Effects of different forms of dyspnoea on pain perception induced by cold-pressor test.


:Although dyspnoea has been shown to attenuate pain, whether different forms of dyspnoea exert a similar inhibitory effect on pain has never been tested. We examined the effects of two different forms of dyspnoea, i.e., "air hunger" sensation (AIR HUNGER) and "work/effort" sensation (WORK/EFFORT), on pain induced by a cold-pressor test. Dyspnoea was induced by two different dyspnoea stimuli (i.e., AIR HUNGER and WORK/EFFORT stimuli) and the magnitudes of both sensations were evaluated by using a visual analogue scale (VAS). At equi-dyspneic VAS levels of two different forms of dyspnoea, pain was induced and the unpleasantness of pain was assessed by pain VAS, pain threshold time (PTT) and pain endurance time (PET). Both AIR HUNGER and WORK/EFFORT caused an increase in PTT and an increase in PET or a decrease in maximal pain VAS. Our findings suggest that AIR HUNGER and WORK/EFFORT exert a similar analgesic effect although the WORK/EFFORT-induced analgesia was slightly more effective.


Yashiro E,Nozaki-Taguchi N,Isono S,Nishino T




Has Abstract


2011-08-15 00:00:00














  • Cough reflex sensitivity does not correlate with the esophageal sensitivity to acid in patients with gastroesophageal reflux disease.

    abstract::The sensitization of cough reflex observed in patients with gastroesophageal reflux disease (GERD) is attributed to activation of vagal C-fibers innervating the esophagus by acid, while the heartburn in GERD is mediated by esophageal acid sensitive C-fibers derived from (dorsal root ganglia) DRG. Here we explored the ...

    journal_title:Respiratory physiology & neurobiology

    pub_type: 杂志文章


    authors: Duricek M,Nosakova L,Zatko T,Pecova R,Hyrdel R,Banovcin P Jr

    更新日期:2018-11-01 00:00:00

  • Amelioration of allergic asthma by Ziziphora clinopodioides via upregulation of aquaporins and downregulation of IL4 and IL5.

    abstract::Ziziphora clinopodioides has been frequently used as an anti asthmatic plant in traditional medication. Recent work explores the anti-asthmatic activity of Z. clinopodioides in allergen-induced asthmatic mice. Intraperitoneal sensitization followed by intranasal challenge were given with ovalbumin (allergen) to develo...

    journal_title:Respiratory physiology & neurobiology

    pub_type: 杂志文章


    authors: Ahsan F,Shabbir A,Shahzad M,Mobashar A,Sharif M,Basheer MI,Tareen RB,Syed NI

    更新日期:2019-08-01 00:00:00

  • Validation of a quantitative method to measure neural respiratory drive in children during sleep.

    abstract:AIMS:Quantitatively measure and validate analysis of neural respiratory drive (NRD) using a commercial polysomnography system in children during sleep. METHOD:Surface electromyogram of the diaphragm (sEMGdi) recorded from primary snoring children were analysed. A subset was re-analysed to assess intra- and inter-inves...

    journal_title:Respiratory physiology & neurobiology

    pub_type: 杂志文章


    authors: Chuang SY,Teng A,Butler JE,Gandevia SC,Selvadurai H,Jaffe A

    更新日期:2017-05-01 00:00:00

  • Pulmonary rehabilitation and BDNF levels in patients with chronic obstructive pulmonary disease: A pilot study.

    abstract:BACKGROUND:COPD physiopathology involves multiple pathways and evidence indicates that brain-derived neurotrophic factor (BDNF) is an important biomarker associated with parameters of COPD severity. This study aimed to analyze the time course of the effects of a pulmonary rehabilitation program (PRP) on BDNF levels and...

    journal_title:Respiratory physiology & neurobiology

    pub_type: 杂志文章


    authors: de Araujo CLP,da Silva IRV,Reinaldo GP,Peccin PK,Pochmann D,Teixeira PJZ,Elsner VR,Dal Lago P

