Endogenous glutamatergic inputs to the Parabrachial Nucleus/Kölliker-Fuse Complex determine respiratory rate.

Abstract:

:The Kölliker-Fuse Nucleus (KF) has been widely investigated for its contribution to "inspiratory off-switch" while more recent studies showed that activation of the Parabrachial Nucleus (PBN) shortened expiratory duration. This study used an adult, in vivo, decerebrate rabbit model to delineate the contribution of each site to inspiratory and expiratory duration through sequential block of glutamatergic excitation with the receptor antagonists 2,3-dihydroxy-6-nitro-7-sulfamoyl-benzo[f]quinoxaline-2,3-dione (NBQX) and d(-)-2-amino-5-phosphonopentanoic acid (AP5). Glutamatergic disfacilitation caused large increases in inspiratory and expiratory duration and minor decrease in peak phrenic activity (PPA). Hypoxia only partially reversed respiratory rate depression but PPA was increased to >200 % of control. The contribution of PBN activity to inspiratory and expiratory duration was equal while block of the KF affected inspiratory duration more than expiratory. We conclude that in the in vivo preparation respiratory rate greatly depends on PBN/KF activity, which contributes to the "inspiratory on- "and "off-switch", but is of minor importance for the magnitude of phrenic motor output.

authors

Navarrete-Opazo AA,Cook-Snyder DR,Miller JR,Callison JJ,McCarthy N,Palkovic B,Stuth EAE,Zuperku EJ,Stucke AG

doi

10.1016/j.resp.2020.103401

subject

Has Abstract

pub_date

2020-06-01 00:00:00

pages

103401

eissn

1569-9048

issn

1878-1519

pii

S1569-9048(19)30400-8

journal_volume

277

pub_type

杂志文章
  • Evolution of bubbles from gas micronuclei formed on the luminal aspect of ovine large blood vessels.

    abstract::It has been shown that tiny gas nanobubbles form spontaneously on a smooth hydrophobic surface submerged in water. These nanobubbles were shown to be the source of gas micronuclei from which bubbles evolved during decompression of silicon wafers. We suggest that the hydrophobic inner surface of blood vessels may be a ...

    journal_title:Respiratory physiology & neurobiology

    pub_type: 杂志文章

    doi:10.1016/j.resp.2013.04.013

    authors: Arieli R,Marmur A

    更新日期:2013-08-01 00:00:00

  • How does lobeline injected intravenously produce a cough?

    abstract::In order to examine, whether the lobeline-induced cough is a true reflex or a voluntary effort to get rid of its irritating sensations in the upper respiratory tract, we systematically studied the cough response to lobeline, of subjects who were unable to make conscious discriminations i.e. were either comatose (n=4) ...

    journal_title:Respiratory physiology & neurobiology

    pub_type: 临床试验,杂志文章

    doi:10.1016/j.resp.2004.09.001

    authors: Raj H,Bakshi GS,Tiwari RR,Anand A,Paintal AS

    更新日期:2005-01-15 00:00:00

  • Central histamine contributes to the inspiratory off-switch mechanism via H1 receptors in mice.

    abstract::Central histaminergic neurons are distributed in areas of the medulla and pons concerned with respiratory rhythm generation, but their effects on breathing pattern are unknown. We examined breathing pattern during hypercapnic responses in wild type (WT) and H1 receptor knockout (H1RKO) mice at 9-10 weeks of age before...

    journal_title:Respiratory physiology & neurobiology

    pub_type: 杂志文章

    doi:10.1016/j.resp.2004.07.016

    authors: Miyamoto K,Iwase M,Kimura H,Homma I

    更新日期:2004-11-30 00:00:00

  • Allergen-induced asthma in C57Bl/6 mice: hyper-responsiveness, inflammation and remodelling.

    abstract::The relationship among airway responsiveness, inflammation and remodelling in asthma is incompletely understood. To investigate potential mechanistic associations, allergen-induced asthma was studied in C57Bl/6 mice. Mice were sensitized and challenged with ovalbumin (OVA) using sub-acute (SA) or chronic (C) protocols...

    journal_title:Respiratory physiology & neurobiology

    pub_type: 杂志文章

    doi:10.1016/j.resp.2009.08.005

    authors: Pinelli V,Marchica CL,Ludwig MS

    更新日期:2009-10-31 00:00:00

  • Systemic inflammation impairs respiratory chemoreflexes and plasticity.

