD(V (A)/Q ) is related to blood-to-gas PCO(2) differences that are elevated in disease, thereby allowing better discrimination. The 2C model accurately described functional V (A)/Q characteristics in 26 normal and bronchoconstricted dogs during non-steady state rebreathing and could be used to quantify the effect of reduced O(2) diffusing capacity in diseased lungs. These comparisons indicate that 2C adequately describes V (A)/Q mismatch and can be useful in clinical or experimental situations where other techniques are not feasible.

journal_name

Respir Physiol Neurobiol

journal_title

Respiratory physiology & neurobiology

authors

Loeppky JA,Caprihan A,Altobelli SA,Icenogle MV,Scotto P,Vidal Melo MF

doi

10.1016/j.resp.2005.06.002

keywords:

subject

Has Abstract

pub_date

2006-03-28 00:00:00

pages

74-92

issue

1

eissn

1569-9048

issn

1878-1519

pii

S1569-9048(05)00162-X

journal_volume

151

pub_type

杂志文章

相关文献

RESPIRATORY PHYSIOLOGY & NEUROBIOLOGY文献大全
  • The ventilatory response to carbon dioxide and sustained hypoxia is enhanced after episodic hypoxia in OSA patients.

    abstract：:Our primary hypothesis was that the acute ventilatory response to carbon dioxide in the presence of sustained hypoxia {VRCO2 (hypoxia)} or hyperoxia {VRCO2 (hyperoxia)} would increase in subjects with obstructive sleep apnea (OSA) after exposure to episodic hypoxia. Secondarily, we hypothesized that chronic (i.e. year...

    journal_title：Respiratory physiology & neurobiology

    pub_type： 临床试验,杂志文章

    doi：10.1016/j.resp.2005.04.019

    authors： Khodadadeh B,Badr MS,Mateika JH

    更新日期：2006-02-28 00:00:00

  • Sleep-disordered breathing and oxidative stress in preclinical chronic mountain sickness (excessive erythrocytosis).

    abstract：:Chronic mountain sickness (CMS) is considered to be a loss of ventilatory acclimatization to high altitude (>2500m) resulting in marked arterial hypoxemia and polycythemia. This case-control study explores the possibility that sleep-disordered breathing (SDB) and associated oxidative stress contribute to the etiology ...

    journal_title：Respiratory physiology & neurobiology

    pub_type： 杂志文章

    doi：10.1016/j.resp.2013.01.016

    authors： Julian CG,Vargas E,Gonzales M,Dávila RD,Ladenburger A,Reardon L,Schoo C,Powers RW,Lee-Chiong T,Moore LG

    更新日期：2013-04-01 00:00:00

  • Respiratory pathology in the Optn-/- mouse model of Amyotrophic Lateral Sclerosis.

    abstract：:Amyotrophic Lateral Sclerosis (ALS) is a devastating neurodegenerative disorder that results in death due to respiratory failure. Many genetic defects are associated with ALS; one such defect is a mutation in the gene encoding optineurin (OPTN). Using an optineurin null mouse (Optn-/-), we sought to characterize the i...

    journal_title：Respiratory physiology & neurobiology

    pub_type： 杂志文章

    doi：10.1016/j.resp.2020.103525

    authors： McCall AL,Dhindsa JS,Pucci LA,Kahn AF,Fusco AF,Biswas DD,Strickland LM,Tseng HC,ElMallah MK

    更新日期：2020-11-01 00:00:00

  • Intermittent hypoxia, respiratory plasticity and sleep apnea in humans: present knowledge and future investigations.

    abstract：:This review examines the role that respiratory plasticity has in the maintenance of breathing stability during sleep in individuals with sleep apnea. The initial portion of the review considers the manner in which repetitive breathing events may be initiated in individuals with sleep apnea. Thereafter, the role that t...

    journal_title：Respiratory physiology & neurobiology

    pub_type： 杂志文章,评审

    doi：10.1016/j.resp.2013.04.010

    authors： Mateika JH,Syed Z

    更新日期：2013-09-15 00:00:00

  • Hypoxic incubation creates differential morphological effects during specific developmental critical windows in the embryo of the chicken (Gallus gallus).

    abstract：:Hypoxia inhibits vertebrate development, but the magnitude and timing of organ-specific effects are poorly understood. Chick embryos were exposed continuously to hypoxia (15% O2) throughout Days 1-6, 6-12, 12-18 or Days 1-18 of development, followed by morphometric measurements of major organ systems. Early hypoxic ex...