    更新日期:2019-01-01 00:00:00

  • Non-invasive measurement of cardiac output: evaluation of new infrared absorption spectrometer.

    abstract::The mass spectrometer (MS) traditionally has been the instrument of choice for measuring cardiac output (Q (T)) non-invasively using the foreign gas uptake method. However, the size and cost of the MS has hampered widespread adoption of this technique outside of the laboratory. Here, we present results, from six norma...

    journal_title:Respiratory physiology & neurobiology

    pub_type: 临床试验,杂志文章


    authors: Baum MM,Moss JA,Kumar S,Wagner PD

    更新日期:2006-09-28 00:00:00

  • The role of the pontine respiratory complex in the response to intermittent hypoxia.

    abstract::These experiments were designed to determine the effects of EEG state on the response of rats to intermittent hypoxia and to test the hypotheses that short-term potentiation (STP) and ventilatory long term facilitation (vLTF) are state dependent; and that neurons with NMDA receptors in the dorso-ventral pontine respir...

    journal_title:Respiratory physiology & neurobiology

    pub_type: 杂志文章


    authors: Boon JA,Milsom WK

    更新日期:2010-04-30 00:00:00

  • Airway nociceptors activated by pro-inflammatory cytokines.

    abstract::The present studies evaluate whether the vagus nerves link the lungs' immune and neural systems by transmitting information through pulmonary nociceptors. Single unit activities from pulmonary nociceptors [C fiber receptors (CFRs) and high threshold Adelta fiber receptors (HTARs)] were recorded from the cervical vagus...

    journal_title:Respiratory physiology & neurobiology

    pub_type: 杂志文章


    authors: Yu J,Lin S,Zhang J,Otmishi P,Guardiola JJ

    更新日期:2007-05-14 00:00:00

  • Validation of a two-compartment model of ventilation/perfusion distribution.

    abstract::Ventilation (V (A)) to perfusion (Q ) heterogeneity (V (A)/Q ) analyses by a two-compartment lung model (2C), utilizing routine gas exchange measurements and a computer solution to account for O(2) and CO(2) measurements, were compared with multiple inert gas elimination technique (MIGET) analyses and a multi-compartm...

    journal_title:Respiratory physiology & neurobiology

    pub_type: 杂志文章


    authors: Loeppky JA,Caprihan A,Altobelli SA,Icenogle MV,Scotto P,Vidal Melo MF

    更新日期:2006-03-28 00:00:00

  • Effects of dietary inorganic nitrate on static and dynamic breath-holding in humans.

    abstract::Inorganic nitrate has been shown to reduce oxygen cost during exercise. Since the nitrate-nitrite-NO pathway is facilitated during hypoxia, we investigated the effects of dietary nitrate on oxygen consumption and cardiovascular responses during apnea. These variables were measured in two randomized, double-blind, plac...

    journal_title:Respiratory physiology & neurobiology

    pub_type: 杂志文章,随机对照试验


    authors: Schiffer TA,Larsen FJ,Lundberg JO,Weitzberg E,Lindholm P

    更新日期:2013-01-15 00:00:00

  • Dyspnea on exertion in obese men.

    abstract::Recently, we reported that dyspnea on exertion is strongly associated with an increased oxygen cost of breathing in otherwise healthy obese women; the mechanism of dyspnea on exertion in obese men is unknown. Obese men underwent measurements of body composition, fat distribution, pulmonary function, steady state and m...

    journal_title:Respiratory physiology & neurobiology

    pub_type: 杂志文章


    authors: Bernhardt V,Wood HE,Moran RB,Babb TG

    更新日期:2013-01-15 00:00:00

  • Regulation of alveolar fluid clearance and ENaC expression in lung by exogenous angiotensin II.

    abstract::Angiotensin II (Ang II) has been demonstrated as a pro-inflammatory effect in acute lung injury, but studies of the effect of Ang II on the formation of pulmonary edema and alveolar filling remains unclear. Therefore, in this study the regulation of alveolar fluid clearance (AFC) and the expression of epithelial sodiu...

