Effects of prolonged exercise to exhaustion on left-ventricular function and pulmonary gas exchange.


:The purpose of this study was to simultaneously examine left-ventricular (LV) function and pulmonary gas exchange during prolonged constant-rate cycling in an attempt to explain the exercise-induced impairment in gas exchange. Eleven competitive cyclists rode their racing bicycles on a computerized cycle trainer at 25 W below the lactate threshold until exhaustion (exercise time = 2.51 +/- 0.86 h). LV systolic function was evaluated with two-dimensional echocardiography while arterial blood gases were used to assess pulmonary gas exchange. All variables were assessed concurrently before, during, and after exercise. LV function and cardiac output increased at the onset of exercise and were maintained until exhaustion. The alveolar-arterial P(O(2)) difference (A-a D(O(2))) increased within 15 min of the onset of exercise, was unchanged through to exhaustion, and returned to baseline 5 min post-exercise. Gas exchange was not related to cardiovascular function at the onset, or at end exercise. The results indicate that the widening A-aD(O(2)) during exercise is due to a readily reversible change in gas exchange function.


Stickland MK,Anderson WD,Haykowsky MJ,Welsh RC,Petersen SR,Jones RL





Has Abstract


2004-09-15 00:00:00














  • Overview: the neurochemistry of respiratory control.

    abstract::This special issue of Respiratory Physiology and Neurobiology surveys a broad range of topics focused on the neurochemical control of breathing. A variety of approaches have integrated the neurochemistry of breathing with the physiology of individual neurons, with the neuroanatomy of brainstem and forebrain respirator...

    journal_title:Respiratory physiology & neurobiology

    pub_type: 社论


    authors: McCrimmon DR,Mitchell GS,Alheid GF

    更新日期:2008-12-10 00:00:00

  • Posture primarily affects lung tissue distribution with minor effect on blood flow and ventilation.

    abstract::We used quantitative single photon emission computed tomography to estimate the proportion of the observed redistribution of blood flow and ventilation that is due to lung tissue shift with a change in posture. Seven healthy volunteers were studied awake, breathing spontaneously. Regional blood flow and ventilation we...

    journal_title:Respiratory physiology & neurobiology

    pub_type: 杂志文章


    authors: Petersson J,Rohdin M,Sánchez-Crespo A,Nyrén S,Jacobsson H,Larsson SA,Lindahl SG,Linnarsson D,Neradilek B,Polissar NL,Glenny RW,Mure M

    更新日期:2007-06-15 00:00:00

  • Endogenous glutamatergic inputs to the Parabrachial Nucleus/Kölliker-Fuse Complex determine respiratory rate.

    abstract::The Kölliker-Fuse Nucleus (KF) has been widely investigated for its contribution to "inspiratory off-switch" while more recent studies showed that activation of the Parabrachial Nucleus (PBN) shortened expiratory duration. This study used an adult, in vivo, decerebrate rabbit model to delineate the contribution of eac...

    journal_title:Respiratory physiology & neurobiology

    pub_type: 杂志文章


    authors: Navarrete-Opazo AA,Cook-Snyder DR,Miller JR,Callison JJ,McCarthy N,Palkovic B,Stuth EAE,Zuperku EJ,Stucke AG

    更新日期:2020-06-01 00:00:00

  • Aerobic exercise training without weight loss reduces dyspnea on exertion in obese women.

    abstract::Dyspnea on exertion (DOE) is a common symptom in obesity. We investigated whether aerobic exercise training without weight loss could reduce DOE. Twenty-two otherwise healthy obese women participated in a 12-week supervised aerobic exercise training program, exercising 30 min/day at 70-80% heart rate reserve, 4 days/w...

    journal_title:Respiratory physiology & neurobiology

    pub_type: 杂志文章


    authors: Bernhardt V,Stickford JL,Bhammar DM,Babb TG

    更新日期:2016-01-15 00:00:00

  • Short-term cardiovascular and autonomic effects of inhaled salbutamol.

    abstract::Asthma independently increases the risk of developing cardiovascular disease. As inhaled β-agonists have systemic cardiovascular effects, and elevations in arterial stiffness and sympathetic nerve activity are associated with increased cardiovascular morbidity/mortality, this study examines the effect of salbutamol us...