    journal_title：Respiratory physiology & neurobiology

    pub_type： 杂志文章

    doi：10.1016/j.resp.2004.09.005

    authors： Chan T,Burggren W

    更新日期：2005-02-15 00:00:00

  • Hypocapnia during hypoxic exercise and its impact on cerebral oxygenation, ventilation and maximal whole body O₂ uptake.

    abstract：:With hypoxic exposure ventilation is elevated through the hypoxic ventilatory response. We tested the hypothesis that the resulting hypocapnia reduces maximal exercise capacity by decreasing (i) cerebral blood flow and oxygenation and (ii) the ventilatory drive. Eight subjects performed two incremental exercise tests ...

    journal_title：Respiratory physiology & neurobiology

    pub_type： 杂志文章

    doi：10.1016/j.resp.2012.08.012

    authors： Siebenmann C,Sørensen H,Jacobs RA,Haider T,Rasmussen P,Lundby C

    更新日期：2013-01-15 00:00:00

  • Relaxin-3 receptor (RXFP3) activation in the nucleus of the solitary tract modulates respiratory rate and the arterial chemoreceptor reflex in rat.

    abstract：:The neuropeptide relaxin-3 is expressed by the pontine nucleus incertus. Relaxin-3 and synthetic agonist peptides modulate arousal and cognitive processes via activation of the relaxin-family peptide 3 receptor (RXFP3). Despite the presence of RXFP3 in the nucleus of the solitary tract (NTS), the ability of RXFP3 to m...

    journal_title：Respiratory physiology & neurobiology

    pub_type： 杂志文章

    doi：10.1016/j.resp.2019.103310

    authors： Furuya WI,Dhingra RR,Gundlach AL,Hossain MA,Dutschmann M

    更新日期：2020-01-01 00:00:00

  • Fetal lung development in the elephant reflects the adaptations required for snorkeling in adult life.

    abstract：:The adult elephant is unique among mammals in that the pleural membranes are thickened and the pleural cavity is obliterated by connective tissue. It has been suggested that this peculiar anatomy developed because the animal can snorkel at depth, and this behavior subjects the microvessels in the parietal pleura to a ...

    journal_title：Respiratory physiology & neurobiology

    pub_type： 杂志文章

    doi：10.1016/s1569-9048(03)00199-x

    authors： West JB,Fu Z,Gaeth AP,Short RV

    更新日期：2003-11-14 00:00:00

  • Asthmatic cough and airway oxidative stress.

    abstract：:The mechanisms of cough in asthma are unclear. Asthma is associated with an oxidative stress. Many reactive oxygen species sensitize or activate sensory C-fibers which are capable to induce cough. It was hypothesized that oxidative stress in the airways might contribute to the cough severity in asthma. Exhaled breath ...

    journal_title：Respiratory physiology & neurobiology

    pub_type： 杂志文章

    doi：10.1016/j.resp.2012.04.006

    authors： Koskela HO,Purokivi MK,Nieminen RM,Moilanen E

    更新日期：2012-05-31 00:00:00

  • DLNO/DLCO ratio evolution under targeted therapy in patients with pulmonary hypertension.

    abstract：:The ratio of the diffusing capacity of the lung for carbon monoxide (DLCO) and for nitric oxide (DLNO) measured simultaneously is modified in patients with precapillary pulmonary hypertension (PH). The potential impact of targeted therapy on the DLCO/DLNO ratio is unknown. Simultaneous measurements of DLNO and DLCO we...

    journal_title：Respiratory physiology & neurobiology

    pub_type： 杂志文章

    doi：10.1016/j.resp.2020.103467

    authors： Catella J,Costes F,Gaultier JB,Court Fortune I,Tulane C,De Magalhaes E,Accassat S,Chomette-Ballereau S,Chapelle C,Bertoletti L

    更新日期：2020-08-01 00:00:00

  • Functional genomics of sleep.

    abstract：:Functional genomics is a systematic and high-throughput effort to analyze the functions of genes and gene products. Functional genomics is divided into gene- and phenotype-driven approaches. Gene-driven approaches to the functional genomics of sleep have demonstrated that transcripts of many genes change as a function...

    journal_title：Respiratory physiology & neurobiology

    pub_type： 杂志文章,评审

    doi：10.1016/s1569-9048(03)00045-4

    authors： Mackiewicz M,Pack AI

    更新日期：2003-05-30 00:00:00

  • Upright posture increases oxyhemoglobin saturation in Peruvian highlanders.

