Respiratory factors do not limit maximal symptom-limited exercise in patients with mild cystic fibrosis lung disease.


:To evaluate whether respiratory factors limit exercise capacity in patients with mild cystic fibrosis (CF) lung disease (mean FEV(1) = 76 +/- 7.7% predicted) we stressed the respiratory system of seven patients using added dead space (V(D)). Primary outcomes were exercise duration (Ex(dur)) and maximal oxygen uptake (VO(2max)). Dyspnoea/leg-discomfort were assessed at end-exercise. Ex(dur) was identical between control and V(D) studies (520 +/- 152 versus 511 +/ -166 s, p = NS) as was VO(2max)(1.6 +/- 0.5 versus 1.6 +/- 0.6 L/min, p = NS). Significant resting, sub-maximal and maximal workload increases in minute ventilation (V(E)) were detected (70.8 +/- 13.7 versus 79.5 +/- 16.9 L/min, p < 0.05). Analysis of breathing pattern revealed increases in V(E) were attributable to increases in tidal volume (2.0 +/- 0.5 versus 2.2 +/- 0.6 L, p < 0.05) with no change in respiratory frequency. There was no difference in dyspnoea/leg discomfort between tests. The increase in V(E) in response to V(D), with no change in [Exdur/VO(2max) suggests maximal symptom-limited exercise limitation is not primarily limited by respiratory factors in mild CF lung disease. Focused investigation and treatment of non-respiratory factors contributing to exercise limitation may improve exercise rehabilitation in this patient group.


Dodd JD,Barry SC,Gallagher CG





Has Abstract


2006-06-01 00:00:00














  • Cough reflex sensitivity does not correlate with the esophageal sensitivity to acid in patients with gastroesophageal reflux disease.

    abstract::The sensitization of cough reflex observed in patients with gastroesophageal reflux disease (GERD) is attributed to activation of vagal C-fibers innervating the esophagus by acid, while the heartburn in GERD is mediated by esophageal acid sensitive C-fibers derived from (dorsal root ganglia) DRG. Here we explored the ...

    journal_title:Respiratory physiology & neurobiology

    pub_type: 杂志文章


    authors: Duricek M,Nosakova L,Zatko T,Pecova R,Hyrdel R,Banovcin P Jr

    更新日期:2018-11-01 00:00:00

  • ATP in central respiratory control: a three-part signaling system.

    abstract::The landmark demonstrations in 2005 that ATP released centrally during hypoxia and hypercapnia contributes to the respective ventilatory responses validated a decade-old hypothesis and ignited interest in the potential significance of P2 receptor signaling in central respiratory control. Our objective in this review i...

    journal_title:Respiratory physiology & neurobiology

    pub_type: 杂志文章,评审


    authors: Funk GD,Huxtable AG,Lorier AR

    更新日期:2008-12-10 00:00:00

  • Numerical simulation of respiratory flow patterns within human lung.

    abstract::A computational fluid dynamics (CFD) modelling approach is used to study the unsteady respiratory airflow dynamics within a human lung. The three-dimensional asymmetric bifurcation model of the central airway based on the morphological data given by Horsfield et al. (J. Appl. Physiol. 67 (1971) 207) was used in the pr...

    journal_title:Respiratory physiology & neurobiology

    pub_type: 杂志文章


    authors: Calay RK,Kurujareon J,Holdø AE

    更新日期:2002-04-01 00:00:00

  • Responses induced by acetylcholine and ATP in the rabbit petrosal ganglion.

    abstract::Acetylcholine and ATP appear to mediate excitatory transmission between receptor (glomus) cells and the petrosal ganglion (PG) neuron terminals in the carotid body. In most species these putative transmitters are excitatory, while inhibitory effects had been reported in the rabbit. We studied the effects of the applic...

    journal_title:Respiratory physiology & neurobiology

    pub_type: 杂志文章


    authors: Soto CR,Ortiz FC,Vargas RV,Arroyo J,Alcayaga J

    更新日期:2010-07-31 00:00:00

  • Pre-junctional muscarinic autoreceptors in bovine airways.