    journal_title:Respiratory physiology & neurobiology

    pub_type: 杂志文章


    authors: Edgell H,Moore LE,Chung C,Byers BW,Stickland MK

    更新日期:2016-09-01 00:00:00

  • Genetic CLC-1 chloride channel deficiency modifies diaphragm muscle isometric contractile properties.

    abstract::Genetic deficiency of the muscle chloride channel CLC-1 leads to myotonia congenita in humans as well as myotonia in mice and goats. The hallmark of myotonia is delayed muscle relaxation due to persistent electrical discharges in the muscle. The present study tested the hypothesis that performance of CLC-1 deficient d...

    journal_title:Respiratory physiology & neurobiology

    pub_type: 杂志文章


    authors: van Lunteren E,Moyer M,Pollarine J

    更新日期:2007-03-15 00:00:00

  • Prolonged partial obstruction during sleep is a NREM phenomenon.

    abstract:OBJECTIVE:Prolonged partial obstruction (PPO) is a common finding in sleep studies. Although not verified, it seems to emerge in deep sleep. We study the effect of PPO on sleep architecture or sleep electroencephalography (EEG) frequency. METHODS:Fifteen OSA patients, 15 PPO + OSA patients and 15 healthy subjects unde...

    journal_title:Respiratory physiology & neurobiology

    pub_type: 杂志文章


    authors: Himanen SL,Martikkala L,Sulkamo S,Rutanen A,Huupponen E,Tenhunen M,Saunamäki T

    更新日期:2018-09-01 00:00:00

  • Volume feedback during cough in anesthetized cats, effects of occlusions and modulation summary.

    abstract::The study investigates the effects of 6 occlusion conditions on the mechanically induced cough reflex in 15 anesthetized (pentobarbital) spontaneously breathing cats (14♂, 1♀). Esophageal pressure and integrated EMG activities of inspiratory (I) diaphragm and expiratory (E) abdominal muscles were recorded and analyzed...

    journal_title:Respiratory physiology & neurobiology

    pub_type: 杂志文章


    authors: Poliacek I,Veternik M,Martvon L,Simera M,Pitts T,Kotmanova Z,Babalova L,Kralikova O,Cibulkova L,Jakus J,Plevkova J

    更新日期:2021-01-01 00:00:00

  • Six-week inspiratory resistance training ameliorates endurance performance but does not affect obesity-related metabolic biomarkers in obese adults: A randomized controlled trial.

    abstract::This investigation examined the effects of a six-week inspiratory resistance training (IRT) on metabolic health biomarkers, pulmonary function, and endurance in obese individuals. Twenty-eight obese adults (BMI > 27 kg/m2 Taiwan obesity criteria) were randomly assigned to either IRT (IRT; N = 16) or sham control (PLA;...

    journal_title:Respiratory physiology & neurobiology

    pub_type: 杂志文章,随机对照试验


    authors: Kuo YC,Chang HL,Cheng CF,Mündel T,Liao YH

    更新日期:2020-02-01 00:00:00

  • Interaction of tobacco smoke exposure and ovalbumin-sensitization promotes goblet cell and submucosal gland metaplasia in guinea pigs.

    abstract::Exposure to irritants such as tobacco smoke (TS) causes acute airway inflammation. Chronic exposure may cause airway remodeling contributing to enhanced airway resistance. We hypothesize that combining airway sensitization and inhalation of irritants enhances the number of mucous producing cells beyond either agent al...

    journal_title:Respiratory physiology & neurobiology

    pub_type: 杂志文章


    authors: Pavuluri S,Hanus V,Bergren DR

    更新日期:2013-12-01 00:00:00

  • Regulation of alveolar fluid clearance and ENaC expression in lung by exogenous angiotensin II.

    abstract::Angiotensin II (Ang II) has been demonstrated as a pro-inflammatory effect in acute lung injury, but studies of the effect of Ang II on the formation of pulmonary edema and alveolar filling remains unclear. Therefore, in this study the regulation of alveolar fluid clearance (AFC) and the expression of epithelial sodiu...

