当前位置： SCI文献检索 > RESPIRATORY PHYSIOLOGY & NEUROBIOLOGY期刊下所有文献 > Apnoeic response to stimulation of peripheral GABA receptors in rats.

Apnoeic response to stimulation of peripheral GABA receptors in rats.

Abstract：

:Respiratory effects of intracarotid injection of gamma-amino-butyric acid (GABA) were investigated in two groups of rats. In the first group of 12 rats the effects of GABA were checked in the intact state, following bilateral vagotomy and GABA receptor blockade. The second group consisted of five initially vagotomized rats, challenged with GABA prior to and after bilateral carotid chemodenervation (CSN-cut). All rats were urethane and chloralose anaesthetized and spontaneously breathing. Injection of 39 micromol/kg GABA prior to and after vagotomy induced an expiratory apnoea of, respectively 5.5+/-0.84 sec and 3.9+/-0.6 sec duration (mean+/-S.E.M.), P>0.05 in all 12 rats. In breaths that followed the apnoea tidal volume increased above the control level by 23.3% (P<0.01) and 25.6% (P<0.01) pre- and post-vagotomy, respectively. Blockade of GABA receptors with bicuculline and picrotoxin abolished the inhibition of breathing. In five vagotomized rats with intact carotid sinus nerves (CSNs) intracarotid GABA challenge increased tidal volume by 39% compared with baseline breathing (P<0.05). Section of the CSNs precluded the occurrence of apnoea and undergoing respiratory changes evoked by GABA. Intracarotid GABA caused significant decrease in the mean blood pressure independent of the neural state, but the fall was delayed by CSNs neurotomy. Results of this study indicate that GABA given systemically induces apnoea followed by post-apnoeic hyperventilation. Carotid bodies are required for the ventilatory response to GABA; vagal afferents are not involved in this response.

journal_name

Respir Physiol Neurobiol

journal_title

Respiratory physiology & neurobiology

authors

Kaczyńska K,Szereda-Przestaszewska M

doi

10.1016/s1569-9048(02)00021-6

keywords:

subject

Has Abstract

pub_date

2002-08-01 00:00:00

pages

189-97

issue

3

eissn

1569-9048

issn

1878-1519

pii

S1569904802000216

journal_volume

131

pub_type

杂志文章

相关文献

RESPIRATORY PHYSIOLOGY & NEUROBIOLOGY文献大全
  • Interaction between defects in ventilatory and thermoregulatory control in mice lacking 5-HT neurons.

    abstract：:We have previously shown that mice with near-complete absence of 5-HT neurons (Lmx1bf/f/p) display a blunted hypercapnic ventilatory response (HCVR) and impaired cold-induced thermogenesis, but have normal baseline ventilation (), core body temperature (TCore) and hypoxic ventilatory responses (HVR) at warm ambient te...

    journal_title：Respiratory physiology & neurobiology

    pub_type： 杂志文章

    doi：10.1016/j.resp.2008.08.003

    authors： Hodges MR,Richerson GB

    更新日期：2008-12-31 00:00:00

  • Allergen challenge during halothane compared to isoflurane anesthesia induces a more potent peripheral lung response.

    abstract：:Allergen instillation in anaesthetized vs. awake animals results in increased distribution of allergen in the lung. Halothane is a more potent bronchodilator of the small airways than isoflurane. As small airways contribute to asthma pathogenesis, we questioned whether intranasal challenge under halothane vs. isoflura...

    journal_title：Respiratory physiology & neurobiology

    pub_type： 杂志文章

    doi：10.1016/j.resp.2013.07.005

    authors： Borges MC,Marchica CL,Narayanan V,Ludwig MS

    更新日期：2013-10-01 00:00:00

  • Respiratory control during air-breathing exercise in humans following an 8 h exposure to hypoxia.

    abstract：:Hypoxic exposure lasting a few hours results in an elevation of ventilation and a lowering of end-tidal P(CO2) (P(ET(CO2))) that persists on return to breathing air. We sought to determine whether this increment in ventilation is fixed (hypothesis 1), or whether it increases in proportion to the rise in metabolic rate...

    journal_title：Respiratory physiology & neurobiology

    pub_type： 临床试验,杂志文章

    doi：10.1016/j.resp.2008.06.008

    authors： Herigstad M,Fatemian M,Robbins PA

    更新日期：2008-08-31 00:00:00

  • Effect of chronic heart failure in older rats on respiratory muscle and hindlimb blood flow during submaximal exercise.

