Abstract:
:It had been demonstrated previously that the circadian patterns of activity and state of arousal are not essential for the manifestation of the daily patterns of pulmonary ventilation (V(E)), tidal volume (V(T)) and breathing frequency (f). In this study we investigated the extent of the linkage between the circadian pattern of breathing and those of body temperature (T(b)) and metabolic rate (oxygen consumption, V(O2), and carbon dioxide production, V(CO2)). Rats were instrumented for measurements of T(b) (by telemetry), and placed in a chamber for continuous 13-day period of measurement of breathing (by a modification of the barometric methodology), and of V(O2) and V(CO2) (by an open flow method). After the first 4 days in control conditions under a 12 h light:12 h dark (L:D) cycle, a perturbation was introduced on day 4, with an L-phase prolongation of 12 h, and on day 9, with an D-phase prolongation of 12 h. During the control days 1-4, all variables had daily oscillations (higher values in D), in phase with each other. During the perturbations (days 4-13), changes in T(b), V(O2) and V(CO2), averaged over the whole period, correlated significantly better with f than with V(T). Day-by-day X-Y loops indicated that V (E), V(T) and f could lead significantly the changes of T(b), V(O2) and V(CO2), and that these relations changed throughout the perturbation period. In addition, f and V(T) did not change necessarily in phase with each other. It is concluded that neither the oscillation in T(b) nor that in metabolism can be considered the direct cause of the daily oscillation of breathing. Presumably, the circadian pattern of breathing reflects the interplay of the daily patterns of many variables, none acting as the primary guide of the breathing daily rhythm.
journal_name
Respir Physiol Neurobioljournal_title
Respiratory physiology & neurobiologyauthors
Mortola JPdoi
10.1016/j.resp.2006.05.007subject
Has Abstractpub_date
2007-02-15 00:00:00pages
137-46issue
2eissn
1569-9048issn
1878-1519pii
S1569-9048(06)00178-9journal_volume
155pub_type
杂志文章abstract:BACKGROUND:A sustained elevation in respiratory drive following removal of the inducing stimulus is known as respiratory long-term facilitation (rLTF). We investigated whether an acute exposure to intermittent negative airway pressure (INAP) elicits rLTF in humans. METHOD:13 healthy males (20.9 ± 2.8 years) undertook ...
journal_title:Respiratory physiology & neurobiology
pub_type: 杂志文章
doi:10.1016/j.resp.2019.05.016
更新日期:2019-09-01 00:00:00
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pub_type: 杂志文章
doi:10.1016/j.resp.2019.04.005
更新日期:2019-08-01 00:00:00
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doi:10.1016/s0034-5687(01)00337-1
更新日期:2002-04-01 00:00:00
abstract::Sleep disordered breathing (SDB) with recurrent apnea is a major health problem affecting several million adult men and women. Humans with SDB are prone to develop hypertension. Studies on rodents established that exposure to chronic intermittent hypoxia (CIH) alone is sufficient to induce hypertension similar to that...
journal_title:Respiratory physiology & neurobiology
pub_type: 杂志文章,评审
doi:10.1016/j.resp.2015.01.001
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journal_title:Respiratory physiology & neurobiology
pub_type: 杂志文章
doi:10.1016/j.resp.2017.03.003
更新日期:2017-08-01 00:00:00
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journal_title:Respiratory physiology & neurobiology
pub_type: 杂志文章
doi:10.1016/j.resp.2013.04.024
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journal_title:Respiratory physiology & neurobiology
pub_type: 杂志文章
doi:10.1016/j.resp.2019.103365
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journal_title:Respiratory physiology & neurobiology
pub_type: 杂志文章,评审
doi:10.1016/j.resp.2011.03.026
更新日期:2011-08-31 00:00:00
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journal_title:Respiratory physiology & neurobiology
pub_type: 杂志文章
doi:10.1016/j.resp.2009.08.010
更新日期:2009-10-31 00:00:00
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journal_title:Respiratory physiology & neurobiology
pub_type: 杂志文章
doi:10.1016/j.resp.2014.01.009
更新日期:2014-04-01 00:00:00
abstract::Maximal O(2) consumption (V(O)(2) max) is an index of integrated cardiopulmonary function. After having defined it, discussed its limitation, and described its measurement, we present data during and after space flight and simulation. During gravity withdrawal, V(O)(2) max stays unchanged. It suddenly drops when the s...
journal_title:Respiratory physiology & neurobiology
pub_type: 杂志文章
doi:10.1016/j.resp.2009.03.012
更新日期:2009-10-01 00:00:00
abstract::Vascular endothelial growth factor (VEGF) and erythropoietin (EPO) exert neurotrophic and neuroprotective effects in the CNS. We recently demonstrated that VEGF, EPO and their receptors (VEGF-R2, EPO-R) are expressed in phrenic motor neurons, and that cervical spinal VEGF-R2 and EPO-R activation elicit long-lasting ph...
