Abstract:
:Previously we have reported that association of cigarette smoke (CS) and chronic hypoxia (CH) interact positively to physiopathologically remodel pulmonary circulation. In present study we have exposed guinea pigs to CS smoke (four cigarettes/day; 3 months; CS) and to chronic hypoxia (12% O(2), 15 days; CH) alone or in combination (CSCH animals) and evaluated airways remodeling and resistance assessed as Penh (enhance pause). We measured Penh while animals breathe air, 10% O(2) and 5% CO(2) and found that CS and CH animals have higher Penh than controls; Penh was even larger in CSCH animals. A rough parallelism between Penh and thickness of bronchiolar wall and muscular layer and Goblet cell number was noticed. We conclude that CS and CH association accelerates CS-induced respiratory system damage, evidenced by augmented airway resistance, bronchial wall thickness and muscularization and Goblet cell number. Our findings would suggest that appearance of hypoxia would aggravate any preexisting pulmonary pathology by increasing airways resistance and reactivity.
journal_name
Respir Physiol Neurobioljournal_title
Respiratory physiology & neurobiologyauthors
Olea E,Ferrer E,Prieto-Lloret J,Gonzalez-Martin C,Vega-Agapito V,Gonzalez-Obeso E,Agapito T,Peinado V,Obeso A,Barbera JA,Gonzalez Cdoi
10.1016/j.resp.2011.09.013subject
Has Abstractpub_date
2011-12-15 00:00:00pages
305-13issue
2-3eissn
1569-9048issn
1878-1519pii
S1569-9048(11)00347-8journal_volume
179pub_type
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journal_title:Respiratory physiology & neurobiology
pub_type: 临床试验,杂志文章
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journal_title:Respiratory physiology & neurobiology
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pub_type: 杂志文章
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