    abstract：:Submaximal exercise diaphragm blood flow (BF) is elevated in young chronic heart failure (CHF) rats, while it is unknown if this occurs in older animals. Respiratory and hindlimb muscle BFs (radiolabeled microspheres) were measured at rest and during submaximal exercise (20m/min, 5% grade) in older healthy (n=7) and C...

    journal_title：Respiratory physiology & neurobiology

    pub_type： 杂志文章

    doi：10.1016/j.resp.2017.05.002

    authors： Smith JR,Hageman KS,Harms CA,Poole DC,Musch TI

    更新日期：2017-09-01 00:00:00

  • Non-invasive CPAP in mild and moderate ARDS secondary to SARS-CoV-2.

    abstract：BACKGROUND:During the COVID-19 outbreak, a very high number of infected patients developed pneumonia and many of them complicated with acute respiratory distress syndrome. The optimal management of respiratory failure and the role of lung ultrasound imaging in the evaluation of efficacy of treatment are unknown. METHO...

    journal_title：Respiratory physiology & neurobiology

    pub_type： 杂志文章

    doi：10.1016/j.resp.2020.103489

    authors： Pagano A,Porta G,Bosso G,Allegorico E,Serra C,Dello Vicario F,Minerva V,Russo T,Altruda C,Arbo P,Mercurio V,Numis FG

    更新日期：2020-09-01 00:00:00

  • Neuromodulation of hypoglossal motoneurons during sleep.

    abstract：:Hypoglossal motoneurons are influenced by a variety of neuromodulators, some of which change dynamically across sleep-wake states to alter motoneuron excitability and responses to pharmacological manipulations. Determining the mechanisms underlying the modulation of hypoglossal motoneurons during sleep is relevant to ...

    journal_title：Respiratory physiology & neurobiology

    pub_type： 杂志文章,评审

    doi：10.1016/j.resp.2008.06.012

    authors： Horner RL

    更新日期：2008-12-10 00:00:00

  • An acute exposure to intermittent negative airway pressure elicits respiratory long-term facilitation in awake humans.

    abstract：BACKGROUND:A sustained elevation in respiratory drive following removal of the inducing stimulus is known as respiratory long-term facilitation (rLTF). We investigated whether an acute exposure to intermittent negative airway pressure (INAP) elicits rLTF in humans. METHOD:13 healthy males (20.9 ± 2.8 years) undertook ...

    journal_title：Respiratory physiology & neurobiology

    pub_type： 杂志文章

    doi：10.1016/j.resp.2019.05.016

    authors： Griffin HS,Al Humoud S,Benson JG,Cooper BG,Coomaraswamy K,Balanos GM

    更新日期：2019-09-01 00:00:00

  • Ventilatory responses to acute hypoxia in neurokinin-1 receptor deficient mice.

    abstract：:The regulatory effect of substance P on respiration is mediated via neurokinin (NK) receptors. While previous studies suggest that NK-1 receptors are involved, little is known about the role NK-2 receptors in ventilatory responses to hypoxia. Ventilatory responses to acute hypoxia (8% O2 in N2) were measured by indire...

    journal_title：Respiratory physiology & neurobiology

    pub_type： 杂志文章

    doi：10.1016/j.resp.2007.07.012

    authors： Grasemann H,Gerard NP,De Sanctis GT

    更新日期：2007-11-15 00:00:00

  • Prelimbic prefrontal cortex mediates respiratory responses to mild and potent prolonged, but not brief, stressors.

    abstract：:The prefrontal cortex is one of the key areas of the central mechanism of cardiovascular and respiratory control. Disinhibition of the prelimbic medial prefrontal cortex elicits tachypnoeic responses in anesthetized rats (Hassan et al., J. Physiol. 591: 6069-6088, 2013). The current study examines the effects of inhib...

    journal_title：Respiratory physiology & neurobiology

    pub_type： 杂志文章

    doi：10.1016/j.resp.2014.07.009

    authors： Bondarenko E,Hodgson DM,Nalivaiko E

    更新日期：2014-12-01 00:00:00

  • Nasal high-frequency oscillatory ventilation inhibits gastroesophageal reflux in the neonatal period.

    abstract：:Nasal high-frequency oscillatory ventilation (nHFOV) in neonates is increasingly considered due to enhanced alveolar ventilation, absence of patient-ventilator asynchrony and lessened ventilator-induced lung injury. Although any type of non-invasive respiratory support can lead to gastric distension via esophageal air...

