Intermittent hypoxia-induced cardiorespiratory long-term facilitation: A new role for microglia.

Abstract:

:Intermittent hypoxia induces plasticity in neural networks controlling breathing and cardiovascular function. Studies demonstrate that mechanisms causing cardiorespiratory plasticity rely on intracellular signalling pathways that are activated by specific neurotransmitters. Peptides such as serotonin, PACAP and orexin are well-known for their physiological significance in regulating the cardiorespiratory system. Their receptor counterparts are present in cardiorespiratory centres of the brainstem medulla and spinal cord. Microglial cells are also important players in inducing plasticity. The phenotype and function of microglial cells can change based on the physiological state of the central nervous system. Here, we propose that in the autonomic nuclei of the ventral brainstem the relationship between neurotransmitters and neurokines, neurons and microglia determines the overall neural function of the central cardiorespiratory system.

authors

Kim SJ,Kim YJ,Kakall Z,Farnham MM,Pilowsky PM

doi

10.1016/j.resp.2016.03.012

subject

Has Abstract

pub_date

2016-06-01 00:00:00

pages

30-8

eissn

1569-9048

issn

1878-1519

pii

S1569-9048(16)30029-5

journal_volume

226

pub_type

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