Abstract:
:Previously we have reported that association of cigarette smoke (CS) and chronic hypoxia (CH) interact positively to physiopathologically remodel pulmonary circulation. In present study we have exposed guinea pigs to CS smoke (four cigarettes/day; 3 months; CS) and to chronic hypoxia (12% O(2), 15 days; CH) alone or in combination (CSCH animals) and evaluated airways remodeling and resistance assessed as Penh (enhance pause). We measured Penh while animals breathe air, 10% O(2) and 5% CO(2) and found that CS and CH animals have higher Penh than controls; Penh was even larger in CSCH animals. A rough parallelism between Penh and thickness of bronchiolar wall and muscular layer and Goblet cell number was noticed. We conclude that CS and CH association accelerates CS-induced respiratory system damage, evidenced by augmented airway resistance, bronchial wall thickness and muscularization and Goblet cell number. Our findings would suggest that appearance of hypoxia would aggravate any preexisting pulmonary pathology by increasing airways resistance and reactivity.
journal_name
Respir Physiol Neurobioljournal_title
Respiratory physiology & neurobiologyauthors
Olea E,Ferrer E,Prieto-Lloret J,Gonzalez-Martin C,Vega-Agapito V,Gonzalez-Obeso E,Agapito T,Peinado V,Obeso A,Barbera JA,Gonzalez Cdoi
10.1016/j.resp.2011.09.013subject
Has Abstractpub_date
2011-12-15 00:00:00pages
305-13issue
2-3eissn
1569-9048issn
1878-1519pii
S1569-9048(11)00347-8journal_volume
179pub_type
杂志文章abstract:BACKGROUND:A sustained elevation in respiratory drive following removal of the inducing stimulus is known as respiratory long-term facilitation (rLTF). We investigated whether an acute exposure to intermittent negative airway pressure (INAP) elicits rLTF in humans. METHOD:13 healthy males (20.9 ± 2.8 years) undertook ...
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pub_type: 杂志文章,随机对照试验
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journal_title:Respiratory physiology & neurobiology
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journal_title:Respiratory physiology & neurobiology
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journal_title:Respiratory physiology & neurobiology
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journal_title:Respiratory physiology & neurobiology
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journal_title:Respiratory physiology & neurobiology
pub_type: 杂志文章
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更新日期:2011-07-31 00:00:00
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journal_title:Respiratory physiology & neurobiology
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更新日期:2015-04-01 00:00:00
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journal_title:Respiratory physiology & neurobiology
pub_type: 杂志文章
doi:10.1016/j.resp.2007.10.010
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journal_title:Respiratory physiology & neurobiology
pub_type: 杂志文章
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更新日期:2012-04-30 00:00:00
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journal_title:Respiratory physiology & neurobiology
pub_type: 杂志文章
doi:10.1016/j.resp.2004.07.017
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journal_title:Respiratory physiology & neurobiology
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abstract::Chronic mountain sickness (CMS) is considered to be a loss of ventilatory acclimatization to high altitude (>2500m) resulting in marked arterial hypoxemia and polycythemia. This case-control study explores the possibility that sleep-disordered breathing (SDB) and associated oxidative stress contribute to the etiology ...
journal_title:Respiratory physiology & neurobiology
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