Vascular KATP channels mitigate severe muscle O2 delivery-utilization mismatch during contractions in chronic heart failure rats.

Abstract:

:The vascular ATP-sensitive K+ (KATP) channel is a mediator of skeletal muscle microvascular oxygenation (PO2mv) during contractions in health. We tested the hypothesis that KATP channel function is preserved in chronic heart failure (CHF) and therefore its inhibition would reduce PO2mv and exacerbate the time taken to reach the PO2mv steady-state during contractions of the spinotrapezius muscle. Moreover, we hypothesized that subsequent KATP channel activation would oppose the effects of this inhibition. Muscle PO2mv (phosphorescence quenching) was measured during 180s of 1-Hz twitch contractions (∼6V) under control, glibenclamide (GLI, KATP channel antagonist; 5mg/kg) and pinacidil (PIN, KATP channel agonist; 5mg/kg) conditions in 16 male Sprague-Dawley rats with CHF induced via myocardial infarction (coronary artery ligation, left ventricular end-diastolic pressure: 18±1mmHg). GLI reduced baseline PO2mv (control: 28.3±0.9, GLI: 24.8±1.0mmHg, p<0.05), lowered mean PO2mv (average PO2mv during the overall time taken to reach the steady-state; control: 20.6±0.6, GLI: 17.6±0.3mmHg, p<0.05), and slowed the attainment of steady-state PO2mv (overall mean response time; control: 66.1±10.2, GLI: 93.6±7.8s, p<0.05). PIN opposed these effects on the baseline PO2mv, mean PO2mv and time to reach the steady-state PO2mv (p<0.05 for all vs. GLI). Inhibition of KATP channels exacerbates the transient mismatch between muscle O2 delivery and utilization in CHF rats and this effect is opposed by PIN. These data reveal that the KATP channel constitutes one of the select few well-preserved mechanisms of skeletal muscle microvascular oxygenation control in CHF.

authors

Holdsworth CT,Ferguson SK,Colburn TD,Fees AJ,Craig JC,Hirai DM,Poole DC,Musch TI

doi

10.1016/j.resp.2017.01.009

subject

Has Abstract

pub_date

2017-04-01 00:00:00

pages

33-40

eissn

1569-9048

issn

1878-1519

pii

S1569-9048(16)30337-8

journal_volume

238

pub_type

杂志文章
  • Dynamics of oxygen uptake following exercise onset in rat skeletal muscle.

    abstract::Technical limitations have precluded measurement of the V(O(2)) profile within contracting muscle (mV(O(2))) and hence it is not known to what extent V(O(2)) dynamics measured across limbs in humans or muscles in the dog are influenced by transit delays between the muscle microvasculature and venous effluent. Measurem...

    journal_title:Respiratory physiology & neurobiology

    pub_type: 杂志文章

    doi:10.1016/s1569-9048(02)00183-0

    authors: Behnke BJ,Barstow TJ,Kindig CA,McDonough P,Musch TI,Poole DC

    更新日期:2002-11-19 00:00:00

  • Phrenic motor unit recruitment during ventilatory and non-ventilatory behaviors.

    abstract::Phrenic motoneurons are located in the cervical spinal cord and innervate the diaphragm muscle, the main inspiratory muscle in mammals. Similar to other skeletal muscles, phrenic motoneurons and diaphragm muscle fibers form motor units which are the final element of neuromotor control. In addition to their role in sus...

    journal_title:Respiratory physiology & neurobiology

    pub_type: 杂志文章,评审

    doi:10.1016/j.resp.2011.06.028

    authors: Mantilla CB,Sieck GC

    更新日期:2011-10-15 00:00:00

  • Modelling pulmonary blood flow.

    abstract::Computational model analysis has been used widely to understand and interpret complexity of interactions in the pulmonary system. Pulmonary blood transport is a multi-scale phenomenon that involves scale-dependent structure and function, therefore requiring different model assumptions for the microcirculation and the ...

    journal_title:Respiratory physiology & neurobiology

    pub_type: 杂志文章,评审

    doi:10.1016/j.resp.2008.02.016

    authors: Tawhai MH,Burrowes KS

    更新日期:2008-11-30 00:00:00

  • Comparisons of effects of intravenous and inhaled methacholine on airway physiology in a murine asthma model.

    abstract::Airway responses to intravenous (i.v.) and inhaled (i.h.) delivery of methacholine (MCh) in BALB/c and C57BL/6 mouse strains have been compared with and without ovalbumin (OVA)-induced airway inflammation. Bronchial reactivity to MCh was assessed in anaesthetised and tracheostomised animals by using an animal ventilat...