    journal_title:Respiratory physiology & neurobiology

    pub_type: 杂志文章


    authors: Deng J,Wang DX,Deng W,Li CY,Tong J,Ma H

    更新日期:2012-04-15 00:00:00

  • Prelimbic prefrontal cortex mediates respiratory responses to mild and potent prolonged, but not brief, stressors.

    abstract::The prefrontal cortex is one of the key areas of the central mechanism of cardiovascular and respiratory control. Disinhibition of the prelimbic medial prefrontal cortex elicits tachypnoeic responses in anesthetized rats (Hassan et al., J. Physiol. 591: 6069-6088, 2013). The current study examines the effects of inhib...

    journal_title:Respiratory physiology & neurobiology

    pub_type: 杂志文章


    authors: Bondarenko E,Hodgson DM,Nalivaiko E

    更新日期:2014-12-01 00:00:00

  • Ventilatory pattern and chemosensitivity in M1 and M3 muscarinic receptor knockout mice.

    abstract::Acetylcholine (ACh) acting through muscarinic receptors is thought to be involved in the control of breathing, notably in central and peripheral chemosensory afferents and in regulations related to sleep-wake states. By using whole-body plethysmography, we compared baseline breathing at rest and ventilatory responses ...

    journal_title:Respiratory physiology & neurobiology

    pub_type: 杂志文章


    authors: Boudinot E,Yamada M,Wess J,Champagnat J,Foutz AS

    更新日期:2004-02-25 00:00:00

  • Evolution of bubbles from gas micronuclei formed on the luminal aspect of ovine large blood vessels.

    abstract::It has been shown that tiny gas nanobubbles form spontaneously on a smooth hydrophobic surface submerged in water. These nanobubbles were shown to be the source of gas micronuclei from which bubbles evolved during decompression of silicon wafers. We suggest that the hydrophobic inner surface of blood vessels may be a ...

    journal_title:Respiratory physiology & neurobiology

    pub_type: 杂志文章


    authors: Arieli R,Marmur A

    更新日期:2013-08-01 00:00:00

  • Recent findings in cardiovascular physiology with space travel.

    abstract::The cardiovascular system undergoes major changes in stress with space flight primarily related to the elimination of the head-to-foot gravitational force. A major observation has been that the central venous pressure is not elevated early in space flight yet stroke volume is increased at least early in flight. Recent...

    journal_title:Respiratory physiology & neurobiology

    pub_type: 杂志文章


    authors: Hughson RL

    更新日期:2009-10-01 00:00:00

  • Blood gases and cardiovascular shunt in the South American lungfish (Lepidosiren paradoxa) during normoxia and hyperoxia.

    abstract::The South American lungfish (Lepidosiren paradoxa) has an arterial P(O(2)) (Pa(O(2))) as high as 70-100 mmHg, corresponding to Hb-O(2) saturations from 90% to 95%, which indicates a moderate cardiovascular right to left (R-L) shunt. In hyperoxia (50% O(2)), we studied animals in: (1) aerated water combined with aerial...

    journal_title:Respiratory physiology & neurobiology

    pub_type: 杂志文章


    authors: Bassi M,Giusti H,da Silva GS,Amin-Naves J,Glass ML

    更新日期:2010-08-31 00:00:00

  • Chronic mountain sickness score was related with health status score but not with hemoglobin levels at high altitudes.

    abstract::Chronic mountain sickness (CMS) or lack of adaptation to live in high altitudes is related to environmental hypoxia and excessive erythrocytosis (EE) (hemoglobin >21 and >19 g/dL for men and women, respectively). Diagnosis of CMS ("Qinghai CMS Score") is based on seven signs/symptoms (breathlessness and/or palpitation...

    journal_title:Respiratory physiology & neurobiology

    pub_type: 杂志文章


    authors: Gonzales GF,Rubio J,Gasco M

    更新日期:2013-08-15 00:00:00

  • Dynamics of metabolic compensation and hematological changes in chicken (Gallus gallus) embryos exposed to hypercapnia with varying oxygen.