    journal_title:Respiratory physiology & neurobiology

    pub_type: 杂志文章


    authors: Deng J,Wang DX,Deng W,Li CY,Tong J,Ma H

    更新日期:2012-04-15 00:00:00

  • Arrest of 5HT neuron differentiation delays respiratory maturation and impairs neonatal homeostatic responses to environmental challenges.

    abstract::Serotonin (5HT) is a powerful modulator of respiratory circuitry in vitro but its role in the development of breathing behavior in vivo is poorly understood. Here we show, using 5HT neuron-deficient Pet-1 (Pet-1(-/-)) neonates, that serotonergic function is required for the normal timing of postnatal respiratory matur...

    journal_title:Respiratory physiology & neurobiology

    pub_type: 杂志文章


    authors: Erickson JT,Shafer G,Rossetti MD,Wilson CG,Deneris ES

    更新日期:2007-10-15 00:00:00

  • Autophagy inhibition protects from alveolar barrier dysfunction in LPS-induced ALI mice by targeting alveolar epithelial cells.

    abstract:OBJECTIVE:The aim of this study was to investigate whether autophagy is enhanced in alveolar epithelial cells as well as its role in alveolar barrier function of in lipopolysaccharide (LPS)-induced ALI mice. MATERIALS AND METHODS:Autophagy inhibitors, including 3-methyladenine (3-MA) and chloroquine (CLQ), and LPS wer...

    journal_title:Respiratory physiology & neurobiology

    pub_type: 杂志文章


    authors: Guo L,Wu X,Zhao S,Zhang X,Qian G,Li S

    更新日期:2021-01-01 00:00:00

  • Inter-individual differences in control of alveolar capillary blood volume in exercise and hypoxia.

    abstract::We compared by non-invasive technique the adaptive response of alveolar capillary network to edemagenic conditions (exercise and high altitude [HA, PIO2 107mmHg] in subjects with different resting sea level (SL) capillary blood volume (normalized to alveolar volume, Vc/Va): Group 1 (N=10, Vc/Va=16.1±6.8ml/L- mean±SD) ...

    journal_title:Respiratory physiology & neurobiology

    pub_type: 杂志文章


    authors: Bartesaghi M,Beretta E,Pollastri L,Scotti V,Mandolesi G,Lanfranconi F,Miserocchi G

    更新日期:2014-01-01 00:00:00

  • TrkB is necessary for the normal development of the lung.

    abstract::Normal development of the lung requires coordinated activation of cascades of signaling pathways initiated by growth factors signaling through their receptors. TrkB and its ligands, brain-derived neurotrophic factor (BDNF) and neurotrophin-4, belong to the neurotrophin family of growth factors, which are expressed in ...

    journal_title:Respiratory physiology & neurobiology

    pub_type: 杂志文章


    authors: García-Suárez O,Pérez-Pinera P,Laurà R,Germana A,Esteban I,Cabo R,Silos-Santiago I,Cobo JL,Vega JA

    更新日期:2009-07-31 00:00:00

  • Respiratory inductive plethysmography to assess respiratory variability and complexity in humans.

    abstract::Human ventilation is aperiodic, exhibiting a breath-by-breath variability and a complexity of which the characteristics may be interesting physiologically and clinically. In the present study, we tested the ability of respiratory inductive plethysmography (RIP) to describe these properties. Indeed, RIP does not have t...

    journal_title:Respiratory physiology & neurobiology

    pub_type: 杂志文章


    authors: Fiamma MN,Samara Z,Baconnier P,Similowski T,Straus C

    更新日期:2007-05-14 00:00:00

  • Bronchial responsiveness in an elastase-induced mouse model of emphysema.

    abstract::Bronchial responsiveness during methacholine (MCh) challenge was analysed in an elastase-induced mouse model of emphysema to explore the magnitude of the response in this model. Swiss mice were intratracheally instilled with saline or elastase (0.3 or 0.6 U). Twenty days afterward, mechanical ventilation data were col...

    journal_title:Respiratory physiology & neurobiology

    pub_type: 杂志文章


    authors: Santos LM,de Brito Cervilha DA,Cabral LD,Garcia ÉK,Teixeira VP,Brito JM,Moriya HT,Soncini R