    journal_title:Respiratory physiology & neurobiology

    pub_type: 杂志文章

    doi:10.1016/j.resp.2008.12.005

    authors: Jonasson S,Hedenstierna G,Hedenström H,Hjoberg J

    更新日期:2009-02-28 00:00:00

  • Oral treatment with desipramine improves breathing and life span in Rett syndrome mouse model.

    abstract::Rett syndrome is a neurodevelopmental disease due to Mecp2 gene mutations that is associated to complex neurological symptoms, with bioaminergic deficits and life-threatening apneas related to sudden and unexpected death. In male mice, Mecp2-deficiency similarly induces medullary bioaminergic deficits, severe apneas a...

    journal_title:Respiratory physiology & neurobiology

    pub_type: 杂志文章

    doi:10.1016/j.resp.2007.08.009

    authors: Zanella S,Mebarek S,Lajard AM,Picard N,Dutschmann M,Hilaire G

    更新日期:2008-01-01 00:00:00

  • Sex differences in the respiratory-sympathetic coupling in rats exposed to chronic intermittent hypoxia.

    abstract::Obstructive sleep apnea (OSA) is a complex disease in which humans face episodes of intermittent hypoxia and it affects men and women. Patients with OSA present hypertension and sympathetic overactivity among several other dysfunctions. Therefore, one important question remains: are the autonomic dysfunctions associat...

    journal_title:Respiratory physiology & neurobiology

    pub_type: 杂志文章,评审

    doi:10.1016/j.resp.2017.09.003

    authors: Souza GMPR,Amorim MR,Moraes DJA,Machado BH

    更新日期:2018-10-01 00:00:00

  • Effects of mitochondrial poisons on glutathione redox potential and carotid body chemoreceptor activity.

    abstract::Low oxygen sensing in chemoreceptor cells involves the inhibition of specific plasma membrane K(+) channels, suggesting that mitochondria-derived reactive oxygen species (ROS) link hypoxia to K(+) channel inhibition, subsequent cell depolarization and activation of neurotransmitter release. We have used several mitoch...

    journal_title:Respiratory physiology & neurobiology

    pub_type: 杂志文章

    doi:10.1016/j.resp.2008.10.020

    authors: Gomez-Niño A,Agapito MT,Obeso A,Gonzalez C

    更新日期:2009-01-01 00:00:00

  • Effect of domperidone on ventilation and polycythemia after 5 weeks of chronic hypoxia in rats.

    abstract::Chronically hypoxic humans and some mammals have attenuated ventilatory responses, which have been associated with high dopamine level in carotid bodies. Alveolar hypoventilation and blunted ventilatory response have been recognized to be at the basis of Chronic Mountain Sickness by generating arterial hypoxemia and p...

    journal_title:Respiratory physiology & neurobiology

    pub_type: 杂志文章

    doi:10.1016/s1569-9048(03)00065-x

    authors: Gamboa J,Macarlupú JL,Rivera-Chira M,Monge-C C,León-Velarde F

    更新日期:2003-04-15 00:00:00

  • Morphometry and allometry of the postnatal lung development in the quokka wallaby (Setonix brachyurus): a light microscopic study.

    abstract::The postnatally developing lungs of the quokka wallaby, Setonix brachyurus, were investigated macroscopically and by light microscopic morphometry. Lung, parenchymal and non-parenchymal volumes as well as the components of the latter two were analysed by regression analysis. The lungs comprised a single undivided left...

    journal_title:Respiratory physiology & neurobiology

    pub_type: 杂志文章

    doi:10.1016/s1569-9048(02)00204-5

    authors: Makanya AN,Haenni B,Burri PH

    更新日期:2003-02-19 00:00:00

  • Ventilatory pattern and chemosensitivity in M1 and M3 muscarinic receptor knockout mice.

    abstract::Acetylcholine (ACh) acting through muscarinic receptors is thought to be involved in the control of breathing, notably in central and peripheral chemosensory afferents and in regulations related to sleep-wake states. By using whole-body plethysmography, we compared baseline breathing at rest and ventilatory responses ...

    journal_title:Respiratory physiology & neurobiology

    pub_type: 杂志文章

    doi:10.1016/j.resp.2003.10.006

    authors: Boudinot E,Yamada M,Wess J,Champagnat J,Foutz AS

    更新日期:2004-02-25 00:00:00

  • Multidimensional aspects of dyspnea in obese patients referred for cardiopulmonary exercise testing.