    abstract：:At high altitude, hypoxia amplifies oxyhemoglobin saturation (SPO2) swings with changes in respiratory mechanics. Our objective was to examine the effects of posture on SPO2 and determine predictors of postural SPO2 changes in highlanders. 50 native highlanders from Puno, Peru (3825 m) assumed supine and upright-seate...

    journal_title：Respiratory physiology & neurobiology

    pub_type： 杂志文章

    doi：10.1016/j.resp.2019.04.015

    authors： Arias RS,Etienne B,Polotsky VY,Checkley W,Schwartz AR,Pham LV

    更新日期：2019-08-01 00:00:00

  • Differential responses of autonomic function in sea level residents, acclimatized lowlanders at >3500 m and Himalayan high altitude natives at >3500 m: A cross-sectional study.

    abstract：:We studied the differential responses of autonomic function in sea level residents (SLR), acclimatized lowlanders (ALH) in high altitude (HA) and HA natives (HAN) at >3500 m. Out of 771 male volunteers included in this cross-sectional study, SLR, ALH and HAN groups were comprised of 351, 307 and 113 volunteers, respec...

    journal_title：Respiratory physiology & neurobiology

    pub_type： 杂志文章,多中心研究,随机对照试验

    doi：10.1016/j.resp.2018.04.002

    authors： Dhar P,Sharma VK,Das SK,Barhwal K,Hota SK,Singh SB

    更新日期：2018-08-01 00:00:00

  • The effect of time of day on apnoea index in the sleeping rat.

    abstract：:This study tested the hypothesis that apnoea index would be greater during daytime sleep than nighttime sleep in the rat. Electroencephalogram and electromyogram were monitored via biotelemetry implant and respiration was measured using whole body plethysmography in six male rats in two separate 34h recording sessions...

    journal_title：Respiratory physiology & neurobiology

    pub_type： 杂志文章

    doi：10.1016/j.resp.2006.02.007

    authors： Stephenson R,Horner RL

    更新日期：2006-12-01 00:00:00

  • Degeneracy as a substrate for respiratory regulation.

    abstract：:Recent studies in vivo and in vitro suggest that both respiratory rhythmogenesis and its central chemosensory modulation arise from multiple, mechanistically and/or anatomically distinct networks whose outputs are similar. These observations are consistent with degeneracy, defined as the ability of structurally distin...

    journal_title：Respiratory physiology & neurobiology

    pub_type： 杂志文章,评审

    doi：10.1016/j.resp.2010.04.013

    authors： Mellen NM

    更新日期：2010-06-30 00:00:00

  • Brainstem-mediated sniffing and respiratory modulation during odor stimulation.

    abstract：:The trigeminal and olfactory systems interact during sensory processing of odor. Here, we investigate odor-evoked modulations of brainstem respiratory networks in a decerebrated perfused brainstem preparation of rat with intact olfactory bulbs. Intranasal application of non-trigeminal odors (rose) did not evoke respir...

    journal_title：Respiratory physiology & neurobiology

    pub_type： 杂志文章

    doi：10.1016/j.resp.2016.07.008

    authors： Pérez de Los Cobos Pallares F,Bautista TG,Stanić D,Egger V,Dutschmann M

    更新日期：2016-11-01 00:00:00

  • Assessment of extravascular lung water by quantitative ultrasound and CT in isolated bovine lung.

    abstract：:Lung ultrasonography (LUS) and computed tomography (CT) were compared for quantitative assessment of extravascular lung water (EVLW) in 10 isolated bovine lung lobes. LUS and CT were obtained at different inflation pressures before and after instillation with known amounts of hypotonic saline. A video-based quantitati...

    journal_title：Respiratory physiology & neurobiology

    pub_type： 杂志文章

    doi：10.1016/j.resp.2013.04.002

    authors： Corradi F,Ball L,Brusasco C,Riccio AM,Baroffio M,Bovio G,Pelosi P,Brusasco V

    更新日期：2013-07-01 00:00:00

  • Prenatal development of the pulmonary surfactant system and the influence of hypoxia.

    abstract：:Pulmonary surfactant fulfils diverse functions at the lung air-liquid interface of all air-breathing vertebrates. Neurohormonal regulation of surfactant synthesis and secretion is highly conserved among non-mammalian amniotes. Although the pattern of surfactant lipid maturation is similar among species, the onset and ...