    abstract::In day 15 chicken embryos, we determined the time course responses of acid-base balance and hematological respiratory variables during 24h exposure to 15, 20, 40 or 90% O(2), in the presence of 5% CO(2). Hypercapnic respiratory acidosis was initially (2h) only slightly (∼20%) compensated by metabolic alkalosis in norm...

    journal_title:Respiratory physiology & neurobiology

    pub_type: 杂志文章


    authors: Mueller CA,Tazawa H,Burggren WW

    更新日期:2013-01-15 00:00:00

  • Spinal vascular endothelial growth factor (VEGF) and erythropoietin (EPO) induced phrenic motor facilitation after repetitive acute intermittent hypoxia.

    abstract::Vascular endothelial growth factor (VEGF) and erythropoietin (EPO) exert neurotrophic and neuroprotective effects in the CNS. We recently demonstrated that VEGF, EPO and their receptors (VEGF-R2, EPO-R) are expressed in phrenic motor neurons, and that cervical spinal VEGF-R2 and EPO-R activation elicit long-lasting ph...

    journal_title:Respiratory physiology & neurobiology

    pub_type: 杂志文章


    authors: Dale EA,Mitchell GS

    更新日期:2013-02-01 00:00:00

  • Respiratory response to systemic inhibition of the Na+/H+ exchanger type 3 in intact rats.

    abstract::The Na+/H+ exchangers (NHEs) are a family of antiporters involved in the maintenance of neural steady-state intracellular pH. The NHE3 seems to be the predominant subtype in central chemosensitive cells. We aimed to analyze the effect of a selective NHE3 inhibition on the respiratory pattern in spontaneously breathing...

    journal_title:Respiratory physiology & neurobiology

    pub_type: 杂志文章


    authors: Ribas-Salgueiro JL,Matarredona ER,Sarmiento M,Ribas J,Pásaro R

    更新日期:2009-02-28 00:00:00

  • Prenatal development of the pulmonary surfactant system and the influence of hypoxia.

    abstract::Pulmonary surfactant fulfils diverse functions at the lung air-liquid interface of all air-breathing vertebrates. Neurohormonal regulation of surfactant synthesis and secretion is highly conserved among non-mammalian amniotes. Although the pattern of surfactant lipid maturation is similar among species, the onset and ...

    journal_title:Respiratory physiology & neurobiology

    pub_type: 杂志文章,评审


    authors: Orgeig S,Morrison JL,Daniels CB

    更新日期:2011-08-31 00:00:00

  • Bronchial responsiveness in an elastase-induced mouse model of emphysema.

    abstract::Bronchial responsiveness during methacholine (MCh) challenge was analysed in an elastase-induced mouse model of emphysema to explore the magnitude of the response in this model. Swiss mice were intratracheally instilled with saline or elastase (0.3 or 0.6 U). Twenty days afterward, mechanical ventilation data were col...

    journal_title:Respiratory physiology & neurobiology

    pub_type: 杂志文章


    authors: Santos LM,de Brito Cervilha DA,Cabral LD,Garcia ÉK,Teixeira VP,Brito JM,Moriya HT,Soncini R

    更新日期:2014-04-01 00:00:00

  • Respiration-related control of abdominal motoneurons.

    abstract::The abdominal muscles form part of the expiratory pump in cooperation with the other expiratory muscles, primarily the internal intercostal and triangularis sterni muscles. The discharge of abdominal muscles is divided into four main patterns: augmenting, plateau, spindle and decrementing. The patterns tend to be spec...

    journal_title:Respiratory physiology & neurobiology

    pub_type: 杂志文章,评审


    authors: Iizuka M

    更新日期:2011-10-15 00:00:00

  • Fetal lung development in the elephant reflects the adaptations required for snorkeling in adult life.

    abstract::The adult elephant is unique among mammals in that the pleural membranes are thickened and the pleural cavity is obliterated by connective tissue. It has been suggested that this peculiar anatomy developed because the animal can snorkel at depth, and this behavior subjects the microvessels in the parietal pleura to a ...