    journal_title：Respiratory physiology & neurobiology

    pub_type： 杂志文章

    doi：10.1016/j.resp.2018.02.003

    authors： Cantin D,Djeddi D,Samson N,Nadeau C,Praud JP

    更新日期：2018-05-01 00:00:00

  • Comparisons of effects of intravenous and inhaled methacholine on airway physiology in a murine asthma model.

    abstract：:Airway responses to intravenous (i.v.) and inhaled (i.h.) delivery of methacholine (MCh) in BALB/c and C57BL/6 mouse strains have been compared with and without ovalbumin (OVA)-induced airway inflammation. Bronchial reactivity to MCh was assessed in anaesthetised and tracheostomised animals by using an animal ventilat...

    journal_title：Respiratory physiology & neurobiology

    pub_type： 杂志文章

    doi：10.1016/j.resp.2008.12.005

    authors： Jonasson S,Hedenstierna G,Hedenström H,Hjoberg J

    更新日期：2009-02-28 00:00:00

  • Nitric oxide inhibitor altitude-dependently elevates pulmonary arterial pressure in high-altitude adapted yaks.

    abstract：:We studied the effect of N(w)-nitro-L-arginine (NLA) on yak pulmonary vascular tone in a climatic (hypobaric/hyperbaric adjusted) chamber. Five young male yaks that had been born and reared at an altitude greater than 3800 m a.s.l. were used. After measuring control values, 20 mg/kg of NLA was administered via the jug...

    journal_title：Respiratory physiology & neurobiology

    pub_type： 杂志文章

    doi：10.1016/j.resp.2004.12.002

    authors： Ishizaki T,Koizumi T,Ruan Z,Wang Z,Chen Q,Sakai A

    更新日期：2005-04-15 00:00:00

  • Airway nociceptors activated by pro-inflammatory cytokines.

    abstract：:The present studies evaluate whether the vagus nerves link the lungs' immune and neural systems by transmitting information through pulmonary nociceptors. Single unit activities from pulmonary nociceptors [C fiber receptors (CFRs) and high threshold Adelta fiber receptors (HTARs)] were recorded from the cervical vagus...

    journal_title：Respiratory physiology & neurobiology

    pub_type： 杂志文章

    doi：10.1016/j.resp.2006.11.005

    authors： Yu J,Lin S,Zhang J,Otmishi P,Guardiola JJ

    更新日期：2007-05-14 00:00:00

  • The sensing of respiratory gases in fish: Mechanisms and signalling pathways.

    abstract：:Chemoreception in fish is critical for sensing changes in the chemical composition of the external and internal environments and is often the first step in a cascade of events leading to cardiorespiratory and metabolic adjustments. Of paramount importance is the ability to sense changes in the levels of the three resp...

    journal_title：Respiratory physiology & neurobiology

    pub_type： 杂志文章,评审

    doi：10.1016/j.resp.2015.06.007

    authors： Perry SF,Tzaneva V

    更新日期：2016-04-01 00:00:00

  • Time course of ventilatory acclimatisation to hypoxia in a model of anemic transgenic mice.

    abstract：:We questioned the assumption that polycythemia is essential for adaptation to chronic hypoxia. Thus, the objective of our study was to determine if anemic Epo-TAg(h) mice could survive in hypoxia despite low oxygen carrying capacity. We explored the possibility that ventilatory acclimatisation is involved in the strat...

    journal_title：Respiratory physiology & neurobiology

    pub_type： 杂志文章

    doi：10.1016/j.resp.2005.08.006

    authors： Macarlupú JL,Buvry A,Morel OE,León-Velarde F,Richalet JP,Favret F

    更新日期：2006-08-01 00:00:00

  • Ovarian steroids act as respiratory stimulant and antioxidant against the causes and consequences of sleep-apnea in women.

    abstract：:Evidence supports the importance of ovarian hormones as potential tools against sleep apneas in women. On one hand, progesterone is largely acknowledged as being a respiratory stimulant that reduces the frequency of apneas, but the underlying mechanisms remain poorly understood. Recent studies in mice showed that the ...

    journal_title：Respiratory physiology & neurobiology

    pub_type： 杂志文章,评审

    doi：10.1016/j.resp.2017.01.013

    authors： Boukari R,Laouafa S,Ribon-Demars A,Bairam A,Joseph V

    更新日期：2017-05-01 00:00:00

  • Right and left vagus nerves regulate breathing by multiplicative interaction.

    abstract：:Although it has been recognized for more than a century, we still do not know how the two vagus nerves interact to produce Hering-Breuer reflex. In the current study, we tested the hypothesis that the vagus nerves interact via a multiplicative effect. We examined the Hering-Breuer reflex before and after unilateral (f...

