Abstract：
:Pulmonary ventilation (V̇I) in awake and sleeping goats does not change when antagonists to several excitatory G protein-coupled receptors are dialyzed unilaterally into the ventral respiratory column (VRC). Concomitant changes in excitatory neuromodulators in the effluent mock cerebral spinal fluid (mCSF) suggest neuromodulatory compensation. Herein, we studied neuromodulatory compensation during dialysis of agonists to inhibitory G protein-coupled or ionotropic receptors into the VRC. Microtubules were implanted into the VRC of goats for dialysis of mCSF mixed with agonists to either μ-opioid (DAMGO) or GABAA (muscimol) receptors. We found: (1) V̇I decreased during unilateral but increased during bilateral dialysis of DAMGO, (2) dialyses of DAMGO destabilized breathing, (3) unilateral dialysis of muscimol increased V̇I, and (4) dialysis of DAMGO decreased GABA in the effluent mCSF. We conclude: (1) neuromodulatory compensation can occur during altered inhibitory neuromodulator receptor activity, and (2) the mechanism of compensation differs between G protein-coupled excitatory and inhibitory receptors and between G protein-coupled and inotropic inhibitory receptors.
journal_name
Respir Physiol Neurobioljournal_title
Respiratory physiology & neurobiologyauthors
Langer TM 3rd,Neumueller SE,Crumley E,Burgraff NJ,Talwar S,Hodges MR,Pan L,Forster HVdoi
10.1016/j.resp.2017.01.007subject
Has Abstractpub_date
2017-05-01 00:00:00pages
10-25eissn
1569-9048issn
1878-1519pii
S1569-9048(16)30161-6journal_volume
239pub_type
杂志文章abstract：:This project aimed to investigate the direction of artificial sputum movement during mechanical ventilation (MV) and bagging (MH) using a tube model. Three solutions of artificial sputum (ultrasonic gel, viscosity 100, 200 and 300 poise (P)) were prepared. About 1 ml of gel was placed in a glass tube connected to a te...
journal_title：Respiratory physiology & neurobiology
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doi：10.1016/s1569-9048(02)00071-x
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pub_type： 杂志文章
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journal_title：Respiratory physiology & neurobiology
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abstract：:This special issue of Respiratory Physiology and Neurobiology surveys a broad range of topics focused on the neurochemical control of breathing. A variety of approaches have integrated the neurochemistry of breathing with the physiology of individual neurons, with the neuroanatomy of brainstem and forebrain respirator...
journal_title：Respiratory physiology & neurobiology
pub_type： 社论
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journal_title：Respiratory physiology & neurobiology
pub_type： 临床试验,杂志文章
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abstract：:We tested the hypotheses that: (1) carotid body size can be measured by computed tomographic angiography (CTA) with high inter-observer agreement, and (2) patients with sleep apnea exhibit larger carotid bodies than those without sleep apnea. A chart review was conducted from patients who underwent neck CTA and polyso...
journal_title：Respiratory physiology & neurobiology
pub_type： 杂志文章
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journal_title：Respiratory physiology & neurobiology
pub_type： 杂志文章,评审
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journal_title：Respiratory physiology & neurobiology
pub_type： 杂志文章
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journal_title：Respiratory physiology & neurobiology
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journal_title：Respiratory physiology & neurobiology
pub_type： 杂志文章
doi：10.1016/j.resp.2007.12.003
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pub_type： 杂志文章
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journal_title：Respiratory physiology & neurobiology
pub_type： 杂志文章
doi：10.1016/j.resp.2004.09.005
更新日期：2005-02-15 00:00:00
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journal_title：Respiratory physiology & neurobiology
pub_type： 杂志文章
doi：10.1016/j.resp.2009.08.010
更新日期：2009-10-31 00:00:00
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journal_title：Respiratory physiology & neurobiology
pub_type： 杂志文章
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journal_title：Respiratory physiology & neurobiology
pub_type： 杂志文章,评审
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更新日期：2009-11-30 00:00:00
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journal_title：Respiratory physiology & neurobiology
pub_type： 杂志文章,评审
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journal_title：Respiratory physiology & neurobiology
pub_type： 杂志文章
doi：10.1016/j.resp.2007.10.010
更新日期：2008-02-29 00:00:00
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journal_title：Respiratory physiology & neurobiology
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journal_title：Respiratory physiology & neurobiology
pub_type： 杂志文章
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journal_title：Respiratory physiology & neurobiology
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journal_title：Respiratory physiology & neurobiology
pub_type： 杂志文章
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abstract：:The sensitization of cough reflex observed in patients with gastroesophageal reflux disease (GERD) is attributed to activation of vagal C-fibers innervating the esophagus by acid, while the heartburn in GERD is mediated by esophageal acid sensitive C-fibers derived from (dorsal root ganglia) DRG. Here we explored the ...
journal_title：Respiratory physiology & neurobiology
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更新日期：2018-11-01 00:00:00