    abstract:UNLABELLED:We searched for pre-junctional inhibitory muscarinic receptors in isolated bovine trachealis strips and bronchial rings. Electric stimulation (ES)-induced tritiated acetylcholine ([(3)H]-ACh)-release and isometric contractions were determined in muscles incubated with the non-selective muscarinic agonist pil...

    journal_title:Respiratory physiology & neurobiology

    pub_type: 杂志文章


    authors: Baroffio M,Crimi E,Brichetto L,Zappi L,Rehder K,Brusasco V

    更新日期:2012-01-15 00:00:00

  • Alveolar barrier function assessed by hydrophobic and hydrophilic fluorescent solutes in rabbit lung.

    abstract::Loss of alveolar barrier function is important in the development of pulmonary edema, but quantitation of its integrity has been difficult in the intact lung. We report a new non-radioactive method to assess paracellular and transcellular permeability of alveolar barrier in buffer-perfused rabbit lungs. Changes in alv...

    journal_title:Respiratory physiology & neurobiology

    pub_type: 杂志文章


    authors: Huang YC,Piantadosi CA

    更新日期:2002-10-23 00:00:00

  • Plasticity of respiratory structures--adaptive remodeling of fish gills induced by ambient oxygen and temperature.

    abstract::While a large surface area combined with short diffusion distances make fish gills well suited for gas exchange, these properties leads to costly water and ion fluxes and exposure to toxic substances and pathogens. Thus, gill morphology is likely to be a compromise between opposing demands. It has become clear that so...

    journal_title:Respiratory physiology & neurobiology

    pub_type: 杂志文章,评审


    authors: Sollid J,Nilsson GE

    更新日期:2006-11-01 00:00:00

  • Effect of accessory ostia on maxillary sinus ventilation: a computational fluid dynamics (CFD) study.

    abstract::We evaluated, by CFD simulation, effects of accessory ostium (AO) on maxillary sinus ventilation. A three-dimensional nasal model was constructed from an adult CT scan with two left maxillary AOs (sinus I) and one right AO (sinus II), then compared to an identical control model with all AOs sealed (sinuses III and IV)...

    journal_title:Respiratory physiology & neurobiology

    pub_type: 杂志文章


    authors: Zhu JH,Lee HP,Lim KM,Gordon BR,Wang de Y

    更新日期:2012-08-15 00:00:00

  • An acute exposure to intermittent negative airway pressure elicits respiratory long-term facilitation in awake humans.

    abstract:BACKGROUND:A sustained elevation in respiratory drive following removal of the inducing stimulus is known as respiratory long-term facilitation (rLTF). We investigated whether an acute exposure to intermittent negative airway pressure (INAP) elicits rLTF in humans. METHOD:13 healthy males (20.9 ± 2.8 years) undertook ...

    journal_title:Respiratory physiology & neurobiology

    pub_type: 杂志文章


    authors: Griffin HS,Al Humoud S,Benson JG,Cooper BG,Coomaraswamy K,Balanos GM

    更新日期:2019-09-01 00:00:00

  • DLNO/DLCO ratio evolution under targeted therapy in patients with pulmonary hypertension.

    abstract::The ratio of the diffusing capacity of the lung for carbon monoxide (DLCO) and for nitric oxide (DLNO) measured simultaneously is modified in patients with precapillary pulmonary hypertension (PH). The potential impact of targeted therapy on the DLCO/DLNO ratio is unknown. Simultaneous measurements of DLNO and DLCO we...

    journal_title:Respiratory physiology & neurobiology

    pub_type: 杂志文章


    authors: Catella J,Costes F,Gaultier JB,Court Fortune I,Tulane C,De Magalhaes E,Accassat S,Chomette-Ballereau S,Chapelle C,Bertoletti L

    更新日期:2020-08-01 00:00:00

  • Reappraisal of DLCO adjustment to interpret the adaptive response of the air-blood barrier to hypoxia.

    abstract::DLCO measured in hypoxia must be corrected due to the higher affinity (increase in coefficient θ) of CO with Hb. We propose an adjustment accounting for individual changes in the equation relating DLCO to subcomponents Dm (membrane diffusive capacity) and Vc (lung capillary volume): 1/DLCO=1/Dm+1/θVc. We adjusted the ...