    journal_title：Respiratory physiology & neurobiology

    pub_type： 杂志文章,评审

    doi：10.1016/j.resp.2011.05.015

    authors： Orgeig S,Morrison JL,Daniels CB

    更新日期：2011-08-31 00:00:00

  • Ventilatory control in ALS.

    abstract：:Amyotrophic lateral sclerosis (ALS) is a fatal, progressive neurodegenerative disease. ALS selectively causes degeneration in upper and lower (spinal) motor neurons, leading to muscle weakness, paralysis and death by ventilatory failure. Although ventilatory failure is generally the cause of death in ALS, little is kn...

    journal_title：Respiratory physiology & neurobiology

    pub_type： 杂志文章,评审

    doi：10.1016/j.resp.2013.05.016

    authors： Nichols NL,Van Dyke J,Nashold L,Satriotomo I,Suzuki M,Mitchell GS

    更新日期：2013-11-01 00:00:00

  • Activation of opioid μ-receptors, but not δ- or κ-receptors, switches pulmonary C-fiber-mediated rapid shallow breathing into an apnea in anesthetized rats.

    abstract：:Rapid shallow breathing (RSB) is mainly mediated by bronchopulmonary C-fibers (PCFs). We asked whether this RSB could be modulated by opioids. In anesthetized rats right atrial bolus injection of phenylbiguanide (PBG) to evoke RSB was repeated after: (1) intravenously giving fentanyl (μ-receptor agonist), DPDPE (δ-rec...

    journal_title：Respiratory physiology & neurobiology

    pub_type： 杂志文章

    doi：10.1016/j.resp.2012.06.032

    authors： Zhang Z,Zhang C,Zhou M,Xu F

    更新日期：2012-09-30 00:00:00

  • Maternal cigarette smoke exposure disturbs glutamate/GABA balance in pFRG of neonatal rats.

    abstract：:We previously found that maternal cigarette smoke (CS) exposure resulted in impairment of central chemoreception and oxidative stress and mitochondrial dysfunction of parafacial respiratory group (pFRG, a critical site for mammalian central chemoreception) in neonatal rats. The present work was carried out to identify...

    journal_title：Respiratory physiology & neurobiology

    pub_type： 杂志文章

    doi：10.1016/j.resp.2020.103383

    authors： Fu Y,Lei F,Wang J,Wang W,Zheng Y

    更新日期：2020-03-01 00:00:00

  • The blood transfer conductance for nitric oxide: Infinite vs. finite θNO.

    abstract：:Whether the specific blood transfer conductance for nitric oxide (NO) with hemoglobin (θNO) is finite or infinite is controversial but important in the calculation of alveolar capillary membrane conductance (DmCO) and pulmonary capillary blood volume (VC) from values of lung diffusing capacity for carbon monoxide (DLC...

    journal_title：Respiratory physiology & neurobiology

    pub_type： 杂志文章,评审

    doi：10.1016/j.resp.2016.12.007

    authors： Coffman KE,Chase SC,Taylor BJ,Johnson BD

    更新日期：2017-07-01 00:00:00

  • Gz- and not Gi-proteins are coupled to pre-junctional μ-opioid receptors in bovine airways.

    abstract：:We investigated the signal transmission pathway by which activation of μ-opioid receptors attenuates acetylcholine (ACh) release in bovine trachealis. Electrical stimulation (ES)-induced [(3)H]-ACh release was determined in bovine tracheal smooth muscle strips pre-incubated with either the Gi-protein inhibitor pertuss...

    journal_title：Respiratory physiology & neurobiology

    pub_type： 杂志文章

    doi：10.1016/j.resp.2013.07.021

    authors： Baroffio M,Brichetto L,Franco L,Crimi E,Rehder K,Brusasco V

    更新日期：2013-10-01 00:00:00

  • The effect of moderate-intensity aerobic training on pulmonary function and estrogen receptor-alpha gene in postmenopausal women with vitamin D deficiency: A randomized control trial.

    abstract：BACKGROUND:The impact of aerobic training on pulmonary function by modulating gene expression of estrogen receptor-alpha (ERα), sex hormones and 25-hydroxy vitamin D (Vit D) in postmenopausal women (PMW) with Vit D deficiency is uncertain. OBJECTIVE:The purpose of this study was to examine the effect of 12 weeks of mo...