    更新日期:2014-04-01 00:00:00

  • Respiratory dynamics in phonation and breathing-A real-time MRI study.

    abstract::The respiratory system is a central part of voice production, but for phonation neither the underlying functional relations between diaphragm (DPH) and rib cage (RC), nor differences to normal breathing are yet understood. This study aims to compare respiratory dynamics in phonation and breathing via dynamic MRI of th...

    journal_title:Respiratory physiology & neurobiology

    pub_type: 杂志文章


    authors: Traser L,Özen AC,Burk F,Burdumy M,Bock M,Richter B,Echternach M

    更新日期:2017-02-01 00:00:00

  • Sleep-disordered breathing and oxidative stress in preclinical chronic mountain sickness (excessive erythrocytosis).

    abstract::Chronic mountain sickness (CMS) is considered to be a loss of ventilatory acclimatization to high altitude (>2500m) resulting in marked arterial hypoxemia and polycythemia. This case-control study explores the possibility that sleep-disordered breathing (SDB) and associated oxidative stress contribute to the etiology ...

    journal_title:Respiratory physiology & neurobiology

    pub_type: 杂志文章


    authors: Julian CG,Vargas E,Gonzales M,Dávila RD,Ladenburger A,Reardon L,Schoo C,Powers RW,Lee-Chiong T,Moore LG

    更新日期:2013-04-01 00:00:00

  • Effect of heavy-intensity 'priming' exercise on oxygen uptake and muscle deoxygenation kinetics during moderate-intensity step-transitions initiated from an elevated work rate.

    abstract::We examined the effect of heavy-intensity 'priming' exercise on the rate of adjustment of pulmonary O2 uptake (τV˙O2p) initiated from elevated intensities. Fourteen men (separated into two groups: τV˙O2p≤25s [Fast] or τV˙O2p>25s [Slow]) completed step-transitions from 20W to 45% lactate threshold (LT; lower-step, LS) ...

    journal_title:Respiratory physiology & neurobiology

    pub_type: 杂志文章


    authors: Nederveen JP,Keir DA,Love LK,Rossiter HB,Kowalchuk JM

    更新日期:2017-01-01 00:00:00

  • Developmental trajectories, critical windows and phenotypic alteration during cardio-respiratory development.

    abstract::Embryo-environment interactions affecting cardio-respiratory development in vertebrates have been extensively studied, but an equally extensive conceptual framework for interpreting and interrelating these developmental events has lagged behind. In this review, we consider the conceptual constructs of "developmental p...

    journal_title:Respiratory physiology & neurobiology

    pub_type: 杂志文章,评审


    authors: Burggren WW,Reyna KS

    更新日期:2011-08-31 00:00:00

  • Effects of dietary inorganic nitrate on static and dynamic breath-holding in humans.

    abstract::Inorganic nitrate has been shown to reduce oxygen cost during exercise. Since the nitrate-nitrite-NO pathway is facilitated during hypoxia, we investigated the effects of dietary nitrate on oxygen consumption and cardiovascular responses during apnea. These variables were measured in two randomized, double-blind, plac...

    journal_title:Respiratory physiology & neurobiology

    pub_type: 杂志文章,随机对照试验


    authors: Schiffer TA,Larsen FJ,Lundberg JO,Weitzberg E,Lindholm P

    更新日期:2013-01-15 00:00:00

  • Mice-to-men comparison of inhaled drug-aerosol deposition and clearance.

    abstract::Part of the effective prediction of the pharmacokinetics of drugs (or toxic particles) requires extrapolation of experimental data sets from animal studies to humans. As the respiratory tracts of rodents and humans are anatomically very different, there is a need to study airflow and drug-aerosol deposition patterns i...

    journal_title:Respiratory physiology & neurobiology

    pub_type: 杂志文章


    authors: Kolanjiyil AV,Kleinstreuer C,Kleinstreuer NC,Pham W,Sadikot RT

    更新日期:2019-02-01 00:00:00

  • Fasudil reversed MCT-induced and chronic hypoxia-induced pulmonary hypertension by attenuating oxidative stress and inhibiting the expression of Trx1 and HIF-1α.