    journal_title:Respiratory physiology & neurobiology

    pub_type: 杂志文章


    authors: Beretta E,Lanfranconi F,Grasso GS,Bartesaghi M,Alemayehu HK,Miserocchi G

    更新日期:2017-04-01 00:00:00

  • Prelimbic prefrontal cortex mediates respiratory responses to mild and potent prolonged, but not brief, stressors.

    abstract::The prefrontal cortex is one of the key areas of the central mechanism of cardiovascular and respiratory control. Disinhibition of the prelimbic medial prefrontal cortex elicits tachypnoeic responses in anesthetized rats (Hassan et al., J. Physiol. 591: 6069-6088, 2013). The current study examines the effects of inhib...

    journal_title:Respiratory physiology & neurobiology

    pub_type: 杂志文章


    authors: Bondarenko E,Hodgson DM,Nalivaiko E

    更新日期:2014-12-01 00:00:00

  • Evolution of bubbles from gas micronuclei formed on the luminal aspect of ovine large blood vessels.

    abstract::It has been shown that tiny gas nanobubbles form spontaneously on a smooth hydrophobic surface submerged in water. These nanobubbles were shown to be the source of gas micronuclei from which bubbles evolved during decompression of silicon wafers. We suggest that the hydrophobic inner surface of blood vessels may be a ...

    journal_title:Respiratory physiology & neurobiology

    pub_type: 杂志文章


    authors: Arieli R,Marmur A

    更新日期:2013-08-01 00:00:00

  • Time course of ventilatory acclimatisation to hypoxia in a model of anemic transgenic mice.

    abstract::We questioned the assumption that polycythemia is essential for adaptation to chronic hypoxia. Thus, the objective of our study was to determine if anemic Epo-TAg(h) mice could survive in hypoxia despite low oxygen carrying capacity. We explored the possibility that ventilatory acclimatisation is involved in the strat...

    journal_title:Respiratory physiology & neurobiology

    pub_type: 杂志文章


    authors: Macarlupú JL,Buvry A,Morel OE,León-Velarde F,Richalet JP,Favret F

    更新日期:2006-08-01 00:00:00

  • Ovarian steroids act as respiratory stimulant and antioxidant against the causes and consequences of sleep-apnea in women.

    abstract::Evidence supports the importance of ovarian hormones as potential tools against sleep apneas in women. On one hand, progesterone is largely acknowledged as being a respiratory stimulant that reduces the frequency of apneas, but the underlying mechanisms remain poorly understood. Recent studies in mice showed that the ...

    journal_title:Respiratory physiology & neurobiology

    pub_type: 杂志文章,评审


    authors: Boukari R,Laouafa S,Ribon-Demars A,Bairam A,Joseph V

    更新日期:2017-05-01 00:00:00

  • "Spirometric" lung age reference equations: A narrative review.

    abstract::The aim of the present paper was to conduct a narrative review of the published norms of the "spirometric" lung-age (SLA). A literature search which covered the period 1970 to June 2017, was conducted using the Pubmed. The search strategy had used the following MeSH words: "Spirometry"[Majr]) AND "Aging"[Majr]. Six or...

    journal_title:Respiratory physiology & neurobiology

    pub_type: 杂志文章,评审


    authors: Khelifa MB,Salem HB,Sfaxi R,Chatti S,Rouatbi S,Saad HB

    更新日期:2018-01-01 00:00:00

  • Effects of dietary inorganic nitrate on static and dynamic breath-holding in humans.

    abstract::Inorganic nitrate has been shown to reduce oxygen cost during exercise. Since the nitrate-nitrite-NO pathway is facilitated during hypoxia, we investigated the effects of dietary nitrate on oxygen consumption and cardiovascular responses during apnea. These variables were measured in two randomized, double-blind, plac...

    journal_title:Respiratory physiology & neurobiology

    pub_type: 杂志文章,随机对照试验


    authors: Schiffer TA,Larsen FJ,Lundberg JO,Weitzberg E,Lindholm P

    更新日期:2013-01-15 00:00:00

  • Comparisons of effects of intravenous and inhaled methacholine on airway physiology in a murine asthma model.