    journal_title:Respiratory physiology & neurobiology

    pub_type: 杂志文章


    authors: West JB,Fu Z,Gaeth AP,Short RV

    更新日期:2003-11-14 00:00:00

  • Chronic intermittent hyperoxia alters the development of the hypoxic ventilatory response in neonatal rats.

    abstract::Chronic exposure to sustained hyperoxia alters the development of the respiratory control system, but the respiratory effects of chronic intermittent hyperoxia have rarely been investigated. We exposed newborn rats to short, repeated bouts of 30% O2 or 60% O2 (5 bouts h(-1)) for 4-15 days and then assessed their hypox...

    journal_title:Respiratory physiology & neurobiology

    pub_type: 杂志文章


    authors: Logan S,Tobin KE,Fallon SC,Deng KS,McDonough AB,Bavis RW

    更新日期:2016-01-01 00:00:00

  • Circadian dependence of receptors that mediate wake-related excitatory drive to hypoglossal motoneurons.

    abstract::Serotonin (5-HT), norepinephrine and orexins (ORX) are the three best established mediators of wake-related activation of hypoglossal (XII) motoneurons that innervate the muscles of the tongue. Since the tongue's use is temporarily closely aligned with the rest-activity cycle, we tested whether expression of mRNA for ...

    journal_title:Respiratory physiology & neurobiology

    pub_type: 杂志文章


    authors: Volgin DV,Stettner GM,Kubin L

    更新日期:2013-09-15 00:00:00

  • Different respiratory behaviors disclosed by induced bronchoconstriction in mild asthma patients.

    abstract::Respiratory responses to bronchoconstriction in asthma have been partially assessed and their significance is unclear. In 44 mild asthma patients we investigated respiratory responses during increasing levels of methacholine-induced bronchoconstriction. Inspiratory muscle activity, tidal volume, inspiratory and expira...

    journal_title:Respiratory physiology & neurobiology

    pub_type: 杂志文章


    authors: Lavorini F,Magni C,Chellini E,Camiciottoli G,Pistolesi M,Fontana GA

    更新日期:2013-12-01 00:00:00

  • MicroRNA-328 is involved in wound repair process in human bronchial epithelial cells.

    abstract::Our aim was to investigate the role of microRNA on epithelial wound repair by global microRNA silencing. We have also analysed the influence of five miRNAs (miR-328, miR-342, miR-411, miR-609, miR-888, previously identified) on wound repair in 16HBE14o-bronchial epithelial cell line. Cells were transfected with siRNAs...

    journal_title:Respiratory physiology & neurobiology

    pub_type: 杂志文章


    authors: Narożna B,Langwinski W,Jackson C,Lackie P,Holloway JW,Szczepankiewicz A

    更新日期:2017-08-01 00:00:00

  • Phrenic motor unit recruitment during ventilatory and non-ventilatory behaviors.

    abstract::Phrenic motoneurons are located in the cervical spinal cord and innervate the diaphragm muscle, the main inspiratory muscle in mammals. Similar to other skeletal muscles, phrenic motoneurons and diaphragm muscle fibers form motor units which are the final element of neuromotor control. In addition to their role in sus...

    journal_title:Respiratory physiology & neurobiology

    pub_type: 杂志文章,评审


    authors: Mantilla CB,Sieck GC

    更新日期:2011-10-15 00:00:00

  • Progesterone increases hypoxic ventilatory response and reduces apneas in newborn rats.

    abstract::We hypothesized that progesterone may enhance the hypoxic ventilatory response and reduce the occurrence of apneas in newborn male rats. We studied 10-day-old rats chronically exposed to progesterone (Prog) or vehicle through the milk of lactating mothers. Respiratory and metabolic recordings were performed using whol...

    journal_title:Respiratory physiology & neurobiology

    pub_type: 杂志文章


    authors: Lefter R,Morency CE,Joseph V

    更新日期:2007-04-16 00:00:00