    abstract::We investigated the contributions of obesity on multidimensional aspects of dyspnea on exertion (DOE) in patients referred for clinical cardiopulmonary exercise testing (CPET). Ratings of perceived breathlessness (RPB, Borg scale 0-10) were collected in obese (BMI ≥ 30; n = 47) and nonobese (BMI ≤ 25; n = 27) patients...

    journal_title:Respiratory physiology & neurobiology

    pub_type: 杂志文章

    doi:10.1016/j.resp.2019.103365

    authors: Balmain BN,Weinstein K,Bernhardt V,Marines-Price R,Tomlinson AR,Babb TG

    更新日期:2020-03-01 00:00:00

  • Carbon monoxide (CO) and hydrogen sulfide (H(2)S) in hypoxic sensing by the carotid body.

    abstract::Carotid bodies are sensory organs for monitoring arterial blood oxygen (O(2)) levels, and the ensuing reflexes maintain cardio-respiratory homeostasis during hypoxia. This article provides a brief update of the role of carbon monoxide (CO) and hydrogen sulfide (H(2)S) in hypoxic sensing by the carotid body. Glomus cel...

    journal_title:Respiratory physiology & neurobiology

    pub_type: 杂志文章,评审

    doi:10.1016/j.resp.2012.05.022

    authors: Prabhakar NR

    更新日期:2012-11-15 00:00:00

  • Neutrophils in asthma--a review.

    abstract::Asthma is a chronic inflammatory disease, with an array of cells involved in the pathogenesis of the disease. The role of neutrophils in the development of bronchial asthma is found to be complex, as they may trigger activation of immunocompetent cells and are a potent source of free oxygen radicals and enzymes partic...

    journal_title:Respiratory physiology & neurobiology

    pub_type: 杂志文章,评审

    doi:10.1016/j.resp.2014.12.004

    authors: Ciepiela O,Ostafin M,Demkow U

    更新日期:2015-04-01 00:00:00

  • Effects of five nights of normobaric hypoxia on the ventilatory responses to acute hypoxia and hypercapnia.

    abstract::This study examined the effects of five nights of normobaric hypoxia on ventilatory responses to acute isocapnic hypoxia (AHVR) and hyperoxic hypercapnia (AHCVR). Twelve male subjects (26.6 +/- 4.1 years, standard deviation (S.D.)) slept 8-9 h per day overnight for 5 consecutive days at a simulated altitude of 4,300 m...

    journal_title:Respiratory physiology & neurobiology

    pub_type: 杂志文章

    doi:10.1016/s1569-9048(03)00190-3

    authors: Ainslie PN,Kolb JC,Ide K,Poulin MJ

    更新日期:2003-11-14 00:00:00

  • Acute and chronic responses of the upper airway to inspiratory loading in healthy awake humans: an MRI study.

    abstract::We assessed upper airway responses to acute and chronic inspiratory loading. In Experiment I, 11 healthy subjects underwent T(2)-weighted magnetic resonance imaging (MRI) of upper airway dilator muscles (genioglossus and geniohyoid) before and up to 10 min after a single bout of pressure threshold inspiratory muscle t...

    journal_title:Respiratory physiology & neurobiology

    pub_type: 临床试验,杂志文章

    doi:10.1016/j.resp.2007.01.008

    authors: How SC,McConnell AK,Taylor BJ,Romer LM

    更新日期:2007-08-01 00:00:00

  • The contribution of the pulmonary microvascular pressure in the maintenance of an open lung during mechanical ventilation.

    abstract::Changes in pulmonary hemodynamics modify the mechanical properties of the lungs. The effects of alterations in pulmonary capillary pressure (Pc) were investigated on the airway and lung tissue mechanics during positive-pressure ventilation and following lung recruitment maneuvers. Isolated, mechanically normoventilate...

    journal_title:Respiratory physiology & neurobiology

    pub_type: 杂志文章

    doi:10.1016/j.resp.2006.12.004

    authors: Albu G,Habre W,Fontao F,Morel DR,Petak F

    更新日期:2007-08-01 00:00:00

  • Arrest of 5HT neuron differentiation delays respiratory maturation and impairs neonatal homeostatic responses to environmental challenges.

    abstract::Serotonin (5HT) is a powerful modulator of respiratory circuitry in vitro but its role in the development of breathing behavior in vivo is poorly understood. Here we show, using 5HT neuron-deficient Pet-1 (Pet-1(-/-)) neonates, that serotonergic function is required for the normal timing of postnatal respiratory matur...