    abstract::Airway responses to intravenous (i.v.) and inhaled (i.h.) delivery of methacholine (MCh) in BALB/c and C57BL/6 mouse strains have been compared with and without ovalbumin (OVA)-induced airway inflammation. Bronchial reactivity to MCh was assessed in anaesthetised and tracheostomised animals by using an animal ventilat...

    journal_title:Respiratory physiology & neurobiology

    pub_type: 杂志文章


    authors: Jonasson S,Hedenstierna G,Hedenström H,Hjoberg J

    更新日期:2009-02-28 00:00:00

  • Orexinergic modulation of breathing across vigilance states.

    abstract::Basal respiration and respiratory reflex regulations are considerably different during the awake and sleep states. Tidal volume and respiratory frequency diminish during sleep, and hypoxic and hypercapnic ventilatory responses also decline during sleep. Reduced metabolic demand during sleep cannot completely explain t...

    journal_title:Respiratory physiology & neurobiology

    pub_type: 杂志文章,评审


    authors: Kuwaki T

    更新日期:2008-12-10 00:00:00

  • Sleep disordered breathing following spinal cord injury.

    abstract::Individuals with spinal cord injury (SCI) commonly complain about difficulty in sleeping. Although various sleep disordered breathing definitions and indices are used that make comparisons between studies difficult, it seems evident that the frequency of sleep disorders is higher in individuals with SCI, especially wi...

    journal_title:Respiratory physiology & neurobiology

    pub_type: 杂志文章,评审


    authors: Biering-Sørensen F,Jennum P,Laub M

    更新日期:2009-11-30 00:00:00

  • Amelioration of allergic asthma by Ziziphora clinopodioides via upregulation of aquaporins and downregulation of IL4 and IL5.

    abstract::Ziziphora clinopodioides has been frequently used as an anti asthmatic plant in traditional medication. Recent work explores the anti-asthmatic activity of Z. clinopodioides in allergen-induced asthmatic mice. Intraperitoneal sensitization followed by intranasal challenge were given with ovalbumin (allergen) to develo...

    journal_title:Respiratory physiology & neurobiology

    pub_type: 杂志文章


    authors: Ahsan F,Shabbir A,Shahzad M,Mobashar A,Sharif M,Basheer MI,Tareen RB,Syed NI

    更新日期:2019-08-01 00:00:00

  • Sex differences in the respiratory-sympathetic coupling in rats exposed to chronic intermittent hypoxia.

    abstract::Obstructive sleep apnea (OSA) is a complex disease in which humans face episodes of intermittent hypoxia and it affects men and women. Patients with OSA present hypertension and sympathetic overactivity among several other dysfunctions. Therefore, one important question remains: are the autonomic dysfunctions associat...

    journal_title:Respiratory physiology & neurobiology

    pub_type: 杂志文章,评审


    authors: Souza GMPR,Amorim MR,Moraes DJA,Machado BH

    更新日期:2018-10-01 00:00:00

  • Optoelectronic plethysmography compared to spirometry during maximal exercise.

    abstract::The purpose of this study was to compare simultaneous measurements of tidal volume (Vt) by optoelectronic plethysmography (OEP) and spirometry during a maximal cycling exercise test to quantify possible differences between methods. Vt measured simultaneously by OEP and spirometry was collected during a maximal exercis...

    journal_title:Respiratory physiology & neurobiology

    pub_type: 杂志文章


    authors: Layton AM,Moran SL,Garber CE,Armstrong HF,Basner RC,Thomashow BM,Bartels MN

    更新日期:2013-01-15 00:00:00

  • Nitric oxide inhibitor altitude-dependently elevates pulmonary arterial pressure in high-altitude adapted yaks.

    abstract::We studied the effect of N(w)-nitro-L-arginine (NLA) on yak pulmonary vascular tone in a climatic (hypobaric/hyperbaric adjusted) chamber. Five young male yaks that had been born and reared at an altitude greater than 3800 m a.s.l. were used. After measuring control values, 20 mg/kg of NLA was administered via the jug...

