Abstract:
:This review summarizes the recent neuroanatomical and physiological studies that form the neural basis for the state-dependent changes in airway resistance. Here, we review only the interactions between the brain regions generating quiet (non-rapid eye movement, NREM) and active (rapid eye movement, REM) sleep stages and CNS pathways controlling cholinergic outflow to the airways. During NREM and REM sleep, bronchoconstrictive responses are heightened and conductivity of the airways is lower as compared to the waking state. The decrease in conductivity of the lower airways parallels the sleep-induced decline in the discharge of brainstem monoaminergic cell groups and GABAergic neurons of the ventrolateral periaqueductal midbrain region, all of which provide inhibitory inputs to airway-related vagal preganglionic neurons (AVPNs). Withdrawal of central inhibitory influences to AVPNs results in a shift from inhibitory to excitatory transmission that leads to an increase in airway responsiveness, cholinergic outflow to the lower airways and consequently, bronchoconstriction. In healthy subjects, these changes are clinically unnoticed. However, in patients with bronchial asthma, sleep-related alterations in lung functions are troublesome, causing intensified bronchopulmonary symptoms (nocturnal asthma), frequent arousals, decreased quality of life, and increased mortality. Unquestionably, the studies revealing neural mechanisms that underlie sleep-related alterations of airway function will provide new directions in the treatment and prevention of sleep-induced worsening of airway diseases.
journal_name
Respir Physiol Neurobioljournal_title
Respiratory physiology & neurobiologyauthors
Haxhiu MA,Rust CF,Brooks C,Kc Pdoi
10.1016/j.resp.2005.07.009keywords:
subject
Has Abstractpub_date
2006-03-28 00:00:00pages
1-30issue
1eissn
1569-9048issn
1878-1519pii
S1569-9048(05)00205-3journal_volume
151pub_type
杂志文章,评审abstract::Chronic exposure to sustained hyperoxia alters the development of the respiratory control system, but the respiratory effects of chronic intermittent hyperoxia have rarely been investigated. We exposed newborn rats to short, repeated bouts of 30% O2 or 60% O2 (5 bouts h(-1)) for 4-15 days and then assessed their hypox...
journal_title:Respiratory physiology & neurobiology
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journal_title:Respiratory physiology & neurobiology
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pub_type: 临床试验,杂志文章
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journal_title:Respiratory physiology & neurobiology
pub_type: 杂志文章
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journal_title:Respiratory physiology & neurobiology
pub_type: 杂志文章
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journal_title:Respiratory physiology & neurobiology
pub_type: 杂志文章
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journal_title:Respiratory physiology & neurobiology
pub_type: 杂志文章
doi:10.1016/j.resp.2018.03.011
更新日期:2018-11-01 00:00:00
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journal_title:Respiratory physiology & neurobiology
pub_type: 杂志文章
doi:10.1016/j.resp.2008.01.003
更新日期:2008-04-30 00:00:00
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journal_title:Respiratory physiology & neurobiology
pub_type: 杂志文章
doi:10.1016/j.resp.2018.10.006
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journal_title:Respiratory physiology & neurobiology
pub_type: 杂志文章
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更新日期:2021-01-06 00:00:00
abstract::Despite its necessity for understanding healthy brain aging, the influence of exercise intensity on cerebrovascular kinetics is currently unknown. We, therefore characterized middle cerebral artery blood flow velocity (MCAv) kinetics associated with two exercise intensities: low and moderate. We hypothesized that incr...
journal_title:Respiratory physiology & neurobiology
pub_type: 杂志文章
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journal_title:Respiratory physiology & neurobiology
pub_type: 杂志文章
doi:10.1016/j.resp.2007.09.012
更新日期:2008-02-01 00:00:00
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journal_title:Respiratory physiology & neurobiology
pub_type: 杂志文章,评审
doi:10.1016/j.resp.2013.04.010
更新日期:2013-09-15 00:00:00
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journal_title:Respiratory physiology & neurobiology
pub_type: 杂志文章,评审
doi:10.1016/j.resp.2015.09.017
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journal_title:Respiratory physiology & neurobiology
pub_type: 杂志文章
doi:10.1016/j.resp.2006.07.003
更新日期:2007-03-15 00:00:00
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journal_title:Respiratory physiology & neurobiology
pub_type: 杂志文章
doi:10.1016/j.resp.2016.07.008
更新日期:2016-11-01 00:00:00
abstract::Chronically hypoxic humans and some mammals have attenuated ventilatory responses, which have been associated with high dopamine level in carotid bodies. Alveolar hypoventilation and blunted ventilatory response have been recognized to be at the basis of Chronic Mountain Sickness by generating arterial hypoxemia and p...
journal_title:Respiratory physiology & neurobiology
pub_type: 杂志文章
doi:10.1016/s1569-9048(03)00065-x
更新日期:2003-04-15 00:00:00
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journal_title:Respiratory physiology & neurobiology
pub_type: 杂志文章
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journal_title:Respiratory physiology & neurobiology
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journal_title:Respiratory physiology & neurobiology
pub_type: 杂志文章
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更新日期:2005-04-15 00:00:00
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journal_title:Respiratory physiology & neurobiology
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journal_title:Respiratory physiology & neurobiology
pub_type: 杂志文章
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journal_title:Respiratory physiology & neurobiology
pub_type: 杂志文章
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journal_title:Respiratory physiology & neurobiology
pub_type: 杂志文章
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更新日期:2016-04-01 00:00:00
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journal_title:Respiratory physiology & neurobiology
pub_type: 杂志文章,评审
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更新日期:2008-11-30 00:00:00
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journal_title:Respiratory physiology & neurobiology
pub_type: 杂志文章,评审
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journal_title:Respiratory physiology & neurobiology
pub_type: 杂志文章
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更新日期:2016-08-01 00:00:00
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journal_title:Respiratory physiology & neurobiology
pub_type: 杂志文章
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更新日期:2007-04-16 00:00:00
abstract::Asthma is a chronic inflammatory disease, with an array of cells involved in the pathogenesis of the disease. The role of neutrophils in the development of bronchial asthma is found to be complex, as they may trigger activation of immunocompetent cells and are a potent source of free oxygen radicals and enzymes partic...
journal_title:Respiratory physiology & neurobiology
pub_type: 杂志文章,评审
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journal_title:Respiratory physiology & neurobiology
pub_type: 杂志文章
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