Abstract：
:With hypoxic exposure ventilation is elevated through the hypoxic ventilatory response. We tested the hypothesis that the resulting hypocapnia reduces maximal exercise capacity by decreasing (i) cerebral blood flow and oxygenation and (ii) the ventilatory drive. Eight subjects performed two incremental exercise tests at 3454 m altitude in a blinded manner. In one trial end-tidal [Formula: see text] was clamped to 40 mmHg by CO(2)-supplementation. Mean blood flow velocity in the middle cerebral artery (MCAv(mean)) was determined by trans-cranial Doppler sonography and cerebral oxygenation by near infra-red spectroscopy. Without CO(2)-supplementation, [Formula: see text] decreased to 30 ± 3 mmHg (P<0.0001 vs isocapnic trial). Although CO(2)-supplementation increased MCAv(mean) by 17 ± 14% (P<0.0001) and attenuated the decrease in cerebral oxygenation (-4.7 ± 0.9% vs -5.4 ± 0.9%; P=0.002) this did not affect maximal O(2)-uptake. Clamping [Formula: see text] increased ventilation during submaximal but not during maximal exercise (P=0.99). We conclude that although hypocapnia promotes a decrease in MCAv(mean) and cerebral oxygenation, this does not limit maximal O(2)-uptake. Furthermore, hypocapnia does not restrict ventilation during maximal hypoxic exercise.
journal_name
Respir Physiol Neurobioljournal_title
Respiratory physiology & neurobiologyauthors
Siebenmann C,Sørensen H,Jacobs RA,Haider T,Rasmussen P,Lundby Cdoi
10.1016/j.resp.2012.08.012subject
Has Abstractpub_date
2013-01-15 00:00:00pages
461-7issue
2eissn
1569-9048issn
1878-1519pii
S1569-9048(12)00233-9journal_volume
185pub_type
杂志文章abstract：:We previously showed that medroxyprogesterone acetate (MPA) effectively decreases the arterial CO(2) levels in postmenopausal women with partial upper airway obstruction. The aim of the present study was to analyze the effects of MPA on the inspiratory flow shapes during sleep. Eight postmenopausal women with hypoxemi...
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