    journal_title:Respiratory physiology & neurobiology

    pub_type: 杂志文章


    authors: Ishizaki T,Koizumi T,Ruan Z,Wang Z,Chen Q,Sakai A

    更新日期:2005-04-15 00:00:00

  • Effects of different forms of dyspnoea on pain perception induced by cold-pressor test.

    abstract::Although dyspnoea has been shown to attenuate pain, whether different forms of dyspnoea exert a similar inhibitory effect on pain has never been tested. We examined the effects of two different forms of dyspnoea, i.e., "air hunger" sensation (AIR HUNGER) and "work/effort" sensation (WORK/EFFORT), on pain induced by a ...

    journal_title:Respiratory physiology & neurobiology

    pub_type: 杂志文章


    authors: Yashiro E,Nozaki-Taguchi N,Isono S,Nishino T

    更新日期:2011-08-15 00:00:00

  • SiO2-induced release of sVEGFRs from pulmonary macrophages.

    abstract:BACKGROUND:The inhalation of silicon dioxide (SiO2) particles causes silicosis, a stubborn pulmonary disease that is characterized by alveolar inflammation during the early stage. Soluble cytokine receptors (SCRs) play important roles in regulating inflammation by either attenuating or promoting cytokine signaling. How...

    journal_title:Respiratory physiology & neurobiology

    pub_type: 杂志文章


    authors: Chao J,Lv Y,Chen J,Wang J,Yao H

    更新日期:2018-01-01 00:00:00

  • MicroRNA-328 is involved in wound repair process in human bronchial epithelial cells.

    abstract::Our aim was to investigate the role of microRNA on epithelial wound repair by global microRNA silencing. We have also analysed the influence of five miRNAs (miR-328, miR-342, miR-411, miR-609, miR-888, previously identified) on wound repair in 16HBE14o-bronchial epithelial cell line. Cells were transfected with siRNAs...

    journal_title:Respiratory physiology & neurobiology

    pub_type: 杂志文章


    authors: Narożna B,Langwinski W,Jackson C,Lackie P,Holloway JW,Szczepankiewicz A

    更新日期:2017-08-01 00:00:00

  • Ventilatory responses to acute hypoxia in neurokinin-1 receptor deficient mice.

    abstract::The regulatory effect of substance P on respiration is mediated via neurokinin (NK) receptors. While previous studies suggest that NK-1 receptors are involved, little is known about the role NK-2 receptors in ventilatory responses to hypoxia. Ventilatory responses to acute hypoxia (8% O2 in N2) were measured by indire...

    journal_title:Respiratory physiology & neurobiology

    pub_type: 杂志文章


    authors: Grasemann H,Gerard NP,De Sanctis GT

    更新日期:2007-11-15 00:00:00

  • Postnatal development of eupneic ventilation and metabolism in rats chronically exposed to moderate hyperoxia.

    abstract::Newborn rats chronically exposed to moderate hyperoxia (60% O2) exhibit abnormal respiratory control, including decreased eupneic ventilation. To further characterize this plasticity and explore its proximate mechanisms, rats were exposed to either 21% O2 (Control) or 60% O2 (Hyperoxia) from birth until studied at 3-1...

    journal_title:Respiratory physiology & neurobiology

    pub_type: 杂志文章


    authors: Bavis RW,van Heerden ES,Brackett DG,Harmeling LH,Johnson SM,Blegen HJ,Logan S,Nguyen GN,Fallon SC

    更新日期:2014-07-01 00:00:00

  • Effects of prolonged exercise to exhaustion on left-ventricular function and pulmonary gas exchange.

    abstract::The purpose of this study was to simultaneously examine left-ventricular (LV) function and pulmonary gas exchange during prolonged constant-rate cycling in an attempt to explain the exercise-induced impairment in gas exchange. Eleven competitive cyclists rode their racing bicycles on a computerized cycle trainer at 25...

    journal_title:Respiratory physiology & neurobiology

    pub_type: 杂志文章


    authors: Stickland MK,Anderson WD,Haykowsky MJ,Welsh RC,Petersen SR,Jones RL

    更新日期:2004-09-15 00:00:00