    abstract::Many lung and central nervous system disorders require robust and appropriate physiological responses to assure adequate breathing. Factors undermining the efficacy of ventilatory control will diminish the ability to compensate for pathology, threatening life itself. Although most of these same disorders are associate...

    journal_title:Respiratory physiology & neurobiology

    pub_type: 杂志文章,评审

    doi:10.1016/j.resp.2011.06.017

    authors: Huxtable AG,Vinit S,Windelborn JA,Crader SM,Guenther CH,Watters JJ,Mitchell GS

    更新日期:2011-09-30 00:00:00

  • Glucocorticoids inhibits the repair of airway epithelial cells via the activation of wnt pathway.

    abstract:BACKGROUND:The purpose of this study was to explore the effect of Wnt pathway on the inhibition of airway epithelial cells repair by glucocorticoid. MATERIALS AND METHODS:The expression of E-cadherin in asthma mice model was detected by immunocytochemistry. XAV939 was used to treat 16HBE, and the expressions of relate...

    journal_title:Respiratory physiology & neurobiology

    pub_type: 杂志文章

    doi:10.1016/j.resp.2019.103283

    authors: Yu Z,Jiang Y,Sun C

    更新日期:2020-01-01 00:00:00

  • Interaction of tobacco smoke exposure and ovalbumin-sensitization promotes goblet cell and submucosal gland metaplasia in guinea pigs.

    abstract::Exposure to irritants such as tobacco smoke (TS) causes acute airway inflammation. Chronic exposure may cause airway remodeling contributing to enhanced airway resistance. We hypothesize that combining airway sensitization and inhalation of irritants enhances the number of mucous producing cells beyond either agent al...

    journal_title:Respiratory physiology & neurobiology

    pub_type: 杂志文章

    doi:10.1016/j.resp.2013.07.019

    authors: Pavuluri S,Hanus V,Bergren DR

    更新日期:2013-12-01 00:00:00

  • Prenatal development of the pulmonary surfactant system and the influence of hypoxia.

    abstract::Pulmonary surfactant fulfils diverse functions at the lung air-liquid interface of all air-breathing vertebrates. Neurohormonal regulation of surfactant synthesis and secretion is highly conserved among non-mammalian amniotes. Although the pattern of surfactant lipid maturation is similar among species, the onset and ...

    journal_title:Respiratory physiology & neurobiology

    pub_type: 杂志文章,评审

    doi:10.1016/j.resp.2011.05.015

    authors: Orgeig S,Morrison JL,Daniels CB

    更新日期:2011-08-31 00:00:00

  • Comparisons of effects of intravenous and inhaled methacholine on airway physiology in a murine asthma model.

    abstract::Airway responses to intravenous (i.v.) and inhaled (i.h.) delivery of methacholine (MCh) in BALB/c and C57BL/6 mouse strains have been compared with and without ovalbumin (OVA)-induced airway inflammation. Bronchial reactivity to MCh was assessed in anaesthetised and tracheostomised animals by using an animal ventilat...

    journal_title:Respiratory physiology & neurobiology

    pub_type: 杂志文章

    doi:10.1016/j.resp.2008.12.005

    authors: Jonasson S,Hedenstierna G,Hedenström H,Hjoberg J

    更新日期:2009-02-28 00:00:00

  • Dynamic pulmonary hyperinflation occurs without expiratory flow limitation in chronic heart failure during exercise.

    abstract::To assess the occurrence of tidal expiratory flow limitation (EFL) and/or dynamic pulmonary hyperinflation (DH) in chronic heart failure (CHF) during exercise 15 patients with stable systolic CHF, aged 69 ± 6yr, underwent pulmonary function testing and incremental cardio-pulmonary exercise testing. They subsequently p...

    journal_title:Respiratory physiology & neurobiology

    pub_type: 杂志文章

    doi:10.1016/j.resp.2013.06.017

    authors: Chiari S,Torregiani C,Boni E,Bassini S,Vizzardi E,Tantucci C

    更新日期:2013-10-01 00:00:00

  • Inflammatory and immunomodulatory mechanisms in the carotid body.

    abstract::Evidence is available about the role of inflammatory/immunological factors in the physiology and plasticity of the carotid body, with potential clinical implications in obstructive sleep apnea syndrome and sudden infant death syndrome. In humans, lymphomonocytic aggregations (chronic carotid glomitis) have been report...