    journal_title:Respiratory physiology & neurobiology

    pub_type: 杂志文章

    doi:10.1016/j.resp.2007.06.002

    authors: Erickson JT,Shafer G,Rossetti MD,Wilson CG,Deneris ES

    更新日期:2007-10-15 00:00:00

  • Central histamine contributes to the inspiratory off-switch mechanism via H1 receptors in mice.

    abstract::Central histaminergic neurons are distributed in areas of the medulla and pons concerned with respiratory rhythm generation, but their effects on breathing pattern are unknown. We examined breathing pattern during hypercapnic responses in wild type (WT) and H1 receptor knockout (H1RKO) mice at 9-10 weeks of age before...

    journal_title:Respiratory physiology & neurobiology

    pub_type: 杂志文章

    doi:10.1016/j.resp.2004.07.016

    authors: Miyamoto K,Iwase M,Kimura H,Homma I

    更新日期:2004-11-30 00:00:00

  • Development of ventilatory chemoreflexes in Coturnix quail chicks.

    abstract::Compared to mammals, little is known about the development of the respiratory control system in birds. In the present study, ventilation and metabolism were measured in Coturnix quail chicks exposed to room air, hypoxia (11 % O2), and hypercapnia (4% CO2) at 0-1, 3-4, and 6-7 days posthatching (dph). Mass-specific ven...

    journal_title:Respiratory physiology & neurobiology

    pub_type: 杂志文章

    doi:10.1016/j.resp.2020.103411

    authors: Song MJ,Pratt AE,Bavis RW

    更新日期:2020-05-01 00:00:00

  • Morphological differences of the carotid body among C57/BL6 (B6), A/J, and CSS B6A1 mouse strains.

    abstract::The C57/BL6 (B6) mouse strain exhibits post-hypoxic frequency decline and periodic breathing, as well as greater amount of irregular breathing during rest in comparison to the A/J and to the B6a1, a chromosomal substitution strain whereby the A/J chromosome 1 is bred onto the B6 background (Han et al., 2002; Yamauchi ...

    journal_title:Respiratory physiology & neurobiology

    pub_type: 杂志文章

    doi:10.1016/j.resp.2011.04.021

    authors: Chai S,Gillombardo CB,Donovan L,Strohl KP

    更新日期:2011-08-15 00:00:00

  • Evolution of bubbles from gas micronuclei formed on the luminal aspect of ovine large blood vessels.

    abstract::It has been shown that tiny gas nanobubbles form spontaneously on a smooth hydrophobic surface submerged in water. These nanobubbles were shown to be the source of gas micronuclei from which bubbles evolved during decompression of silicon wafers. We suggest that the hydrophobic inner surface of blood vessels may be a ...

    journal_title:Respiratory physiology & neurobiology

    pub_type: 杂志文章

    doi:10.1016/j.resp.2013.04.013

    authors: Arieli R,Marmur A

    更新日期:2013-08-01 00:00:00

  • Does menstrual cycle phase affect lung diffusion capacity during exercise?

    abstract::Resting lung diffusing capacity (DLCO) decreases during the early and late-follicular phases of the menstrual cycle presumably due to capillary blood volume (VC) changes; however, it is not known if these differences exist during exercise. We hypothesized that DLCO would increase during the mid-luteal phase of the men...

    journal_title:Respiratory physiology & neurobiology

    pub_type: 杂志文章

    doi:10.1016/j.resp.2014.10.014

    authors: Smith JR,Brown KR,Murphy JD,Harms CA

    更新日期:2015-01-01 00:00:00

  • Allergen-induced asthma in C57Bl/6 mice: hyper-responsiveness, inflammation and remodelling.

    abstract::The relationship among airway responsiveness, inflammation and remodelling in asthma is incompletely understood. To investigate potential mechanistic associations, allergen-induced asthma was studied in C57Bl/6 mice. Mice were sensitized and challenged with ovalbumin (OVA) using sub-acute (SA) or chronic (C) protocols...

    journal_title:Respiratory physiology & neurobiology

    pub_type: 杂志文章

    doi:10.1016/j.resp.2009.08.005

    authors: Pinelli V,Marchica CL,Ludwig MS

    更新日期:2009-10-31 00:00:00

  • Orexin A activates retrotrapezoid neurons in mice.

    abstract::The retrotrapezoid nucleus (RTN), located at the ventral surface of the medulla oblongata, contains glutamatergic Phox2b-expressing interneurons that have central respiratory chemoreceptor properties. RTN also operates as a relay for hypothalamic pathways that regulate breathing, one of which probably originates from ...