journal_title:Respiratory physiology & neurobiology
pub_type: 杂志文章
doi:10.1016/j.resp.2012.10.014
更新日期:2013-02-01 00:00:00
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journal_title:Respiratory physiology & neurobiology
pub_type: 杂志文章
doi:10.1016/j.resp.2006.08.002
更新日期:2007-04-16 00:00:00
abstract::Exposure to tobacco smoke is a major risk factor for the sudden infant death syndrome. Nicotine is thought to be the ingredient in tobacco smoke that is responsible for a multitude of cardiorespiratory effects during development, and pre- rather than postnatal exposure is considered to be most detrimental. Nicotine in...
journal_title:Respiratory physiology & neurobiology
pub_type: 杂志文章,评审
doi:10.1016/j.resp.2005.05.004
更新日期:2005-11-15 00:00:00
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journal_title:Respiratory physiology & neurobiology
pub_type: 临床试验,杂志文章
doi:10.1016/j.resp.2004.01.005
更新日期:2004-06-25 00:00:00
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journal_title:Respiratory physiology & neurobiology
pub_type: 杂志文章
doi:10.1016/j.resp.2012.10.002
更新日期:2013-01-15 00:00:00
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journal_title:Respiratory physiology & neurobiology
pub_type: 杂志文章,评审
doi:10.1016/j.resp.2015.06.007
更新日期:2016-04-01 00:00:00
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journal_title:Respiratory physiology & neurobiology
pub_type: 杂志文章
doi:10.1016/j.resp.2008.12.005
更新日期:2009-02-28 00:00:00
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journal_title:Respiratory physiology & neurobiology
pub_type: 杂志文章
doi:10.1016/j.resp.2014.07.014
更新日期:2014-10-01 00:00:00
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journal_title:Respiratory physiology & neurobiology
pub_type: 杂志文章,评审
doi:10.1016/j.resp.2011.05.015
更新日期:2011-08-31 00:00:00
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journal_title:Respiratory physiology & neurobiology
pub_type: 杂志文章
doi:10.1016/j.resp.2021.103616
更新日期:2021-01-14 00:00:00
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journal_title:Respiratory physiology & neurobiology
pub_type: 杂志文章
doi:10.1016/j.resp.2011.02.001
更新日期:2011-05-31 00:00:00
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journal_title:Respiratory physiology & neurobiology
pub_type: 杂志文章
doi:10.1016/j.resp.2020.103510
更新日期:2020-10-01 00:00:00
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journal_title:Respiratory physiology & neurobiology
pub_type: 杂志文章,评审
doi:10.1016/j.resp.2011.06.028
更新日期:2011-10-15 00:00:00
abstract::The cardiovascular system undergoes major changes in stress with space flight primarily related to the elimination of the head-to-foot gravitational force. A major observation has been that the central venous pressure is not elevated early in space flight yet stroke volume is increased at least early in flight. Recent...
journal_title:Respiratory physiology & neurobiology
pub_type: 杂志文章
doi:10.1016/j.resp.2009.07.017
更新日期:2009-10-01 00:00:00
abstract::This special issue of Respiratory Physiology and Neurobiology surveys a broad range of topics focused on the neurochemical control of breathing. A variety of approaches have integrated the neurochemistry of breathing with the physiology of individual neurons, with the neuroanatomy of brainstem and forebrain respirator...
journal_title:Respiratory physiology & neurobiology
pub_type: 社论
doi:10.1016/j.resp.2008.07.021
更新日期:2008-12-10 00:00:00
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journal_title:Respiratory physiology & neurobiology
pub_type: 杂志文章
doi:10.1016/j.resp.2016.01.003
更新日期:2016-06-01 00:00:00
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journal_title:Respiratory physiology & neurobiology
pub_type: 杂志文章
doi:10.1016/j.resp.2010.03.005
更新日期:2010-04-30 00:00:00
abstract::This project aimed to investigate the direction of artificial sputum movement during mechanical ventilation (MV) and bagging (MH) using a tube model. Three solutions of artificial sputum (ultrasonic gel, viscosity 100, 200 and 300 poise (P)) were prepared. About 1 ml of gel was placed in a glass tube connected to a te...
journal_title:Respiratory physiology & neurobiology
pub_type: 杂志文章
doi:10.1016/s1569-9048(02)00071-x
更新日期:2002-09-04 00:00:00
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journal_title:Respiratory physiology & neurobiology
pub_type: 杂志文章,评审
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