    journal_title:Respiratory physiology & neurobiology

    pub_type: 杂志文章,评审

    doi:10.1016/j.resp.2013.02.017

    authors: Porzionato A,Macchi V,De Caro R,Di Giulio C

    更新日期:2013-06-01 00:00:00

  • Prelimbic prefrontal cortex mediates respiratory responses to mild and potent prolonged, but not brief, stressors.

    abstract::The prefrontal cortex is one of the key areas of the central mechanism of cardiovascular and respiratory control. Disinhibition of the prelimbic medial prefrontal cortex elicits tachypnoeic responses in anesthetized rats (Hassan et al., J. Physiol. 591: 6069-6088, 2013). The current study examines the effects of inhib...

    journal_title:Respiratory physiology & neurobiology

    pub_type: 杂志文章

    doi:10.1016/j.resp.2014.07.009

    authors: Bondarenko E,Hodgson DM,Nalivaiko E

    更新日期:2014-12-01 00:00:00

  • Effect of hypoxia on expiratory muscle activity in fetal sheep.

    abstract::The fetal respiratory response to acute hypoxia is characterized by depression, often to apnea. This study examined the effect of hypoxia on the electromyogram (EMG) of the thyroarytenoid (TA) muscle. Under anesthesia catheters were placed in the fetal sheep carotid artery, fourth cerebral ventricle, trachea and amnio...

    journal_title:Respiratory physiology & neurobiology

    pub_type: 杂志文章

    doi:10.1016/j.resp.2010.03.003

    authors: Bissonnette JM,Hohimer AR,Knopp SJ

    更新日期:2010-04-30 00:00:00

  • Studying respiratory rhythm generation in a developing bird: Hatching a new experimental model using the classic in vitro brainstem-spinal cord preparation.

    abstract::It has been more than thirty years since the in vitro brainstem-spinal cord preparation was first presented as a method to study automatic breathing behaviors in the neonatal rat. This straightforward preparation has led to an incredible burst of information about the location and coordination of several spontaneously...

    journal_title:Respiratory physiology & neurobiology

    pub_type: 杂志文章

    doi:10.1016/j.resp.2015.08.007

    authors: Vincen-Brown MA,Whitesitt KC,Quick FG,Pilarski JQ

    更新日期:2016-04-01 00:00:00

  • The role of BIM-EL and BCL2-α on the efficacy of erlotinib and gefitinib in lung cancer.

    abstract::Tyrosine kinase inhibitors (TKI), erlotinib and gefitinib are small molecule inhibitors which are used for the treatment of lung cancer. But, the development of drug resistance has been reported as one of the major setbacks in oncology. This study focused on the mechanisms leading to secondary resistance by assessing ...

    journal_title:Respiratory physiology & neurobiology

    pub_type: 杂志文章

    doi:10.1016/j.resp.2014.09.022

    authors: Simasi J,Oelkrug C,Schubert A,Nieber K,Gillissen A

    更新日期:2015-04-01 00:00:00

  • Reflex inhibition of human inspiratory muscles in response to contralateral phrenic nerve stimulation.

    abstract::In animals, high-intensity unilateral stimulation of the phrenic nerve results in short-latency inhibition of phrenic and intercostal nerve activity bilaterally. This study provides the first demonstration in human subjects of a short-latency inhibitory response in the contralateral scalene, parasternal intercostal an...

    journal_title:Respiratory physiology & neurobiology

    pub_type: 临床试验,杂志文章

    doi:10.1016/s1569-9048(03)00161-7

    authors: Butler JE,McKenzie DK,Gandevia SC

    更新日期:2003-10-16 00:00:00

  • The sensing of respiratory gases in fish: Mechanisms and signalling pathways.

    abstract::Chemoreception in fish is critical for sensing changes in the chemical composition of the external and internal environments and is often the first step in a cascade of events leading to cardiorespiratory and metabolic adjustments. Of paramount importance is the ability to sense changes in the levels of the three resp...

    journal_title:Respiratory physiology & neurobiology

    pub_type: 杂志文章,评审

    doi:10.1016/j.resp.2015.06.007

    authors: Perry SF,Tzaneva V

    更新日期:2016-04-01 00:00:00

  • Blood gases and cardiovascular shunt in the South American lungfish (Lepidosiren paradoxa) during normoxia and hyperoxia.

    abstract::The South American lungfish (Lepidosiren paradoxa) has an arterial P(O(2)) (Pa(O(2))) as high as 70-100 mmHg, corresponding to Hb-O(2) saturations from 90% to 95%, which indicates a moderate cardiovascular right to left (R-L) shunt. In hyperoxia (50% O(2)), we studied animals in: (1) aerated water combined with aerial...