    journal_title:Respiratory physiology & neurobiology

    pub_type: 杂志文章

    doi:10.1016/j.resp.2010.12.003

    authors: Lazarenko RM,Stornetta RL,Bayliss DA,Guyenet PG

    更新日期:2011-02-15 00:00:00

  • Amelioration of allergic asthma by Ziziphora clinopodioides via upregulation of aquaporins and downregulation of IL4 and IL5.

    abstract::Ziziphora clinopodioides has been frequently used as an anti asthmatic plant in traditional medication. Recent work explores the anti-asthmatic activity of Z. clinopodioides in allergen-induced asthmatic mice. Intraperitoneal sensitization followed by intranasal challenge were given with ovalbumin (allergen) to develo...

    journal_title:Respiratory physiology & neurobiology

    pub_type: 杂志文章

    doi:10.1016/j.resp.2019.04.005

    authors: Ahsan F,Shabbir A,Shahzad M,Mobashar A,Sharif M,Basheer MI,Tareen RB,Syed NI

    更新日期:2019-08-01 00:00:00

  • Respiratory responses to olfactory stimuli in Parkinson's disease.

    abstract::There are many reports of olfactory impairment in patients with Parkinson's disease (PD) and the impairment can be observed before the appearance of typical PD symptom. Accordingly, olfactory screening tests may predict disease onset and indicates a need for early treatment before classic signs of the disease. Olfacti...

    journal_title:Respiratory physiology & neurobiology

    pub_type: 杂志文章

    doi:10.1016/j.resp.2008.01.003

    authors: Masaoka Y,Satoh H,Kawamura M,Homma I

    更新日期:2008-04-30 00:00:00

  • The locus coeruleus and central chemosensitivity.

    abstract::The locus coeruleus (LC) lies in the dorsal pons and supplies noradrenergic (NA) input to many regions of the brain, including respiratory control areas. The LC may provide tonic input for basal respiratory drive and is involved in central chemosensitivity since focal acidosis of the region stimulates ventilation and ...

    journal_title:Respiratory physiology & neurobiology

    pub_type: 杂志文章,评审

    doi:10.1016/j.resp.2010.04.024

    authors: Gargaglioni LH,Hartzler LK,Putnam RW

    更新日期:2010-10-31 00:00:00

  • Epidemiological and immunological reasons for pertussis vaccination in adolescents and adults.

    abstract::The resurgence of pertussis has been the subject of considerable debate. Hypotheses to explain increased reporting in developed countries have focused mainly on three aspects: (1) increased recognition of the disease in adolescents and adults; (2) waning of vaccine-induced immunity and (3) loss of vaccine efficacy due...

    journal_title:Respiratory physiology & neurobiology

    pub_type: 杂志文章,评审

    doi:10.1016/j.resp.2013.02.007

    authors: Nitsch-Osuch A,Korzeniewski K,Kuchar E,Zielonka T,Życińska K,Wardyn K

    更新日期:2013-06-01 00:00:00

  • Impact of short term forced oral breathing induced by nasal occlusion on respiratory function in mice.

    abstract::Inconsistent findings regarding the experimental nasal obstruction on respiratory functions in small animals have been reported. The purpose of this study was to investigate the impact of short term forced oral breathing on respiratory functions as well as the therapeutic implication of esophageal intubation in BALB/c...

    journal_title:Respiratory physiology & neurobiology

    pub_type: 杂志文章

    doi:10.1016/j.resp.2014.09.024

    authors: Xie J,Xi Y,Zhang Q,Lai K,Zhong N

    更新日期:2015-01-01 00:00:00

  • Absence of mutations in HCRT, HCRTR1 and HCRTR2 in patients with ROHHAD.

    abstract:BACKGROUND AND OBJECTIVES:Rapid-onset obesity with hypothalamic dysfunction, hypoventilation, and autonomic dysregulation (ROHHAD) is a rare pediatric disease of unknown cause. Here, in response to a recent case report describing a ROHHAD patient who suffered from secondary narcolepsy confirmed by an absence of hypocre...

    journal_title:Respiratory physiology & neurobiology

    pub_type: 杂志文章

    doi:10.1016/j.resp.2015.11.002

    authors: Barclay SF,Rand CM,Gray PA,Gibson WT,Wilson RJ,Berry-Kravis EM,Ize-Ludlow D,Bech-Hansen NT,Weese-Mayer DE

    更新日期:2016-01-15 00:00:00