    journal_title：Respiratory physiology & neurobiology

    pub_type： 杂志文章

    doi：10.1016/j.resp.2015.07.015

    authors： Song N,Liu J,Proctor M,Yu J

    更新日期：2015-12-01 00:00:00

  • Early application of caffeine improves white matter development in very preterm infants.

    abstract：:The aim of this study was to evaluate the effect of early prophylactic caffeine treatment on white matter development in very preterm infants using cerebral magnetic resonance imaging. A total of 194 preterm infants (≤32 weeks gestational age) were randomly assigned to the caffeine (n = 96) or placebo (n = 93) treatme...

    journal_title：Respiratory physiology & neurobiology

    pub_type： 杂志文章

    doi：10.1016/j.resp.2020.103495

    authors： Liu S,Zhang X,Liu Y,Yuan X,Yang L,Zhang R,Zhang X,Wang X,Xu F,Zhu C

    更新日期：2020-10-01 00:00:00

  • Effects on breathing of agonists to μ-opioid or GABAA receptors dialyzed into the ventral respiratory column of awake and sleeping goats.

    abstract：:Pulmonary ventilation (V̇I) in awake and sleeping goats does not change when antagonists to several excitatory G protein-coupled receptors are dialyzed unilaterally into the ventral respiratory column (VRC). Concomitant changes in excitatory neuromodulators in the effluent mock cerebral spinal fluid (mCSF) suggest neu...

    journal_title：Respiratory physiology & neurobiology

    pub_type： 杂志文章

    doi：10.1016/j.resp.2017.01.007

    authors： Langer TM 3rd,Neumueller SE,Crumley E,Burgraff NJ,Talwar S,Hodges MR,Pan L,Forster HV

    更新日期：2017-05-01 00:00:00

  • Electric synapses in the carotid body-nerve complex.

    abstract：:Slices of rat carotid bodies, or cultured glomus cells, were used to study intercellular coupling. This phenomenon occurs because gap junctions allow passage of currents and dyes from one cell to another. There is a two-way resistive coupling between glomus cells (GC/GC coupling), which is accompanied by activity of i...

    journal_title：Respiratory physiology & neurobiology

    pub_type： 杂志文章,评审

    doi：10.1016/j.resp.2007.01.013

    authors： Eyzaguirre C

    更新日期：2007-07-01 00:00:00

  • Correlations between the circadian patterns of body temperature, metabolism and breathing in rats.

    abstract：:It had been demonstrated previously that the circadian patterns of activity and state of arousal are not essential for the manifestation of the daily patterns of pulmonary ventilation (V(E)), tidal volume (V(T)) and breathing frequency (f). In this study we investigated the extent of the linkage between the circadian ...

    journal_title：Respiratory physiology & neurobiology

    pub_type： 杂志文章

    doi：10.1016/j.resp.2006.05.007

    authors： Mortola JP

    更新日期：2007-02-15 00:00:00

  • Abraham Guz memorial: Still unresolved hypotheses: Lung reflexes and perceptions of breathing.

    abstract：:This article constitutes a review of the studies performed by the group of the late A. Guz and other authors on the subjects of lung reflexes and perceptions of respiration. The experimental data suggest that the lung inflation and deflation reflexes are present in man, mediated by large myelinated afferent nerve fibr...

    journal_title：Respiratory physiology & neurobiology

    pub_type： 历史文章,杂志文章,评审

    doi：10.1016/j.resp.2015.06.005

    authors： Noble MI

    更新日期：2015-10-01 00:00:00

  • Role of aquaporins in lung liquid physiology.

    abstract：:Aquaporins (AQPs) are small, integral membrane proteins that facilitate water transport across cell membranes in response to osmotic gradients. Water transport across epithelia and endothelia in the peripheral lung and airways occurs during airway hydration, alveolar fluid transport and submucosal gland secretion. Sev...

    journal_title：Respiratory physiology & neurobiology

    pub_type： 杂志文章,评审

    doi：10.1016/j.resp.2007.02.012

    authors： Verkman AS

    更新日期：2007-12-15 00:00:00

  • Hypoxic incubation creates differential morphological effects during specific developmental critical windows in the embryo of the chicken (Gallus gallus).

    abstract：:Hypoxia inhibits vertebrate development, but the magnitude and timing of organ-specific effects are poorly understood. Chick embryos were exposed continuously to hypoxia (15% O2) throughout Days 1-6, 6-12, 12-18 or Days 1-18 of development, followed by morphometric measurements of major organ systems. Early hypoxic ex...