    journal_title:Respiratory physiology & neurobiology

    pub_type: 杂志文章

    doi:10.1016/j.resp.2010.06.004

    authors: Bassi M,Giusti H,da Silva GS,Amin-Naves J,Glass ML

    更新日期:2010-08-31 00:00:00

  • Respiratory pathology in the Optn-/- mouse model of Amyotrophic Lateral Sclerosis.

    abstract::Amyotrophic Lateral Sclerosis (ALS) is a devastating neurodegenerative disorder that results in death due to respiratory failure. Many genetic defects are associated with ALS; one such defect is a mutation in the gene encoding optineurin (OPTN). Using an optineurin null mouse (Optn-/-), we sought to characterize the i...

    journal_title:Respiratory physiology & neurobiology

    pub_type: 杂志文章

    doi:10.1016/j.resp.2020.103525

    authors: McCall AL,Dhindsa JS,Pucci LA,Kahn AF,Fusco AF,Biswas DD,Strickland LM,Tseng HC,ElMallah MK

    更新日期:2020-11-01 00:00:00

  • Arrest of 5HT neuron differentiation delays respiratory maturation and impairs neonatal homeostatic responses to environmental challenges.

    abstract::Serotonin (5HT) is a powerful modulator of respiratory circuitry in vitro but its role in the development of breathing behavior in vivo is poorly understood. Here we show, using 5HT neuron-deficient Pet-1 (Pet-1(-/-)) neonates, that serotonergic function is required for the normal timing of postnatal respiratory matur...

    journal_title:Respiratory physiology & neurobiology

    pub_type: 杂志文章

    doi:10.1016/j.resp.2007.06.002

    authors: Erickson JT,Shafer G,Rossetti MD,Wilson CG,Deneris ES

    更新日期:2007-10-15 00:00:00

  • Spinal pathways mediating phrenic activation during high frequency spinal cord stimulation.

    abstract::High frequency spinal cord stimulation (HF-SCS) is a method of inspiratory muscle activation resulting in phrenic motoneuron activation via stimulation of spinal cord pathways. The specific pathways mediating this response, however, are unknown. The aim of this study was to assess the potential role of upper cervical ...

    journal_title:Respiratory physiology & neurobiology

    pub_type: 杂志文章

    doi:10.1016/j.resp.2012.12.003

    authors: Dimarco AF,Kowalski KE

    更新日期:2013-03-01 00:00:00

  • M(1)/M(3) and M(2)/M(4) muscarinic receptor double-knockout mice present distinct respiratory phenotypes.

    abstract::We investigated the role of muscarinic acetylcholine receptors in the control of breathing. Baseline breathing at rest and ventilatory responses to brief exposures to hypoxia (10% O(2)) and hypercapnia (3% and 5% CO(2)), measured by whole-body plethysmography in partially restrained animals, were compared in mice lack...

    journal_title:Respiratory physiology & neurobiology

    pub_type: 杂志文章

    doi:10.1016/j.resp.2007.12.001

    authors: Boudinot E,Champagnat J,Foutz AS

    更新日期:2008-03-20 00:00:00

  • Circadian dependence of receptors that mediate wake-related excitatory drive to hypoglossal motoneurons.

    abstract::Serotonin (5-HT), norepinephrine and orexins (ORX) are the three best established mediators of wake-related activation of hypoglossal (XII) motoneurons that innervate the muscles of the tongue. Since the tongue's use is temporarily closely aligned with the rest-activity cycle, we tested whether expression of mRNA for ...

    journal_title:Respiratory physiology & neurobiology

    pub_type: 杂志文章

    doi:10.1016/j.resp.2013.04.024

    authors: Volgin DV,Stettner GM,Kubin L

    更新日期:2013-09-15 00:00:00

  • Hypoxic incubation creates differential morphological effects during specific developmental critical windows in the embryo of the chicken (Gallus gallus).

    abstract::Hypoxia inhibits vertebrate development, but the magnitude and timing of organ-specific effects are poorly understood. Chick embryos were exposed continuously to hypoxia (15% O2) throughout Days 1-6, 6-12, 12-18 or Days 1-18 of development, followed by morphometric measurements of major organ systems. Early hypoxic ex...

    journal_title:Respiratory physiology & neurobiology

    pub_type: 杂志文章

    doi:10.1016/j.resp.2004.09.005

    authors: Chan T,Burggren W

    更新日期:2005-02-15 00:00:00

  • Low exertional inspiratory capacity is not related to dynamic inspiratory muscle weakness in heart failure.

