Abstract：
:This article constitutes a review of the studies performed by the group of the late A. Guz and other authors on the subjects of lung reflexes and perceptions of respiration. The experimental data suggest that the lung inflation and deflation reflexes are present in man, mediated by large myelinated afferent nerve fibres in the vagus nerves, but that the inflation reflex is weaker than in animals, possibly due to central neuronal inhibition. The authors of animal results on the deflation reflex differ as to the afferent fibres involved in the vagi, but it is argued, on the basis of the data, that the preferred hypothesis is that increased activity of the large myelinated mediates the inflation reflex, and decreased activity in these same fibres mediates the deflation reflex. Smaller myelinated fibres are thought to mediate cough and increased breathing in response to airway irritation, while small non-myelinated C fibres mediate hyperpnoea in response to parenchymal congestion and various disease states. The unpleasant sensation at the break point of breath-holding is not chemically mediated but may depend on a complex response involving vagal afferent, phrenic efferent and phrenic afferent pathways. Other experiments in humans on perception of various unpleasant respiratory sensations are discussed with unclear conclusions.
journal_name
Respir Physiol Neurobioljournal_title
Respiratory physiology & neurobiologyauthors
Noble MIdoi
10.1016/j.resp.2015.06.005subject
Has Abstractpub_date
2015-10-01 00:00:00pages
46-53eissn
1569-9048issn
1878-1519pii
S1569-9048(15)30007-0journal_volume
217pub_type
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journal_title：Respiratory physiology & neurobiology
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journal_title：Respiratory physiology & neurobiology
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journal_title：Respiratory physiology & neurobiology
pub_type： 杂志文章
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更新日期：2004-07-20 00:00:00
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journal_title：Respiratory physiology & neurobiology
pub_type： 杂志文章,评审
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pub_type： 杂志文章
doi：10.1016/s1569-9048(02)00149-0
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journal_title：Respiratory physiology & neurobiology
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pub_type： 杂志文章
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journal_title：Respiratory physiology & neurobiology
pub_type： 杂志文章,评审
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pub_type： 临床试验,杂志文章
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更新日期：2004-06-25 00:00:00
abstract：:Lower thoracic spinal cord stimulation (SCS) results in the generation of large positive airway pressures. The potential effects of diaphragm co-activation during SCS were investigated in 10 anesthetized dogs. Diaphragm compound action potentials (CMAPs) were present during SCS at the T10 and T12 levels. In group 1, a...
journal_title：Respiratory physiology & neurobiology
pub_type： 杂志文章
doi：10.1016/j.resp.2007.06.007
更新日期：2007-10-15 00:00:00
abstract：BACKGROUND:Aquaporin 5 (AQP5) is widely expressed in various organ and tissues. In light of the novel oncogenic properties of aquaporins (AQPs), here we investigated the effect of AQP5 knockdown by RNAi on transmembrane osmotic water permeability, cell migration potential and cell volume regulation ability. METHODS:AQ...
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pub_type： 杂志文章
doi：10.1016/j.resp.2011.02.001
更新日期：2011-05-31 00:00:00
