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Early postnatal exposure to allergen and ozone leads to hyperinnervation of the pulmonary epithelium.

Abstract：

:Airway injury in infant monkeys exposed to ozone and/or house dust mite allergen (HDMA) is associated with a loss of epithelial innervation. In this study, we evaluated for persistence/recovery of the altered epithelial innervation. Thirty-day-old rhesus monkeys were exposed to repeated episodes of HDMA and/or ozone from 1 to 6 months of age and subsequently allowed to recover for 6 months in the absence of further ozone exposure and/or minimal HDMA challenge (sufficient to maintain allergen sensitization). At 1 year of age, nerve density in intrapulmonary airways was immunohistochemically evaluated using antibodies directed against protein gene product 9.5. Hyperinnervation and irregular epithelial nerve distribution was observed in both HDMA- and ozone-exposed groups; most prominent alterations were observed in animals exposed to HDMA plus ozone. Therefore, while adaptive mechanisms exist that re-establish epithelial innervation following cessation or diminution of exposure to HDMA and/or ozone, the recovery is associated with persistent proliferative mechanisms that result in hyperinnervation of the airways.

journal_name

Respir Physiol Neurobiol

journal_title

Respiratory physiology & neurobiology

authors

Kajekar R,Pieczarka EM,Smiley-Jewell SM,Schelegle ES,Fanucchi MV,Plopper CG

doi

10.1016/j.resp.2006.03.002

subject

Has Abstract

pub_date

2007-01-15 00:00:00

pages

55-63

issue

1

eissn

1569-9048

issn

1878-1519

pii

S1569-9048(06)00104-2

journal_volume

155

pub_type

杂志文章

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