Abstract：
:The lung surfactant dipalmitoylphosphatidylcholine (DPPC) most probably leaks into the blood, settling on the luminal aspect of blood vessels to create active hydrophobic spots (AHS). Nanobubbles are formed at these spots from dissolved gas. We hypothesized that when a large molecule in the blood comes into contact with a nanobubble at the AHS, its tertiary structure is disrupted. An epitope not previously having undergone thymus education may then prompt an autoimmune response. There are thus two independent processes which may share the blame for autoimmune disease: spillage of large molecules into the blood, and the creation of AHS. DPPC was measured in 10 diabetes type 1 patients and 10 control subjects. DPPC in the diabetic group was 4.63 ± 0.68 μg/mL, non-significantly higher than in the control group (4.23 ± 0.94 μg/mL). However, in the diabetic group, DPPC was high when the samples were taken within 1.5 years of disease onset. This is closer to the time of AHS production, which takes place ahead of the disease. Further investigation, with sampling for DPPC as soon as possible after onset of the disease, may provide additional support for our hypothesis. If proved true, this may open up considerable therapeutic potential.
journal_name
Respir Physiol Neurobioljournal_title
Respiratory physiology & neurobiologyauthors
Arieli R,Khatib S,Khattib A,Bukovetzky E,Gottfried ODdoi
10.1016/j.resp.2020.103615subject
Has Abstractpub_date
2021-01-06 00:00:00pages
103615eissn
1569-9048issn
1878-1519pii
S1569-9048(20)30274-3journal_volume
286pub_type
杂志文章abstract：:Obstructive sleep apnea (OSA) is a complex disease in which humans face episodes of intermittent hypoxia and it affects men and women. Patients with OSA present hypertension and sympathetic overactivity among several other dysfunctions. Therefore, one important question remains: are the autonomic dysfunctions associat...
journal_title：Respiratory physiology & neurobiology
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journal_title：Respiratory physiology & neurobiology
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journal_title：Respiratory physiology & neurobiology
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journal_title：Respiratory physiology & neurobiology
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journal_title：Respiratory physiology & neurobiology
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journal_title：Respiratory physiology & neurobiology
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journal_title：Respiratory physiology & neurobiology
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journal_title：Respiratory physiology & neurobiology
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journal_title：Respiratory physiology & neurobiology
pub_type： 杂志文章,评审
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journal_title：Respiratory physiology & neurobiology
pub_type： 杂志文章
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journal_title：Respiratory physiology & neurobiology
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journal_title：Respiratory physiology & neurobiology
pub_type： 杂志文章,评审
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journal_title：Respiratory physiology & neurobiology
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更新日期：2017-05-01 00:00:00
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journal_title：Respiratory physiology & neurobiology
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doi：10.1016/j.resp.2007.08.009
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journal_title：Respiratory physiology & neurobiology
pub_type： 杂志文章,随机对照试验
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journal_title：Respiratory physiology & neurobiology
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journal_title：Respiratory physiology & neurobiology
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pub_type： 杂志文章
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journal_title：Respiratory physiology & neurobiology
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journal_title：Respiratory physiology & neurobiology
pub_type： 杂志文章
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journal_title：Respiratory physiology & neurobiology
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journal_title：Respiratory physiology & neurobiology
pub_type： 杂志文章
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更新日期：2018-01-01 00:00:00
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journal_title：Respiratory physiology & neurobiology
pub_type： 杂志文章,评审
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journal_title：Respiratory physiology & neurobiology
pub_type： 杂志文章,评审
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