    journal_title：Respiratory physiology & neurobiology

    pub_type： 杂志文章

    doi：10.1016/j.resp.2004.09.005

    authors： Chan T,Burggren W

    更新日期：2005-02-15 00:00:00

  • Vascular KATP channels mitigate severe muscle O2 delivery-utilization mismatch during contractions in chronic heart failure rats.

    abstract：:The vascular ATP-sensitive K+ (KATP) channel is a mediator of skeletal muscle microvascular oxygenation (PO2mv) during contractions in health. We tested the hypothesis that KATP channel function is preserved in chronic heart failure (CHF) and therefore its inhibition would reduce PO2mv and exacerbate the time taken to...

    journal_title：Respiratory physiology & neurobiology

    pub_type： 杂志文章

    doi：10.1016/j.resp.2017.01.009

    authors： Holdsworth CT,Ferguson SK,Colburn TD,Fees AJ,Craig JC,Hirai DM,Poole DC,Musch TI

    更新日期：2017-04-01 00:00:00

  • Impact of sleep disordered breathing on carotid body size.

    abstract：:We tested the hypotheses that: (1) carotid body size can be measured by computed tomographic angiography (CTA) with high inter-observer agreement, and (2) patients with sleep apnea exhibit larger carotid bodies than those without sleep apnea. A chart review was conducted from patients who underwent neck CTA and polyso...

    journal_title：Respiratory physiology & neurobiology

    pub_type： 杂志文章

    doi：10.1016/j.resp.2016.10.013

    authors： Welch BT,Petersen-Jones HG,Eugene AR,Brinjikji W,Kallmes DF,Curry TB,Joyner MJ,Limberg JK

    更新日期：2017-02-01 00:00:00

  • Arrest of 5HT neuron differentiation delays respiratory maturation and impairs neonatal homeostatic responses to environmental challenges.

    abstract：:Serotonin (5HT) is a powerful modulator of respiratory circuitry in vitro but its role in the development of breathing behavior in vivo is poorly understood. Here we show, using 5HT neuron-deficient Pet-1 (Pet-1(-/-)) neonates, that serotonergic function is required for the normal timing of postnatal respiratory matur...

    journal_title：Respiratory physiology & neurobiology

    pub_type： 杂志文章

    doi：10.1016/j.resp.2007.06.002

    authors： Erickson JT,Shafer G,Rossetti MD,Wilson CG,Deneris ES

    更新日期：2007-10-15 00:00:00

  • Validation of a quantitative method to measure neural respiratory drive in children during sleep.

    abstract：AIMS:Quantitatively measure and validate analysis of neural respiratory drive (NRD) using a commercial polysomnography system in children during sleep. METHOD:Surface electromyogram of the diaphragm (sEMGdi) recorded from primary snoring children were analysed. A subset was re-analysed to assess intra- and inter-inves...

    journal_title：Respiratory physiology & neurobiology

    pub_type： 杂志文章

    doi：10.1016/j.resp.2017.02.004

    authors： Chuang SY,Teng A,Butler JE,Gandevia SC,Selvadurai H,Jaffe A

    更新日期：2017-05-01 00:00:00

  • Semi-automated assessment of transdiaphragmatic pressure variability across motor behaviors.

    abstract：:We developed and tested a semi-automated algorithm to generate large data sets of ventilatory information (amplitude, premotor drive and timing) across a range of motor behaviors. Adult spontaneously breathing, anesthetized mice (n = 27) underwent measurements of transdiaphragmatic pressure (Pdi) during eupnea, hypoxi...

    journal_title：Respiratory physiology & neurobiology

    pub_type： 杂志文章

    doi：10.1016/j.resp.2015.05.009

    authors： Medina-Martínez JS,Greising SM,Sieck GC,Mantilla CB

    更新日期：2015-08-15 00:00:00

  • Ontogenesis of oxygen chemoreception in aquatic vertebrates.

    abstract：:In aquatic vertebrates, peripheral O(2) chemoreceptors initiate compensatory physiological and behavioural responses to hypoxia, beginning at very early stages of development, to maintain sufficient gas exchange across the skin or gills. This review highlights the morphological and physiological studies, particularly ...

    journal_title：Respiratory physiology & neurobiology

    pub_type： 杂志文章,评审

    doi：10.1016/j.resp.2006.01.004

    authors： Jonz MG,Nurse CA

    更新日期：2006-11-01 00:00:00