Abstract：
:We assessed upper airway responses to acute and chronic inspiratory loading. In Experiment I, 11 healthy subjects underwent T(2)-weighted magnetic resonance imaging (MRI) of upper airway dilator muscles (genioglossus and geniohyoid) before and up to 10 min after a single bout of pressure threshold inspiratory muscle training (IMT) at 60% maximal inspiratory mouth pressure (MIP). T(2) values for genioglossus and geniohyoid were increased versus control (p<0.001), suggesting that these airway dilator muscles are activated in response to acute IMT. In Experiment II, nine subjects underwent 2D-Flash sequence MRI of the upper airway during quiet breathing and while performing single inspirations against resistive loads (10%, 30% and 50% MIP); this procedure was repeated after 6 weeks of IMT. Lateral narrowing of the upper airway occurred at all loads, whilst anteroposterior narrowing occurred at the level of the laryngopharynx at loads > or =30% MIP. Changes in upper airway morphology and narrowing after IMT were undetectable using MRI.
journal_name
Respir Physiol Neurobioljournal_title
Respiratory physiology & neurobiologyauthors
How SC,McConnell AK,Taylor BJ,Romer LMdoi
10.1016/j.resp.2007.01.008subject
Has Abstractpub_date
2007-08-01 00:00:00pages
270-80issue
2-3eissn
1569-9048issn
1878-1519pii
S1569-9048(07)00013-4journal_volume
157pub_type
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