Abstract:
:Functional genomics is a systematic and high-throughput effort to analyze the functions of genes and gene products. Functional genomics is divided into gene- and phenotype-driven approaches. Gene-driven approaches to the functional genomics of sleep have demonstrated that transcripts of many genes change as a function of behavioral state. A phenotype-driven approach includes identification and characterization of gene function through the analyses of natural polygenic traits, creation of transgenic animals or high-throughput mutagenesis. Identification of a gene for narcolepsy through QTL analyses and concomitantly using a transgenic approach is one example of the phenotype-driven approach to the functional genomics of sleep. Though the majority of functional genomics is currently performed in mice, the rat is emerging as an important model for genomic research. Since rest in Drosophila shares many features with mammalian sleep, this allows a comparative functional genomics approach to the study of rest and sleep. The concepts outlined here for the functional genomics of sleep are applicable to respiration research.
journal_name
Respir Physiol Neurobioljournal_title
Respiratory physiology & neurobiologyauthors
Mackiewicz M,Pack AIdoi
10.1016/s1569-9048(03)00045-4keywords:
subject
Has Abstractpub_date
2003-05-30 00:00:00pages
207-20issue
2-3eissn
1569-9048issn
1878-1519pii
S1569904803000454journal_volume
135pub_type
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journal_title:Respiratory physiology & neurobiology
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journal_title:Respiratory physiology & neurobiology
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journal_title:Respiratory physiology & neurobiology
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journal_title:Respiratory physiology & neurobiology
pub_type: 临床试验,杂志文章
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journal_title:Respiratory physiology & neurobiology
pub_type: 杂志文章
doi:10.1016/j.resp.2012.11.010
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journal_title:Respiratory physiology & neurobiology
pub_type: 杂志文章,评审
doi:10.1016/j.resp.2008.05.010
更新日期:2008-11-30 00:00:00
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journal_title:Respiratory physiology & neurobiology
pub_type: 杂志文章
doi:10.1016/s1569-9048(02)00149-0
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journal_title:Respiratory physiology & neurobiology
pub_type: 杂志文章
doi:10.1016/j.resp.2012.12.003
更新日期:2013-03-01 00:00:00
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journal_title:Respiratory physiology & neurobiology
pub_type: 杂志文章
doi:10.1016/j.resp.2011.02.001
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journal_title:Respiratory physiology & neurobiology
pub_type: 杂志文章,评审
doi:10.1016/j.resp.2006.01.004
更新日期:2006-11-01 00:00:00
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journal_title:Respiratory physiology & neurobiology
pub_type: 杂志文章,随机对照试验
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更新日期:2017-09-01 00:00:00
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journal_title:Respiratory physiology & neurobiology
pub_type: 杂志文章,评审
doi:10.1016/j.resp.2008.07.018
更新日期:2008-12-10 00:00:00
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journal_title:Respiratory physiology & neurobiology
pub_type: 杂志文章
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journal_title:Respiratory physiology & neurobiology
pub_type: 杂志文章
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journal_title:Respiratory physiology & neurobiology
pub_type: 杂志文章,评审
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journal_title:Respiratory physiology & neurobiology
pub_type: 杂志文章
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journal_title:Respiratory physiology & neurobiology
pub_type: 杂志文章
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更新日期:2008-12-31 00:00:00
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journal_title:Respiratory physiology & neurobiology
pub_type: 杂志文章
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journal_title:Respiratory physiology & neurobiology
pub_type: 杂志文章
doi:10.1016/j.resp.2004.09.005
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pub_type: 杂志文章
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journal_title:Respiratory physiology & neurobiology
pub_type: 杂志文章
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journal_title:Respiratory physiology & neurobiology
pub_type: 杂志文章,评审
doi:10.1016/j.resp.2005.07.009
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journal_title:Respiratory physiology & neurobiology
pub_type: 杂志文章
doi:10.1016/j.resp.2005.08.003
更新日期:2006-06-01 00:00:00