    abstract::Reduction in inspiratory capacity (IC) during exercise has been reported in chronic heart failure (CHF). Since inspiratory muscle dysfunction may be present to a variable degree, the assumption that IC reduction during exercise represents an increase in end-expiratory lung volume must be made with caution. This interp...

    journal_title:Respiratory physiology & neurobiology

    pub_type: 杂志文章

    doi:10.1016/j.resp.2018.04.005

    authors: Plachi F,Balzan FM,Gass R,Dorneles RG,Zambiazi R,da Silva DP,Sanches PR,Clausell NO,Berton DC

    更新日期:2018-08-01 00:00:00

  • Pulmonary mechanics and lung histology in acute lung injury induced by Bothrops jararaca venom.

    abstract::Pulmonary mechanics [static (Est) and dynamic (Edyn) elastances, resistive (DeltaP1) and viscoelastic pressures (DeltaP2)], histology, and bronchoalveolar lavage fluid (BALF) from BALB/c mice were analysed 1, 24, 48 and 72 h after intravenous injection of saline or Bothrops jararaca crude venom [0.3 (V0.3) or 1 (V1) m...

    journal_title:Respiratory physiology & neurobiology

    pub_type: 杂志文章

    doi:10.1016/j.resp.2003.10.002

    authors: Silveira KS,Boechem NT,do Nascimento SM,Murakami YL,Barboza AP,Melo PA,Castro P,de Moraes VL,Rocco PR,Zin WA

    更新日期:2004-01-15 00:00:00

  • Sensitivity of bronchopulmonary receptors to cold and heat mediated by transient receptor potential cation channel subtypes in an ex vivo rat lung preparation.

    abstract::Changes in airway temperature can result in respiratory responses such as cough, bronchoconstriction and mucosal secretion after cold exposure and hyperventilation after heat exposure. In the present investigation, we examined the activity of bronchopulmonary receptors in response to activators of thermo-sensitive tra...

    journal_title:Respiratory physiology & neurobiology

    pub_type: 杂志文章

    doi:10.1016/j.resp.2011.05.011

    authors: Zhou Y,Sun B,Li Q,Luo P,Dong L,Rong W

    更新日期:2011-08-15 00:00:00

  • Dynamics of oxygen uptake following exercise onset in rat skeletal muscle.

    abstract::Technical limitations have precluded measurement of the V(O(2)) profile within contracting muscle (mV(O(2))) and hence it is not known to what extent V(O(2)) dynamics measured across limbs in humans or muscles in the dog are influenced by transit delays between the muscle microvasculature and venous effluent. Measurem...

    journal_title:Respiratory physiology & neurobiology

    pub_type: 杂志文章

    doi:10.1016/s1569-9048(02)00183-0

    authors: Behnke BJ,Barstow TJ,Kindig CA,McDonough P,Musch TI,Poole DC

    更新日期:2002-11-19 00:00:00

  • An astrocyte toxin influences the pattern of breathing and the ventilatory response to hypercapnia in neonatal rats.

    abstract::Recent in vitro data suggest that astrocytes may modulate respiration. To examine this question in vivo, we treated 5-day-old rat pups with methionine sulfoximine (MS), a compound that alters carbohydrate and glutamate metabolism in astrocytes, but not neurons. MS-treated pups displayed a reduced breathing frequency (...

    journal_title:Respiratory physiology & neurobiology

    pub_type: 杂志文章

    doi:10.1016/j.resp.2005.01.009

    authors: Young JK,Dreshaj IA,Wilson CG,Martin RJ,Zaidi SI,Haxhiu MA

    更新日期:2005-05-12 00:00:00

  • Vascular KATP channels mitigate severe muscle O2 delivery-utilization mismatch during contractions in chronic heart failure rats.

    abstract::The vascular ATP-sensitive K+ (KATP) channel is a mediator of skeletal muscle microvascular oxygenation (PO2mv) during contractions in health. We tested the hypothesis that KATP channel function is preserved in chronic heart failure (CHF) and therefore its inhibition would reduce PO2mv and exacerbate the time taken to...

    journal_title:Respiratory physiology & neurobiology

    pub_type: 杂志文章

    doi:10.1016/j.resp.2017.01.009

    authors: Holdsworth CT,Ferguson SK,Colburn TD,Fees AJ,Craig JC,Hirai DM,Poole DC,Musch TI

    更新日期:2017-04-01 00:00:00