    abstract::Antioxidant therapy attenuates pulmonary hypertension (PH). In the present study, we tested the antioxidant effects of fasudil against PH in rats. Monocrotaline (MCT)-induced and chronic hypoxia-induced PH models of rats were established, and the haemodynamic and pathomorphologic results of three different doses of fa...

    journal_title:Respiratory physiology & neurobiology

    pub_type: 杂志文章


    authors: Liu M,Wang Y,Zheng L,Zheng W,Dong K,Chen S,Zhang B,Li Z

    更新日期:2014-09-15 00:00:00

  • Hypocapnia is associated with increased upper airway expiratory resistance during sleep.

    abstract::We hypothesized that hypocapnia is responsible for increased expiratory resistance during NREM sleep. Hypocapnia was induced by hypoxic hyperventilation in 21 subjects (aged 29.4 ± 7.8 yrs, 10 women, BMI 24.4 ± 4.3 kg/m(2)). Isocapnic hypoxia was induced in 12 subjects of whom, 6 underwent hypocapnic hypoxia in the sa...

    journal_title:Respiratory physiology & neurobiology

    pub_type: 杂志文章


    authors: Sankri-Tarbichi AG,Richardson NN,Chowdhuri S,Rowley JA,Safwan Badr M

    更新日期:2011-07-31 00:00:00

  • Maximal O(2) consumption: Effects of gravity withdrawal and resumption.

    abstract::Maximal O(2) consumption (V(O)(2) max) is an index of integrated cardiopulmonary function. After having defined it, discussed its limitation, and described its measurement, we present data during and after space flight and simulation. During gravity withdrawal, V(O)(2) max stays unchanged. It suddenly drops when the s...

    journal_title:Respiratory physiology & neurobiology

    pub_type: 杂志文章


    authors: Ferretti G,Capelli C

    更新日期:2009-10-01 00:00:00

  • Salbutamol improves markers of epithelial function in mice with chronic allergic pulmonary inflammation.

    abstract::We investigated the effects of salbutamol on the markers of epithelial function in a murine model of chronic allergic pulmonary inflammation by recording the ciliary beat frequency (CBF) and the transepithelial potential difference (PD) in vivo. Mice were sensitized and received four challenges of ovalbumin (OVA group...

    journal_title:Respiratory physiology & neurobiology

    pub_type: 杂志文章


    authors: Toledo AC,Arantes-Costa FM,Macchione M,Saldiva PH,Negri EM,Lorenzi-Filho G,Martins MA

    更新日期:2011-07-31 00:00:00

  • Trophic factor expression in phrenic motor neurons.

    abstract::The function of a motor neuron and the muscle fibers it innervates (i.e., a motor unit) determines neuromotor output. Unlike other skeletal muscles, respiratory muscles (e.g., the diaphragm, DIAm) must function from birth onwards in sustaining ventilation. DIAm motor units are capable of both ventilatory and non-venti...

    journal_title:Respiratory physiology & neurobiology

    pub_type: 杂志文章,评审


    authors: Mantilla CB,Sieck GC

    更新日期:2008-12-10 00:00:00

  • A critical postnatal period of heightened vulnerability to lipopolysaccharide.

    abstract::Evidence of respiratory abnormalities and vulnerability to infection during a critical period of development have been implicated in Sudden Infant Death Syndrome (SIDS). Here we investigated whether the acute hypoxic ventilatory response (HVR) exhibits a heightened vulnerability to the endotoxin lipopolysaccharide (LP...

    journal_title:Respiratory physiology & neurobiology

    pub_type: 杂志文章


    authors: Rourke KS,Mayer CA,MacFarlane PM

    更新日期:2016-10-01 00:00:00

  • Neural drive to respiratory muscles in the spontaneously breathing rat pup.

    abstract::The neonatal rodent serves as useful and appropriate model within which to study respiratory system development. Despite an extensive literature that documents respiratory control in vitro, in vivo studies have relied upon whole body plethysmography to determine measures of respiratory frequency and tidal volume. Howe...

    journal_title:Respiratory physiology & neurobiology

    pub_type: 杂志文章


    authors: Kidder IJ,Mudery JA,Bailey EF

    更新日期:2014-10-01 00:00:00