    journal_title：Respiratory physiology & neurobiology

    pub_type： 杂志文章

    doi：10.1016/j.resp.2020.103510

    authors： Malandish A,Tartibian B,Rahmati M,Afsargharehbagh R,Sheikhlou Z

    更新日期：2020-10-01 00:00:00

  • Inflammatory and immunomodulatory mechanisms in the carotid body.

    abstract：:Evidence is available about the role of inflammatory/immunological factors in the physiology and plasticity of the carotid body, with potential clinical implications in obstructive sleep apnea syndrome and sudden infant death syndrome. In humans, lymphomonocytic aggregations (chronic carotid glomitis) have been report...

    journal_title：Respiratory physiology & neurobiology

    pub_type： 杂志文章,评审

    doi：10.1016/j.resp.2013.02.017

    authors： Porzionato A,Macchi V,De Caro R,Di Giulio C

    更新日期：2013-06-01 00:00:00

  • Oral treatment with desipramine improves breathing and life span in Rett syndrome mouse model.

    abstract：:Rett syndrome is a neurodevelopmental disease due to Mecp2 gene mutations that is associated to complex neurological symptoms, with bioaminergic deficits and life-threatening apneas related to sudden and unexpected death. In male mice, Mecp2-deficiency similarly induces medullary bioaminergic deficits, severe apneas a...

    journal_title：Respiratory physiology & neurobiology

    pub_type： 杂志文章

    doi：10.1016/j.resp.2007.08.009

    authors： Zanella S,Mebarek S,Lajard AM,Picard N,Dutschmann M,Hilaire G

    更新日期：2008-01-01 00:00:00

  • Hypercapnia attenuates inspiratory amplitude and expiratory time responsiveness to hypoxia in vagotomized and vagal-intact rats.

    abstract：:A negative influence of central chemosensitivity on peripheral chemoreflex response has been demonstrated recently in a decerebrate-vagotomized rat preparation in situ with separate carotid body and brainstem perfusions. Here, we report similar negative influences of hypercapnia on the hypoxic respiratory response in ...

    journal_title：Respiratory physiology & neurobiology

    pub_type： 杂志文章

    doi：10.1016/j.resp.2012.01.008

    authors： Tin C,Song G,Poon CS

    更新日期：2012-04-15 00:00:00

  • Posture primarily affects lung tissue distribution with minor effect on blood flow and ventilation.

    abstract：:We used quantitative single photon emission computed tomography to estimate the proportion of the observed redistribution of blood flow and ventilation that is due to lung tissue shift with a change in posture. Seven healthy volunteers were studied awake, breathing spontaneously. Regional blood flow and ventilation we...

    journal_title：Respiratory physiology & neurobiology

    pub_type： 杂志文章

    doi：10.1016/j.resp.2006.11.001

    authors： Petersson J,Rohdin M,Sánchez-Crespo A,Nyrén S,Jacobsson H,Larsson SA,Lindahl SG,Linnarsson D,Neradilek B,Polissar NL,Glenny RW,Mure M

    更新日期：2007-06-15 00:00:00

  • Effects of bi-level positive airway pressure on ventilatory and perceptual responses to exercise in comorbid heart failure-COPD.

    abstract：:This study tested the hypothesis that, by increasing the volume available for tidal expansion (inspiratory capacity, IC), bi-level positive airway pressure (BiPAP™) would lead to greater beneficial effects on dyspnea and exercise intolerance in comorbid heart failure (HF)-chronic obstructive pulmonary disease (COPD) t...

    journal_title：Respiratory physiology & neurobiology

    pub_type： 杂志文章

    doi：10.1016/j.resp.2019.04.008

    authors： Souza A,Sperandio PA,Mazzuco A,Alencar MCN,Arbex FF,Oliveira M,Medeiros W,Rocha A,Nery LE,O Donnell DE,Neder JA

    更新日期：2019-08-01 00:00:00

  • Effects of prolonged exercise to exhaustion on left-ventricular function and pulmonary gas exchange.

    abstract：:The purpose of this study was to simultaneously examine left-ventricular (LV) function and pulmonary gas exchange during prolonged constant-rate cycling in an attempt to explain the exercise-induced impairment in gas exchange. Eleven competitive cyclists rode their racing bicycles on a computerized cycle trainer at 25...

    journal_title：Respiratory physiology & neurobiology

    pub_type： 杂志文章

    doi：10.1016/j.resp.2004.06.002

    authors： Stickland MK,Anderson WD,Haykowsky MJ,Welsh RC,Petersen SR,Jones RL

    更新日期：2004-09-15 00:00:00